The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Bifidobacteria and Their Molecular Communication with the Immune System
Open accessAbstract
Bifidobacterium represents a genus within the phylum Actinobacteria which is one of the major phyla in the healthy intestinal tract of humans. Bifidobacterium is one of the most abundant genera in adults, but its predominance is even more pronounced in infants, especially during lactation, in which they can constitute the majority of the total bacterial population. They are one of the first pioneering colonizers of the early gut microbiota, and they are known to play important roles in the metabolism of dietary components, otherwise indigestible in the upper parts of the intestine, and in the maturation of the immune system. Bifidobacteria have been shown to interact with human immune cells and to modulate specific pathways, involving innate and adaptive immune processes. In this mini review, we provide an overview of the current knowledge on the immunomodulatory properties of bifidobacteria and the mechanisms and molecular players underlying these processes, focusing on the corresponding implications for human health. We deal with in vitro models suitable for studying strain-specific immunomodulatory activities. These include peripheral blood mononuclear cells and T cell mediated immune responses, both effector and regulatory cell responses, as well as the modulation of the phenotype of dendritic cells, among others. Furthermore, preclinical studies, mainly germ-free, gnotobiotic and conventional murine models, and human clinical trials, are also discussed. Finally, we highlight evidence supporting the immunomodulatory effects of bifidobacterial molecules (proteins and peptides, exopolysaccharides, metabolites and DNA), as well as the role of bifidobacterial metabolism in maintaining immune homeostasis through cross-feeding mechanisms.
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Cites
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Cited by
Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review
Di Vincenzo, F., Del Gaudio, A., Petito, V., Lopetuso, L. R., & Scaldaferri, F. (2024) · Internal and Emergency Medicine · doi:10.1007/s11739-023-03374-w · Cited by 1,498
High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review
Malesza, I. J., Malesza, M., Walkowiak, J., Mussin, N., Walkowiak, D., Aringazina, R., Bartkowiak-Wieczorek, J., & Mądry, E. (2021) · Cells · doi:10.3390/cells10113164 · Cited by 782
Sun, S., Luo, L., Liang, W., Yin, Q., Guo, J., Rush, A. M., Lv, Z., Liang, Q., Fischbach, M. A., Sonnenburg, J. L., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1921223117 · Cited by 277
Ganesan, K., Chung, S. K., Vanamala, J., & Xu, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123720 · Cited by 221
Park, M., Choi, J., & Lee, H.-J. (2020) · Nutrients · doi:10.3390/nu12061815 · Cited by 139
Metadata
- Authors
- Ruiz, L., Delgado, S., Ruas-Madiedo, P., Sánchez, B., & Margolles, A.
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2017-12-04
- Volume
- 8
- Pages
- 2345-2345
- ISSN
- 1664-302X (ISSN-L)
- OpenAlex
- W2774458980
- Cited by
- 326
- References
- 105
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ruiz, L., Delgado, S., Ruas-Madiedo, P., Sánchez, B., & Margolles, A. (2017). Bifidobacteria and Their Molecular Communication with the Immune System. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2017.02345
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
