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Cellular Specificity of NF-κB Function in the Nervous System
Open accessAbstract
Nuclear Factor Kappa B (NF-κB) is a ubiquitously expressed transcription factor with key functions in a wide array of biological systems. While the role of NF-κB in processes, such as host immunity and oncogenesis has been more clearly defined, an understanding of the basic functions of NF-κB in the nervous system has lagged behind. The vast cell-type heterogeneity within the central nervous system (CNS) and the interplay between cell-type specific roles of NF-κB contributes to the complexity of understanding NF-κB functions in the brain. In this review, we will focus on the emerging understanding of cell-autonomous regulation of NF-κB signaling as well as the non-cell-autonomous functional impacts of NF-κB activation in the mammalian nervous system. We will focus on recent work which is unlocking the pleiotropic roles of NF-κB in neurons and glial cells (including astrocytes and microglia). Normal physiology as well as disorders of the CNS in which NF-κB signaling has been implicated will be discussed with reference to the lens of cell-type specific responses.
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“Activation of NFκB by inflammatory stimuli is mediated by phosphorylation and ubiquitin-mediated degradation of IκB which disinhibits NFκB, allowing for nuclear translocation to target genes and activation of transcription [140].”
From ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020) · cites this paper as [140]
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Metadata
- Authors
- Dresselhaus, E. C., & Meffert, M. K.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Meffert, Mollie K.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2019-05-09
- Volume
- 10
- Pages
- 1043-1043
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC6520659
- OpenAlex
- W2944682402
- Cited by
- 345
- References
- 129
- Citations by year
- 2026: 37 · 2025: 46 · 2024: 54 · 2023: 48 · 2022: 54 · 2021: 58 · 2020: 45 · 2019: 2
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- NF-κB, nervous system, cell type specificity, central nervous system, neurons, glial cells, astrocytes, microglia, cell-autonomous signaling, non-cell-autonomous signaling, central nervous system disorders, neuroinflammation
- MeSH terms
- Animals, Central Nervous System, Humans, Nervous System, Neuroglia, Neurons, Organ Specificity, Signal Transduction, NF-kappa B, Microglia
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