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Cited by 61Oral microbiology and periodontitis researchGut microbiota and healthDental Health and Care Utilization

Oral microbiota and metabolites: key players in oral health and disorder, and microbiota-based therapies

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Bostanghadiri, Narjess, Kouhzad, Mobina, Taki, Elahe, Elahi, Zahra, Khoshbayan, Amin, Navidifar, Tahereh, Darban-Sarokhalil, Davood·2024·Frontiers in Microbiology
DOI 10.3389/fmicb.2024.1431785PMC PMC11368800
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Abstract

The review aimed to investigate the diversity of oral microbiota and its influencing factors, as well as the association of oral microbiota with oral health and the possible effects of dysbiosis and oral disorder. The oral cavity harbors a substantial microbial burden, which is particularly notable compared to other organs within the human body. In usual situations, the microbiota exists in a state of equilibrium; however, when this balance is disturbed, a multitude of complications arise. Dental caries, a prevalent issue in the oral cavity, is primarily caused by the colonization and activity of bacteria, particularly streptococci. Furthermore, this environment also houses other pathogenic bacteria that are associated with the onset of gingival, periapical, and periodontal diseases, as well as oral cancer. Various strategies have been employed to prevent, control, and treat these disorders. Recently, techniques utilizing microbiota, like probiotics, microbiota transplantation, and the replacement of oral pathogens, have caught the eye. This extensive examination seeks to offer a general view of the oral microbiota and their metabolites concerning oral health and disease, and also the resilience of the microbiota, and the techniques used for the prevention, control, and treatment of disorders in this specific area.

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  • Individuals with a higher abundance of nitrate-reducing bacteria (e.g., Neisseria, Rothia, Actinomyces and Veillonella) exhibit greater nitrite production.

    “Individuals with a higher abundance of nitrate-reducing bacteria (e.g., Neisseria, Rothia, Actinomyces and Veillonella) exhibit greater nitrite production [31,32].”

    From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [32]

    The ‘External factors’ section (page unavailable) says oral bacteria convert salivary nitrate to nitrite, and the ‘Role of oral microbiota metabolites in health’ table (page unavailable) lists Neisseria, Rothia, Actinomyces and Veillonella under nitrate. The paper does not state that individuals with higher abundances of these bacteria produce more nitrite than other individuals. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Ageing is associated with reduced microbial diversity and decreased abundance of nitrate-reducing genera, which could limit NO bioactivation.

    “Ageing is associated with reduced microbial diversity and decreased abundance of nitrate-reducing genera (e.g., Neisseria, Rothia and Actinomyces), which could limit NO bioactivation [32].”

    From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [32]

    The ‘Role of oral microbiota metabolites in health’ section lists Neisseria, Rothia, and Actinomyces among nitrate-associated genera, and ‘External factors’ describes oral bacterial nitrate conversion as part of the pathway to NO. The paper says age can alter oral microbial diversity, but the passages do not establish that ageing reduces diversity or the abundance of those genera. No page numbers were available in our copy. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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References 184 · Cited by 61

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  1. Abdi M. Ranjbar R. (2022). A review on antiviral efficacy of Bifidobacterium species. Rev. Res. Med. Microbiol. 33, 74– 81. doi: 10.1097/MRM.0000000000000295 · DOI
  2. Abranches J. Zeng L. Kajfasz J. K. Palmer S. Chakraborty B. Wen Z.. (2018). Biology of oral streptococci. Microbiol. Spectr. 6, 10– 128. doi: 10.1128/microbiolspec.GPP3-0042-2018, PMID: 30338752 PMC6287261 · DOI
  3. Abusleme L. Dupuy A. K. Dutzan N. Silva N. Burleson J. A. Strausbaugh L. D.. (2013). The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation. ISME J. 7, 1016– 1025. doi: 10.1038/ismej.2012.174, PMID: 23303375 PMC3635234 · DOI
  4. Abusleme L. Hoare A. Hong B. Y. Diaz P. I. (2021). Microbial signatures of health, gingivitis, and periodontitis. Periodontology 86, 57– 78. doi: 10.1111/prd.12362 33690899 · DOI · Paper page
  5. Adams R. I. Bateman A. C. Bik H. M. Meadow J. F. (2015). Microbiota of the indoor environment: a meta-analysis. Microbiome 3, 1– 18. doi: 10.1186/s40168-015-0108-3 26459172 PMC4604073 · DOI
  6. Aghazadeh Z. Pouralibaba F. Yari Khosroushahi A. (2017). The prophylactic effect of Acetobacter syzygii probiotic species against squamous cell carcinoma. J. Dent. Res. Dent. Clin. Dent. Prospects 11, 208– 214. doi: 10.15171/joddd.2017.037, PMID: 29354246 PMC5768952 · DOI
  7. Al Bataineh M. T. Dash N. R. Elkhazendar M. Alnusairat D. A. M. H. Darwish I. M. I. Al-Hajjaj M. S.. (2020). Revealing oral microbiota composition and functionality associated with heavy cigarette smoking. J. Transl. Med. 18, 1– 10. doi: 10.1186/s12967-020-02579-3 33167991 PMC7653996 · DOI
  8. Aleksandrowicz P. Brzezińska-Błaszczyk E. Dudko A. Agier J. (2020). Archaea occurrence in the subgingival biofilm in patients with Peri-implantitis and periodontitis. Int. J. Periodontics Restorative Dent. 40, 677– 683. doi: 10.11607/prd.4670 32925997 · DOI
  9. Allaker R. P. Ian Douglas C. W. (2015). Non-conventional therapeutics for oral infections. Virulence 6, 196– 207. doi: 10.4161/21505594.2014.983783, PMID: 25668296 PMC4601402 · DOI
  10. Aloul K. M. Nielsen J. E. Defensor E. B. Lin J. S. Fortkort J. A. Shamloo M.. (2022). Upregulating human cathelicidin antimicrobial peptide LL-37 expression May prevent severe COVID-19 inflammatory responses and reduce microthrombosis. Front. Immunol. 13: 880961. doi: 10.3389/fimmu.2022.880961, PMID: 35634307 PMC9134243 · DOI
  11. Arboleya S. Sánchez B. Milani C. Duranti S. Solís G. Fernández N.. (2015). Intestinal microbiota development in preterm neonates and effect of perinatal antibiotics. J. Pediatr. 166, 538– 544. doi: 10.1016/j.jpeds.2014.09.041, PMID: 25444008 · DOI
  12. Bäckhed F. Fraser C. M. Ringel Y. Sanders M. E. Sartor R. B. Sherman P. M.. (2012). Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications. Cell Host Microbe 12, 611– 622. doi: 10.1016/j.chom.2012.10.012, PMID: 23159051 · DOI · Paper page
  13. Bai Y. Ma K. Li J. Li J. Bi C. Shan A. (2021). Deoxynivalenol exposure induces liver damage in mice: inflammation and immune responses, oxidative stress, and protective effects of Lactobacillus rhamnosus GG. Food Chem. Toxicol. 156: 112514. doi: 10.1016/j.fct.2021.112514 34400200 · DOI
  14. Barbour A. Elebyary O. Fine N. Oveisi M. Glogauer M. (2022). Metabolites of the oral microbiome: important mediators of multikingdom interactions. FEMS Microbiol. Rev. 46: fuab039. doi: 10.1093/femsre/fuab039, PMID: 34227664 · DOI
  15. Beck J. D. Philips K. Moss K. Divaris K. Morelli T. Offenbacher S. (2020). Advances in precision oral health. Periodontol. 82, 268– 285. doi: 10.1111/prd.12314 31850630 · DOI
  16. Bhattacharjya S. Zhang Z. Ramamoorthy A. (2024). LL-37: structures, antimicrobial activity, and influence on amyloid-related diseases. Biomol. Ther. 14: 320. doi: 10.3390/biom14030320, PMID: 38540740 PMC10968335 · DOI
  17. Bikker F. J. (2020). The importance of saliva to oral health; from haddock to histatin. Ned. Tijdschr. Tandheelkd. 127, 551– 555. doi: 10.5177/ntvt.2020.10.19094 33156296 · DOI
  18. Bonfiglio G. Neroni B. Radocchia G. Marazzato M. Pantanella F. Schippa S. (2020). Insight into the possible use of the predator Bdellovibrio bacteriovorus as a probiotic. Nutrients 12: 2252. doi: 10.3390/nu12082252 32731403 PMC7468853 · DOI
  19. Bosch M. Nart J. Audivert S. Bonachera M. A. Alemany A. S. Fuentes M. C.. (2012). Isolation and characterization of probiotic strains for improving oral health. Arch. Oral Biol. 57, 539– 549. doi: 10.1016/j.archoralbio.2011.10.006, PMID: 22054727 · DOI
  20. Bostanci N. Krog M. C. Hugerth L. W. Bashir Z. Fransson E. Boulund F.. (2021). Dysbiosis of the human Oral microbiome during the menstrual cycle and vulnerability to the external exposures of smoking and dietary sugar. Front. Cell. Infect. Microbiol. 11: 625229. doi: 10.3389/fcimb.2021.625229, PMID: 33816334 PMC8018275 · DOI
  21. Bostanghadiri N. Razavi S. Shariati A. Talebi M. Mirkalantari S. Emami Razavi A.. (2023). Exploring the interplay between Fusobacterium nucleatum with the expression of microRNA, and inflammatory mediators in colorectal cancer. Front. Microbiol. 14: 1302719. doi: 10.3389/fmicb.2023.1302719, PMID: 38075864 PMC10701916 · DOI
  22. Bowen W. H. Burne R. A. Wu H. Koo H. (2018). Oral biofilms: pathogens, matrix, and polymicrobial interactions in microenvironments. Trends Microbiol. 26, 229– 242. doi: 10.1016/j.tim.2017.09.008, PMID: 29097091 PMC5834367 · DOI · Paper page
  23. Brogden K. A. (2005). Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat. Rev. Microbiol. 3, 238– 250. doi: 10.1038/nrmicro1098 15703760 · DOI · Paper page
  24. Brookes Z. L. S. Bescos R. Belfield L. A. Ali K. Roberts A. (2020). Current uses of chlorhexidine for management of oral disease: a narrative review. J. Dent. 103: 103497. doi: 10.1016/j.jdent.2020.103497, PMID: 33075450 PMC7567658 · DOI
  25. Bryden W. L. (2012). Mycotoxin contamination of the feed supply chain: implications for animal productivity and feed security. Anim. Feed Sci. Technol. 173, 134– 158. doi: 10.1016/j.anifeedsci.2011.12.014 · DOI
  26. Bürgers R. Hahnel S. Reichert T. E. Rosentritt M. Behr M. Gerlach T.. (2010). Adhesion of Candida albicans to various dental implant surfaces and the influence of salivary pellicle proteins. Acta Biomater. 6, 2307– 2313. doi: 10.1016/j.actbio.2009.11.003, PMID: 19925892 · DOI
  27. Bushin L. B. Covington B. C. Rued B. E. Federle M. J. Seyedsayamdost M. R. (2020). Discovery and biosynthesis of Streptosactin, a Sactipeptide with an alternative topology encoded by commensal Bacteria in the human microbiome. J. Am. Chem. Soc. 142, 16265– 16275. doi: 10.1021/jacs.0c05546, PMID: 32845143 · DOI
  28. Busscher H. J. Mulder A. F. Van Der Mei H. C. (1999). In vitro adhesion to enamel and in vivo colonization of tooth surfaces by lactobacilli from a bio-yoghurt. Caries Res. 33, 403– 404. doi: 10.1159/000016541, PMID: 10460966 · DOI
  29. Caglar E. Cildir S. K. Ergeneli S. Sandalli N. Twetman S. (2006). Salivary mutans streptococci and lactobacilli levels after ingestion of the probiotic bacterium Lactobacillus reuteri ATCC 55730 by straws or tablets. Acta Odontol. Scand. 64, 314– 318. doi: 10.1080/00016350600801709 16945898 · DOI
  30. Caglar E. Sandalli N. Twetman S. Kavaloglu S. Ergeneli S. Selvi S. (2005). Effect of yogurt with Bifidobacterium DN-173 010 on salivary mutans streptococci and lactobacilli in young adults. Acta Odontol. Scand. 63, 317– 320. doi: 10.1080/00016350510020070 16512103 · DOI
  31. Camanocha A. Dewhirst F. E. (2014). Host-associated bacterial taxa from Chlorobi, Chloroflexi, GN02, Synergistetes, SR1, TM7, and WPS-2 Phyla/candidate divisions. J. Oral Microbiol. 6. doi: 10.3402/jom.v6.25468, PMID: 25317252 PMC4192840 · DOI
  32. Caselli E. Fabbri C. D’accolti M. Soffritti I. Bassi C. Mazzacane S.. (2020). Defining the oral microbiome by whole-genome sequencing and resistome analysis: the complexity of the healthy picture. BMC Microbiol. 20: 120. doi: 10.1186/s12866-020-01801-y, PMID: 32423437 PMC7236360 · DOI
  33. Chuang L. C. Huang C. S. Ou-Yang L. W. Lin S. Y. (2011). Probiotic Lactobacillus paracasei effect on cariogenic bacterial flora. Clin. Oral Investig. 15, 471– 476. doi: 10.1007/s00784-010-0423-9, PMID: 20502929 PMC3133768 · DOI
  34. Dabdoub S. M. Ganesan S. M. Kumar P. S. (2016). Comparative metagenomics reveals taxonomically idiosyncratic yet functionally congruent communities in periodontitis. Sci. Rep. 6: 38993. doi: 10.1038/srep38993, PMID: 27991530 PMC5172196 · DOI
  35. Dagli N. Dagli R. (2014). Possible use of essential oils in dentistry. J. Int. Oral Health 6, i– ii., PMID: 25083049 PMC4109163
  36. Dale B. A. Krisanaprakornkit S. (2001). Defensin antimicrobial peptides in the oral cavity. J. Oral Pathol. Med. 30, 321– 327. doi: 10.1034/j.1600-0714.2001.300601.x 11459317 · DOI
  37. Dale B. A. Tao R. Kimball J. R. Jurevic R. J. (2006). Oral antimicrobial peptides and biological control of caries. BMC Oral Health 6: S13. doi: 10.1186/1472-6831-6-S1-S13, PMID: 16934114 PMC2147588 · DOI
  38. Dame-Teixeira N. De Cena J. A. Côrtes D. A. Belmok A. Dos Anjos Borges L. G. Marconatto L.. (2020). Presence of Archaea in dental caries biofilms. Arch. Oral Biol. 110: 104606. doi: 10.1016/j.archoralbio.2019.104606 31739075 · DOI
  39. De Sousa-Pereira P. Amado F. Abrantes J. Ferreira R. Esteves P. J. Vitorino R. (2013). An evolutionary perspective of mammal salivary peptide families: cystatins, histatins, statherin and PRPs. Arch. Oral Biol. 58, 451– 458. doi: 10.1016/j.archoralbio.2012.12.011, PMID: 23352445 · DOI
  40. Delaviz Y. Liu T. W. Deonarain A. R. Finer Y. Shokati B. Santerre J. P. (2019). Physical properties and cytotoxicity of antimicrobial dental resin adhesives containing dimethacrylate oligomers of ciprofloxacin and metronidazole. Dent. Mater. 35, 229– 243. doi: 10.1016/j.dental.2018.11.016, PMID: 30502964 · DOI
  41. Denny P. Hagen F. K. Hardt M. Liao L. Yan W. Arellanno M.. (2008). The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. J. Proteome Res. 7, 1994– 2006. doi: 10.1021/pr700764j, PMID: 18361515 PMC2839126 · DOI
  42. Dhaifalah I. Andrys C. Drahosova M. Musilova I. Adamik Z. Kacerovsky M. (2014). Azurocidin levels in maternal serum in the first trimester can predict preterm prelabor rupture of membranes. J. Matern. Fetal Neonatal Med. 27, 511– 515. doi: 10.3109/14767058.2013.820698 23808364 · DOI
  43. Di Spirito F. Pelella S. Argentino S. Sisalli L. Sbordone L. (2022). Oral manifestations and the role of the oral healthcare workers in COVID-19. Oral Dis. 28, 1003– 1004. doi: 10.1111/odi.13688, PMID: 33084209 · DOI
  44. Dosoky N. S. Setzer W. N. (2018). Chemical composition and biological activities of essential oils of Curcuma species. Nutrients 10: 1196. doi: 10.3390/nu10091196 30200410 PMC6164907 · DOI
  45. Duanis-Assaf D. Steinberg D. Shemesh M. (2020). Efficiency of Bacillus subtilis metabolism of sugar alcohols governs its probiotic effect against cariogenic Streptococcus mutans. Artif. Cells Nanomed. Biotechnol. 48, 1222– 1230. doi: 10.1080/21691401.2020.1822855, PMID: 32955386 · DOI
  46. Duran-Pinedo A. E. (2021). Metatranscriptomic analyses of the oral microbiome. Periodontology 85, 28– 45. doi: 10.1111/prd.12350 33226688 · DOI
  47. Efenberger M. Agier J. Pawłowska E. Brzezińska-Błaszczyk E. (2015). Archaea prevalence in inflamed pulp tissues. Cent. Eur. J. Immunol. 40, 194– 200. doi: 10.5114/ceji.2015.51358, PMID: 26557034 PMC4637383 · DOI
  48. Elyemni M. Louaste B. Nechad I. Elkamli T. Bouia A. Taleb M.. (2019). Extraction of essential oils of Rosmarinus officinalis L. by two different methods: Hydrodistillation and microwave assisted Hydrodistillation. ScientificWorldJournal 2019: 3659432. doi: 10.1155/2019/3659432 31057339 PMC6463580 · DOI
  49. Ferrazzano G. F. Amato I. Ingenito A. De Natale A. Pollio A. (2009). Anti-cariogenic effects of polyphenols from plant stimulant beverages (cocoa, coffee, tea). Fitoterapia 80, 255– 262. doi: 10.1016/j.fitote.2009.04.006, PMID: 19397954 · DOI
  50. Ferreira C. M. Vieira A. T. Vinolo M. A. R. Oliveira F. A. Curi R. Martins F. D. S. (2014). The central role of the gut microbiota in chronic inflammatory diseases. J Immunol Res 2014, 1– 12. doi: 10.1155/2014/689492, PMID: 25309932 PMC4189530 · DOI
  51. Franzosa E. A. Huang K. Meadow J. F. Gevers D. Lemon K. P. Bohannan B. J.. (2015). Identifying personal microbiomes using metagenomic codes. Proc. Natl. Acad. Sci. USA 112, E2930– E2938. doi: 10.1073/pnas.1423854112, PMID: 25964341 PMC4460507 · DOI
  52. Fujiwara N. Tsuruda K. Iwamoto Y. Kato F. Odaki T. Yamane N.. (2017). Significant increase of oral bacteria in the early pregnancy period in Japanese women. J. Investig. Clin. Dent. 8: e12189. doi: 10.1111/jicd.12189, PMID: 26345599 · DOI
  53. Ge Y. Wang S. Zhou X. Wang H. Xu H. H. Cheng L. (2015). The use of quaternary ammonium to combat dental caries. Materials (Basel) 8, 3532– 3549. doi: 10.3390/ma8063532, PMID: 26635932 PMC4665981 · DOI
  54. Godlewska U. Brzoza P. Sroka A. Majewski P. Jentsch H. Eckert M.. (2017). Antimicrobial and attractant roles for chemerin in the oral cavity during inflammatory gum disease. Front. Immunol. 8: 353. doi: 10.3389/fimmu.2017.00353 28424689 PMC5372799 · DOI
  55. Gomez-Arango L. F. Barrett H. L. Mcintyre H. D. Callaway L. K. Morrison M. Dekker Nitert M. (2017). Antibiotic treatment at delivery shapes the initial oral microbiome in neonates. Sci. Rep. 7: 43481. doi: 10.1038/srep43481, PMID: 28240736 PMC5378909 · DOI
  56. Gordon Y. J. Romanowski E. G. Mcdermott A. M. (2005). A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs. Curr. Eye Res. 30, 505– 515. doi: 10.1080/02713680590968637, PMID: 16020284 PMC1497874 · DOI
  57. Gorr S. U. (2009). Antimicrobial peptides of the oral cavity. Periodontol. 51, 152– 180. doi: 10.1111/j.1600-0757.2009.00310.x 19878474 · DOI
  58. Gorr S. U. (2012). Antimicrobial peptides in periodontal innate defense. Front. Oral Biol. 15, 84– 98. doi: 10.1159/000329673, PMID: 22142958 PMC3704226 · DOI
  59. Grant M. Kilsgård O. Åkerman S. Klinge B. Demmer R. T. Malmström J.. (2019). The human salivary antimicrobial peptide profile according to the oral microbiota in health, periodontitis and smoking. J. Innate Immun. 11, 432– 444. doi: 10.1159/000494146, PMID: 30485856 PMC6738235 · DOI
  60. Güncü G. N. Yilmaz D. Könönen E. Gürsoy U. K. (2015). Salivary antimicrobial peptides in early detection of periodontitis. Front. Cell. Infect. Microbiol. 5: 99. doi: 10.3389/fcimb.2015.00099 26734583 PMC4689996 · DOI
  61. Gutt B. Ren Q. Hauser-Gerspach I. Kardas P. Stübinger S. Astasov-Frauenhoffer M.. (2018). Beneficial Oral biofilms as smart bioactive interfaces. Front. Microbiol. 9: 107. doi: 10.3389/fmicb.2018.00107, PMID: 29445368 PMC5797747 · DOI
  62. Hampelska K. Jaworska M. M. Babalska Z. Ł. Karpiński T. M. (2020). The role of oral microbiota in intra-oral halitosis. J. Clin. Med. 9: 2484. doi: 10.3390/jcm9082484, PMID: 32748883 PMC7465478 · DOI
  63. Hannig C. Hannig M. Kensche A. Carpenter G. (2017). The mucosal pellicle–an underestimated factor in oral physiology. Arch. Oral Biol. 80, 144– 152. doi: 10.1016/j.archoralbio.2017.04.001, PMID: 28419912 · DOI
  64. Harris F. Dennison S. R. Phoenix D. A. (2009). Anionic antimicrobial peptides from eukaryotic organisms. Curr. Protein Pept. Sci. 10, 585– 606. doi: 10.2174/138920309789630589, PMID: 19751192 · DOI
  65. Heilbronner S. Krismer B. Brötz-Oesterhelt H. Peschel A. (2021). The microbiome-shaping roles of bacteriocins. Nat. Rev. Microbiol. 19, 726– 739. doi: 10.1038/s41579-021-00569-w 34075213 · DOI
  66. Herremans K. M. Riner A. N. Cameron M. E. Mckinley K. L. Triplett E. W. Hughes S. J.. (2022). The oral microbiome, pancreatic cancer and human diversity in the age of precision medicine. Microbiome 10: 93. doi: 10.1186/s40168-022-01262-7, PMID: 35701831 PMC9199224 · DOI
  67. Holmes A. R. Gilbert C. Wells J. M. Jenkinson H. F. (1998). Binding properties of Streptococcus gordonii SspA and SspB (antigen I/II family) polypeptides expressed on the cell surface of Lactococcus lactis MG1363. Infect. Immun. 66, 4633– 4639. doi: 10.1128/IAI.66.10.4633-4639.1998, PMID: 9746559 PMC108570 · DOI
  68. Hu H. Burrow M. F. Leung W. K. (2023). Proteomic profile of in situ acquired pellicle on tooth and restorative material surfaces. J. Dent. 129: 104389. doi: 10.1016/j.jdent.2022.104389 36526084 · DOI
  69. Inchingolo F. Inchingolo A. M. Malcangi G. De Leonardis N. Sardano R. Pezzolla C.. (2023). The benefits of probiotics on Oral health: Systematic Review of the Literature. Pharmaceuticals (Basel) 16: 1313. doi: 10.3390/ph16091313 37765121 PMC10534711 · DOI
  70. Isogai E. Hirata M. Isogai H. Matuo K. Kimura K. Yokota K.. (2003). Antimicrobial activity of synthetic human CAP18 peptides to Streptococcus sanguis isolated from patients with Behçet's disease. Adv. Exp. Med. Biol. 528, 195– 200. doi: 10.1007/0-306-48382-3_38, PMID: 12918689 · DOI
  71. Jafri H. Ahmad I. (2020). Thymus vulgaris essential oil and thymol inhibit biofilms and interact synergistically with antifungal drugs against drug resistant strains of Candida albicans and Candida tropicalis. J. Mycol. Med. 30: 100911. doi: 10.1016/j.mycmed.2019.100911 32008964 · DOI
  72. Jang H. Patoine A. Wu T. T. Castillo D. A. Xiao J. (2021). Oral microflora and pregnancy: a systematic review and meta-analysis. Sci. Rep. 11: 16870. doi: 10.1038/s41598-021-96495-1, PMID: 34413437 PMC8377136 · DOI
  73. Jaspers I. (2014). Cigarette smoke effects on innate immune mechanisms in the nasal mucosa. Potential effects on the microbiome. Ann. Am. Thorac. Soc. 11, S38– S42. doi: 10.1513/AnnalsATS.201306-154MG, PMID: 24437404 · DOI
  74. Jia Y.-J. Liao Y. He Y.-Q. Zheng M.-Q. Tong X.-T. Xue W.-Q.. (2021). Association between oral microbiota and cigarette smoking in the Chinese population. Front. Cell. Infect. Microbiol. 11: 658203. doi: 10.3389/fcimb.2021.658203, PMID: 34123872 PMC8195269 · DOI
  75. Jiang W. X. Hu Y. J. Gao L. He Z. Y. Zhu C. L. Ma R.. (2015). The impact of various time intervals on the supragingival plaque dynamic core microbiome. PLoS One 10: e0124631. doi: 10.1371/journal.pone.0124631, PMID: 25942317 PMC4420457 · DOI
  76. Jiao Y. Wu L. Huntington N. D. Zhang X. (2020). Crosstalk between gut microbiota and innate immunity and its implication in autoimmune diseases. Front. Immunol. 11: 282. doi: 10.3389/fimmu.2020.00282, PMID: 32153586 PMC7047319 · DOI · Paper page
  77. Jin Baek K. Choi Y. S. Kang C. K. Choi Y. (2017). The proteolytic activity of Porphyromonas gingivalis is critical in a murine model of periodontitis. J. Periodontol. 88, 218– 224. doi: 10.1902/jop.2016.160262, PMID: 27689784 · DOI
  78. Kajjari S. Joshi R. S. Hugar S. M. Gokhale N. Meharwade P. Uppin C. (2022). The effects of lavender essential oil and its clinical implications in dentistry: a review. Int. J. Clin. Pediatr. Dent. 15, 385– 388. doi: 10.5005/jp-journals-10005-2378, PMID: 35991803 PMC9357533 · DOI
  79. Kapas S. Pahal K. Cruchley A. T. Hagi-Pavli E. Hinson J. P. (2004). Expression of adrenomedullin and its receptors in human salivary tissue. J. Dent. Res. 83, 333– 337. doi: 10.1177/154405910408300412, PMID: 15044509 · DOI
  80. Karadağlıoğlu Ö. Ulusoy N. Başer K. H. C. Hanoğlu A. Şık İ. (2019). Antibacterial activities of herbal toothpastes combined with essential oils against Streptococcus mutans. Pathogens 8: 8. doi: 10.3390/pathogens8010020 30717107 PMC6471008 · DOI
  81. Karan N. B. (2019). Influence of lavender oil inhalation on vital signs and anxiety: a randomized clinical trial. Physiol. Behav. 211: 112676. doi: 10.1016/j.physbeh.2019.112676, PMID: 31505191 · DOI · Paper page
  82. Karpiński T. M. (2019). Role of oral microbiota in cancer development. Microorganisms 7: 20. doi: 10.3390/microorganisms7010020, PMID: 30642137 PMC6352272 · DOI
  83. Kay J. Thadhani E. Samson L. Engelward B. (2019). Inflammation-induced DNA damage, mutations and cancer. DNA Repair (Amst) 83: 102673. doi: 10.1016/j.dnarep.2019.102673, PMID: 31387777 PMC6801086 · DOI
  84. Khurshid Z. Naseem M. Sheikh Z. Najeeb S. Shahab S. Zafar M. S. (2016). Oral antimicrobial peptides: types and role in the oral cavity. Saudi Pharm. J. 24, 515– 524. doi: 10.1016/j.jsps.2015.02.015, PMID: 27752223 PMC5059823 · DOI
  85. Kistler J. O. Booth V. Bradshaw D. J. Wade W. G. (2013). Bacterial community development in experimental gingivitis. PLoS One 8: e71227. doi: 10.1371/journal.pone.0071227, PMID: 23967169 PMC3743832 · DOI
  86. Kobayashi R. Kobayashi T. Sakai F. Hosoya T. Yamamoto M. Kurita-Ochiai T. (2017). Oral administration of Lactobacillus gasseri SBT2055 is effective in preventing Porphyromonas gingivalis-accelerated periodontal disease. Sci. Rep. 7: 545. doi: 10.1038/s41598-017-00623-9, PMID: 28373699 PMC5428773 · DOI
  87. Kutta H. May J. Jaehne M. Münscher A. Paulsen F. P. (2006). Antimicrobial defence mechanisms of the human parotid duct. J. Anat. 208, 609– 619. doi: 10.1111/j.1469-7580.2006.00567.x 16637884 PMC2100215 · DOI
  88. La Rosa G. R. M. Gattuso G. Pedullà E. Rapisarda E. Nicolosi D. Salmeri M. (2020). Association of oral dysbiosis with oral cancer development. Oncol. Lett. 19, 3045– 3058. doi: 10.3892/ol.2020.11441 32211076 PMC7079586 · DOI
  89. Lakhdar L. Hmamouchi M. Rida S. Ennibi O. (2012). Antibacterial activity of essential oils against periodontal pathogens: a qualitative systematic review. Odontostomatol. Trop. 35, 38– 46., PMID: 23513511
  90. Lee W.-H. Chen H.-M. Yang S.-F. Liang C. Peng C.-Y. Lin F.-M.. (2017). Bacterial alterations in salivary microbiota and their association in oral cancer. Sci. Rep. 7: 16540. doi: 10.1038/s41598-017-16418-x, PMID: 29184122 PMC5705712 · DOI
  91. Lee J. W. Shin J. G. Kim E. H. Kang H. E. Yim I. B. Kim J. Y.. (2004). Immunomodulatory and antitumor effects in vivo by the cytoplasmic fraction of Lactobacillus casei and Bifidobacterium longum. J. Vet. Sci. 5, 41– 48. doi: 10.4142/jvs.2004.5.1.41, PMID: 15028884 · DOI · Paper page
  92. Li C. L. Liu D. L. Jiang Y. T. Zhou Y. B. Zhang M. Z. Jiang W.. (2009). Prevalence and molecular diversity of Archaea in subgingival pockets of periodontitis patients. Oral Microbiol. Immunol. 24, 343– 346. doi: 10.1111/j.1399-302X.2009.00514.x, PMID: 19572899 · DOI
  93. Li D. Xi W. Zhang Z. Ren L. Deng C. Chen J.. (2020). Oral microbial community analysis of the patients in the progression of liver cancer. Microb. Pathog. 149: 104479. doi: 10.1016/j.micpath.2020.104479 32920149 · DOI
  94. Lin Y. Chen J. Zhou X. Li Y. (2021). Inhibition of Streptococcus mutans biofilm formation by strategies targeting the metabolism of exopolysaccharides. Crit. Rev. Microbiol. 47, 667– 677. doi: 10.1080/1040841X.2021.1915959 33938347 · DOI
  95. Lin W. Jiang W. Hu X. Gao L. Ai D. Pan H.. (2018). Ecological shifts of supragingival microbiota in association with pregnancy. Front. Cell. Infect. Microbiol. 8: 24. doi: 10.3389/fcimb.2018.00024, PMID: 29497601 PMC5819318 · DOI
  96. Lin T. H. Lin C. H. Pan T. M. (2018). The implication of probiotics in the prevention of dental caries. Appl. Microbiol. Biotechnol. 102, 577– 586. doi: 10.1007/s00253-017-8664-z, PMID: 29192351 · DOI
  97. Lippi G. Mattiuzzi C. (2020). The global burden of pancreatic cancer. Arch. Med. Sci. 16, 820– 824. doi: 10.5114/aoms.2020.94845, PMID: 32542083 PMC7286317 · DOI
  98. Liu Y.-L. Nascimento M. Burne R. A. (2012). Progress toward understanding the contribution of alkali generation in dental biofilms to inhibition of dental caries. Int. J. Oral Sci. 4, 135– 140. doi: 10.1038/ijos.2012.54 22996271 PMC3465751 · DOI
  99. Liu X. Tong X. Zhu J. Tian L. Jie Z. Zou Y.. (2021). Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome. Cell Discov. 7: 117. doi: 10.1038/s41421-021-00356-0, PMID: 34873157 PMC8648780 · DOI
  100. Loozen G. Boon N. Pauwels M. Slomka V. Rodrigues Herrero E. Quirynen M.. (2015). Effect of Bdellovibrio bacteriovorus HD100 on multispecies oral communities. Anaerobe 35, 45– 53. doi: 10.1016/j.anaerobe.2014.09.011, PMID: 25252124 · DOI
  101. López-García B. Lee P. H. Yamasaki K. Gallo R. L. (2005). Anti-fungal activity of cathelicidins and their potential role in Candida albicans skin infection. J. Invest. Dermatol. 125, 108– 115. doi: 10.1111/j.0022-202X.2005.23713.x 15982310 · DOI
  102. Lopez-Lopez A. Camelo-Castillo A. Ferrer M. D. Simon-Soro A. Mira A. (2017). Health-associated niche inhabitants as Oral probiotics: the case of Streptococcus dentisani. Front. Microbiol. 8: 379. doi: 10.3389/fmicb.2017.00379 28344574 PMC5344910 · DOI
  103. Machado T. Q. Da Fonseca A. C. C. Duarte A. B. S. Robbs B. K. De Sousa D. P. (2022). A narrative review of the antitumor activity of monoterpenes from essential oils: an update. Biomed. Res. Int. 2022, 1– 20. doi: 10.1155/2022/6317201 PMC9155973 35655488 · DOI
  104. Macy E. (2015). Penicillin allergy: optimizing diagnostic protocols, public health implications, and future research needs. Curr. Opin. Allergy Clin. Immunol. 15, 308– 313. doi: 10.1097/ACI.0000000000000173 26110680 · DOI
  105. Mai S. Mauger M. T. Niu L. N. Barnes J. B. Kao S. Bergeron B. E.. (2017). Potential applications of antimicrobial peptides and their mimics in combating caries and pulpal infections. Acta Biomater. 49, 16– 35. doi: 10.1016/j.actbio.2016.11.026, PMID: 27845274 · DOI
  106. Mark Welch J. L. Rossetti B. J. Rieken C. W. Dewhirst F. E. Borisy G. G. (2016). Biogeography of a human oral microbiome at the micron scale. Proc. Natl. Acad. Sci. 113, E791– E800. doi: 10.1073/pnas.1522149113 26811460 PMC4760785 · DOI · Paper page
  107. Meena N. Verma P. Pande R. Kumar M. Watts A. Gupta O. (2020). Bioavailability and nutritional analysis of flavonoids. Plant Phenol. Sustain. Agricult. 1, 135– 156. doi: 10.1007/978-981-15-4890-1_6 · DOI
  108. Mira A. Simon-Soro A. Curtis M. A. (2017). Role of microbial communities in the pathogenesis of periodontal diseases and caries. J. Clin. Periodontol. 44, S23– s38. doi: 10.1111/jcpe.12671 28266108 · DOI
  109. Mishra S. Rath S. Mohanty N. (2020). Probiotics-a complete oral healthcare package. J. Integr. Med. 18, 462– 469. doi: 10.1016/j.joim.2020.08.005, PMID: 32907783 · DOI
  110. Mohan S. Epstein J. B. (2003). Carcinogenesis and cyclooxygenase: the potential role of COX-2 inhibition in upper aerodigestive tract cancer. Oral Oncol. 39, 537– 546. doi: 10.1016/S1368-8375(03)00035-6, PMID: 12798395 · DOI
  111. Murakami M. Ohtake T. Dorschner R. A. Gallo R. L. (2002). Cathelicidin antimicrobial peptides are expressed in salivary glands and saliva. J. Dent. Res. 81, 845– 850. doi: 10.1177/154405910208101210, PMID: 12454100 · DOI
  112. Nabavizade M. Sobhnamayan F. Bahrami H. Rafieian-Kopaei M. Abbaszadegan A. (2018). Evaluation of the wettability of a resin-based sealer in contact with some herbal irrigants. Dent. Res. J. (Isfahan) 15, 130– 135. doi: 10.4103/1735-3327.226527, PMID: 29576777 PMC5858072 · DOI
  113. Nagaraj T. Ravi B. Sankara S. N. Madhu K. Kailasam S. (2012). Probiotics and Oral health. J. Ind. Acad. Oral Med. Radiol. 24, 146– 148. doi: 10.5005/jp-journals-10011-1281 · DOI
  114. Nascimento M. (2017). Oral microbiota transplant: a potential new therapy for oral diseases. J. Calif. Dent. Assoc. 45, 565– 568. doi: 10.1080/19424396.2017.12222506 29497269 PMC5828680 · DOI
  115. Nascimento M. M. (2018). Potential uses of arginine in dentistry. Adv. Dent. Res. 29, 98– 103. doi: 10.1177/0022034517735294, PMID: 29355411 PMC5784480 · DOI · Paper page
  116. Nascimento M. M. Alvarez A. J. Huang X. Hanway S. Perry S. Luce A.. (2019). Arginine metabolism in Supragingival Oral biofilms as a potential predictor of caries risk. JDR Clin. Trans. Res. 4, 262– 270. doi: 10.1177/2380084419834234, PMID: 31039043 PMC6572888 · DOI
  117. Näse L. Hatakka K. Savilahti E. Saxelin M. Pönkä A. Poussa T.. (2001). Effect of long-term consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children. Caries Res. 35, 412– 420. doi: 10.1159/000047484, PMID: 11799281 · DOI
  118. Nath S. Zilm P. Jamieson L. Kapellas K. Goswami N. Ketagoda K.. (2021). Development and characterization of an oral microbiome transplant among Australians for the treatment of dental caries and periodontal disease: a study protocol. PLoS One 16: e0260433. doi: 10.1371/journal.pone.0260433, PMID: 34843568 PMC8629173 · DOI
  119. Navidifar T. Mahdizade Ari M. Alipourkermani A. Afifirad R. Asadollahi P. Veisi A.. (2023). Clinical efficacy of probiotics on Oral health: a systematic review of clinical trials. Curr. Pharm. Biotechnol. 24, 1916– 1927. doi: 10.2174/1389201024666230405135457, PMID: 37038663 · DOI
  120. Nowicki E. M. Shroff R. Singleton J. A. Renaud D. E. Wallace D. Drury J.. (2018). Microbiota and metatranscriptome changes accompanying the onset of gingivitis. MBio 9: e00575-18. doi: 10.1128/mBio.00575-18, PMID: 29666288 PMC5904416 · DOI
  121. O’Mullane D. M. Baez R. J. Jones S. Lennon M. A. Petersen P. E. Rugg-Gunn A. J.. (2016). Fluoride and oral health. Community Dent. Health 33, 69– 99. 27352462
  122. Oliveira S. G. Nishiyama R. R. Trigo C. A. C. Mattos-Guaraldi A. L. Dávila A. M. R. Jardim R.. (2021). Core of the saliva microbiome: an analysis of the MG-RAST data. BMC Oral Health 21: 351. doi: 10.1186/s12903-021-01719-5, PMID: 34271900 PMC8283749 · DOI
  123. Olson J. C. Cuff C. F. Lukomski S. Lukomska E. Canizales Y. Wu B.. (2011). Use of 16S ribosomal RNA gene analyses to characterize the bacterial signature associated with poor oral health in West Virginia. BMC Oral Health 11: 7. doi: 10.1186/1472-6831-11-7, PMID: 21362199 PMC3061962 · DOI
  124. Ouhara K. Komatsuzawa H. Yamada S. Shiba H. Fujiwara T. Ohara M.. (2005). Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, {beta}-defensins and LL37, produced by human epithelial cells. J. Antimicrob. Chemother. 55, 888– 896. doi: 10.1093/jac/dki103, PMID: 15886266 · DOI
  125. Parcina Amizic I. Cigic L. Gavic L. Radic M. Biocina Lukenda D. Tonkic M.. (2017). Antimicrobial efficacy of probiotic-containing toothpastes: an in vitro evaluation. Med. Glas. (Zenica) 14, 139– 144. doi: 10.17392/870-16, PMID: 28165440 · DOI
  126. Pozhitkov A. E. Leroux B. G. Randolph T. W. Beikler T. Flemmig T. F. Noble P. A. (2015). Towards microbiome transplant as a therapy for periodontitis: an exploratory study of periodontitis microbial signature contrasted by oral health, caries and edentulism. BMC Oral Health 15: 125. doi: 10.1186/s12903-015-0109-4, PMID: 26468081 PMC4607249 · DOI
  127. Pusateri C. R. Monaco E. A. Edgerton M. (2009). Sensitivity of Candida albicans biofilm cells grown on denture acrylic to antifungal proteins and chlorhexidine. Arch. Oral Biol. 54, 588– 594. doi: 10.1016/j.archoralbio.2009.01.016, PMID: 19249746 PMC2693315 · DOI
  128. Qiu W. Zhou Y. Li Z. Huang T. Xiao Y. Cheng L.. (2020). Application of antibiotics/antimicrobial agents on dental caries. Biomed. Res. Int. 2020, 1– 11. doi: 10.1155/2020/5658212 PMC7013294 32076608 · DOI
  129. Radaic A. Kapila Y. L. (2021). The oralome and its dysbiosis: new insights into oral microbiome-host interactions. Comput. Struct. Biotechnol. J. 19, 1335– 1360. doi: 10.1016/j.csbj.2021.02.010, PMID: 33777334 PMC7960681 · DOI
  130. Radu C. M. Radu C. C. Bochiș S. A. Arbănași E. M. Lucan A. I. Murvai V. R.. (2023). Revisiting the therapeutic effects of essential oils on the oral microbiome. Pharmacy (Basel) 11: 33. doi: 10.3390/pharmacy11010033 36827671 PMC9958697 · DOI
  131. Reddy M. S. Shetty S. R. Vannala V. (2019). Embracing personalized medicine in dentistry. J. Pharm. Bioallied Sci. 11, S92– s96. doi: 10.4103/JPBS.JPBS_297_18 31198319 PMC6555331 · DOI
  132. Reiznautt C. M. Ribeiro J. S. Kreps E. Da Rosa W. L. O. De Lacerda H. Peralta S. L.. (2021). Development and properties of endodontic resin sealers with natural oils. J. Dent. 104: 103538. doi: 10.1016/j.jdent.2020.103538, PMID: 33248212 · DOI
  133. Ridyard K. E. Overhage J. (2021). The potential of human peptide LL-37 as an antimicrobial and anti-biofilm agent. Antibiotics (Basel) 10: 650. doi: 10.3390/antibiotics10060650 34072318 PMC8227053 · DOI
  134. Rosier B. Marsh P. Mira A. (2018). Resilience of the oral microbiota in health: mechanisms that prevent dysbiosis. J. Dent. Res. 97, 371– 380. doi: 10.1177/0022034517742139 29195050 · DOI · Paper page
  135. Rosier B. T. Moya-Gonzalvez E. M. Corell-Escuin P. Mira A. (2020). Isolation and characterization of nitrate-reducing bacteria as potential probiotics for oral and systemic health. Front. Microbiol. 11: 555465. doi: 10.3389/fmicb.2020.555465, PMID: 33042063 PMC7522554 · DOI
  136. Roslund K. Lehto M. Pussinen P. Hartonen K. Groop P.-H. Halonen L.. (2021). Identifying volatile in vitro biomarkers for oral bacteria with proton-transfer-reaction mass spectrometry and gas chromatography–mass spectrometry. Sci. Rep. 11: 16897. doi: 10.1038/s41598-021-96287-7, PMID: 34413397 PMC8377122 · DOI
  137. Saadaoui M. Singh P. Al Khodor S. (2021). Oral microbiome and pregnancy: a bidirectional relationship. J. Reprod. Immunol. 145: 103293. doi: 10.1016/j.jri.2021.103293 33676065 · DOI
  138. Saha S. Chopra A. Kamath S. U. Kashyap N. N. (2023). Can acid produced from probiotic bacteria alter the surface roughness, microhardness, and elemental composition of enamel? An in vitro study. Odontology 111, 929– 941. doi: 10.1007/s10266-023-00804-1, PMID: 36995435 PMC10492682 · DOI
  139. Sancho-Vaello E. Gil-Carton D. François P. Bonetti E. J. Kreir M. Pothula K. R.. (2020). The structure of the antimicrobial human cathelicidin LL-37 shows oligomerization and channel formation in the presence of membrane mimics. Sci. Rep. 10: 17356. doi: 10.1038/s41598-020-74401-5, PMID: 33060695 PMC7562864 · DOI
  140. Sedghi L. Dimassa V. Harrington A. Lynch S. V. Kapila Y. L. (2021). The oral microbiome: role of key organisms and complex networks in oral health and disease. Periodontology 87, 107– 131. doi: 10.1111/prd.12393 PMC8457218 34463991 · DOI · Paper page
  141. Sorbara M. T. Pamer E. G. (2022). Microbiome-based therapeutics. Nat. Rev. Microbiol. 20, 365– 380. doi: 10.1038/s41579-021-00667-9 34992261 · DOI · Paper page
  142. Sun J. Tang Q. Yu S. Xie M. Xie Y. Chen G.. (2020). Role of the oral microbiota in cancer evolution and progression. Cancer Med. 9, 6306– 6321. doi: 10.1002/cam4.3206, PMID: 32638533 PMC7476822 · DOI
  143. Takahashi D. Shukla S. K. Prakash O. Zhang G. (2010). Structural determinants of host defense peptides for antimicrobial activity and target cell selectivity. Biochimie 92, 1236– 1241. doi: 10.1016/j.biochi.2010.02.023 20188791 · DOI
  144. Thurnheer T. Belibasakis G. N. (2018). Effect of sodium fluoride on oral biofilm microbiota and enamel demineralization. Arch. Oral Biol. 89, 77– 83. doi: 10.1016/j.archoralbio.2018.02.010, PMID: 29482049 · DOI
  145. Toscano-Garibay J. D. Arriaga-Alba M. Sánchez-Navarrete J. Mendoza-García M. Flores-Estrada J. J. Moreno-Eutimio M. A.. (2017). Antimutagenic and antioxidant activity of the essential oils of Citrus sinensis and Citrus latifolia. Sci. Rep. 7: 11479. doi: 10.1038/s41598-017-11818-5, PMID: 28904369 PMC5597616 · DOI
  146. Verma D. Garg P. K. Dubey A. K. (2018). Insights into the human oral microbiome. Arch. Microbiol. 200, 525– 540. doi: 10.1007/s00203-018-1505-3 29572583 · DOI
  147. Vinasco K. Mitchell H. M. Kaakoush N. O. Castano-Rodriguez N. (2019). Microbial carcinogenesis: lactic acid bacteria in gastric cancer. Biochim. Biophys. Acta 1872: 188309. doi: 10.1016/j.bbcan.2019.07.004, PMID: 31394110 · DOI
  148. Vyhnalova T. Danek Z. Gachova D. Linhartova P. B. (2021). The role of the oral microbiota in the etiopathogenesis of oral squamous cell carcinoma. Microorganisms 9: 1549. doi: 10.3390/microorganisms9081549, PMID: 34442627 PMC8400438 · DOI
  149. Wade W. G. (2013). The oral microbiome in health and disease. Pharmacol. Res. 69, 137– 143. doi: 10.1016/j.phrs.2012.11.006 23201354 · DOI · Paper page
  150. Welch J. L. M. Ramírez-Puebla S. T. Borisy G. G. (2020). Oral microbiome geography: micron-scale habitat and niche. Cell Host Microbe 28, 160– 168. doi: 10.1016/j.chom.2020.07.009, PMID: 32791109 PMC7604680 · DOI
  151. Wescombe P. A. Hale J. D. Heng N. C. Tagg J. R. (2012). Developing oral probiotics from Streptococcus salivarius. Future Microbiol. 7, 1355– 1371. doi: 10.2217/fmb.12.113 23231486 · DOI
  152. Willis J. R. Gabaldon T. (2020). The human Oral microbiome in health and disease: from sequences to ecosystems. Microorganisms 8: 308. doi: 10.3390/microorganisms8020308, PMID: 32102216 PMC7074908 · DOI
  153. Wilmarth P. A. Riviere M. A. Rustvold D. L. Lauten J. D. Madden T. E. David L. L. (2004). Two-dimensional liquid chromatography study of the human whole saliva proteome. J. Proteome Res. 3, 1017– 1023. doi: 10.1021/pr049911o, PMID: 15473691 · DOI
  154. Wu D.-D. Ngowi E. E. Zhai Y.-K. Wang Y.-Z. Khan N. H. Kombo A. F.. (2022). Role of hydrogen sulfide in Oral disease. Oxidative Med. Cell. Longev. 2022, 1– 14. doi: 10.1155/2022/1886277 PMC8807043 35116090 · DOI
  155. Xiao H. Fan Y. Li Y. Dong J. Zhang S. Wang B.. (2021). Oral microbiota transplantation fights against head and neck radiotherapy-induced oral mucositis in mice. Comput. Struct. Biotechnol. J. 19, 5898– 5910. doi: 10.1016/j.csbj.2021.10.028, PMID: 34815834 PMC8579069 · DOI
  156. Yang C.-Y. Yeh Y.-M. Yu H.-Y. Chin C.-Y. Hsu C.-W. Liu H.. (2018). Oral microbiota community dynamics associated with oral squamous cell carcinoma staging. Front. Microbiol. 9: 862. doi: 10.3389/fmicb.2018.00862 29774014 PMC5943489 · DOI
  157. Ye C. Kapila Y. (2021). Oral microbiome shifts during pregnancy and adverse pregnancy outcomes: hormonal and immunologic changes at play. Periodontology 87, 276– 281. doi: 10.1111/prd.12386 PMC8457099 34463984 · DOI
  158. Zasloff M. (2019). Antimicrobial peptides of multicellular organisms: my perspective. Adv. Exp. Med. Biol. 1117, 3– 6. doi: 10.1007/978-981-13-3588-4_1, PMID: 30980349 · DOI
  159. Zhang J. S. Chu C.-H. Yu O. Y. (2022). Oral microbiome and dental caries development. Dent. J. 10: 184. doi: 10.3390/dj10100184, PMID: 36285994 PMC9601200 · DOI
  160. Zhang Y. Ding Y. Guo Q. (2022). Probiotic species in the Management of Periodontal Diseases: an overview. Front. Cell. Infect. Microbiol. 12: 806463. doi: 10.3389/fcimb.2022.806463, PMID: 35402306 PMC8990095 · DOI
  161. Zhang L. Liu Y. Zheng H. J. Zhang C. P. (2020). The oral microbiota may have influence on oral cancer. Front. Cell. Infect. Microbiol. 9: 476. doi: 10.3389/fcimb.2019.00476, PMID: 32010645 PMC6974454 · DOI
  162. Zhang G. Lu M. Liu R. Tian Y. Vu V. H. Li Y.. (2020). Inhibition of Streptococcus mutans biofilm formation and virulence by Lactobacillus plantarum K41 isolated from traditional Sichuan pickles. Front. Microbiol. 11: 774. doi: 10.3389/fmicb.2020.00774, PMID: 32425911 PMC7203412 · DOI
  163. Zhang M. Tang H. Yuan Y. Ou Z. Chen Z. Xu Y.. (2023). The role of indoor microbiome and metabolites in shaping Children’s nasal and Oral microbiota: a pilot multi-Omic analysis. Meta 13: 1040. doi: 10.3390/metabo13101040, PMID: 37887365 PMC10608577 · DOI
  164. Zhang M. Wang F. Jiang L. Liu R. Zhang L. Lei X.. (2013). Lactobacillus salivarius REN inhibits rat oral cancer induced by 4-nitroquioline 1-oxide. Cancer Prev. Res. (Phila.) 6, 686– 694. doi: 10.1158/1940-6207.CAPR-12-0427, PMID: 23658366 · DOI
  165. Zhang Y. Wang X. Li H. Ni C. Du Z. Yan F. (2018). Human oral microbiota and its modulation for oral health. Biomed. Pharmacother. 99, 883– 893. doi: 10.1016/j.biopha.2018.01.146, PMID: 29710488 · DOI
  166. Zhou Z. Ling G. Ding N. Xun Z. Zhu C. Hua H.. (2018). Molecular analysis of oral microflora in patients with primary Sjögren's syndrome by using high-throughput sequencing. PeerJ 6: e5649. doi: 10.7717/peerj.5649, PMID: 30280027 PMC6166617 · DOI
  167. Żółkiewicz J. Marzec A. Ruszczyński M. Feleszko W. (2020). Postbiotics-a step beyond pre- and probiotics. Nutrients 12: 2189. doi: 10.3390/nu12082189, PMID: 32717965 PMC7468815 · DOI
  168. Zomorodian K. Ghadiri P. Saharkhiz M. J. Moein M. R. Mehriar P. Bahrani F.. (2015). Antimicrobial activity of seven essential oils from Iranian aromatic plants against common causes of oral infections. Jundishapur J. Microbiol. 8: e17766. doi: 10.5812/jjm.17766 25793100 PMC4353034 · DOI

Authors
Bostanghadiri, N., Kouhzad, M., Taki, E., Elahi, Z., Khoshbayan, A., Navidifar, T., & Darban-Sarokhalil, D.
Affiliations
  • Iran University of Medical Sciences (IR)
  • Islamic Azad University North Tehran Branch (IR)
  • Kermanshah University of Medical Sciences (IR)
Corresponding author
Navidifar, Tahereh
ORCID
Venue
Frontiers in Microbiology
Publisher
Frontiers Media SA
Published
2024-08-20
Volume
15
Pages
1431785-1431785
ISSN
1664-302X (ISSN-L)
DOI
10.3389/fmicb.2024.1431785
PMC
PMC11368800
OpenAlex
W4401976819
Cited by
61
References
184
Citations by year
2026: 27 · 2025: 31 · 2024: 3
FWCI
4.94
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Microbiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
Keywords
oral microbiota, oral dysbiosis, oral health, dental caries, Streptococcus, periodontal disease, gingival disease, periapical lesions, oral cancer, probiotics, microbiota transplantation, microbiota-based therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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