The DOI matches its Crossref record; 208 of the 208 references it cites were found in a registry or an index.
Regulation of short-chain fatty acids in the immune system
Open accessAbstract
A growing body of research suggests that short-chain fatty acids (SCFAs), metabolites produced by intestinal symbiotic bacteria that ferment dietary fibers (DFs), play a crucial role in the health status of symbiotes. SCFAs act on a variety of cell types to regulate important biological processes, including host metabolism, intestinal function, and immune function. SCFAs also affect the function and fate of immune cells. This finding provides a new concept in immune metabolism and a better understanding of the regulatory role of SCFAs in the immune system, which impacts the prevention and treatment of disease. The mechanism by which SCFAs induce or regulate the immune response is becoming increasingly clear. This review summarizes the different mechanisms through which SCFAs act in cells. According to the latest research, the regulatory role of SCFAs in the innate immune system, including in NLRP3 inflammasomes, receptors of TLR family members, neutrophils, macrophages, natural killer cells, eosinophils, basophils and innate lymphocyte subsets, is emphasized. The regulatory role of SCFAs in the adaptive immune system, including in T-cell subsets, B cells, and plasma cells, is also highlighted. In addition, we discuss the role that SCFAs play in regulating allergic airway inflammation, colitis, and osteoporosis by influencing the immune system. These findings provide evidence for determining treatment options based on metabolic regulation.
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Cites
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Cited by
Varghese, S., Rao, S., Khattak, A., Zamir, F., & Chaari, A. (2024) · Nutrients · doi:10.3390/nu16213663 · Cited by 152
Beyond the gut: decoding the gut–immune–brain axis in health and disease
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Metadata
- Authors
- Liu, X.-F., Shao, J.-H., Liao, Y.-T., Wang, L.-N., Jia, Y., Dong, P.-J., Liu, Z.-Z., He, D.-D., Li, C., & Zhang, X.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2023-05-05
- Volume
- 14
- Pages
- 1186892-1186892
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W4377564738
- Cited by
- 403
- References
- 208
- FWCI
- 30.11
- Type
- journal article
- Language
- en
- Open access
- gold
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- Liu, X.-F., Shao, J.-H., Liao, Y.-T., Wang, L.-N., Jia, Y., Dong, P.-J., Liu, Z.-Z., He, D.-D., Li, C., & Zhang, X. (2023). Regulation of short-chain fatty acids in the immune system. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2023.1186892
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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