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Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review
Open accessAbstract
Hydroxyapatite (HAp) has been considered for decades an ideal biomaterial for bone repair due to its compositional and crystallographic similarity to bio-apatites in hard tissues. However, fabrication of porous HAp acting as a template (scaffold) for supporting bone regeneration and growth has been a challenge to biomaterials scientists. The introduction of additive manufacturing technologies, which provide the advantages of a relatively fast, precise, controllable and potentially scalable fabrication process, has opened new horizons in the field of bioceramic scaffolds. This review focuses on 3D-printed HAp scaffolds and related composite systems, where the calcium phosphate phase is combined with other ceramics or polymers improving the mechanical properties and/or imparting special extra-functionalities. The main applications of 3D-printed HAp scaffolds in bone tissue engineering are presented and discussed; furthermore, this review also emphasizes the most recent achievements towards the development and testing of multifunctional HAp-based systems combining multiple properties for advanced therapy (e.g. bone regeneration, antibacterial effect, angiogenesis and cancer treatment).
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“Additive manufacturing is one of the widely used techniques that can develop scaffolds with a controllable shape having required porosity [77,78].”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [78]
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Metadata
- Authors
- Kumar, A., Kargozar, S., Baino, F., & Han, S. S.
- Affiliations
- Yeungnam University (KR)
- Mashhad University of Medical Sciences (IR)
- Politecnico di Torino (IT)
- Corresponding author
- Kumar, Anuj
- Baino, Francesco
- Han, Sung Soo
- Venue
- Frontiers in Materials
- Publisher
- Frontiers Media SA
- Published
- 2019-12-17
- Volume
- 6
- ISSN
- 2296-8016 (ISSN-L)
- OpenAlex
- W2995341222
- Cited by
- 189
- References
- 182
- Citations by year
- 2026: 18 · 2025: 20 · 2024: 34 · 2023: 31 · 2022: 33 · 2021: 38 · 2020: 15
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Materials (publishedVersion, cc-by)
- PORTO@Iris (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- INFM-OAR (INFN Catania) (submittedVersion, cc-by)
- Zenodo (CERN European Organization for Nuclear Research)
- Funders
- National Research Foundation
- Yeungnam University
- National Research Foundation of Korea
- Ministry of Education, Science and Technology (2017R1D1A3B03036276)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Industrial and Manufacturing Engineering › Additive Manufacturing and 3D Printing Technologies
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- hydroxyapatite, 3D printing, bioceramic scaffolds, composite scaffolds, bone tissue engineering, bone regeneration, porous scaffolds, calcium phosphate, antibacterial scaffolds, angiogenesis, cancer therapy, multifunctional biomaterials
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