The DOI matches its Crossref record; 115 of the 116 references it cites were found in a registry or an index.
Immunomodulating Activity and Therapeutic Effects of Short Chain Fatty Acids and Tryptophan Post-biotics in Inflammatory Bowel Disease
Open accessAbstract
Crohn's disease (CD) and Ulcerative colitis (UC) are grouped as Inflammatory Bowel Diseases (IBD). The IBD is associated to a multifaceted interplay between immunologic, microbial, genetic, and environmental factors. Nowadays, the gut microbiota (GM) dysbiosis has been indicated as a cause in the IBD development, affecting the impaired cross-talk between GM and immune cells. Moreover, recent studies have uncovered a crucial role for bacterial post-biotics (metabolites) in the orchestration of the host immune response, as they could be messengers between the GM and the immune system. In addition, transgenic mouse models showed that SCFAs (Short Chain Fatty Acids) and Tryptophan (Trp) post-biotics play important immunomodulatory effects, regulating both innate and adaptive immune cell generation, their function and trafficking. Here, we present an overview on the main microbial post-biotics and their effects on the gut mucosa with specific emphasis on their relevance for IBD. Finally, we discuss the therapeutic potential of SCFA and Trp post-biotics on IBD through approaches based on the "immunonutrition," defined as a modulation of the immune system provided by specific interventions that modify dietary nutrients.
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“Supplementation with both Lactobacillus strains and synthetic AhR agonists ameliorated intestinal inflammation in IBD patients.101”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [101]
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1 retracted
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Items 201–204 of 204
Frandeș, S. I., Frandes, O., Macarie, M., & Bataga, S. M. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15187270
Hong, S. P., Kim, K. W., Im, Y., Jang, J., Cheon, D. H., Lee, E. K., Han, Y. M., Park, J. W., Lee, H. J., Park, H., et al. (2026) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izag176
The Potential Role of Postbiotics in Periodontitis Treatment and Preventive Dentistry
Rostami, M. N., Roudsari, M. B., Abasi, M., Khaneshi, N., Gerayeli, M., Yousefi, M., Amini, A., Alizadeh, A., & Fazel, F. (2026) · Current Microbiology · doi:10.1007/s00284-026-05179-4
The intestinal microbiome in inflammatory bowel disease and spondyloarthritides
Alizadeh, M. A., Siaton, B. C., Hudhud, D. N., von Rosenvinge, E. C., Cross, R. K., & Ravel, J. (2026) · Communications Medicine · doi:10.1038/s43856-026-01919-6
Metadata
- Authors
- Russo, E., Giudici, F., Fiorindi, C., Ficari, F., Scaringi, S., & Amedei, A.
- Affiliations
- University of Florence (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Corresponding author
- Amedei, Amedeo
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2019-11-22
- Volume
- 10
- Pages
- 2754-2754
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC6883404
- OpenAlex
- W2991131426
- Cited by
- 204
- References
- 116
- Citations by year
- 2026: 18 · 2025: 30 · 2024: 34 · 2023: 32 · 2022: 40 · 2021: 35 · 2020: 15
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ente Cassa di Risparmio di Firenze
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- inflammatory bowel disease, Crohn's disease, ulcerative colitis, short-chain fatty acids, tryptophan metabolites, gut dysbiosis, immunomodulation, immunonutrition, dietary nutrients, intestinal mucosa, immune cell trafficking
- MeSH terms
- Gastrointestinal Microbiome, Animals, Fatty Acids, Volatile, Humans, Intestinal Mucosa, Tryptophan, Inflammatory Bowel Diseases, Mice
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