The DOI matches its Crossref record; 180 of the 182 references it cites were found in a registry or an index.
Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review
Open accessAbstract
Hydroxyapatite (HAp) has been considered for decades an ideal biomaterial for bone repair due to its compositional and crystallographic similarity to bio-apatites in hard tissues. However, fabrication of porous HAp acting as a template (scaffold) for supporting bone regeneration and growth has been a challenge to biomaterials scientists. The introduction of additive manufacturing technologies, which provide the advantages of a relatively fast, precise, controllable and potentially scalable fabrication process, has opened new horizons in the field of bioceramic scaffolds. This review focuses on 3D-printed HAp scaffolds and related composite systems, where the calcium phosphate phase is combined with other ceramics or polymers improving the mechanical properties and/or imparting special extra-functionalities. The main applications of 3D-printed HAp scaffolds in bone tissue engineering are presented and discussed; furthermore, this review also emphasizes the most recent achievements towards the development and testing of multifunctional HAp-based systems combining multiple properties for advanced therapy (e.g. bone regeneration, antibacterial effect, angiogenesis and cancer treatment).
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“Additive manufacturing is one of the widely used techniques that can develop scaffolds with a controllable shape having required porosity [77,78].”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [78]
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1 retracted
Xu, S., Xu, S., Zhou, P., Cheng, X., Xie, Y., Liang, C., & Li, C. (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s50685 · Cited by 146
RetractedPorous scaffold design for tissue engineering
Hollister, S. J. (2005) · Nature Materials · doi:10.1038/nmat1421 · Cited by 3,979
Sydney Gladman, A., Matsumoto, E. A., Nuzzo, R. G., Mahadevan, L., & Lewis, J. A. (2016) · Nature Materials · doi:10.1038/nmat4544 · Cited by 3,027
Hench, L. L. (2006) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-006-0432-z · Cited by 2,510
Properties of osteoconductive biomaterials: calcium phosphates.
Legeros, R. (2002) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-200202000-00009 · Cited by 2,003
25th Anniversary Article: Engineering Hydrogels for Biofabrication
Malda, J., Visser, J., Melchels, F. P., Jüngst, T., Hennink, W. E., Dhert, W. J. A., Groll, J., & Hutmacher, D. W. (2013) · Advanced Materials · doi:10.1002/adma.201302042 · Cited by 1,901
(2026) · Key engineering materials · doi:10.4028/www.scientific.net/kem · Cited by 1,726
Current advances and future perspectives in extrusion-based bioprinting
Ozbolat, I. T., & Hospodiuk, M. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.10.076 · Cited by 1,642
Synthesis methods for nanosized hydroxyapatite with diverse structures
Sadat‐Shojai, M., Khorasani, M. T., Dinpanah‐Khoshdargi, E., & Jamshidi, A. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.04.012 · Cited by 1,546
45S5 Bioglass®-derived glass–ceramic scaffolds for bone tissue engineering
Chen, Q. Z., Thompson, I. D., & Boccaccini, A. R. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.11.025 · Cited by 1,244
Research works printed but not linked: 4
- Dorozhkin, 2017, Hydroxyapatite and Other Calcium Orthophosphates: General Information and History
- Hull, 1986, Apparatus for Production of Three-Dimensional Objects by Stereolithography
- Sumer, 2013, Autogenous cortical bone and bioactive glass grafting for treatment of intraosseous periodontal defects, Eur. J. Dent., 7, 6, 10.1055/s-009-44516 · DOI
- Suvannapruk, 2018, Properties alteration of anti-tuberculosis drugs loaded 3D printed hydroxyapatite by polycaprolactone coating, 94
Cited by
Sorted by citations
Fabrication of Biomedical Scaffolds Using Biodegradable Polymers.
Kirillova, A., Yeazel, T. R., Asheghali, D., Petersen, S. R., Dort, S., Gall, K., & Becker, M. L. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01200 · Cited by 368
Hydroxyapatite for Biomedical Applications: A Short Overview
Fiume, E., Magnaterra, G., Rahdar, A., Verné, E., & Baino, F. (2021) · Ceramics · doi:10.3390/ceramics4040039 · Cited by 316
Self-citationMohammadinejad, R., Kumar, A., Ranjbar‐Mohammadi, M., Ashrafizadeh, M., Han, S. S., Khang, G., & Roveimiab, Z. (2020) · Polymers · doi:10.3390/polym12010176 · Cited by 219
Self-citation3D Bioprinted Scaffolds for Bone Tissue Engineering: State-Of-The-Art and Emerging Technologies
Yazdanpanah, Z., Johnston, J. D., Cooper, D. M. L., & Chen, D. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.824156 · Cited by 201
Miri, Z., Haugen, H. J., Loča, D., Rossi, F., Perale, G., Moghanian, A., & Ma, Q. (2023) · Journal of the European Ceramic Society · doi:10.1016/j.jeurceramsoc.2023.09.003 · Cited by 165
Metadata
- Authors
- Kumar, A., Kargozar, S., Baino, F., & Han, S. S.
- Affiliations
- Yeungnam University (KR)
- Mashhad University of Medical Sciences (IR)
- Politecnico di Torino (IT)
- Corresponding author
- Kumar, Anuj
- Baino, Francesco
- Han, Sung Soo
- Venue
- Frontiers in Materials
- Publisher
- Frontiers Media SA
- Published
- 2019-12-17
- Volume
- 6
- ISSN
- 2296-8016 (ISSN-L)
- OpenAlex
- W2995341222
- Cited by
- 189
- References
- 182
- Citations by year
- 2026: 18 · 2025: 20 · 2024: 34 · 2023: 31 · 2022: 33 · 2021: 38 · 2020: 15
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Materials (publishedVersion, cc-by)
- PORTO@Iris (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- INFM-OAR (INFN Catania) (submittedVersion, cc-by)
- Zenodo (CERN European Organization for Nuclear Research)
- Funders
- National Research Foundation
- Yeungnam University
- National Research Foundation of Korea
- Ministry of Education, Science and Technology (2017R1D1A3B03036276)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Industrial and Manufacturing Engineering › Additive Manufacturing and 3D Printing Technologies
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- hydroxyapatite, 3D printing, bioceramic scaffolds, composite scaffolds, bone tissue engineering, bone regeneration, porous scaffolds, calcium phosphate, antibacterial scaffolds, angiogenesis, cancer therapy, multifunctional biomaterials
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