The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.
From bench to bedside: the history and progress of CAR T cell therapy
Open accessAbstract
Chimeric antigen receptor (CAR) T cell therapy represents a major breakthrough in cancer care since the approval of tisagenlecleucel by the Food and Drug Administration in 2017 for the treatment of pediatric and young adult patients with relapsed or refractory acute lymphocytic leukemia. As of April 2023, six CAR T cell therapies have been approved, demonstrating unprecedented efficacy in patients with B-cell malignancies and multiple myeloma. However, adverse events such as cytokine release syndrome and immune effector cell-associated neurotoxicity pose significant challenges to CAR T cell therapy. The severity of these adverse events correlates with the pretreatment tumor burden, where a higher tumor burden results in more severe consequences. This observation is supported by the application of CD19-targeted CAR T cell therapy in autoimmune diseases including systemic lupus erythematosus and antisynthetase syndrome. These results indicate that initiating CAR T cell therapy early at low tumor burden or using debulking strategy prior to CAR T cell infusion may reduce the severity of adverse events. In addition, CAR T cell therapy is expensive and has limited effectiveness against solid tumors. In this article, we review the critical steps that led to this groundbreaking therapy and explore ongoing efforts to overcome these challenges. With the promise of more effective and safer CAR T cell therapies in development, we are optimistic that a broader range of cancer patients will benefit from this revolutionary therapy in the foreseeable future.
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Cites
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Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia
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Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia
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CD28/B7 SYSTEM OF T CELL COSTIMULATION
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Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma.
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“In April 2021 and February 2022, two BCMA-specific CAR T cell therapies were approved for the treatment of multiple myeloma, namely idecabtagene vicleucel (Abecma) and ciltacabtagene autoleucel (Carvykti) (63, 64).”
BackgroundSelf-citationAdoptive cell transfer as personalized immunotherapy for human cancer
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Egan, J. R., Marí‐Buyé, N., Benítez‐Cano, E. V., Costa, M., Wanika, L., Chappell, M. J., Schultz, U., Ochs, J., Effenberger, M., Horna, D., et al. (2025) · Biotechnology Progress · doi:10.1002/btpr.70045 · Cited by 10
Corcoran, W. K., Cosio, A., Edelstein, H. I., & Leonard, J. N. (2025) · GEN Biotechnology · doi:10.1089/genbio.2024.0057 · Cited by 4
Manufacturing of CAR-T cells using in-house vectors and the CliniMACS Prodigy
Kerbauy, L. N., & Mesquita, F. P. (2026) · JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY · doi:10.46765/2675-374x.2025v7n1e338
Metadata
- Authors
- Mitra, A., Barua, A., Huang, L., Ganguly, S., Feng, Q., & He, B.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2023-05-15
- Volume
- 14
- Pages
- 1188049-1188049
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W4376615273
- Cited by
- 466
- References
- 144
- FWCI
- 48.25
- Type
- journal article
- Language
- en
- Open access
- gold
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