Cited by 189Bone Tissue Engineering MaterialsAdditive Manufacturing and 3D Printing Technologies3D Printing in Biomedical Research

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Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review

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Kumar, Anuj, Kargozar, Saeid, Baino, Francesco, Han, Sung Soo·2019·Frontiers in Materials

DOI 10.3389/fmats.2019.00313

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Abstract

Hydroxyapatite (HAp) has been considered for decades an ideal biomaterial for bone repair due to its compositional and crystallographic similarity to bio-apatites in hard tissues. However, fabrication of porous HAp acting as a template (scaffold) for supporting bone regeneration and growth has been a challenge to biomaterials scientists. The introduction of additive manufacturing technologies, which provide the advantages of a relatively fast, precise, controllable and potentially scalable fabrication process, has opened new horizons in the field of bioceramic scaffolds. This review focuses on 3D-printed HAp scaffolds and related composite systems, where the calcium phosphate phase is combined with other ceramics or polymers improving the mechanical properties and/or imparting special extra-functionalities. The main applications of 3D-printed HAp scaffolds in bone tissue engineering are presented and discussed; furthermore, this review also emphasizes the most recent achievements towards the development and testing of multifunctional HAp-based systems combining multiple properties for advanced therapy (e.g. bone regeneration, antibacterial effect, angiogenesis and cancer treatment).

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Authors: Kumar, A., Kargozar, S., Baino, F., & Han, S. S.
Affiliations: Yeungnam University (KR)
Mashhad University of Medical Sciences (IR)
Politecnico di Torino (IT)
Corresponding author: Kumar, Anuj
Baino, Francesco
Han, Sung Soo
ORCID: Kumar, Anuj
Kargozar, Saeid
Baino, Francesco
Han, Sung Soo
Venue: Frontiers in Materials
Publisher: Frontiers Media SA
Published: 2019-12-17
Volume: 6
ISSN: 2296-8016 (ISSN-L)
DOI: 10.3389/fmats.2019.00313
OpenAlex: W2995341222
Cited by: 189
References: 182
Citations by year: 2026: 18 · 2025: 20 · 2024: 34 · 2023: 31 · 2022: 33 · 2021: 38 · 2020: 15
FWCI: 1.73
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Materials (publishedVersion, cc-by)
PORTO@Iris (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
INFM-OAR (INFN Catania) (submittedVersion, cc-by)
Zenodo (CERN European Organization for Nuclear Research)
Funders: National Research Foundation
Yeungnam University
National Research Foundation of Korea
Ministry of Education, Science and Technology (2017R1D1A3B03036276)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Physical Sciences › Engineering › Industrial and Manufacturing Engineering › Additive Manufacturing and 3D Printing Technologies
Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords: hydroxyapatite, 3D printing, bioceramic scaffolds, composite scaffolds, bone tissue engineering, bone regeneration, porous scaffolds, calcium phosphate, antibacterial scaffolds, angiogenesis, cancer therapy, multifunctional biomaterials

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Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review

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