The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
NF-κB Pathway as a Potential Target for Treatment of Critical Stage COVID-19 Patients
Open accessAbstract
Patients infected with SARS-CoV-2 show a wide spectrum of clinical manifestations ranging from mild febrile illness and cough up to acute respiratory distress syndrome, multiple organ failure, and death. Data from patients with severe clinical manifestations compared to patients with mild symptoms indicate that highly dysregulated exuberant inflammatory responses correlate with severity of disease and lethality. Epithelial-immune cell interactions and elevated cytokine and chemokine levels, i.e. cytokine storm, seem to play a central role in severity and lethality in COVID-19. The present perspective places a central cellular pro-inflammatory signal pathway, NF-κB, in the context of recently published data for COVID-19 and provides a hypothesis for a therapeutic approach aiming at the simultaneous inhibition of whole cascades of pro-inflammatory cytokines and chemokines. The simultaneous inhibition of multiple cytokines/chemokines is expected to have much higher therapeutic potential as compared to single target approaches to prevent cascade (i.e. redundant, triggering, amplifying, and synergistic) effects of multiple induced cytokines and chemokines in critical stage COVID-19 patients.
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Dexamethasone in Hospitalized Patients with Covid-19
The RECOVERY Collaborative Group (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2021436 · Cited by 11,477
Effect of Dexamethasone in Hospitalized Patients with COVID-19 – Preliminary Report
Horby, P., Lim, W. S., Emberson, J., Mafham, M., Bell, J., Linsell, L., Staplin, N., Brightling, C., Ustianowski, A., Elmahi, E., et al. (2020) · doi:10.1101/2020.06.22.20137273 · Cited by 11,475
Pathological findings of COVID-19 associated with acute respiratory distress syndrome
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Endothelial cell infection and endotheliitis in COVID-19
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Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19
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The pathogenesis and treatment of the `Cytokine Storm' in COVID-19
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Cited by
NF‐κB signaling in inflammation and cancer
Zhang, T., Ma, C., Zhang, Z., Zhang, H., & Hu, H. (2021) · MedComm · doi:10.1002/mco2.104 · Cited by 574
Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications
Zhang, F., Lau, R. I., Liu, Q., Su, Q., Chan, F. K. L., & Ng, S. C. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00698-4 · Cited by 267
Parisi, G. F., Carota, G., Castruccio Castracani, C., Spampinato, M., Manti, S., Papale, M., Di Rosa, M., Barbagallo, I., & Leonardi, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052465 · Cited by 43
Metadata
- Authors
- Kircheis, R., Haasbach, E., Lueftenegger, D., Heyken, W. T., Ocker, M., & Planz, O.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2020-12-10
- Volume
- 11
- Pages
- 598444-598444
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W3110713218
- Cited by
- 201
- References
- 20
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kircheis, R., Haasbach, E., Lueftenegger, D., Heyken, W. T., Ocker, M., & Planz, O. (2020). NF-κB Pathway as a Potential Target for Treatment of Critical Stage COVID-19 Patients. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2020.598444
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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