Defining a Healthy Human Gut Microbiome: Current Concepts, Future Directions, and Clinical Applications
Open accessAbstract
Indigenous microbiota are an essential component in the modern concept of human health, but the composition and functional characteristics of a healthy microbiome remain to be precisely defined. Patterns of microbial colonization associated with disease states have been documented, but the health-associated microbial patterns and their functional characteristics are less clear. A healthy microbiome, considered in the context of body habitat or body site, could be described in terms of ecologic stability (i.e., ability to resist community structure change under stress or to rapidly return to baseline following a stress-related change), by an idealized (presumably health-associated) composition or by a desirable functional profile (including metabolic and trophic provisions to the host). Elucidation of the properties of healthy microbiota would provide a target for dietary interventions and/or microbial modifications aimed at sustaining health in generally healthy populations and improving the health of individuals exhibiting disrupted microbiota and associated diseases.
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The effects of the intestinal microbiota on the development, function, and homeostasis of the enteric immune system are well documented.
“The effects of the intestinal microbiota on the development, function, and homeostasis of the enteric immune system are well documented (5, 158).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [5]
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- Authors
- Bäckhed, F., Fraser, C. M., Ringel, Y., Sanders, M. E., Sartor, R. B., Sherman, P. M., Versalovic, J., Young, V., & Finlay, B. B.
- Affiliations
- Sahlgrenska University Hospital (SE)
- University of Maryland, Baltimore (US)
- University of North Carolina at Chapel Hill (US)
- University of Toronto (CA)
- Baylor College of Medicine (US)
- University of Michigan (US)
- University of British Columbia (CA)
- Corresponding author
- Finlay, B. Brett
- ORCID
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 12
- Issue
- 5
- Pages
- 611-622
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2133275312
- Cited by
- 836
- References
- 85
- Citations by year
- 2026: 48 · 2025: 52 · 2024: 76 · 2023: 80 · 2022: 88 · 2021: 78 · 2020: 86 · 2019: 74 · 2018: 62 · 2017: 65 · 2016: 38 · 2015: 43 · 2014: 33 · 2013: 12
- FWCI
- 11.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, microbial colonization, microbiota composition, microbiota function, host-microbe interactions, dietary intervention, microbiota-targeted therapy, dysbiosis
- MeSH terms
- Anti-Bacterial Agents, Humans, Intestinal Diseases, Probiotics, Gastrointestinal Tract, Metagenome, Prebiotics, Microbial Consortia
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