Transcriptome profiling of mouse colonic eosinophils reveals a key role for eosinophils in the induction of s100a8 and s100a9 in mucosal healing
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Eosinophils are bone marrow-derived cells that have been largely implicated in Th2-associated diseases. Recent data highlights a key role for eosinophils in mucosal innate immune responses especially in the gastrointestinal (GI) tract, which is one of the largest eosinophil reservoirs in the body. Although eosinophils express and synthesize a plethora of proteins that can mediate their effector activities, the transcriptome signature of eosinophils in mucosal inflammation and subsequent repair has been considerably overlooked. We demonstrate that eosinophils are recruited to the colon in acute inflammatory stages where they promote intestinal inflammation and remain in substantial numbers throughout the mucosal healing process. Microarray analysis of primary colonic eosinophils that were sorted at distinct stages of mucosal inflammation and repair revealed dynamic regulation of colonic eosinophil mRNA expression. The clinically relevant genes s100a8 and s100a9 were strikingly increased in colonic eosinophils (up to 550-fold and 80-fold, respectively). Furthermore, local and systemic expression of s100a8 and s100a9 were nearly diminished in eosinophil-deficient ΔdblGATA mice, and were re-constituted upon adoptive transfer of eosinophils. Taken together, these data may provide new insight into the involvement of eosinophils in colonic inflammation and repair, which may have diagnostic and therapeutic implications.
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S100A8/A9 is recognized as both a biomarker of colitis and a promoter of inflammation-associated tumorigenesis.
“Importantly, S100A8/A9 has been recognized as both a biomarker of colitis and a promoter of inflammation-associated tumorigenesis [16–18].”
From Inhibition of SPI1 by ADAP Regulates S100A8/A9 Signaling in Macrophages to Control the Development of Colitis (2026) · cites this paper as [18]
The Results and Discussion report increased S100A8/A9 expression during experimental colitis, including in colonic biopsies and serum, which supports its association with colitis but does not establish it as a validated biomarker. The Discussion links S100A8/A9 to cancer and says these proteins can facilitate cancer-cell migration; it does not establish that they promote inflammation-associated tumorigenesis. No page numbers are available in our copy. (LLM, conf=0.84)
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Szklarczyk, D., Morris, J. H., Cook, H., Kuhn, M., Wyder, S., Simonovic, M., Santos, A., Doncheva, N. T., Roth, A., Bork, P., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkw937 · Cited by 6,980 · see citing works
Rothenberg, M. E., & Hogan, S. P. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090720 · Cited by 1,356 · see citing works
Eosinophils: changing perspectives in health and disease
Rosenberg, H. F., Dyer, K. D., & Foster, P. S. (2012) · Nature reviews. Immunology · doi:10.1038/nri3341 · Cited by 994 · see citing works
Ehrchen, J. M., Sunderkötter, C. H., Foell, D., Vogl, T., & Roth, J. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1008647 · Cited by 848 · see citing works
Self-citationType 2 Innate Signals Stimulate Fibro/Adipogenic Progenitors to Facilitate Muscle Regeneration
Heredia, J. E., Mukundan, L., Chen, F. M., Mueller, A. A., Deo, R. C., Locksley, R. M., Rando, T. A., & Chawla, A. (2013) · Cell · doi:10.1016/j.cell.2013.02.053 · Cited by 818 · see citing works
Zigmond, E., Varol, C., Farache, J., Elmaliah, E., Satpathy, A. T., Friedlander, G., Mack, M., Shpigel, N. Y., Boneca, I. G., MURPHY, K. M. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.08.026 · Cited by 742 · see citing works
Straumann, A., Spichtin, H., Grize, L., Bucher, K. A., Beglinger, C., & Simon, H. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.09.024 · Cited by 712 · see citing works
S100A8 and S100A9 in inflammation and cancer
Gebhardt, C., Németh, J., Angel, P., & Hess, J. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.05.017 · Cited by 696 · see citing works
Eosinophil-associated TGF-β1 mRNA Expression and Airways Fibrosis in Bronchial Asthma
Minshall, E. M., Leung, D. Y. M., Martin, R. J., Song, Y., Cameron, L., Ernst, P., & Hamid, Q. A. (1997) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.17.3.2733 · Cited by 634 · see citing works
Esophageal remodeling in pediatric eosinophilic esophagitis
Aceves, S. S., Newbury, R., Dohil, R., Bastian, J. F., & Broide, D. H. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.10.016 · Cited by 429 · see citing works
Soufli, I., Toumi, R., Rafa, H., & Touil–Boukoffa, C. (2016) · World Journal of Gastrointestinal Pharmacology and Therapeutics · doi:10.4292/wjgpt.v7.i3.353 · Cited by 344 · see citing works
Eosinophils in health and disease: the LIAR hypothesis
Lee, J. J., Jacobsen, E. A., McGarry, M. P., Schleimer, R. P., & Lee, N. A. (2010) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2010.03484.x · Cited by 335 · see citing works
A role for eosinophils in airway remodelling in asthma
Kay, A. B., Phipps, S., & Robinson, D. S. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.07.006 · Cited by 316 · see citing works
Chu, V. T., Beller, A. V., Rausch, S., Strandmark, J., Zänker, M., Arbach, O., Kruglov, A., & Berek, C. (2014) · Immunity · doi:10.1016/j.immuni.2014.02.014 · Cited by 314 · see citing works
Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair
Knipper, J., Willenborg, S., Brinckmann, J., Bloch, W., Maaß, T., Wagener, R., Krieg, T., Sutherland, T., Munitz, A., Rothenberg, M., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.09.005 · Cited by 313 · see citing works
Self-citationEosinophils secrete IL-4 to facilitate liver regeneration
Goh, Y. P. S., Henderson, N. C., Heredia, J. E., Eagle, A. R., Odegaard, J. I., Lehwald, N., Nguyen, K. D., Sheppard, D., Mukundan, L., Locksley, R. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304046110 · Cited by 281 · see citing works
Ohno, I., Nitta, Y., Yamauchi, K., Hoshi, H., Honma, M., Woolley, K. L., O’Byrne, P. M., Tamura, G., Jordana, M., & Shirato, K. (1996) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.15.3.8810646 · Cited by 258 · see citing works
Horiuchi, T., & Weller, P. F. (1997) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.17.1.2796 · Cited by 238 · see citing works
Rothenberg, M. E., Mishra, A., Brandt, E. B., & Hogan, S. P. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.790114.x · Cited by 235 · see citing works
Vogl, T., Gharibyan, A. L., & Morozova‐Roche, L. A. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13032893 · Cited by 212 · see citing works
Self-citationLevi‐Schaffer, F., Garbuzenko, E., Rubin, A., Reich, R., Pickholz, D., Gillery, P., Emonard, H., Nagler, A., & Maquart, F. X. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9660 · Cited by 206 · see citing works
Eosinophils: ‘new’ roles for ‘old’ cells
Munitz, A., & Levi‐Schaffer, F. (2004) · Allergy · doi:10.1111/j.1398-9995.2003.00442.x · Cited by 195 · see citing works
Self-citationAlarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity
Vogl, T., Eisenblätter, M., Völler, T., Zenker, S., Hermann, S., van Lent, P., Faust, A., Geyer, C., Petersen, B., Roebrock, K., et al. (2014) · Nature Communications · doi:10.1038/ncomms5593 · Cited by 193 · see citing works
Self-citationAhrens, R., Waddell, A., Seidu, L., Blanchard, C., Carey, R. G., Forbes, E., Lampinen, M., Wilson, T. S., Cohen, E., Stringer, K. F., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.7390 · Cited by 164 · see citing works
Self-citationImmunopathogenesis of Experimental Ulcerative Colitis Is Mediated by Eosinophil Peroxidase
Forbes, E., Murase, T., Yang, M., Matthaei, K. I., Lee, J. J., Lee, N. A., Foster, P. S., & Hogan, S. P. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.9.5664 · Cited by 159 · see citing works
Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis
Masterson, J. C., McNamee, E. N., Fillon, S., Hosford, L., Harris, R. F., Fernando, S. D., Jedlicka, P., Iwamoto, R., Jacobsen, E. A., Protheroe, C. A., et al. (2014) · Gut · doi:10.1136/gutjnl-2014-306998 · Cited by 149 · see citing works
Eosinophils alter colonic epithelial barrier function: role for major basic protein
Furuta, G. T., Nieuwenhuis, E. E. S., Karhausen, J., Gleich, G. J., Blumberg, R. S., Lee, J. J., & Ackerman, S. J. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00015.2005 · Cited by 148 · see citing works
Koenders, M. I., Marijnissen, R. J., Devesa, I., Lubberts, E., Joosten, L. A. B., Roth, J., van Lent, P. L. E. M., van de Loo, F. A. J., & van den Berg, W. B. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30418 · Cited by 138 · see citing works
Self-citationWaddell, A., Ahrens, R., Steinbrecher, K. A., Donovan, B., Rothenberg, M. E., Munitz, A., & Hogan, S. P. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003844 · Cited by 104 · see citing works
Self-citationShea‐Donohue, T., Thomas, K., Cody, M. J., Zhao, A., DeTolla, L. J., Kopydlowski, K. M., Fukata, M., Lira, S. A., & Vogel, S. N. (2008) · Innate Immunity · doi:10.1177/1753425908088724 · Cited by 102 · see citing works
Vieira, A. T., Fagundes, C. T., Alessandri, A. L., Castor, M. G. M. E., Guabiraba, R., Borges, V. O., da Silveira, K. D., Vieira, É. L. M., Gonçalves, J. L., Silva, T. A., et al. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090093 · Cited by 92 · see citing works
The eosinophil and airway remodelling in asthma
Venge, P. (2010) · The Clinical Respiratory Journal · doi:10.1111/j.1752-699x.2010.00192.x · Cited by 64 · see citing works
CD300f associates with IL-4 receptor α and amplifies IL-4–induced immune cell responses
Moshkovits, I., Karo-Atar, D., Itan, M., Reichman, H., Rozenberg, P., Morgenstern-Ben-Baruch, N., Shik, D., Ejarque‐Ortíz, A., Hershko, A., Tian, L.-J., et al. (2015) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1507625112 · Cited by 63 · see citing works
Self-citationResistin-like molecule α enhances myeloid cell activation and promotes colitis
Munitz, A., Waddell, A., Seidu, L., Cole, E. T., Ahrens, R., Hogan, S. P., & Rothenberg, M. E. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.10.017 · Cited by 62 · see citing works
Self-citationSIRPα/CD172a Regulates Eosinophil Homeostasis
García, N. V., Umemoto, E., Saito, Y., Yamasaki, M., Hata, E., Matozaki, T., Murakami, M., Jung, Y.-J., Woo, S., Seoh, J., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101008 · Cited by 60 · see citing works
Morgenstern, N. B.-B., Shik, D., Moshkovits, I., Itan, M., Karo‐Atar, D., Bouffi, C., Fulkerson, P. C., Rashkovan, D., Jung, S., Rothenberg, M. E., et al. (2013) · Nature Immunology · doi:10.1038/ni.2757 · Cited by 59 · see citing works
Self-citationRismo, R., Olsen, T., Cui, G., Paulssen, E. J., Christiansen, I., Johnsen, K., Florholmen, J., & Goll, R. (2013) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2012.758773 · Cited by 58 · see citing works
Munitz, A., Cole, E. T., Beichler, A., Groschwitz, K. R., Ahrens, R., Steinbrecher, K. A., Willson, T. A., Han, X., Denson, L. A., Rothenberg, M. E., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.04.006 · Cited by 56 · see citing works
Self-citationThe role of eosinophil major basic protein in angiogenesis
Puxeddu, I., Berkman, N., Efraim, A. H. N. B., Davies, D. E., Ribatti, D., Gleich, G. J., & Levi‐Schaffer, F. (2008) · Allergy · doi:10.1111/j.1398-9995.2008.01822.x · Cited by 54 · see citing works
A protective role for IL-13 receptor α 1 in bleomycin-induced pulmonary injury and repair
Karo‐Atar, D., Bordowitz, A., Wand, O., Pasmanik‐Chor, M., Fernandez, I. E., Itan, M., Frenkel, R., Herbert, D. R., Finkelman, F. D., Eickelberg, O., et al. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.56 · Cited by 50 · see citing works
Self-citationMaltby, S., Wohlfarth, C., Gold, M., Zbytnuik, L. D., Hughes, M. R., & McNagny, K. M. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.100191 · Cited by 47 · see citing works
IL-13 Receptor α1 Differentially Regulates Aeroallergen-Induced Lung Responses
Rothenberg, M. E., Wen, T., Shik, D., Cole, E. T., Mingler, M. M., & Munitz, A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004159 · Cited by 45 · see citing works
Self-citationTNFα ‐ and IL ‐17A‐mediated S100 A 8 expression is regulated by p38 MAPK
Mose, M., Kang, Z., Raaby, L., Iversen, L., & Johansen, C. (2013) · Experimental Dermatology · doi:10.1111/exd.12187 · Cited by 44 · see citing works
Curran, C. S., & Bertics, P. J. (2011) · International Immunology · doi:10.1093/intimm/dxr083 · Cited by 43 · see citing works
Munitz, A., Cole, E. T., Karo‐Atar, D., Finkelman, F. D., & Rothenberg, M. E. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0391oc · Cited by 40 · see citing works
Self-citationNovel model of TH2-polarized chronic ileitis: The SAMP1 mouse
McNamee, E. N., Wermers, J. D., Masterson, J. C., Collins, C. B., Lebsack, M. D. P., Fillon, S., Robinson, Z. D., Grenawalt, J., Lee, J. J., Jedlicka, P., et al. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21148 · Cited by 38 · see citing works
Waddell, A., Ahrens, R., Tsai, Y.-T., Sherrill, J. D., Denson, L. A., Steinbrecher, K. A., & Hogan, S. P. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1200057 · Cited by 37 · see citing works
CMRF35-like molecule 1 (CLM-1) regulates eosinophil homeostasis by suppressing cellular chemotaxis
Moshkovits, I., Shik, D., Itan, M., Karo‐Atar, D., Bernshtein, B., Hershko, A. Y., Campagne, M. V. L., & Munitz, A. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.47 · Cited by 35 · see citing works
Self-citationInhibitory receptors on myeloid cells: New targets for therapy?
Munitz, A. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.10.007 · Cited by 34 · see citing works
Self-citationThe therapeutic value of targeting inflammation in gastrointestinal cancers
Sun, B., & Karin, M. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.04.011 · Cited by 34 · see citing works
Osborne, L. C., Joyce, K. L., Alenghat, T., Sonnenberg, G. F., Giacomin, P., Du, Y., Bergstrom, K., Vallance, B. A., & Nair, M. G. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1200706 · Cited by 33 · see citing works
Karo‐Atar, D., Moshkovits, I., Eickelberg, O., Königshoff, M., & Munitz, A. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0329oc · Cited by 31 · see citing works
Self-citationMucosal healing in the era of biologic agents in treatment of inflammatory bowel disease
Florholmen, J. (2014) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2014.977943 · Cited by 30 · see citing works
S100A9 as a Pharmacological Target Molecule in Inflammation and Cancer
Leanderson, T., Liberg, D., & Ivars, F. (2015) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530315666150316123854 · Cited by 27 · see citing works
A key requirement for CD300f in innate immune responses of eosinophils in colitis
Moshkovits, I., Reichman, H., Karo‐Atar, D., Rozenberg, P., Zigmond, E., Haberman, Y., Morgenstern, N. B.-B., Lampinen, M., Carlson, M., Itan, M., et al. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.37 · Cited by 27 · see citing works
Self-citationInterleukin‐33 requires CMRF 35‐like molecule‐1 expression for induction of myeloid cell activation
Shik, D., Moshkovits, I., Karo‐Atar, D., Reichman, H., & Munitz, A. (2014) · Allergy · doi:10.1111/all.12388 · Cited by 25 · see citing works
Self-citationAlbert, E. J., Duplisea, J. J., Dawicki, W., Haidl, I. D., & Marshall, J. S. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.11.041 · Cited by 21 · see citing works
Curran, C., & Bertics, P. (2012) · Journal of Interferon and Cytokine Research · doi:10.1089/jir.2011.0111 · Cited by 20 · see citing works
Morgenstern, N. B.-B., Mingler, M. K., Stucke, E. M., Besse, J. A., Wen, T., Reichman, H., Munitz, A., & Rothenberg, M. E. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501873 · Cited by 19 · see citing works
Self-citationGrundström, J., Linton, L., Thunberg, S., Forsslund, H., Janczewska, I., Befrits, R., van Hage, M., Gafvelin, G., & Eberhardson, M. (2012) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2012.04600.x · Cited by 18 · see citing works
Phagocyte-specific S100 proteins in the local response to theEchinococcus granulosuslarva
Basika, T., Muñoz‐Wolf, N., Casaravilla, C., Irigoı́n, F., Batthyány, C., Bonilla, M., Salinas, G., Pacheco, J. P., ROTH, J., Durán, R., et al. (2012) · Parasitology · doi:10.1017/s003118201100179x · Cited by 17 · see citing works
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Wang, S., Song, R., Wang, Z., Jing, Z., Wang, S., & Ma, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01298 · Cited by 1,450 · see citing works
Calprotectin: from biomarker to biological function
Jukic, A., Bakiri, L., Wagner, E. F., Tilg, H., & Adolph, T. E. (2021) · Gut · doi:10.1136/gutjnl-2021-324855 · Cited by 500 · see citing works
Lombardi, C., Berti, A., & Cottini, M. (2022) · Current Research in Immunology · doi:10.1016/j.crimmu.2022.03.002 · Cited by 122 · see citing works
Schneider, N., Chandran, P., Sundby, M., Visioli, F., Gonçalves, F. D. C., Burks, S. R., Paz, A. H. D. R., & Frank, J. A. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.06.033 · Cited by 117 · see citing works
The Cellular Functions of Eosinophils: Collegium Internationale Allergologicum (CIA) Update 2020
Simon, H., Yousefi, S., Germič, N., Arnold, I. C., Haczku, A., Karaulov, A. V., Simon, D., & Rosenberg, H. F. (2019) · International Archives of Allergy and Immunology · doi:10.1159/000504847 · Cited by 103 · see citing works
Jacobs, I., Ceulemans, M., Wauters, L. I., Breynaert, C. M., Vermeire, S., Verstockt, B., & Vanuytsel, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.754413 · Cited by 72 · see citing works
The aryl hydrocarbon receptor contributes to tissue adaptation of intestinal eosinophils in mice
Diny, N. L., Schonfeldova, B., Shapiro, M., Winder, M. L., Varsani-Brown, S., & Stockinger, B. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20210970 · Cited by 69 · see citing works
Dolitzky, A., Shapira, G., Grisaru‐Tal, S., Hazut, I., Avlas, S., Gordon, Y., Itan, M., Shomron, N., & Munitz, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.802839 · Cited by 56 · see citing works
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Cui, A., Li, B., Wallace, M. S., Gonye, A. L. K., Oetheimer, C., Patel, H., Tonnerre, P., Holmes, J. A., Lieb, D., Yao, B. S., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2023.02.040 · Cited by 46 · see citing works
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Rodrigo-Muñoz, J. M., Gil‐Martínez, M., Sastre, B., & del Pozo, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137075 · Cited by 46 · see citing works
Masterson, J. C., Menard-Katcher, C. D., Larsen, L. D., Furuta, G. T., & Spencer, L. A. (2021) · Cells · doi:10.3390/cells10020426 · Cited by 36 · see citing works
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Dolitzky, A., Hazut, I., Avlas, S., Grisaru‐Tal, S., Itan, M., Zaffran, I., Levi‐Schaffer, F., Gerlic, M., & Munitz, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1041660 · Cited by 18 · see citing works
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Wang, Z., Adachi, S., Kong, L., Watanabe, D., Nakanishi, Y., Ohteki, T., Hoshi, N., & Kodama, Y. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.02.056 · Cited by 14 · see citing works
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Toledo-Pons, N., Noell, G. G., Jahn, A., Iglesias, A., Durán, M. A., Iglesias, J., Ríos, Á., Scrimini, S., Faner, R., Gigirey, O., et al. (2018) · Respiratory Research · doi:10.1186/s12931-018-0824-x · Cited by 12 · see citing works
Schworer, S. A., Olbrich, C. L., Larsen, L. D., Howard, E. D., Liu, L., Koyama, K., & Spencer, L. A. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae122 · Cited by 9 · see citing works
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Costantini, S., Dolzani, P., Panichi, V., Borzı̀, R. M., Balaji, P., Daglia, M., & Arciola, C. R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262210948 · Cited by 6 · see citing works
Jacobs, I., Deleu, S., Cremer, J., Hertogh, G. D., Vermeire, S., Breynaert, C. M., Vanuytsel, T., & Verstockt, B. (2024) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izae168 · Cited by 4 · see citing works
Vacca, F., Lavender, B., Noble, S., Cait, A., Maclean, K., Mamum, J. C., Yumnam, B., Kawa, T. T., Mules, T. C., Ferrer‐Font, L., et al. (2023) · medRxiv · doi:10.1101/2023.03.14.23287270 · Cited by 3 · see citing works
The Role of Eosinophilic Inflammation in Inflammatory Bowel Diseases: Conductor or “First” Violin?
Babayeva, G. H., Ibrahimli, H. I., Guliyev, F. V., Asadova, G. V., Mahmudov, U. R., Hasanov, R. H., Verdiyev, E. K., Musayev, J. S., Hasanova, A. I., Hasanov, R. A., et al. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1005563 · Cited by 1 · see citing works
Biological functions and clinical significance of calprotectin. Review
Ткач, С. М., Dorofeev, A. E., Kharchenko, N. V., & Kwit, C. B. (2022) · Modern Gastroenterology · doi:10.30978/mg-2022-3-34 · Cited by 1 · see citing works
Wang, Y., Li, X., Lv, X., Zhang, P., & Liu, H. (2026) · Inflammation · doi:10.1007/s10753-025-02363-9
“Importantly, S100A8/A9 has been rec - ognized as both a biomarker of colitis and a promoter of inflammation-associated tumorigenesis [ 16 – 18].”
Tawfik, N. Z., Mohamed, G., Mohamed, M., & Gomaa, A. H. A. (2025) · Egyptian Journal of Dermatology and Venerology · doi:10.4103/ejdv.ejdv_78_24
The roles and diversity of alarmins in the mucosae
Gaultney, R. A., Herbst, A., Yeoh, J., Bessell, E., & Krebs, P. (2025) · Advances in immunology · doi:10.1016/bs.ai.2025.09.001
- Authors
- Reichman, H., Moshkovits, I., Itan, M., Pasmanik-Chor, M., Vogl, T., Roth, J., & Munitz, A.
- Affiliations
- Tel Aviv University (IL)
- University of Münster (DE)
- Corresponding author
- Munitz, Ariel
- Venue
- Scientific Reports
- Published
- 2017-08-02
- Volume
- 7
- Issue
- 1
- Pages
- 7117-7117
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5540981
- OpenAlex
- W2741128589
- Cited by
- 27
- References
- 61
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 5 · 2019: 3 · 2018: 2
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-05-23)
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Science Foundation
- Israel Cancer Association (20150002)
- Israel Science Foundation (886/15)
- Tel Aviv University
- Cancer Biology Research Center, Tel Aviv University
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- eosinophils, S100A8, S100A9, mucosal healing, intestinal inflammation, transcriptome, eosinophil-deficient mice, adoptive transfer, type 2 inflammation, innate immunity, gene expression regulation
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