Cited by 1,450S100 Proteins and AnnexinsBiomarkers in Disease MechanismsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

The DOI matches its Crossref record; 165 of the 165 references it cites were found in a registry or an index.

S100A8/A9 in Inflammation

Open access

Wang, Siwen, Song, Rui, Wang, Ziyi, Jing, Zhaocheng, Wang, Shaoxiong, Ma, Jian·2018·Frontiers in Immunology

DOI 10.3389/fimmu.2018.01298PMC PMC6004386

Open this paper in CoChat — free account Open PDF

Abstract

S100A8 and S100A9 (also known as MRP8 ang MRP14, respectively) are Ca2+ binding proteins belonging to the S100 family. They often exist in the form of heterodimer, while homodimer exists very little because of the stability. S100A8/A9 is constitutively expressed in neutrophils and monocytes as a Ca2+ sensor, participating in cytoskeleton rearrangement and arachidonic acid metabolism. During inflammation, S100A8/A9 is released actively and exerts a critical role in modulating the inflammatory response by stimulating leukocyte recruitment and inducing cytokine secretion. S100A8/A9 serves as a candidate biomarker for diagnosis and follow-up as well as a predictive indicator of therapeutic responses to inflammation-associated diseases. As blockade of S100A8/A9 activity using small-molecule inhibitors or antibodies improves pathological conditions in murine models, the heterodimer has potential as a therapeutic target. In this review, we provide a comprehensive and detailed overview of the distribution and biological functions of S100A8/A9 and highlight its application as a diagnostic and therapeutic target in inflammation-associated diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fimmu.2018.01298

Cites

165 of 165 references verified0 citation errors · 0 not checkable

Statistics

Figure 1 The binding of S100A8/A9 to toll-like receptor (TLR) 4 triggers the MyD88-dependent pathway, appearing to play a vital role in inflammation. MyD88 recruits and activates IRAKs and TRAF6, which activates TAK1 via a TAB-mediated method. The activation of TAK1 facilitates the phosphorylation and activation of IKK and MAPK. Activated IKK phosphorylates and ubiquitinates I-κB, resulting in the liberation of NF-κB from inhibition. NF-κB translocates to the nucleus and induces the expression of pro-inflammatory cytokines. MAPKs, including p38, JNK, and ERK, have been demonstrated to activate c-Jun and c-fos, which translocate to the nucleus and form heterodimer AP-1, another transcription factor. Moreover, MAPK pathways are also involved in S100A8/A9-induced NF-κB activation during inflammation. The upregulated expression of pro-inflammatory genes amplifies the inflammatory response and severely destructs tissues in inflammation-associated diseases.CC BY · PubMed Central

Figure 2 The mitochondrial pathways of S100A8/A9-induced apoptosis. Cellular apoptosis is a cascade that involves a rapid drop in mitochondrial membrane potential. S100A8/A9 increases reactive oxygen species (ROS) production, resulting in the depolarization of mitochondrial membranes and subsequent inhibition of BNIP3, an atypical pro-apoptotic Bcl2-family member, and activation of Bak. After the translocation of Bak and BNIP3 in mitochondria, cytochrome C, Smac, and HtrA2 are concomitantly released from mitochondria into the cytoplasm. They activate caspase-3 in a direct way or in an IAPs-dependent manner to induce apoptosis. Abbreviations: iBNIP3, inhibited BNIP3; aBak, activated Bak.CC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Alzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
Vogl, T., Tenbrock, K., Ludwig, S., Leukert, N., Ehrhardt, C., van Zoelen, M. A. D., Nacken, W., Foell, D., van der Poll, T., Sorg, C., et al. (2007) · Nature Medicine · doi:10.1038/nm1638 · Cited by 1,418 · cited 2×
“S100A9−/− mice are less sensitive to LPS stimulation and more resistant to LPS-induced septic shock (69).”
Background
Proinflammatory Activities of S100: Proteins S100A8, S100A9, and S100A8/A9 Induce Neutrophil Chemotaxis and Adhesion
Ryckman, C., Vandal, K., Rouleau, P., Talbot, M., & Tessier, P. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3233 · Cited by 861
Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses
Corbin, B. D., Seeley, E. H., Raab, A., Feldmann, J., Miller, M. R., Torres, V. J., Anderson, K. L., Dattilo, B. M., Dunman, P. M., Gerads, R., et al. (2008) · Science · doi:10.1126/science.1152449 · Cited by 857
Nutritional immunity beyond iron: a role for manganese and zinc
Kehl-Fie, T. E., & Skaar, E. P. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.11.008 · Cited by 634
Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity
Nagareddy, P. R., Kraakman, M. J., Masters, S. L., Stirzaker, R. A., Gorman, D. J., Grant, R. W., Dragoljevic, D., Hong, E. S., Abdel‐Latif, A., Smyth, S. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.029 · Cited by 530
Antimicrobial actions of calcium binding leucocyte L1 protein, calprotectin
Steinbakk, M., Naess-Andresen, C. F., Fagerhol, M. K., Lingaas, E., Dale, I., & Brandtzaeg, P. (1990) · The Lancet · doi:10.1016/0140-6736(90)93237-j · Cited by 512
Inflammation – Cause or Consequence of Heart Failure or Both?
Linthout, S. V., & Tschöpe, C. (2017) · Current Heart Failure Reports · doi:10.1007/s11897-017-0337-9 · Cited by 484
S100A8/A9: From basic science to clinical application
Pruenster, M., Vogl, T., Roth, J., & Sperandio, M. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.07.015 · Cited by 463
Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes
Soro-Paavonen, A., Watson, A. M. D., Li, J., Paavonen, K., Koitka, A., Calkin, A. C., Barit, D., Coughlan, M. T., Drew, B. G., Lancaster, G. I., et al. (2008) · Diabetes · doi:10.2337/db07-1808 · Cited by 407

Show all 165 references

Sorted by citations

Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19
Silvin, A., Chapuis, N., Dunsmore, G., Goubet, A.-G., Dubuisson, A., Derosa, L., Almire, C., Hénon, C., Kosmider, O., Droin, N., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.002 · Cited by 834
Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis
Alivernini, S., MacDonald, L., Elmesmari, A., Finlay, S., Tolusso, B., Gigante, M. R., Petricca, L., Di Mario, C., Bui, L., Perniola, S., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0939-8 · Cited by 740
Sexual-dimorphism in human immune system aging
Márquez, E. J., Chung, C.-H., Marches, R., Rossi, R. J., Nehar-Belaid, D., Eroglu, A., Mellert, D. J., Kuchel, G. A., Banchereau, J., & Ucar, D. (2020) · Nature Communications · doi:10.1038/s41467-020-14396-9 · Cited by 584
Persistent complement dysregulation with signs of thromboinflammation in active Long Covid
Cervia, C., Brüningk, S. C., Hoch, T., Fan, B., Muzio, G., Thompson, R. C., Ceglarek, L., Meledin, R., Westermann, P., Emmenegger, M., et al. (2024) · Science · doi:10.1126/science.adg7942 · Cited by 437
Microbe-host interplay in atopic dermatitis and psoriasis
Fyhrquist, N., Muirhead, G., Prast‐Nielsen, S., Jeanmougin, M., Oláh, P., Skoog, T., Jules-Clément, G., Feld, M., Barrientos‐Somarribas, M., Sinkko, H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12253-y · Cited by 419
Tumor microenvironment remodeling after neoadjuvant immunotherapy in non-small cell lung cancer revealed by single-cell RNA sequencing
Hu, J., Zhang, L., Xia, H., Yan, Y., Zhu, X., Sun, F., Sun, L., Li, S., Li, D., Wang, J., et al. (2023) · Genome Medicine · doi:10.1186/s13073-023-01164-9 · Cited by 410
Role of S100 proteins in health and disease
Gonzalez, L. L., Garrie, K., & Turner, M. D. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118677 · Cited by 363
An immune-based biomarker signature is associated with mortality in COVID-19 patients
Abers, M. S., Delmonte, O. M., Ricotta, E., Fintzi, J., Fink, D. L., de Jesus, A. A., Zarember, K. A., Alehashemi, S., Oikonomou, V., Desai, J. V., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.144455 · Cited by 345
Plasma Proteomics Identify Biomarkers and Pathogenesis of COVID-19
Shu, T., Ning, W., Wu, D., Xu, J., Han, Q., Huang, M., Zou, X., Yang, Q., Yuan, Y., Bie, Y., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.10.008 · Cited by 337
Acute inflammatory response via neutrophil activation protects against the development of chronic pain
Parisien, M., Lima, L. B. Q., Dagostino, C., El-Hachem, N., Drury, G. L., Grant, A. V., Huising, J., Verma, V., Meloto, C. B., Silva, J. R., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abj9954 · Cited by 335
S100a8/a9 Signaling Causes Mitochondrial Dysfunction and Cardiomyocyte Death in Response to Ischemic/Reperfusion Injury
Li, Y., Chen, B., Yang, X., Zhang, C., Yao, J., Li, P., Liu, Y., Li, Z., Qiao, B., Lau, W. B., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.039262 · Cited by 317
Metallo-β-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design
Bahr, G., González, L. J., & Vila, A. J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00138 · Cited by 288
Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19
Guo, Q., Zhao, Y., Li, J., Liu, J., Yang, X., Guo, X., Kuang, M., Xia, H., Zhang, Z., Cao, L., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.12.016 · Cited by 253
Single-cell transcriptomics combined with interstitial fluid proteomics defines cell type–specific immune regulation in atopic dermatitis
Rojahn, T. B., Vorstandlechner, V., Krausgruber, T., Bauer, W. M., Alkon, N., Bangert, C., Thaler, F. M., Sadeghyar, F., Fortelny, N., Fife, V. E. R., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.03.041 · Cited by 233
Neutrophils: from IBD to the gut microbiota
Danne, C., Skerniškytė, J., Marteyn, B., & Sokol, H. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00871-3 · Cited by 242
Neutrophils as potential therapeutic targets in hepatocellular carcinoma
Geh, D., Leslie, J., Rumney, R., Reeves, H. L., Bird, T. G., & Mann, D. A. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00568-5 · Cited by 223
Transcriptional and epigenetic decoding of the microglial aging process
Li, X., Li, Y., Jin, Y., Zhang, Y., Wu, J., Xu, Z., Huang, Y., Cai, L., Gao, S., Liu, T., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00479-x · Cited by 234
COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects
Smadja, D. M., Mentzer, S. J., Fontenay, M., Laffan, M., Ackermann, M., Helms, J., Jonigk, D. D., Chocron, R., Pier, G. B., Gendron, N., et al. (2021) · Angiogenesis · doi:10.1007/s10456-021-09805-6 · Cited by 204
COVID-19 Patients Upregulate Toll-like Receptor 4-mediated Inflammatory Signaling That Mimics Bacterial Sepsis
Sohn, K. M., Lee, S., Kim, H. J., Cheon, S., Jeong, H., Lee, J.-Y., Kim, I. S., Silwal, P., Kim, Y. J., Paik, S., et al. (2020) · Journal of Korean Medical Science · doi:10.3346/jkms.2020.35.e343 · Cited by 199
The local microenvironment drives activation of neutrophils in human brain tumors
Maas, R. R., Soukup, K., Fournier, N., Massara, M., Galland, S., Kornete, M., Wischnewski, V., Lourenço, J., Croci, D., Álvarez-Prado, Á. F., et al. (2023) · Cell · doi:10.1016/j.cell.2023.08.043 · Cited by 200
Multifunctional Role of S100 Protein Family in the Immune System: An Update
Singh, P., & Ali, S. A. (2022) · Cells · doi:10.3390/cells11152274 · Cited by 204
Transcriptional and proteomic insights into the host response in fatal COVID-19 cases
Wu, M., Chen, Y., Xia, H., Wang, C., Tan, C. Y., Cai, X., Liu, Y., Ji, F., Peng, X., Liu, R., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2018030117 · Cited by 191
Innate immunological pathways in COVID-19 pathogenesis
Paludan, S. R., & Mogensen, T. H. (2022) · Science Immunology · doi:10.1126/sciimmunol.abm5505 · Cited by 188
STING agonist promotes CAR T cell trafficking and persistence in breast cancer
Xu, N., Palmer, D. C., Robeson, A. C., Shou, P., Bommiasamy, H., Laurie, S. J., Willis, C., Dotti, G., Vincent, B. G., Restifo, N. P., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20200844 · Cited by 186
Hexokinase 1 cellular localization regulates the metabolic fate of glucose
Jesus, A. D., Keyhani‐Nejad, F., Pusec, C. M., Goodman, L., Geier, J., Stoolman, J. S., Stanczyk, P. J., Nguyen, T., Xu, K., Suresh, K. V., et al. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.02.028 · Cited by 189
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19
Unterman, A., Sumida, T. S., Nouri, N., Yan, X., Zhao, A., Gasque, V., Schupp, J. C., Asashima, H., Liu, Y., Cosme, C., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27716-4 · Cited by 181
Self-citation
S100A8 and S100A9 in Cancer
Chen, Y., Ouyang, Y., Li, Z., Wang, X., & Ma, J. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188891 · Cited by 165
Self-citation
Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19
Theobald, S. J., Simonis, A., Georgomanolis, T., Kreer, C., Zehner, M., Eisfeld, H. S., Albert, M., Chhen, J., Motameny, S., Erger, F., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202114150 · Cited by 172
Roles of S100A8 , S100A9 and S100A12 in infection, inflammation and immunity
Xia, P., Ji, X., Li, Y., Lian, S., Chen, Z., & Luo, Y. (2023) · Immunology · doi:10.1111/imm.13722 · Cited by 172
Neutrophil extracellular traps (NETs) are increased in the alveolar spaces of patients with ventilator-associated pneumonia
Mikacenic, C. R., Moore, R., Dmyterko, V., West, T. E., Altemeier, W. A., Liles, W. C., & Lood, C. (2018) · Critical Care · doi:10.1186/s13054-018-2290-8 · Cited by 153
Neutrophil calprotectin identifies severe pulmonary disease in COVID-19
Shi, H., Zuo, Y., Yalavarthi, S., Gockman, K., Zuo, M., Madison, J. A., Blair, C., Woodard, W., Lezak, S. P., Lugogo, N. L., et al. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3covcra0720-359r · Cited by 151
Gut bacterial isoamylamine promotes age-related cognitive dysfunction by promoting microglial cell death
Teng, Y., Mu, J., Xu, F., Zhang, X., Sriwastva, M. K., Liu, Q. M., Li, X., Lei, C., Sundaram, K., Hu, X., et al. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.05.005 · Cited by 138
Neutrophils in Tuberculosis-Associated Inflammation and Lung Pathology
Muefong, C. N., & Sutherland, J. S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00962 · Cited by 132
Overexpression of S100A9 in obesity impairs macrophage differentiation via TLR4-NFkB-signaling worsening inflammation and wound healing
Franz, S., Ertel, A., Engel, K. M., Simon, J. C., & Saalbach, A. (2022) · Theranostics · doi:10.7150/thno.67174 · Cited by 129
Hsa_circ_0004287 inhibits macrophage-mediated inflammation in an N6-methyladenosine–dependent manner in atopic dermatitis and psoriasis
Yang, L., Fu, J., Han, X., Zhang, C., Xia, L., Zhu, R., Huang, S., Xiao, W., Yu, H., Gao, Y., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.11.024 · Cited by 125
Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease
Craig, C. F., Filippone, R. T., Stavely, R., Bornstein, J. C., Apostolopoulos, V., & Nurgali, K. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02354-1 · Cited by 124
Exosomal ANGPTL1 attenuates colorectal cancer liver metastasis by regulating Kupffer cell secretion pattern and impeding MMP9 induced vascular leakiness
Jiang, K., Chen, H., Fang, Y., Chen, L., Zhong, C., Bu, T., Dai, S., Pan, X., Fu, D., Qian, Y., et al. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01816-3 · Cited by 127
Comparative analysis of the tumor immune-microenvironment of primary and brain metastases of non-small-cell lung cancer reveals organ-specific and EGFR mutation-dependent unique immune landscape
Song, S. G., Kim, S., Koh, J., Yim, J., Han, B., Kim, Y. A., Jeon, Y. K., & Chung, D. H. (2021) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02840-0 · Cited by 125
Regulation of zinc-dependent enzymes by metal carrier proteins
Thompson, M. W. (2022) · BioMetals · doi:10.1007/s10534-022-00373-w · Cited by 130
Transcriptional Profiling and Functional Analysis of N1/N2 Neutrophils Reveal an Immunomodulatory Effect of S100A9-Blockade on the Pro-Inflammatory N1 Subpopulation
Mihaila, A. C., Ciortan, L., Macarie, R. D., Vadana, M., Cecoltan, S., Preda, M. B., Hudiță, A., Gan, A., Jakobsson, G., Tucureanu, M. M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.708770 · Cited by 118
Transcriptome profiling in swine macrophages infected with African swine fever virus at single-cell resolution
Zheng, Y., Li, S., Li, S., Yu, S., Wang, Q., Zhang, K., Qu, L., Sun, Y., Bi, Y., Tang, F., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2201288119 · Cited by 117
S100‐A9 protein in exosomes derived from follicular fluid promotes inflammation via activation of NF‐κB pathway in polycystic ovary syndrome
Li, H., Huang, X. Y., Chang, X., Yao, J., He, Q., Shen, Z., Ji, Y., & Wang, K. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14642 · Cited by 115
Comparison of viral RNA–host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2
Zhang, S., Huang, W., Ren, L., Ju, X., Gong, M., Rao, J. Y., Sun, L., Li, P., Ding, Q., Wang, J., et al. (2021) · Cell Research · doi:10.1038/s41422-021-00581-y · Cited by 119
S100A9 Regulates MDSCs-Mediated Immune Suppression via the RAGE and TLR4 Signaling Pathways in Colorectal Carcinoma
Huang, M., Wu, R., Chen, L., Peng, Q., Li, S., Zhang, Y., Zhou, L., & Duan, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02243 · Cited by 113
Targeting and exploitation of tumor-associated neutrophils to enhance immunotherapy and drug delivery for cancer treatment
Zhang, Y., Liu, G., Sun, M., & Lü, X. (2020) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2019.0372 · Cited by 113
S100A8/A9 drives the formation of procoagulant platelets through GPIbα
Colicchia, M., Schrottmaier, W. C., Perrella, G., Reyat, J. S., Begum, J., Slater, A., Price, J. M. J., Clark, J. C., Zhi, Z., Simpson, M., et al. (2022) · Blood · doi:10.1182/blood.2021014966 · Cited by 110
Single-cell analysis of skeletal muscle macrophages reveals age-associated functional subpopulations
Krasniewski, L. K., Chakraborty, P., Cui, C., Mazan-Mamczarz, K., Dunn, C., Piao, Y., Fan, J., Shi, C., Wallace, T., Nguyen, C., et al. (2022) · eLife · doi:10.7554/elife.77974 · Cited by 111
S100 family proteins in inflammation and beyond
Sreejit, G., Flynn, M., Patil, M., Krishnamurthy, P., Murphy, A. J., & Nagareddy, P. R. (2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2020.02.006 · Cited by 110
Transcriptomic analysis of human sensory neurons in painful diabetic neuropathy reveals inflammation and neuronal loss
Hall, B. E., Macdonald, E., Cassidy, M. M., Yun, S., Sapio, M. R., Ray, P. R., Doty, M. E., Nara, P., Burton, M. D., Shiers, S. I., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-08100-8 · Cited by 107
Neutrophil signaling during myocardial infarction wound repair
Daseke, M. J., Chalise, U., Becirovic‐Agic, M., Salomon, J., Cook, L. M., Case, A. J., & Lindsey, M. L. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109816 · Cited by 113
S100A8/A9 in COVID-19 pathogenesis: Impact on clinical outcomes
Mellett, L., & Khader, S. A. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.10.004 · Cited by 105
A shift in lung macrophage composition is associated with COVID-19 severity and recovery
Chen, S. T., Park, M. D., Valle, D. M. D., Buckup, M., Tabachnikova, A., Thompson, R. C., Simons, N. W., Mouskas, K., Lee, B. H., Geanon, D., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abn5168 · Cited by 106
Single-cell transcriptome profiling of sepsis identifies HLA-DRlowS100Ahigh monocytes with immunosuppressive function
Yao, R.-Q., Zhao, P., Li, Z., Liu, Y., Zheng, L., Duan, Y., Wang, L., Yang, R., Kang, H., Hao, J.-W., et al. (2023) · Military Medical Research · doi:10.1186/s40779-023-00462-y · Cited by 111
Multifunctional Microgel-Based Cream Hydrogels for Postoperative Abdominal Adhesion Prevention
Liu, B., Kong, Y., Alimi, O. A., Kuss, M. A., Tu, H., Hu, W., Rafay, A., Vikas, K., Shi, W., Lerner, M. L., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c12104 · Cited by 103
DSS-induced inflammation in the colon drives a proinflammatory signature in the brain that is ameliorated by prophylactic treatment with the S100A9 inhibitor paquinimod
Talley, S., Valiauga, R., Anderson, L., Cannon, A. R., Choudhry, M. A., & Campbell, E. M. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02317-6 · Cited by 102
Transdermal psoriasis treatment inspired by tumor microenvironment-mediated immunomodulation and advanced by exosomal engineering
Yang, J., Zhu, J., Lu, S., Qin, H., & Zhou, W. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113664 · Cited by 97
IL-11 induces NLRP3 inflammasome activation in monocytes and inflammatory cell migration to the central nervous system
Seyedsadr, M., Wang, Y., Elzoheiry, M., Gopal, S. S., Jang, S., Duran, G., Chervoneva, I., Kasimoglu, E., Wrobel, J. A., Hwang, D., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2221007120 · Cited by 92
VEXAS Syndrome Is Characterized by Blood and Tissues Inflammasome Pathway Activation and Monocyte Dysregulation
Kosmider, O., Posseme, C., Templé, M., Corneau, A., Carbone, F., Duroyon, E., Breillat, P., Chirayath, T.-W., Oulès, B., Sohier, P., et al. (2022) · Nature Communications · doi:10.1038/s41467-024-44811-4 · Cited by 111
Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade
Zhao, L., Pang, Y., Zhou, Y., Chen, J., Fu, H., Guo, W., Xu, W., Xue, X., Su, G., Sun, L., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01853-w · Cited by 91
Self-citation
Single-Cell RNA-Seq Analysis Reveals Macrophage Involved in the Progression of Human Intervertebral Disc Degeneration
Ling, Z., Liu, Y., Wang, Z., Zhang, Z., Chen, B., Yang, J., Zeng, B., Gao, Y., Jiang, C., Huang, Y., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.833420 · Cited by 87
Self-citation
Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization
Mahon, O. R., Kelly, D. J., McCarthy, G., & Dunne, A. (2019) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2019.10.010 · Cited by 86
Polymorphonuclear myeloid-derived suppressor cells impair the anti-tumor efficacy of GD2.CAR T-cells in patients with neuroblastoma
Tumino, N., Weber, G., Besi, F., Bufalo, F. D., Bertaina, V., Paci, P., Quatrini, L., Antonucci, L., Sinibaldi, M., Quintarelli, C., et al. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01193-0 · Cited by 92
Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction
Jakobsson, G., Papareddy, P., Andersson, H., Mulholland, M., Bhongir, R. K. V., Ljungcrantz, I., Engelbertsen, D., Björkbacka, H., Nilsson, J. Å., Manea, A., et al. (2023) · Critical Care · doi:10.1186/s13054-023-04652-x · Cited by 89
Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host
Lloréns‐Rico, V., Gregory, A., Weyenbergh, J. V., Jansen, S., Buyten, T. V., Qian, J., Braz, M., Menezes, S. M., Mol, P. V., Vanderbeke, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26500-8 · Cited by 84
S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy
Li, J., Shu, X., Xu, J., Su, S. M., Chan, U. I., Mo, L., Liu, J., Zhang, X., Adhav, R., Chen, Q., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29151-5 · Cited by 90
Multimodule characterization of immune subgroups in intrahepatic cholangiocarcinoma reveals distinct therapeutic vulnerabilities
Lin, J., Dai, Y., Sang, C., Song, G., Xiang, B., Zhang, M., Dong, L., Xia, X., Ma, J., Shen, X., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-004892 · Cited by 86
Self-citation
Long non-coding RNAs (lncRNAs) NEAT1 and MALAT1 are differentially expressed in severe COVID-19 patients: An integrated single-cell analysis
Kai, H., Wang, C., Vagts, C. L., Raguveer, V., Finn, P. W., & Perkins, D. L. (2022) · PLoS ONE · doi:10.1371/journal.pone.0261242 · Cited by 84
Premise and peril of Wnt signaling activation through GSK-3β inhibition
Law, S. M., & Zheng, J. (2022) · iScience · doi:10.1016/j.isci.2022.104159 · Cited by 87
Role of Neutrophils in the Pathogenesis of Nonalcoholic Steatohepatitis
Hwang, S., Yun, H., Moon, S., Cho, Y. E., & Gao, B. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.751802 · Cited by 84
Zinc Homeostasis in Platelet-Related Diseases
Mammadova‐Bach, E., & Braun, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215258 · Cited by 85
Epigenetic Regulation of S100A9 and S100A12 Expression in Monocyte-Macrophage System in Hyperglycemic Conditions
Mossel, D. M., Moganti, K., Riabov, V., Weiß, C., Kopf, S., Cordero, J., Dobreva, G. D., Rots, M. G., Klüter, H., Harmsen, M. C., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01071 · Cited by 82
Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis
Palma, C., Rocca, C. L., Gigantino, V., Aquino, G., Piccaro, G., Silvestre, D. D., Brambilla, F., Rossi, R., Bonacina, F., Lepore, M. T., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.016 · Cited by 82
Targeting conserved TIM3 + VISTA + tumor-associated macrophages overcomes resistance to cancer immunotherapy
Vanmeerbeek, I., Naulaerts, S., Sprooten, J., Laureano, R. S., Govaerts, J., Trotta, R., Pretto, S., Zhao, S., Cafarello, S. T., Verelst, J., et al. (2024) · Science Advances · doi:10.1126/sciadv.adm8660 · Cited by 80
Interleukin 17 Promotes Expression of Alarmins S100A8 and S100A9 During the Inflammatory Response of Keratinocytes
Christmann, C., Zenker, S., Martens, L., Hübner, J., Loser, K., Vogl, T., & Roth, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.599947 · Cited by 81
Deficiency of S100A9 Alleviates Sepsis-Induced Acute Liver Injury through Regulating AKT-AMPK-Dependent Mitochondrial Energy Metabolism
Zhang, Y.-T. Y., Wu, F., Teng, F., Guo, S., & Li, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032112 · Cited by 78
Ponatinib Drives Cardiotoxicity by S100A8/A9-NLRP3-IL-1β Mediated Inflammation
Tousif, S., Singh, A. P., Umbarkar, P., Galindo, C. L., Wheeler, N. D., Cora, A. T., Zhang, Q., Prabhu, S. D., & Lal, H. (2023) · Circulation Research · doi:10.1161/circresaha.122.321504 · Cited by 78
Bioinspired Microstructured Janus Bioadhesive for the Prevention of Abdominal and Intrauterine Adhesions
Lv, Y., Cai, F., Zhao, X., Zhu, X., Wei, F., Zheng, Y., Shi, X., & Yang, J. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202314402 · Cited by 77
Re-establishment of macrophage homeostasis by titanium surface modification in type II diabetes promotes osseous healing
Lee, R. S. B., Hamlet, S. M., Moon, H., & Ivanovski, S. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120464 · Cited by 75
Brain cell-derived exosomes in plasma serve as neurodegeneration biomarkers in male cynomolgus monkeys self-administrating oxycodone
Kumar, A., Kim, S., Su, Y., Sharma, M., Kumar, P., Singh, S., Lee, J., Furdui, C. M., Singh, R. N., Hsu, F., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2020.103192 · Cited by 74
Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis, prognosis and drug target discovery
Li, Y., Hou, G., Zhou, H., Wang, Y., Tun, H. M., Zhu, A., Zhao, J., Xiao, F., Liu, D., Liu, D., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00508-4 · Cited by 76
Mitochondria: Insights into Crucial Features to Overcome Cancer Chemoresistance
Genovese, I., Carinci, M., Modesti, L., Aguiari, G., Pinton, P., & Giorgi, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094770 · Cited by 77
S100a8/a9 contributes to sepsis-induced cardiomyopathy by activating ERK1/2-Drp1-mediated mitochondrial fission and respiratory dysfunction
Wu, F., Zhang, Y.-T. Y., Teng, F., Li, H., & Guo, S. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109716 · Cited by 75
Senescent immune cells accumulation promotes brown adipose tissue dysfunction during aging
Xu, F., Wang, L., Zhou, R., Zhou, R., Chen, L., Peng, H., Huang, Y., Guo, Q., Luo, X., & Zhou, H. (2023) · Nature Communications · doi:10.1038/s41467-023-38842-6 · Cited by 78
Retracted
Proteomic landscape of the extracellular matrix in the fibrotic kidney
Li, L., He, M., Tang, X., Huang, J., Li, J., Hong, X., Fu, H., & Liu, Y. (2023) · Kidney International · doi:10.1016/j.kint.2023.01.021 · Cited by 75
Single-Cell RNA Sequencing Identifies New Inflammation-Promoting Cell Subsets in Asian Patients With Chronic Periodontitis
Qian, S., Huang, Q., Chen, R., Mo, J., Zhou, L., Zhao, Y., Li, B., & Lai, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.711337 · Cited by 73
Characterization of Cellular Heterogeneity and an Immune Subpopulation of Human Megakaryocytes
Liu, C., Wu, D., Xia, M., Li, M., Sun, Z., Shen, B., Liu, Y., Jiang, E., Wang, H., Su, P., et al. (2021) · Advanced Science · doi:10.1002/advs.202100921 · Cited by 72
Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice
Lim, W., Ng, B., Widjaja, A. A., Xie, C., Su, L., Ko, N. S. J., Lim, S.-Y., Kwek, X.-Y., Lim, S., Cook, S. A., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227505 · Cited by 78
Tumor-Mediated Neutrophil Polarization and Therapeutic Implications
Raftopoulou, S., Valadez-Cosmes, P., Mihalič, Z. N., Schicho, R., & Kargl, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063218 · Cited by 70
Biological Roles of Fibroblasts in Periodontal Diseases
Naruishi, K. (2022) · Cells · doi:10.3390/cells11213345 · Cited by 71
Allicin ameliorates imiquimod‐induced psoriasis‐like skin inflammation via disturbing the interaction of keratinocytes with IL‐17A
Zhang, L., Ma, X., Shi, R., Zhang, L., Zhao, R., Duan, R., Qin, Y., Gao, S., Li, X., Duan, J., et al. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15983 · Cited by 71
Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans
Yoo, R., Kim, J.-H., Moon, H. Y., Park, J. Y., Cheon, S., Shin, H.-S., Han, D., Kim, Y., Park, S., & Choi, S. H. (2025) · Nature Communications · doi:10.1038/s41467-025-58726-1 · Cited by 75
S100 proteins in obesity: liaisons dangereuses
Riuzzi, F., Chiappalupi, S., Arcuri, C., Giambanco, I., Sorci, G., & Donato, R. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03257-4 · Cited by 70
Myeloperoxidase and Related Biomarkers are Suggestive Footprints of Endothelial Microvascular Inflammation in HFpEF Patients
Hage, C., Michaëlsson, E., Kull, B., Miliotis, T., Svedlund, S., Linde, C. M., Donal, E., Daubert, J., Gan, L., & Lund, L. H. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12700 · Cited by 69
Types of necroinflammation, the effect of cell death modalities on sterile inflammation
Mázló, A., Jenei, V., Sára, B., Molnár, T., Bácsi, A., & Koncz, G. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04883-w · Cited by 69
Integrated genomic and proteomic analyses identify stimulus-dependent molecular changes associated with distinct modes of skeletal muscle atrophy
Hunt, L. C., Graça, F. A., Pagala, V., Wang, Y., Li, Y., Yuan, Z., Fan, Y., Labelle, M., Peng, J., & Demontis, F. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109971 · Cited by 74
Integrative transcriptomics analysis of lung epithelial cells and identification of repurposable drug candidates for COVID-19
Islam, T., Rahman, M. R., Aydın, B., Beklen, H., Arğa, K. Y., & Shahjaman, M. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173594 · Cited by 66
Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass
Inoue, K., Qin, Y., Xia, Y., Han, J., Yuan, R., Sun, J., Xu, R., Jiang, J. X., Greenblatt, M. B., & Zhao, B. (2023) · eLife · doi:10.7554/elife.82118 · Cited by 65
Dynamically remodeled hepatic extracellular matrix predicts prognosis of early-stage cirrhosis
Wu, Y., Cao, Y., Xu, K., Zhu, Y., Qiao, Y., Wu, Y., Chen, J., Li, C., Zeng, R., & Ge, G. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03443-y · Cited by 69
Junctional epithelium and hemidesmosomes: Tape and rivets for solving the “percutaneous device dilemma” in dental and other permanent implants
Fischer, N. G., & Aparicio, C. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.03.019 · Cited by 68
Cutaneous Epithelial to Mesenchymal Transition Activator ZEB1 Regulates Wound Angiogenesis and Closure in a Glycemic Status–Dependent Manner
Singh, K., Sinha, M., Pal, D., Tabasum, S., Gnyawali, S. C., Khona, D. K., Sarkar, S., Mohanty, S. K., Gonzalez, F. S., Khanna, S., et al. (2019) · Diabetes · doi:10.2337/db19-0202 · Cited by 65

Authors: Wang, S., Song, R., Wang, Z., Jing, Z., Wang, S., & Ma, J.
Affiliations: Central South University (CN)
Corresponding author: Ma, Jian
ORCID: Wang, Siwen
Song, Rui
Wang, Ziyi
Jing, Zhaocheng
Wang, Shaoxiong
Ma, Jian
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2018-06-11
Volume: 9
Pages: 1298-1298
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2018.01298
PMC: PMC6004386
OpenAlex: W2808305854
Cited by: 1,450
References: 165
Citations by year: 2026: 176 · 2025: 217 · 2024: 248 · 2023: 225 · 2022: 236 · 2021: 184 · 2020: 119 · 2019: 40 · 2018: 4
FWCI: 8.53
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Frontiers in Immunology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (81672889, 81472694)
Hunan Provincial Science and Technology Department (2016JC2035)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: S100A8/A9, S-100 protein, heterodimer, calcium-binding proteins, inflammation, neutrophils, monocytes, leukocyte recruitment, cytokine production, arachidonic acid metabolism, biomarkers, therapeutic target, small molecule inhibitors
MeSH terms: Animals, Disease Susceptibility, Gene Expression Regulation, Humans, Immunity, Inflammation, Biomarkers, Autoimmunity, Protein Transport, Calgranulin A, Calgranulin B, Host-Pathogen Interactions, Molecular Targeted Therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

S100A8/A9 in Inflammation

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks