The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Mode-of-Action of Antimicrobial Peptides: Membrane Disruption vs. Intracellular Mechanisms
Open accessAbstract
Antimicrobial peptides are an attractive alternative to traditional antibiotics, due to their physicochemical properties, activity toward a broad spectrum of bacteria, and mode-of-actions distinct from those used by current antibiotics. In general, antimicrobial peptides kill bacteria by either disrupting their membrane, or by entering inside bacterial cells to interact with intracellular components. Characterization of their mode-of-action is essential to improve their activity, avoid resistance in bacterial pathogens, and accelerate their use as therapeutics. Here we review experimental biophysical tools that can be employed with model membranes and bacterial cells to characterize the mode-of-action of antimicrobial peptides.
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Cites
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Electrophoretic mobility shift assay (EMSA) for detecting protein–nucleic acid interactions
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Cited by
Antimicrobial Peptides—Mechanisms of Action, Antimicrobial Effects and Clinical Applications
Talapko, J., Meštrović, T., Juzbašić, M., Tomas, M., Erić, S., Horvat Aleksijević, L., Bekić, S., Schwarz, D., Matić, S., Neuberg, M., et al. (2022) · Antibiotics · doi:10.3390/antibiotics11101417 · Cited by 281
Kaur, M., Bhatia, S., Gupta, U., Decker, E., Tak, Y., Bali, M., Gupta, V. K., Dar, R. A., & Bala, S. (2023) · Phytochemistry Reviews · doi:10.1007/s11101-022-09848-7 · Cited by 95
Naik, G. A. R. R., Roy, A. A., Mutalik, S., & Dhas, N. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134977 · Cited by 47
Dermawan, D., & Alotaiq, N. (2025) · Scientific Reports · doi:10.1038/s41598-025-93683-1 · Cited by 19
Grabeck, J., Mayer, J., Miltz, A., Casoria, M., Quagliata, M., Meinberger, D., Klatt, A. R., Wielert, I., Maier, B., Papini, A. M., et al. (2024) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.4c00078 · Cited by 7
Metadata
- Authors
- Benfield, A. H., & Henriques, S. T.
- Venue
- Frontiers in Medical Technology
- Publisher
- Frontiers Media SA
- Published
- 2020-12-11
- Volume
- 2
- Pages
- 610997-610997
- ISSN
- 2673-3129 (ISSN-L)
- OpenAlex
- W3111531342
- Cited by
- 367
- References
- 91
- FWCI
- 17.82
- Type
- journal article
- Language
- en
- Open access
- gold
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- Benfield, A. H., & Henriques, S. T. (2020). Mode-of-Action of Antimicrobial Peptides: Membrane Disruption vs. Intracellular Mechanisms. Frontiers in Medical Technology. https://doi.org/10.3389/fmedt.2020.610997
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
