The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.
CD8+ T Cell Exhaustion in Cancer
Open accessAbstract
A paradigm shift in the understanding of the exhausted CD8+ T cell (T ex) lineage is underway. Originally thought to be a uniform population that progressively loses effector function in response to persistent antigen, single-cell analysis has now revealed that CD8+ T ex is composed of multiple interconnected subpopulations. The heterogeneity within the CD8+ T ex lineage is comprised of immune checkpoint blockade (ICB) permissive and refractory subsets termed stem-like and terminally differentiated cells, respectively. These populations occupy distinct peripheral and intratumoral niches and are characterized by transcriptional processes that govern transitions between cell states. This review presents key findings in the field to construct an updated view of the spatial, transcriptional, and functional heterogeneity of anti-tumoral CD8+ T ex. These emerging insights broadly call for (re-)focusing cancer immunotherapies to center on the driver mechanism(s) underlying the CD8+ T ex developmental continuum aimed at stabilizing functional subsets.
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Cites
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Cited by
Sun, L., Su, Y., Jiao, A., Wang, X., & Zhang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01471-y · Cited by 1,014
Li, Y., Wang, Z., Gao, P., Cao, D., Dong, R., Zhu, M., Fei, Y., Zuo, X., & Cai, J. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05498-9 · Cited by 55
Kremer, K. N., Khammash, H. A., Miranda, A. M., Rutt, L. N., Twardy, S. M., Anton, P. E., Campbell, M. L., Garza-Ortiz, C., Orlicky, D. J., Pelanda, R., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1497788 · Cited by 19
Yuan, Z., Liu, Z., Zhou, M., Wen, H., & Li, B. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.105111 · Cited by 6
Research progress of T cells in cholangiocarcinoma
Wang, Z., Dai, Y., Zhou, Y., Wang, Y., Chen, P., Li, Y., Zhang, Y., Wang, X., Hu, Y., Li, H., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1453344 · Cited by 2
Metadata
- Authors
- Dolina, J. S., Van Braeckel-Budimir, N., Thomas, G. D., & Salek-Ardakani, S.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2021-07-20
- Volume
- 12
- Pages
- 715234-715234
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W3184734893
- Cited by
- 489
- References
- 129
- FWCI
- 24.95
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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