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A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence

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Balasubramanian, Deepak, Schneper, Lisa, Kumari, Hansi, Mathee, Kalai·2013·Nucleic Acids Research
DOI 10.1093/nar/gks1039
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Abstract

Pseudomonas aeruginosa is a metabolically versatile bacterium that is found in a wide range of biotic and abiotic habitats. It is a major human opportunistic pathogen causing numerous acute and chronic infections. The critical traits contributing to the pathogenic potential of P. aeruginosa are the production of a myriad of virulence factors, formation of biofilms and antibiotic resistance. Expression of these traits is under stringent regulation, and it responds to largely unidentified environmental signals. This review is focused on providing a global picture of virulence gene regulation in P. aeruginosa. In addition to key regulatory pathways that control the transition from acute to chronic infection phenotypes, some regulators have been identified that modulate multiple virulence mechanisms. Despite of a propensity for chaotic behaviour, no chaotic motifs were readily observed in the P. aeruginosa virulence regulatory network. Having a 'birds-eye' view of the regulatory cascades provides the forum opportunities to pose questions, formulate hypotheses and evaluate theories in elucidating P. aeruginosa pathogenesis. Understanding the mechanisms involved in making P. aeruginosa a successful pathogen is essential in helping devise control strategies.

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Metadata

Authors
Balasubramanian, D., Schneper, L., Kumari, H., & Mathee, K.
Venue
Nucleic Acids Research
Publisher
Oxford University Press (OUP)
Published
2012-11-10
Volume
41
Issue
1
Pages
1-20
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
DOI
10.1093/nar/gks1039
OpenAlex
W1964344318
Cited by
591
References
13
FWCI
9.53
Type
journal article
Language
en
Open access
gold
Licence
creativecommons.org/licenses/by-nc/3.0 (vor, 1424 d)

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Balasubramanian, D., Schneper, L., Kumari, H., & Mathee, K. (2013). A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence. Nucleic Acids Research. https://doi.org/10.1093/nar/gks1039

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