Cited by 221Gut microbiota and healthProbiotics and Fermented FoodsGastrointestinal motility and disorders

Causal relationship between diet-induced gut microbiota changes and diabetes: a novel strategy to transplant Faecalibacterium prausnitzii in preventing diabetes

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Ganesan, Kumar, Chung, Sookja Kim, Vanamala, Jairam, Xu, Baojun·2018·International Journal of Molecular Sciences

Abstract

The incidence of metabolic disorders, including diabetes, has elevated exponentially during the last decades and enhanced the risk of a variety of complications, such as diabetes and cardiovascular diseases. In the present review, we have highlighted the new insights on the complex relationships between diet-induced modulation of gut microbiota and metabolic disorders, including diabetes. Literature from various library databases and electronic searches (ScienceDirect, PubMed, and Google Scholar) were randomly collected. There exists a complex relationship between diet and gut microbiota, which alters the energy balance, health impacts, and autoimmunity, further causes inflammation and metabolic dysfunction, including diabetes. Faecalibacterium prausnitzii is a butyrate-producing bacterium, which plays a vital role in diabetes. Transplantation of F. prausnitzii has been used as an intervention strategy to treat dysbiosis of the gut's microbial community that is linked to the inflammation, which precedes autoimmune disease and diabetes. The review focuses on literature that highlights the benefits of the microbiota especially, the abundant of F. prausnitzii in protecting the gut microbiota pattern and its therapeutic potential against inflammation and diabetes.

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  • An increased Firmicutes:Bacteroidetes ratio and decreases in protective SCFA-producing bacteria such as F. prausnitzii are often observed.

    “Likewise, an increased Firmicutes:Bacteroidetes ratio (41) and decreases in protective SCFA-producing bacteria (e.g., F. prausnitzii) (89, 204) are often observed.”

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Authors
Ganesan, K., Chung, S. K., Vanamala, J., & Xu, B.
Affiliations
  • Beijing Normal-Hong Kong Baptist University (CN)
  • Pennsylvania State University (US)
Corresponding author
Xu, Baojun
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2018-11-22
Volume
19
Issue
12
Pages
3720
ISSN
1422-0067 (ISSN-L)
OpenAlex
W2901417922
Cited by
221
References
221
Citations by year
2026: 7 · 2025: 30 · 2024: 24 · 2023: 42 · 2022: 33 · 2021: 37 · 2020: 34 · 2019: 14
FWCI
2.08
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Beijing Normal University-Hong Kong Baptist University United International College (R201714)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
Faecalibacterium prausnitzii, gut microbiota, diet, diabetes mellitus, fecal microbiota transplantation, butyrate, dysbiosis, inflammation, metabolic disorders, energy balance, autoimmunity
MeSH terms
Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Faecalibacterium prausnitzii, Butyrates, Diabetes Mellitus, Diet, Dietary Fiber, Feces, Humans, Symbiosis, Probiotics, Gastrointestinal Tract, Dysbiosis

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