Cited by 204Gut microbiota and healthInflammatory Bowel DiseaseProbiotics and Fermented Foods

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Immunomodulating Activity and Therapeutic Effects of Short Chain Fatty Acids and Tryptophan Post-biotics in Inflammatory Bowel Disease

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Russo, Edda, Giudici, Francesco, Fiorindi, Camilla, Ficari, Ferdinando, Scaringi, Stefano, Amedei, Amedeo·2019·Frontiers in Immunology

DOI 10.3389/fimmu.2019.02754PMC PMC6883404

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Abstract

Crohn's disease (CD) and Ulcerative colitis (UC) are grouped as Inflammatory Bowel Diseases (IBD). The IBD is associated to a multifaceted interplay between immunologic, microbial, genetic, and environmental factors. Nowadays, the gut microbiota (GM) dysbiosis has been indicated as a cause in the IBD development, affecting the impaired cross-talk between GM and immune cells. Moreover, recent studies have uncovered a crucial role for bacterial post-biotics (metabolites) in the orchestration of the host immune response, as they could be messengers between the GM and the immune system. In addition, transgenic mouse models showed that SCFAs (Short Chain Fatty Acids) and Tryptophan (Trp) post-biotics play important immunomodulatory effects, regulating both innate and adaptive immune cell generation, their function and trafficking. Here, we present an overview on the main microbial post-biotics and their effects on the gut mucosa with specific emphasis on their relevance for IBD. Finally, we discuss the therapeutic potential of SCFA and Trp post-biotics on IBD through approaches based on the "immunonutrition," defined as a modulation of the immune system provided by specific interventions that modify dietary nutrients.

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Authors: Russo, E., Giudici, F., Fiorindi, C., Ficari, F., Scaringi, S., & Amedei, A.
Affiliations: University of Florence (IT)
Azienda Ospedaliero-Universitaria Careggi (IT)
Corresponding author: Amedei, Amedeo
ORCID: Russo, Edda
Giudici, Francesco
Fiorindi, Camilla
Scaringi, Stefano
Amedei, Amedeo
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2019-11-22
Volume: 10
Pages: 2754-2754
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2019.02754
PMC: PMC6883404
OpenAlex: W2991131426
Cited by: 204
References: 116
Citations by year: 2026: 18 · 2025: 30 · 2024: 34 · 2023: 32 · 2022: 40 · 2021: 35 · 2020: 15
FWCI: 1.99
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Immunology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Florence Research (University of Florence) (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Ente Cassa di Risparmio di Firenze
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: inflammatory bowel disease, Crohn's disease, ulcerative colitis, short-chain fatty acids, tryptophan metabolites, gut dysbiosis, immunomodulation, immunonutrition, dietary nutrients, intestinal mucosa, immune cell trafficking
MeSH terms: Gastrointestinal Microbiome, Animals, Fatty Acids, Volatile, Humans, Intestinal Mucosa, Tryptophan, Inflammatory Bowel Diseases, Mice

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Immunomodulating Activity and Therapeutic Effects of Short Chain Fatty Acids and Tryptophan Post-biotics in Inflammatory Bowel Disease

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