The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis
Open accessAbstract
Neutrophil Extracellular Traps (NETs) are net-like structures composed of DNA-histone complexes and proteins released by activated neutrophils. In addition to their key role in the neutrophil innate immune response, NETs are also involved in autoimmune diseases, like systemic lupus erythematosus, rheumatoid arthritis, psoriasis, and in other non-infectious pathological processes, as coagulation disorders, thrombosis, diabetes, atherosclerosis, vasculitis, and cancer. Recently, a large body of evidence indicates that NETs are involved in cancer progression and metastatic dissemination, both in animal models and cancer patients. Interestingly, a close correlation between cancer cell recruitment of neutrophils in the tumor microenvironment (Tumor Associated Neutrophils. TANs) and NET formation has been also observed either in primary tumors and metastatic sites. Moreover, NETs can also catch circulating cancer cells and promote metastasis. Furthermore, it has been reported that wake dormant cancer cells, causing tumor relapse and metastasis. This review will primarily focus on the pro-tumorigenic activity of NETs in tumors highlighting their ability to serve as a potential target for cancer therapy.
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Cites
Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268
Neutrophil extracellular traps in immunity and disease
Papayannopoulos, V. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.105 · Cited by 3,397
Novel cell death program leads to neutrophil extracellular traps
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Extracellular DNA traps promote thrombosis
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Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice
Albrengues, J., Shields, M. A., Ng, D., Park, C. G., Ambrico, A., Poindexter, M. E., Upadhyay, P., Uyeminami, D. L., Pommier, A., Küttner, V., et al. (2018) · Science · doi:10.1126/science.aao4227 · Cited by 1,476
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Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis
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Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis
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Neutrophil extracellular traps: from physiology to pathology
Hidalgo, A., Libby, P., Soehnlein, O., Aramburu, I. V., Papayannopoulos, V., & Silvestre-Roig, C. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvab329 · Cited by 401
Mousset, A., Lecorgne, E., Bourget, I., Lopez, P., Jenovai, K., Cherfils-Vicini, J., Dominici, C., Rios, G., Girard-Riboulleau, C., Liu, B., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.03.008 · Cited by 266
TGF-β signaling in the tumor metabolic microenvironment and targeted therapies
Shi, X., Yang, J., Deng, S., Xu, H., Wu, D., Zeng, Q., Wang, S., Hu, T., Wu, F., & Zhou, H. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01349-6 · Cited by 262
Neutrophils and Neutrophil-Based Drug Delivery Systems in Anti-Cancer Therapy
Wahnou, H., El Kebbaj, R., Hba, S., Ouadghiri, Z., El Faqer, O., Pinon, A., Liagre, B., Limami, Y., & Duval, R. E. (2025) · Cancers · doi:10.3390/cancers17071232 · Cited by 35
Metadata
- Authors
- Masucci, M. T., Minopoli, M., Del Vecchio, S., & Carriero, M. V.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2020-09-16
- Volume
- 11
- Pages
- 1749-1749
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W3084567979
- Cited by
- 522
- References
- 71
- FWCI
- 17.77
- Type
- journal article
- Language
- en
- Open access
- gold
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- Masucci, M. T., Minopoli, M., Del Vecchio, S., & Carriero, M. V. (2020). The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2020.01749
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