Cited by 348NF-κB Signaling PathwaysNeuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

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Cellular Specificity of NF-κB Function in the Nervous System

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Dresselhaus, Erica C., Meffert, Mollie K.·2019·Frontiers in Immunology

DOI 10.3389/fimmu.2019.01043PMC PMC6520659

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Abstract

Nuclear Factor Kappa B (NF-κB) is a ubiquitously expressed transcription factor with key functions in a wide array of biological systems. While the role of NF-κB in processes, such as host immunity and oncogenesis has been more clearly defined, an understanding of the basic functions of NF-κB in the nervous system has lagged behind. The vast cell-type heterogeneity within the central nervous system (CNS) and the interplay between cell-type specific roles of NF-κB contributes to the complexity of understanding NF-κB functions in the brain. In this review, we will focus on the emerging understanding of cell-autonomous regulation of NF-κB signaling as well as the non-cell-autonomous functional impacts of NF-κB activation in the mammalian nervous system. We will focus on recent work which is unlocking the pleiotropic roles of NF-κB in neurons and glial cells (including astrocytes and microglia). Normal physiology as well as disorders of the CNS in which NF-κB signaling has been implicated will be discussed with reference to the lens of cell-type specific responses.

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Authors: Dresselhaus, E. C., & Meffert, M. K.
Affiliations: Johns Hopkins University (US)
Corresponding author: Meffert, Mollie K.
ORCID: Dresselhaus, Erica C.
Meffert, Mollie K.
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2019-05-09
Volume: 10
Pages: 1043-1043
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2019.01043
PMC: PMC6520659
OpenAlex: W2944682402
Cited by: 345
References: 129
Citations by year: 2026: 37 · 2025: 46 · 2024: 54 · 2023: 48 · 2022: 54 · 2021: 58 · 2020: 45 · 2019: 2
FWCI: 3.88
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Immunology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: NF-κB, nervous system, cell type specificity, central nervous system, neurons, glial cells, astrocytes, microglia, cell-autonomous signaling, non-cell-autonomous signaling, central nervous system disorders, neuroinflammation
MeSH terms: Animals, Central Nervous System, Humans, Nervous System, Neuroglia, Neurons, Organ Specificity, Signal Transduction, NF-kappa B, Microglia

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Cellular Specificity of NF-κB Function in the Nervous System

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