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Cellular Specificity of NF-κB Function in the Nervous System
Open accessAbstract
Nuclear Factor Kappa B (NF-κB) is a ubiquitously expressed transcription factor with key functions in a wide array of biological systems. While the role of NF-κB in processes, such as host immunity and oncogenesis has been more clearly defined, an understanding of the basic functions of NF-κB in the nervous system has lagged behind. The vast cell-type heterogeneity within the central nervous system (CNS) and the interplay between cell-type specific roles of NF-κB contributes to the complexity of understanding NF-κB functions in the brain. In this review, we will focus on the emerging understanding of cell-autonomous regulation of NF-κB signaling as well as the non-cell-autonomous functional impacts of NF-κB activation in the mammalian nervous system. We will focus on recent work which is unlocking the pleiotropic roles of NF-κB in neurons and glial cells (including astrocytes and microglia). Normal physiology as well as disorders of the CNS in which NF-κB signaling has been implicated will be discussed with reference to the lens of cell-type specific responses.
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“Activation of NFκB by inflammatory stimuli is mediated by phosphorylation and ubiquitin-mediated degradation of IκB which disinhibits NFκB, allowing for nuclear translocation to target genes and activation of transcription [140].”
From ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020) · cites this paper as [140]
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A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493
Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469
Shared Principles in NF-κB Signaling
Hayden, M. S., & Ghosh, S. (2008) · Cell · doi:10.1016/j.cell.2008.01.020 · Cited by 4,954
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110
Complement and microglia mediate early synapse loss in Alzheimer mouse models
Hong, S., Beja-Glasser, V. F., Nfonoyim, B. M., Frouin, A., Li, S., Ramakrishnan, S., Merry, K. M., Shi, Q., Rosenthal, A., Barres, B. A., et al. (2016) · Science · doi:10.1126/science.aad8373 · Cited by 3,343 · cited 1×
“Since microglia are active participants in the formation, remodeling, and elimination of synapses, this research may also shed light on the mechanisms which underlie synapse loss in AD (93, 94).”
BackgroundTREM2 Variants in Alzheimer's Disease
Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020
Wang, C.-Y., Mayo, M., Korneluk, R., Goeddel, D., & Baldwin, A. (1998) · Science · doi:10.1126/science.281.5383.1680 · Cited by 2,950
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor
Parkhurst, C. N., Yang, G., Ninan, I., Savas, J. N., Yates, J. R., Lafaille, J. J., Hempstead, B. L., Littman, D. R., & Gan, W.-B. (2013) · Cell · doi:10.1016/j.cell.2013.11.030 · Cited by 2,599
Suppression of TNF-α-Induced Apoptosis by NF-κB
Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M. (1996) · Science · doi:10.1126/science.274.5288.787 · Cited by 2,581
Molecular Architecture of the Mouse Nervous System
Zeisel, A., Hochgerner, H., Lönnerberg, P., Johnsson, A., Memic, F., van der Zwan, J., Häring, M., Braun, E., Borm, L. E., La Manno, G., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.021 · Cited by 2,552
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Items 301–348 of 348
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Protein Transport from Synapse-to-Nucleus and the Regulation of Gene Expression
Karpova, A., Andres‐Alonso, M., Grochowska, K. M., & Kreutz, M. R. (2024) · Springer eBooks · doi:10.1007/978-3-031-68550-7_3
Ren, J., Zhou, Y., Hu, Y., Yang, J., Fang, H., Lyu, X., Guo, J., Shi, X., & Li, Q. (2024) · eLife · doi:10.7554/elife.97424.2
Guo, Y., Hirad, A. H., & Alarfaj, A. A. (2025) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-024-00594-9
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Öztan, G., İşsever, H., & ŞAHİN, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188934
Intestinal Ischemia/Reperfusion Injury Influences Hyaluronan Homeostasis in the Rat Brain
Bosi, A., Baranzini, N., Ponti, A., Moretto, P., Moro, E., Crema, F., Cianci, R., Karousou, E. G., Viola, M., Passi, A. G., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262010064
de Araújo, A. N. V., de Araújo, J. M. D., Dutra, L. M. G., Alves, M. E. F., Alves, A. F., Sousa, M. C. D. P., Salvadori, M. G. D. S. S., Soares, J. K. B., & Aquino, J. D. S. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.110159
Fathallah, S., & Abdellatif, A. (2025) · Clinical Phytoscience · doi:10.1186/s40816-025-00407-z
Arnab, S., Fathi, P. A., Jones, E. C., Meyyappan, A., Nguyen, K. L., Bracchi-Ricard, V. C., Gupta, S., Fischer, R., Tom, V. J., & Bethea, J. R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.24.690195
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Czamara, D., Juntilla, D. L., Nounu, A., Weihs, A. L., Erhart, M., Maier, L., Leskien, M., Tuhkanen, J., Scherff, A. D., Yusupov, N., et al. (2026) · Biological Psychiatry · doi:10.1016/j.biopsych.2026.03.226
Wijesekera, T., Stephens, N. P., Hingnekar, A., Gedamu, H., Dezso, N. R., Strange, M., Risbud, S. M., Dinh, A. D., & Atkinson, N. S. (2025) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2025.1689016
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González‐Cano, S. I., Juárez-Serrano, D., Handal‐Silva, A., Morán-Perales, J. L., Vázquez‐Roque, R. A., Galindo-Ramírez, F., Treviño, S., Guevara, J., & Díaz, A. (2025) · Synapse · doi:10.1002/syn.70036
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Chen, Y., Tian, Z., He, L., Liu, C., Wang, N., Rong, L., & Liu, B. (2021) · Figshare · doi:10.6084/m9.figshare.14374755
Peng, D., Li, J., Deng, Y., Zhu, X., Zhao, L., Zhang, Y., Li, Z., Ou, S., Li, S., & Jiang, Y. (2020) · Figshare · doi:10.6084/m9.figshare.13250655
Cai, L., Gong, Q., Qi, L., Xu, T., Suo, Q., Li, X., Wang, W., Jing, Y., Yang, D., Xu, Z., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19643460
Dittlau, K. S., Terrie, L., Baatsen, P., Kerstens, A., Swert, L. D., Janky, R., Corthout, N., Masrori, P., Damme, P. V., Hyttel, P., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25458004
Chen, Y., Tian, Z., He, L., Liu, C., Wang, N., Rong, L., & Liu, B. (2021) · Figshare · doi:10.6084/m9.figshare.14374758
Su, Y.-Y., Liu, Y.-L., Huang, H.-C., & Lin, C.-C. (2024) · Figshare · doi:10.6084/m9.figshare.26605405
Chen, Y., Tian, Z., He, L., Liu, C., Wang, N., Rong, L., & Liu, B. (2021) · Figshare · doi:10.6084/m9.figshare.14374749
Cai, L., Gong, Q., Qi, L., Xu, T., Suo, Q., Li, X., Wang, W., Jing, Y., Yang, D., Xu, Z., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19643466
Wang, X., Wu, Y., Tian, Y., Hu, H., Zhao, Y., Xue, B., Sun, Z., Wei, A., Xie, F., & 钱令嘉 (2024) · Figshare · doi:10.6084/m9.figshare.25621969
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Cai, L., Gong, Q., Qi, L., Xu, T., Suo, Q., Li, X., Wang, W., Jing, Y., Yang, D., Xu, Z., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19643469
Cai, L., Gong, Q., Qi, L., Xu, T., Suo, Q., Li, X., Wang, W., Jing, Y., Yang, D., Xu, Z., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19643472
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Gupta, H., Singh, S., Kaushik, A. C., Awasthi, A. K., & Sahi, S. (2026) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02463-z
Li, X., Xie, K., Niu, J., Zhang, F., Wu, Z., Wang, S., Li, G., Zhang, Y., Shen, J., Song, C., et al. (2026) · Small · doi:10.1002/smll.202513088
Liu, N., Zhu, X., Liu, S. W., Su, Z., Zhu, C., Tian, M., Yu, J., & Liu, Y. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05749-4
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Xiao, S., Han, Y., Yan, J., Wu, L., Lin, H., Yuan, C., Song, C., & Ye, J. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116594 · Cited by 1
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Kim, S. (2021) · theses.fr (ABES) · doi:10.70675/958849d8z5151z46d1z9e5czdb99754d7055
Eom, Y., Lee, H. K., Kim, Y.-K., Yang, S., Yim, Y., Shin, S., Kim, J.-W., Yoo, H. M., & Lee, S. H. (2026) · Environment International · doi:10.1016/j.envint.2026.110270
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Jia, X.-X., Xu, B., Hu, C., Ruhan, A., Zhang, W.-W., Gao, L., Xiao, K., Qn, S., Chen, C., & Dong, X. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00911
Teixeira, G. R., Costa, A. G. A., Mattos, A. C. D. L., de Araújo, D. S. M., Brito, R., & Calaza, K. D. C. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27156895
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Hegde, S., Begum, A. S., & Kommajosyula, S. P. (2026) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2026.100845
Lee, C., Hsieh, C., & Wang, J.-Y. (2026) · NeuroToxicology · doi:10.1016/j.neuro.2026.103545
Saitta, A., Basilotta, R., Lanza, M., Scuruchi, M., Casili, G., Giovani, P., Copani, A., Esposito, E., Oddo, S., & Caccamo, A. (2026) · Cells · doi:10.3390/cells15161487
Madkour, A. H., Abdelaziz, R. R., Nader, M. A., & Elshal, M. (2026) · Scientific Reports · doi:10.1038/s41598-026-67306-2
Oh, Y. M., Bacallao, E. A., Lee, S.-A., Kim, J., Swinford, S., Smith, G. E., Britt, B., Abdalla, S. M., & Lee, S. W. (2026) · Neuroscience Bulletin · doi:10.1007/s12264-026-01711-5
Jainarayanan, A., Vedula, A., & Soni, N. (2026) · Frontiers in Neural Circuits · doi:10.3389/fncir.2026.1919817
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Metadata
- Authors
- Dresselhaus, E. C., & Meffert, M. K.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Meffert, Mollie K.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2019-05-09
- Volume
- 10
- Pages
- 1043-1043
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC6520659
- OpenAlex
- W2944682402
- Cited by
- 345
- References
- 129
- Citations by year
- 2026: 37 · 2025: 46 · 2024: 54 · 2023: 48 · 2022: 54 · 2021: 58 · 2020: 45 · 2019: 2
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- NF-κB, nervous system, cell type specificity, central nervous system, neurons, glial cells, astrocytes, microglia, cell-autonomous signaling, non-cell-autonomous signaling, central nervous system disorders, neuroinflammation
- MeSH terms
- Animals, Central Nervous System, Humans, Nervous System, Neuroglia, Neurons, Organ Specificity, Signal Transduction, NF-kappa B, Microglia
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