Cited by 836Gut microbiota and healthOral microbiology and periodontitis researchProbiotics and Fermented Foods

Defining a Healthy Human Gut Microbiome: Current Concepts, Future Directions, and Clinical Applications

Open access

Abstract

Indigenous microbiota are an essential component in the modern concept of human health, but the composition and functional characteristics of a healthy microbiome remain to be precisely defined. Patterns of microbial colonization associated with disease states have been documented, but the health-associated microbial patterns and their functional characteristics are less clear. A healthy microbiome, considered in the context of body habitat or body site, could be described in terms of ecologic stability (i.e., ability to resist community structure change under stress or to rapidly return to baseline following a stress-related change), by an idealized (presumably health-associated) composition or by a desirable functional profile (including metabolic and trophic provisions to the host). Elucidation of the properties of healthy microbiota would provide a target for dietary interventions and/or microbial modifications aimed at sustaining health in generally healthy populations and improving the health of individuals exhibiting disrupted microbiota and associated diseases.

Integrity signals

Registry

Crossref · 10.1016/j.chom.2012.10.012

Cites

85 of 85 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. Andrews, 1992, Chronic constipation reversed by restoration of bowel flora. A case and a hypothesis, Eur. J. Gastroenterol. Hepatol., 4, 245
  2. Gibson, 2010, Vol. 7

Cited by

Sorted by citations

Authors
Bäckhed, F., Fraser, C. M., Ringel, Y., Sanders, M. E., Sartor, R. B., Sherman, P. M., Versalovic, J., Young, V., & Finlay, B. B.
Affiliations
  • Sahlgrenska University Hospital (SE)
  • University of Maryland, Baltimore (US)
  • University of North Carolina at Chapel Hill (US)
  • University of Toronto (CA)
  • Baylor College of Medicine (US)
  • University of Michigan (US)
  • University of British Columbia (CA)
Corresponding author
Finlay, B. Brett
Venue
Cell Host & Microbe
Publisher
Elsevier BV
Published
2012-11
Volume
12
Issue
5
Pages
611-622
ISSN
1931-3128 (ISSN-L)
OpenAlex
W2133275312
Cited by
836
References
85
Citations by year
2026: 48 · 2025: 52 · 2024: 76 · 2023: 80 · 2022: 88 · 2021: 78 · 2020: 86 · 2019: 74 · 2018: 62 · 2017: 65 · 2016: 38 · 2015: 43 · 2014: 33 · 2013: 12
FWCI
11.30
Type
journal article
Language
en
Open access
Locations
  • Cell Host & Microbe (publishedVersion)
  • PubMed (publishedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
gut microbiota, microbial colonization, microbiota composition, microbiota function, host-microbe interactions, dietary intervention, microbiota-targeted therapy, dysbiosis
MeSH terms
Anti-Bacterial Agents, Humans, Intestinal Diseases, Probiotics, Gastrointestinal Tract, Metagenome, Prebiotics, Microbial Consortia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review