The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Pseudomonas Exotoxin A: optimized by evolution for effective killing
Open accessAbstract
Pseudomonas Exotoxin A (PE) is the most toxic virulence factor of the pathogenic bacterium Pseudomonas aeruginosa. This review describes current knowledge about the intoxication pathways of PE. Moreover, PE represents a remarkable example for pathoadaptive evolution, how bacterial molecules have been structurally and functionally optimized under evolutionary pressure to effectively impair and kill their host cells.
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“Exotoxin A (ETA) is encoded by the toxA gene and is one of the most potent virulence factors produced by P. aeruginosa112,113.”
From Pseudomonas aeruginosa: ecology, evolution, pathogenesis and antimicrobial susceptibility (2025) · cites this paper as [113]
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Cites
Webb, A. K. (2006) · Cited by 4,369
Rab proteins as membrane organizers
Zerial, M., & McBride, H. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052055 · Cited by 3,381
Rowe, S. M., Miller, S., & Sorscher, E. J. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043184 · Cited by 1,398
Pseudomonas aeruginosa : new insights into pathogenesis and host defenses
Gellatly, S. L., & Hancock, R. E. W. (2013) · Pathogens and Disease · doi:10.1111/2049-632x.12033 · Cited by 1,295
The Epidemiology, Pathogenesis and Treatment of Pseudomonas aeruginosa Infections
Driscoll, J. A., Brody, S. L., & Kollef, M. H. (2007) · Drugs · doi:10.2165/00003495-200767030-00003 · Cited by 884
The Multiple Signaling Systems Regulating Virulence in Pseudomonas aeruginosa
Nadal Jimenez, P., Koch, G., Thompson, J. A., Xavier, K. B., Cool, R. H., & Quax, W. J. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05007-11 · Cited by 736
A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence
Balasubramanian, D., Schneper, L., Kumari, H., & Mathee, K. (2013) · Nucleic Acids Research · doi:10.1093/nar/gks1039 · Cited by 591
Siderophore-mediated signaling regulates virulence factor production in Pseudomonas aeruginosa
Lamont, I. L., Beare, P. A., Ochsner, U., Vasil, A. I., & Vasil, M. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092016999 · Cited by 584
Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis
Marvig, R. L., Sommer, L. M., Molin, S., & Johansen, H. K. (2015) · Nature Genetics · doi:10.1038/ng.3148 · Cited by 582
Kounnas, M. Z., Morris, R. E., Thompson, M. R., FitzGerald, D. J., Strickland, D. K., & Saelinger, C. B. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42291-0 · Cited by 447
Cited by
Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence
Moradali, M. F., Ghods, S., & Rehm, B. H. A. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00039 · Cited by 1,537
Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors
Jurado-Martín, I., Sainz-Mejías, M., & McClean, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063128 · Cited by 698
Pseudomonas aeruginosa: ecology, evolution, pathogenesis and antimicrobial susceptibility
Letizia, M., Diggle, S. P., & Whiteley, M. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01193-8 · Cited by 231
Pseudomonas aeruginosa and microbial keratitis
Hilliam, Y., Kaye, S., & Winstanley, C. (2020) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001110 · Cited by 152
Shimizu, Y., Isoda, K., Taira, Y., Taira, I., Kondoh, M., & Ishida, I. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173596 · Cited by 32
Metadata
- Authors
- Michalska, M., & Wolf, P.
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2015-09-15
- Volume
- 6
- Pages
- 963-963
- ISSN
- 1664-302X (ISSN-L)
- OpenAlex
- W1738289412
- Cited by
- 283
- References
- 48
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- gold
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- Michalska, M., & Wolf, P. (2015). Pseudomonas Exotoxin A: optimized by evolution for effective killing. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2015.00963
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
