Causal relationship between diet-induced gut microbiota changes and diabetes: a novel strategy to transplant Faecalibacterium prausnitzii in preventing diabetes
Open accessAbstract
The incidence of metabolic disorders, including diabetes, has elevated exponentially during the last decades and enhanced the risk of a variety of complications, such as diabetes and cardiovascular diseases. In the present review, we have highlighted the new insights on the complex relationships between diet-induced modulation of gut microbiota and metabolic disorders, including diabetes. Literature from various library databases and electronic searches (ScienceDirect, PubMed, and Google Scholar) were randomly collected. There exists a complex relationship between diet and gut microbiota, which alters the energy balance, health impacts, and autoimmunity, further causes inflammation and metabolic dysfunction, including diabetes. Faecalibacterium prausnitzii is a butyrate-producing bacterium, which plays a vital role in diabetes. Transplantation of F. prausnitzii has been used as an intervention strategy to treat dysbiosis of the gut's microbial community that is linked to the inflammation, which precedes autoimmune disease and diabetes. The review focuses on literature that highlights the benefits of the microbiota especially, the abundant of F. prausnitzii in protecting the gut microbiota pattern and its therapeutic potential against inflammation and diabetes.
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An increased Firmicutes:Bacteroidetes ratio and decreases in protective SCFA-producing bacteria such as F. prausnitzii are often observed.
“Likewise, an increased Firmicutes:Bacteroidetes ratio (41) and decreases in protective SCFA-producing bacteria (e.g., F. prausnitzii) (89, 204) are often observed.”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [204]
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- Authors
- Ganesan, K., Chung, S. K., Vanamala, J., & Xu, B.
- Affiliations
- Beijing Normal-Hong Kong Baptist University (CN)
- Pennsylvania State University (US)
- Corresponding author
- Xu, Baojun
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-11-22
- Volume
- 19
- Issue
- 12
- Pages
- 3720
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC6320976
- OpenAlex
- W2901417922
- Cited by
- 221
- References
- 221
- Citations by year
- 2026: 7 · 2025: 30 · 2024: 24 · 2023: 42 · 2022: 33 · 2021: 37 · 2020: 34 · 2019: 14
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Beijing Normal University-Hong Kong Baptist University United International College (R201714)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Faecalibacterium prausnitzii, gut microbiota, diet, diabetes mellitus, fecal microbiota transplantation, butyrate, dysbiosis, inflammation, metabolic disorders, energy balance, autoimmunity
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Faecalibacterium prausnitzii, Butyrates, Diabetes Mellitus, Diet, Dietary Fiber, Feces, Humans, Symbiosis, Probiotics, Gastrointestinal Tract, Dysbiosis
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