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Cited by 285

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Multiple Roles for Chemokines in Neutrophil Biology

Open access
Capucetti, Arianna, Albano, Francesca, Bonecchi, Raffaella·2020·Frontiers in Immunology

Abstract

Chemokines are recognized as the most critical mediators for selective neutrophil recruitment during inflammatory conditions. Furthermore, they are considered fundamental regulators of neutrophil mobilization from the bone marrow (BM) to the bloodstream and for their homing back at the end of their life for apoptosis and clearance. However, chemokines are also important mediators of neutrophil effector functions including oxidative burst, degranulation, neutrophil extracellular trap (NET)osis, and production of inflammatory mediators. Neutrophils have been historically considered as a homogeneous population. In recent years, several maturation stages and subsets with different phenotypic profiles and effector functions were described both in physiological and pathological conditions such as infections, autoimmunity, and cancer. The aim of this review is to give an overview of the current evidence regarding the role of chemokines and chemokine receptors in neutrophil biology, including their possible role in neutrophil maturation, differentiation, and in defining emerging neutrophil subsets.

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Metadata

Authors
Capucetti, A., Albano, F., & Bonecchi, R.
Venue
Frontiers in Immunology
Published
2020-07-09
Volume
11
Pages
1259-1259
ISSN
1664-3224 (ISSN-L)
OpenAlex
W3046383992
Cited by
285
References
100
FWCI
10.51
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Multiple Roles for Chemokines in Neutrophil Biology. https://app.cochat.ai/papers/10.3389/fimmu.2020.01259
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Capucetti, A., Albano, F., & Bonecchi, R. (2020). Multiple Roles for Chemokines in Neutrophil Biology. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2020.01259

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.