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Cited by 321Gut microbiota and healthInflammatory Bowel DiseaseImmune Response and Inflammation

Crosstalk Between Gut Microbiota and Innate Immunity and Its Implication in Autoimmune Diseases

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Jiao, Yuhao, Wu, Li, Huntington, Nicholas D., Zhang, Xuan·2020·Frontiers in Immunology
DOI 10.3389/fimmu.2020.00282PMC PMC7047319
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Abstract

The emerging concept of microbiota contributing to local mucosal homeostasis has fueled investigation into its specific role in immunology. Gut microbiota is mostly responsible for maintaining the balance between host defense and immune tolerance. Dysbiosis of gut microbiota has been shown to be related to various alterations of the immune system. This review focuses on the reciprocal relationship between gut microbiota and innate immunity compartment, with emphasis on gut-associated lymphoid tissue, innate lymphoid cells, and phagocytes. From a clinical perspective, the review gives a possible explanation of how the "gut microbiota-innate immunity" axis might contribute to the pathogenesis of autoimmune diseases like rheumatoid arthritis, spondyloarthritis, and systemic lupus erythematosus.

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  • Some postbiotics, such as bacteriocins and organic acids, have antibacterial capabilities that can impede the development and spread of dangerous pathogenic microorganisms in the digestive tract, reducing harmful microbes and protecting against infections.

    “Some postbiotics, such as bacteriocins and organic acids, have antibacterial capabilities that can impede the development and spread of dangerous pathogenic microorganisms in the digestive tract.”

    From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [39]

    Split into 2 atoms — 0 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 1 unverifiable. Expand the claim to see per-atom verdicts.

    Experimental — accuracy not yet measured

  • Postbiotics can help the immune system learn to distinguish between innocuous and hazardous chemicals (immunological tolerance), preventing inappropriate immune responses to innocuous antigens and allergens by instructing the immune system and encouraging the growth of regulatory immune cells.

    “Postbiotics can help the immune system learn to distinguish between innocuous and hazardous chemicals, a process known as immunological tolerance. Postbiotics aid in preventing inappropriate immune responses to innocuous antigens and allergens by instructing the immune system and encouraging the growth of regulatory immune cells.”

    From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [39]

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  • Both probiotics and postbiotics have demonstrated positive results in the treatment of inflammatory bowel disease (IBD), and disease severity and remission rates in people with ulcerative colitis and Crohn's disease have been linked to the use of certain probiotics, such as Saccharomyces boulardii and Bifidobacterium breve.

    “Both probiotics and postbiotics have demonstrated positive results in the treatment of inflammatory bowel disease (IBD). Disease severity and remission rates in people with ulcerative colitis and Crohn’s disease have been linked to the use of certain probiotics, such as Saccharomyces boulardii and Bifidobacterium breve.”

    From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [39]

    Split into 2 atoms — 0 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 1 unverifiable. Expand the claim to see per-atom verdicts.

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  • SCFAs might boost the production of anti-inflammatory cytokines like interleukin-10 (IL-10) and encourage the formation of regulatory T cells (Tregs), resulting in a more normal immune response, which decreases inflammation and protects against autoimmune diseases.

    “SCFAs, for instance, might boost the production of anti-inflammatory cytokines like interleukin-10 (IL-10) and encourage the formation of regulatory T cells (Tregs). This results in a more normal immune response, which in turn decreases inflammation and protects against autoimmune diseases.”

    From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [39]

    Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

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  • Probiotics have been investigated for their ability to alleviate irritable bowel syndrome (IBS) symptoms, and certain probiotic strains like Bifidobacterium infantis and Lactobacillus plantarum can reduce inflammation and restore gut barrier function in IBS patients.

    “Bloating, stomach discomfort, and constipation are all signs of irritable bowel syndrome (IBS), and probiotics have been investigated for their ability to alleviate these conditions. Inflammation can be reduced and gut barrier function can be restored in IBS patients by taking certain probiotic strains like Bifidobacterium infantis and Lactobacillus plantarum.”

    From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [39]

    Split into 2 atoms — 0 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 1 unverifiable. Expand the claim to see per-atom verdicts.

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  1. [1]Schopf JW Packer BM. Early Archean (3.3-billion to 3.5-billion-year-old) microfossils from Warrawoona Group, Australia. Science. (1987) 237: 70– 3. 10.1126/science.11539686 11539686 · DOI
  2. [3]Grice EA Kong HH Renaud G Young AC Bouffard GG Blakesley RW. A diversity profile of the human skin microbiota. Genome Res. (2008) 18: 1043– 50. 10.1101/gr.075549.107 18502944 PMC2493393 · DOI
  3. [4]Belkaid Y Segre JA. Dialogue between skin microbiota and immunity. Science. (2014) 346: 954– 9. 10.1126/science.1260144 25414304 · DOI · Paper page
  4. [5]Zoetendal E Rajilić-Stojanović M De Vos W. High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota. Gut. (2008) 57: 1605– 15. 10.1136/gut.2007.133603 18941009 · DOI
  5. [7]Whiteside SA Razvi H Dave S Reid G Burton JP. The microbiome of the urinary tract—a role beyond infection. Nat Rev Urol. (2015) 12: 81. 10.1038/nrurol.2014.361 25600098 · DOI
  6. [8]Blaser MJ Falkow S. What are the consequences of the disappearing human microbiota? Nat Rev Microbiol. (2009) 7: 887. 10.1038/nrmicro2245 19898491 PMC9354563 · DOI
  7. [9]Lederberg J. Infectious history. Science. (2000) 288: 287– 93. 10.1126/science.288.5464.287 10777411 · DOI
  8. [10]Abrams GD Bauer H Sprinz H. Influence of the normal flora on mucosal morphology and cellular renewal in the ileum. A comparison of germ-free and conventional mice. Lab Invest. (1963) 12: 355– 64. 14010768
  9. [11]Gibbons R Socransky S Kapsimalis B. Establishment of human indigenous bacteria in germ-free mice. J Bacteriol. (1964) 88: 1316– 23. 10.1128/JB.88.5.1316-1323.1964 14234787 PMC277410 · DOI
  10. [12]Pollard M Sharon N. Responses of the Peyer's patches in germ-free mice to antigenic stimulation. Infect Immun. (1970) 2: 96– 100. 10.1128/IAI.2.1.96-100.1970 16557807 PMC415970 · DOI
  11. [13]Cebra JJ Periwal SB Lee G Lee F Shroff KE. Development and maintenance of the gut-associated lymphoid tissue (GALT): the roles of enteric bacteria and viruses. J Immunol Res. (1998) 6: 13– 8. 10.1155/1998/68382 9716901 PMC2276005 · DOI
  12. [14]Štěpánková R Šinkora J Hudcovic T Kozakova H Tlaskalova-Hogenova H. Differences in development of lymphocyte subpopulations from gut-associated lymphatic tissue (GALT) of germfree and conventional rats: effect of aging. Folia Microbiol. (1998) 43: 531– 4. 10.1007/BF02820814 9821320 · DOI
  13. [15]Medzhitov R Janeway C Jr. The Toll receptor family and microbial recognition. Trends Microbiol. (2000) 8: 452– 6. 10.1016/S0966-842X(00)01845-X 11044679 · DOI
  14. [17]Turnbaugh PJ Ley RE Hamady M Fraser-Liggett CM Knight R Gordon JI. The human microbiome project. Nature. (2007) 449: 804. 10.1038/nature06244 17943116 PMC3709439 · DOI · Paper page
  15. [18]Chun J Lee J-H Jung Y Kim M Kim S Kim BK. EzTaxon: a web-based tool for the identification of prokaryotes based on 16S ribosomal RNA gene sequences. Int J Syst Evol Microbiol. (2007) 57: 2259– 61. 10.1099/ijs.0.64915-0 17911292 · DOI
  16. [19]Yoon S-H Ha S-M Kwon S Lim J Kim Y Seo H. Introducing EzBioCloud: a taxonomically united database of 16S rRNA gene sequences and whole-genome assemblies. Int J Syst Evol Microbiol. (2017) 67: 1613– 7. 10.1099/ijsem.0.001755 28005526 PMC5563544 · DOI
  17. [20]Handelsman J Rondon MR Brady SF Clardy J Goodman RM. Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products. Chem Biol. (1998) 5: R245– R9. 10.1016/S1074-5521(98)90108-9 9818143 · DOI
  18. [21]Preidis GA Versalovic J. Targeting the human microbiome with antibiotics, probiotics, and prebiotics: gastroenterology enters the metagenomics era. Gastroenterology. (2009) 136: 2015– 31. 10.1053/j.gastro.2009.01.072 19462507 PMC4108289 · DOI
  19. [22]Riesenfeld CS Schloss PD Handelsman J. Metagenomics: genomic analysis of microbial communities. Annu Rev Genet. (2004) 38: 525– 52. 10.1146/annurev.genet.38.072902.091216 15568985 · DOI
  20. [23]Kramer P Bressan P. Humans as superorganisms: how microbes, viruses, imprinted genes, and other selfish entities shape our behavior. Perspect Psychol Sci. (2015) 10: 464– 81. 10.1177/1745691615583131 26177948 · DOI
  21. [24]Gill SR Pop M DeBoy RT Eckburg PB Turnbaugh PJ Samuel BS. Metagenomic analysis of the human distal gut microbiome. Science. (2006) 312: 1355– 9. 10.1126/science.1124234 16741115 PMC3027896 · DOI · Paper page
  22. [25]Thursby E Juge N. Introduction to the human gut microbiota. Biochem J. (2017) 474: 1823– 36. 10.1042/BCJ20160510 28512250 PMC5433529 · DOI · Paper page
  23. [27]Eckburg PB Bik EM Bernstein CN Purdom E Dethlefsen L Sargent M. Diversity of the human intestinal microbial flora. science. (2005) 308: 1635– 8. 10.1126/science.1110591 15831718 PMC1395357 · DOI · Paper page
  24. [29]Ley RE Hamady M Lozupone C Turnbaugh PJ Ramey RR Bircher JS. Evolution of mammals and their gut microbes. Science. (2008) 320: 1647– 51. 10.1126/science.1155725 18497261 PMC2649005 · DOI · Paper page
  25. [31]Ly NP Litonjua A Gold DR Celedón JC. Gut microbiota, probiotics, and vitamin D: interrelated exposures influencing allergy, asthma, and obesity? J Allergy Clin Immunol. (2011) 127: 1087– 94. 10.1016/j.jaci.2011.02.015 21419479 PMC3085575 · DOI
  26. [32]Wang J Thingholm LB Skiecevičiene J Rausch P Kummen M Hov JR. Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota. Nat Genet. (2016) 48: 1396. 10.1038/ng.3695 27723756 PMC5626933 · DOI · Paper page
  27. [33]Wu H-J Wu E. The role of gut microbiota in immune homeostasis and autoimmunity. Gut Microbes. (2012) 3: 4– 14. 10.4161/gmic.19320 22356853 PMC3337124 · DOI · Paper page
  28. [34]Akira S Uematsu S Takeuchi O. Pathogen recognition and innate immunity. J Cell. (2006) 124: 783– 801. 10.1016/j.cell.2006.02.015 16497588 · DOI
  29. [35]Brandtzaeg P Kiyono H Pabst R Russell M. Terminology: nomenclature of mucosa-associated lymphoid tissue. Mucosal Immunol. (2008) 1: 31. 10.1038/mi.2007.9 19079158 · DOI
  30. [36]Mowat AM. Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol. (2003) 3: 331– 41. 10.1038/nri1057 12669023 · DOI
  31. [38]Dunkley M Husband A. Distribution and functional characteristics of antigen-specific helper T cells arising after Peyer's patch immunization. J Immunol. (1987) 61: 475. 2450831 PMC1453437
  32. [39]Kiyono H McGHEE JR Mosteller LM Eldridge J Koopman W Kearney J. Murine Peyer's patch T cell clones. Characterization of antigen-specific helper T cells for immunoglobulin A responses. J Exp Med. (1982) 156: 1115– 30. 10.1084/jem.156.4.1115 6218215 PMC2186816 · DOI
  33. [40]Coombes JL Siddiqui KR Arancibia-Cárcamo CV Hall J Sun C-M Belkaid Y. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β-and retinoic acid–dependent mechanism. J Exp Med. (2007) 204: 1757– 64. 10.1084/jem.20070590 17620361 PMC2118683 · DOI
  34. [41]Siddiqui K Powrie F. CD103+ GALT DCs promote Foxp3+ regulatory T cells. Mucosal Immunol. (2008) 1(Suppl. 1): S34– 8. 10.1038/mi.2008.43 19079226 · DOI
  35. [42]Nelson DL Bundy BM Blaese RM Strober W. Cytotoxic effector cell function in organized gut-associated lymphoid tissue (GALT). Cell Immunol. (1976) 22: 165– 75. 10.1016/0008-8749(76)90017-4 1277291 · DOI
  36. [43]Mora JR Iwata M Eksteen B Song S-Y Junt T Senman B. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science. (2006) 314: 1157– 60. 10.1126/science.1132742 17110582 · DOI
  37. [44]Zigmond E Jung S. Intestinal macrophages: well educated exceptions from the rule. Trends Immunol. (2013) 34: 162– 8. 10.1016/j.it.2013.02.001 23477922 · DOI
  38. [45]Pearson C Uhlig HH Powrie F. Lymphoid microenvironments and innate lymphoid cells in the gut. Trends Immunol. (2012) 33: 289– 96. 10.1016/j.it.2012.04.004 22578693 · DOI
  39. [46]Wojno EDT Artis D Innate lymphoid cells: balancing immunity, inflammation, and tissue repair in the intestine. Cell Host Microbe. (2012) 12: 445– 57. 10.1016/j.chom.2012.10.003 23084914 PMC3584448 · DOI
  40. [47]Mebius RE Rennert P Weissman IL Developing lymph nodes collect CD4+ CD3– LTβ+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells. Immunity. (1997) 7: 493– 504. 10.1016/S1074-7613(00)80371-4 9354470 · DOI
  41. [48]Adachi S Yoshida H Kataoka H Nishikawa S. Three distinctive steps in Peyer's patch formation of murine embryo. Int Immunol. (1997) 9: 507– 14. 10.1093/intimm/9.4.507 9138010 · DOI
  42. [49]Bouskra D Brézillon C Bérard M Werts C Varona R Boneca IG. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature. (2008) 456: 507. 10.1038/nature07450 18987631 · DOI · Paper page
  43. [50]Gordon HA Bruckner-Kardoss E Wostmann BS. Aging in germ-free mice: life tables and lesions observed at natural death. J Gerontol. (1966) 21: 380– 7. 10.1093/geronj/21.3.380 5944800 · DOI
  44. [51]Hamada H Hiroi T Nishiyama Y Takahashi H Masunaga Y Hachimura S. Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine. J Immunol. (2002) 168: 57– 64. 10.4049/jimmunol.168.1.57 11751946 · DOI
  45. [52]Rhee K-J Sethupathi P Driks A Lanning DK Knight KL. Role of commensal bacteria in development of gut-associated lymphoid tissues and preimmune antibody repertoire. J Immunol. (2004) 172: 1118– 24. 10.4049/jimmunol.172.2.1118 14707086 · DOI
  46. [53]Moreau M-C Corthier G. Effect of the gastrointestinal microflora on induction and maintenance of oral tolerance to ovalbumin in C3H/HeJ mice. Infect Immun. (1988) 56: 2766– 8. 10.1128/IAI.56.10.2766-2768.1988 3417356 PMC259643 · DOI
  47. [54]Stanisavljević S Lukić J Momčilović M Miljković M Jevtić B Kojić M. Gut-associated lymphoid tissue, gut microbes and susceptibility to experimental autoimmune encephalomyelitis. Benef Microbes. (2016) 7: 363– 73. 10.3920/BM2015.0159 26839070 · DOI
  48. [55]Round JL Lee SM Li J Tran G Jabri B Chatila TA. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science. (2011) 332: 974– 7. 10.1126/science.1206095 21512004 PMC3164325 · DOI · Paper page
  49. [56]Clarke TB Davis KM Lysenko ES Zhou AY Yu Y Weiser JN. Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity. Nat Med. (2010) 16: 228. 10.1038/nm.2087 20081863 PMC4497535 · DOI · Paper page
  50. [58]Medzhitov R Preston-Hurlburt P Kopp E Stadlen A Chen C Ghosh S. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell. (1998) 2: 253– 8. 10.1016/S1097-2765(00)80136-7 9734363 · DOI
  51. [59]Wesche H Henzel WJ Shillinglaw W Li S Cao Z. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity. (1997) 7: 837– 47. 10.1016/S1074-7613(00)80402-1 9430229 · DOI
  52. [60]Asquith MJ Boulard O Powrie F Maloy KJ. Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease. Gastroenterology. (2010) 139: 519– 29. e2. 10.1053/j.gastro.2010.04.045 20433840 PMC3739016 · DOI
  53. [61]Dessein R Gironella M Vignal C Peyrin-Biroulet L Sokol H Secher T TLR2 is critical for induction of REG3β expression and intestinal clearance of Yersinia pseudotuberculosis. Gut. (2009) 58: 771– 6. 10.1136/gut.2008.168443 19174417 · DOI
  54. [62]Cario E. Barrier-protective function of intestinal epithelial Toll-like receptor 2. Mucosal Immunol. (2008) 1(Suppl. 1): S62– 6. 10.1038/mi.2008.47 19079234 · DOI
  55. [63]Turley SJ Lee J-W Dutton-Swain N Mathis D Benoist C. Endocrine self and gut non-self intersect in the pancreatic lymph nodes. Proc Natl Acad Sci USA. (2005) 102: 17729– 33. 10.1073/pnas.0509006102 16317068 PMC1308925 · DOI
  56. [64]Sorini C Falcone M. Shaping the (auto) immune response in the gut: the role of intestinal immune regulation in the prevention of type 1 diabetes. Am J Clin Exp Immunol. (2013) 2: 156. 23885333 PMC3714176
  57. [65]Spits H Cupedo T. Innate lymphoid cells: emerging insights in development, lineage relationships, and function. Annu Rev Immunol. (2012) 30: 647– 75. 10.1146/annurev-immunol-020711-075053 22224763 · DOI
  58. [66]Chiossone L Dumas PY Vienne M Vivier E Natural killer cells and other innate lymphoid cells in cancer. Nat Rev Immunol. (2018) 18: 671– 88. 10.1038/s41577-018-0061-z 30209347 · DOI
  59. [67]Cherrier DE Serafini N Di Santo JP. Innate lymphoid cell development: a T cell perspective. Immunity. (2018) 48: 1091– 103. 10.1016/j.immuni.2018.05.010 29924975 · DOI · Paper page
  60. [68]Bernink JH Krabbendam L Germar K de Jong E Gronke K Kofoed-Nielsen M. Interleukin-12 and-23 control plasticity of CD127+ group 1 and group 3 innate lymphoid cells in the intestinal lamina propria. Immunity. (2015) 43: 146– 60. 10.1016/j.immuni.2015.06.019 26187413 · DOI
  61. [69]Fuchs A Vermi W Lee JS Lonardi S Gilfillan S Newberry RD. Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12-and IL-15-responsive IFN-γ-producing cells. Immunity. (2013) 38: 769– 81. 10.1016/j.immuni.2013.02.010 23453631 PMC3634355 · DOI
  62. [70]Klose CS Flach M Möhle L Rogell L Hoyler T Ebert K. Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages. Cell. (2014) 157: 340– 56. 10.1016/j.cell.2014.03.030 24725403 · DOI
  63. [71]Hoyler T Klose CS Souabni A Turqueti-Neves A Pfeifer D Rawlins EL. The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells. Immunity. (2012) 37: 634– 48. 10.1016/j.immuni.2012.06.020 23063333 PMC3662874 · DOI
  64. [72]Mjösberg J Bernink J Golebski K Karrich JJ Peters CP Blom B. The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. Immunity. (2012) 37: 649– 59. 10.1016/j.immuni.2012.08.015 23063330 · DOI
  65. [73]Roediger B Kyle R Yip KH Sumaria N Guy TV Kim BS. Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells. Nat Immunol. (2013) 14: 564. 10.1038/ni.2584 23603794 PMC4282745 · DOI
  66. [74]Vivier E Artis D Colonna M Diefenbach A Di Santo JP Eberl G. Innate lymphoid cells: 10 years on. Cell. (2018) 174: 1054– 66. 10.1016/j.cell.2018.07.017 30142344 · DOI
  67. [75]Cording S Medvedovic J Cherrier M Eberl G. Development and regulation of RORγt+ innate lymphoid cells. FEBS Lett. (2014) 588: 4176– 81. 10.1016/j.febslet.2014.03.034 24681095 · DOI
  68. [76]Jiao Y Huntington ND Belz GT Seillet C. Type 1 innate lymphoid cell biology: lessons learnt from natural killer cells. Front Immunol. (2016) 7: 426. 10.3389/fimmu.2016.00426 27785129 PMC5059362 · DOI
  69. [77]Vivier E Ugolini S Blaise D Chabannon C Brossay L. Targeting natural killer cells and natural killer T cells in cancer. Nat Rev Immunol. (2012) 12: 239– 52. 10.1038/nri3174 22437937 PMC5161343 · DOI
  70. [78]Colonna M. Innate lymphoid cells: diversity, plasticity, and unique functions in immunity. Immunity. (2018) 48: 1104– 17. 10.1016/j.immuni.2018.05.013 29924976 PMC6344351 · DOI
  71. [79]Björklund ÅK Forkel M Picelli S Konya V Theorell J Friberg D. The heterogeneity of human CD127+ innate lymphoid cells revealed by single-cell RNA sequencing. Nat Immunol. (2016) 17: 451. 10.1038/ni.3368 26878113 · DOI
  72. [81]Kiss EA Vonarbourg C Kopfmann S Hobeika E Finke D Esser C. Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science. (2011) 334: 1561– 5. 10.1126/science.1214914 22033518 · DOI · Paper page
  73. [83]Lang PA Lang KS Xu HC Grusdat M Parish IA Recher M. Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. Proc Natl Acad Sci USA. (2012) 109: 1210– 5. 10.1073/pnas.1118834109 22167808 PMC3268324 · DOI
  74. [84]Sojka DK Tian Z Yokoyama WM editors. Tissue-resident natural killer cells and their potential diversity. Semin Immunol. (2014) 26: 127– 31. 10.1016/j.smim.2014.01.010 24548893 PMC4459495 · DOI
  75. [85]Viant C Guia S Hennessy RJ Rautela J Pham K Bernat C. Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival. J Exp Med. (2017) 214: 491– 510. 10.1084/jem.20160869 28057804 PMC5294858 · DOI
  76. [86]Caligiuri MA. Human natural killer cells. Blood. (2008) 112: 461– 9. 10.1182/blood-2007-09-077438 18650461 PMC2481557 · DOI
  77. [87]Souza-Fonseca-Guimaraes F Parlato M de Oliveira RB Golenbock D Fitzgerald K Shalova IN. Interferon-γ and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING). J Biol Chem. (2013) 288: 10715– 21. 10.1074/jbc.M112.435602 23443666 PMC3624451 · DOI
  78. [88]Enqvist M Ask EH Forslund E Carlsten M Abrahamsen G Béziat V. Coordinated expression of DNAM-1 and LFA-1 in educated NK cells. J Immunol. (2015) 194: 4518– 27. 10.4049/jimmunol.1401972 25825444 · DOI
  79. [89]Erkeller-Yuksel F Lydyard P Isenberg D. Lack of NK cells in lupus patients with renal involvement. Lupus. (1997) 6: 708– 12. 10.1177/096120339700600905 9412985 · DOI
  80. [90]Huang Z Fu B Zheng SG Li X Sun R Tian Z. Involvement of CD226+ NK cells in immunopathogenesis of systemic lupus erythematosus. J Immunol. (2011) 186: 3421– 31. 10.4049/jimmunol.1000569 21296979 PMC3097030 · DOI
  81. [91]Puxeddu I Bongiorni F Chimenti D Bombardieri S Moretta A Bottino C. Cell surface expression of activating receptors and co-receptors on peripheral blood NK cells in systemic autoimmune diseases. Scand J Rheumatol. (2012) 41: 298– 304. 10.3109/03009742.2011.648657 22632143 · DOI
  82. [92]Fogel LA Yokoyama WM French AR. Natural killer cells in human autoimmune disorders. Arthritis Res Ther. (2013) 15: 216. 10.1186/ar4232 23856014 PMC3979027 · DOI
  83. [93]Bartizal KF Salkowski C Balish E Pleasants JR. The effect of microbial flora, diet, and age on the tumoricidal activity of natural killer cells. J Leukoc Biol. (1984) 36: 739– 50. 10.1002/jlb.36.6.739 6594416 · DOI
  84. [94]Ganal SC Sanos SL Kallfass C Oberle K Johner C Kirschning C. Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota. Immunity. (2012) 37: 171– 86. 10.1016/j.immuni.2012.05.020 22749822 · DOI · Paper page
  85. [95]Rizzello V Bonaccorsi I Dongarra ML Fink LN Ferlazzo G. Role of natural killer and dendritic cell crosstalk in immunomodulation by commensal bacteria probiotics. BioMed Res Int. (2011) 2011: 473097. 10.1155/2011/473097 21660136 PMC3110311 · DOI
  86. [96]Sawa S Cherrier M Lochner M Satoh-Takayama N Fehling HJ Langa F. Lineage relationship analysis of RORγt+ innate lymphoid cells. Science. (2010) 330: 665– 9. 10.1126/science.1194597 20929731 · DOI
  87. [97]Sanos SL Bui VL Mortha A Oberle K Heners C Johner C. RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells. Nat Immunol. (2009) 10: 83. 10.1038/ni.1684 19029903 PMC4217274 · DOI
  88. [98]Satoh-Takayama N Vosshenrich CA Lesjean-Pottier S Sawa S Lochner M Rattis F. Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity. (2008) 29: 958– 70. 10.1016/j.immuni.2008.11.001 19084435 · DOI
  89. [99]Pickert G Neufert C Leppkes M Zheng Y Wittkopf N Warntjen M. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J Exp Med. (2009) 206: 1465– 72. 10.1084/jem.20082683 19564350 PMC2715097 · DOI · Paper page
  90. [100]Sawa S Lochner M Satoh-Takayama N Dulauroy S Bérard M Kleinschek M. RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota. Nat Immunol. (2011) 12: 320. 10.1038/ni.2002 21336274 · DOI
  91. [102]Sonnenberg GF Monticelli LA Elloso MM Fouser LA Artis D. CD4+ lymphoid tissue-inducer cells promote innate immunity in the gut. Immunity. (2011) 34: 122– 34. 10.1016/j.immuni.2010.12.009 21194981 PMC3035987 · DOI
  92. [104]Zheng Y Valdez PA Danilenko DM Hu Y Sa SM Gong Q. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med. (2008) 14: 282. 10.1038/nm1720 18264109 · DOI
  93. [105]Sonnenberg GF Monticelli LA Alenghat T Fung TC Hutnick NA Kunisawa J. Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science. (2012) 336: 1321– 5. 10.1126/science.1222551 22674331 PMC3659421 · DOI
  94. [107]Kruglov AA Grivennikov SI Kuprash DV Winsauer C Prepens S Seleznik GM. Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis. Science. (2013) 342: 1243– 6. 10.1126/science.1243364 24311691 · DOI
  95. [108]Goto Y Obata T Kunisawa J Sato S Ivanov II Lamichhane A. Innate lymphoid cells regulate intestinal epithelial cell glycosylation. Science. (2014) 345: 1254009. 10.1126/science.1254009 25214634 PMC4774895 · DOI
  96. [109]Hepworth MR Monticelli LA Fung TC Ziegler CG Grunberg S Sinha R. Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. Nature. (2013) 498: 113. 10.1038/nature12240 23698371 PMC3699860 · DOI
  97. [110]Hepworth MR Fung TC Masur SH Kelsen JR McConnell FM Dubrot J. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria–specific CD4+ T cells. Science. (2015) 348: 1031– 5. 10.1126/science.aaa4812 25908663 PMC4449822 · DOI
  98. [111]Huang Q Seillet C Belz GT. Shaping innate lymphoid cell diversity. Front Immunol. (2017) 8: 1569. 10.3389/fimmu.2017.01569 29201028 PMC5697340 · DOI
  99. [112]Tsuji M Suzuki K Kitamura H Maruya M Kinoshita K Ivanov II. Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut. Immunity. (2008) 29: 261– 71. 10.1016/j.immuni.2008.05.014 18656387 · DOI
  100. [113]Bernink JH Peters CP Munneke M Te Velde AA Meijer SL Weijer K. Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues. Nat Immunol. (2013) 14: 221. 10.1038/ni.2534 23334791 · DOI
  101. [114]Peterson LW Artis D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol. (2014) 14: 141. 10.1038/nri3608 24566914 · DOI
  102. [115]Thio CL-P Chi P-Y Lai AC-Y Chang Y-J. Regulation of type 2 innate lymphoid cell–dependent airway hyperreactivity by butyrate. J Allergy Clin Immunol. (2018) 142: 1867– 83. e12. 10.1016/j.jaci.2018.02.032 29522844 · DOI
  103. [117]Shaw TN Houston SA Wemyss K Bridgeman HM Barbera TA Zangerle-Murray T. Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression. J Exp Med. (2018) 215: 1507– 18. 10.1084/jem.20180019 29789388 PMC5987925 · DOI
  104. [119]Khosravi A Yáñez A Price JG Chow A Merad M Goodridge HS. Gut microbiota promote hematopoiesis to control bacterial infection. Cell Host Microbe. (2014) 15: 374– 81. 10.1016/j.chom.2014.02.006 24629343 PMC4144825 · DOI
  105. [120]Balmer ML Schürch CM Saito Y Geuking MB Li H Cuenca M. Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling. J Immunol. (2014) 193: 5273– 83. 10.4049/jimmunol.1400762 25305320 · DOI
  106. [121]Cerovic V Bain CC Mowat AM Milling SW. Intestinal macrophages and dendritic cells: what's the difference? Trends Immunol. (2014) 35: 270– 7. 10.1016/j.it.2014.04.003 24794393 · DOI
  107. [122]Schulz O Jaensson E Persson EK Liu X Worbs T Agace WW Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J Exp Med. (2009) 206: 3101– 14. 10.1084/jem.20091925 20008524 PMC2806467 · DOI
  108. [123]Johansson-Lindbom B Svensson M Pabst O Palmqvist C Marquez G Förster R. Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing. J Exp Med. (2005) 202: 1063– 73. 10.1084/jem.20051100 16216890 PMC2213212 · DOI
  109. [124]Farache J Koren I Milo I Gurevich I Kim K-W Zigmond E. Luminal bacteria recruit CD103+ dendritic cells into the intestinal epithelium to sample bacterial antigens for presentation. Immunity. (2013) 38: 581– 95. 10.1016/j.immuni.2013.01.009 23395676 PMC4115273 · DOI
  110. [125]Diehl GE Longman RS Zhang J-X Breart B Galan C Cuesta A Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX3CR1hi cells. Nature. (2013) 494: 116 10.1038/nature11809 23334413 PMC3711636 · DOI
  111. [126]Thaiss CA Levy M Suez J Elinav E. The interplay between the innate immune system and the microbiota. Curr Opin Immunol. (2014) 26: 41– 8. 10.1016/j.coi.2013.10.016 24556399 · DOI
  112. [127]Woo V Alenghat T. Host–microbiota interactions: epigenomic regulation. Curr Opin Immunol. (2017) 44: 52– 60. 10.1016/j.coi.2016.12.001 28103497 PMC5451311 · DOI
  113. [128]Kobayashi T Matsuoka K Sheikh SZ Russo SM Mishima Y Collins C. IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis. J Immunol. (2012) 189: 1792– 9. 10.4049/jimmunol.1200042 22786766 PMC3411910 · DOI
  114. [130]Ji J Shu D Zheng M Wang J Luo C Wang Y. Microbial metabolite butyrate facilitates M2 macrophage polarization and function. Sci Rep. (2016) 6: 24838. 10.1038/srep24838 27094081 PMC4837405 · DOI · Paper page
  115. [131]Trompette A Gollwitzer ES Yadava K Sichelstiel AK Sprenger N Ngom-Bru C. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med. (2014) 20: 159. 10.1038/nm.3444 24390308 · DOI · Paper page
  116. [133]Ma Y Xu X Li M Cai J Wei Q Niu H. Gut microbiota promote the inflammatory response in the pathogenesis of systemic lupus erythematosus. Mol Med. (2019) 25: 35. 10.1186/s10020-019-0102-5 31370803 PMC6676588 · DOI
  117. [134]Chen B Jia X-m Xu J-y Zhao L-d Ji J-y Wu B-x Proinflammatory and autoimmunogenic gut microbiome in systemic lupus erythematosus. bioRxiv. (2019) 621995 10.1101/621995 · DOI
  118. [135]Zhou C Zhao H Xiao X-y Guo R-j Wang Q Chen H Metagenomic profiling of the pro-inflammatory gut microbiota in ankylosing spondylitis. J Autoimmun. (2019) 107: 102360 10.1016/j.jaut.2019.102360 31806420 · DOI
  119. [137]Niu Q Cai B Huang Z-c Shi Y-y Wang L-l. Disturbed Th17/Treg balance in patients with rheumatoid arthritis. Rheumatol Int. (2011) 32: 2731– 6. 10.1007/s00296-011-1984-x 21809006 · DOI
  120. [138]Rogier R Koenders MI Abdollahi-Roodsaz S. Toll-like receptor mediated modulation of T cell response by commensal intestinal microbiota as a trigger for autoimmune arthritis. J Immunol Res. (2015) 2015: 527696. 10.1155/2015/527696 25802876 PMC4352938 · DOI
  121. [139]Genovese M Van den Bosch F Roberson S Bojin S Biagini I Ryan P. LY2439821, a humanized anti–interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I randomized, double-blind, placebo-controlled, proof-of-concept study. Arthritis Rheum. (2010) 62: 929– 39. 10.1002/art.27334 20131262 · DOI
  122. [140]Takayanagi H. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol. (2007) 7: 292. 10.1038/nri2062 17380158 · DOI · Paper page
  123. [141]Abdollahi-Roodsaz S Joosten LA Koenders MI Devesa I Roelofs MF Radstake TR. Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J Clin Invest. (2008) 118: 205– 16. 10.1172/JCI32639 18060042 PMC2104479 · DOI · Paper page
  124. [142]Abdollahi-Roodsaz S Joosten LA Roelofs MF Radstake TR Matera G Popa C. Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis. Arthritis Rheum. (2007) 56: 2957– 67. 10.1002/art.22848 17763416 · DOI
  125. [143]Vaahtovuo J Munukka E Korkeamäki M Luukkainen R Toivanen P. Fecal microbiota in early rheumatoid arthritis. J Rheumatol. (2008) 35: 1500– 5. 18528968
  126. [144]Zhang X Zhang D Jia H Feng Q Wang D Liang D. The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Nat Med. (2015) 21: 895. 10.1038/nm.3914 26214836 · DOI · Paper page
  127. [145]Sun Y Chen Q Lin P Xu R He D Ji W. Characteristics of gut microbiota in patients with rheumatoid arthritis in Shanghai, China. Front Cell Infect Microbiol. (2019) 9: 369. 10.3389/fcimb.2019.00369 31709198 PMC6819506 · DOI
  128. [146]Scher JU Abramson SB. The microbiome and rheumatoid arthritis. Nat Rev Rheumatol. (2011) 7: 569– 78. 10.1038/nrrheum.2011.121 21862983 PMC3275101 · DOI
  129. [147]Elinav E Strowig T Kau AL Henao-Mejia J Thaiss CA Booth CJ. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell. (2011) 145: 745– 57. 10.1016/j.cell.2011.04.022 21565393 PMC3140910 · DOI · Paper page
  130. [148]Martinon F Burns K Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Mol Cell. (2002) 10: 417– 26. 10.1016/S1097-2765(02)00599-3 12191486 · DOI · Paper page
  131. [149]Vande Walle L Van Opdenbosch N Jacques P Fossoul A Verheugen E Vogel P. Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature. (2014) 512: 69– 73. 10.1038/nature13322 25043000 PMC4126806 · DOI
  132. [150]Pianta A Arvikar S Strle K Drouin EE Wang Q Costello CE. Evidence of the immune relevance of Prevotella copri, a gut microbe, in patients with rheumatoid arthritis. Arthritis Rheumatol. (2017) 69: 964– 75. 10.1002/art.40003 27863183 PMC5406252 · DOI
  133. [151]Scher JU Sczesnak A Longman RS Segata N Ubeda C Bielski C. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. elife. (2013) 2: e01202. 10.7554/eLife.01202 24192039 PMC3816614 · DOI · Paper page
  134. [152]Choulaki C Papadaki G Repa A Kampouraki E Kambas K Ritis K. Enhanced activity of NLRP3 inflammasome in peripheral blood cells of patients with active rheumatoid arthritis. Arthritis Res Ther. (2015) 17: 257. 10.1186/s13075-015-0775-2 26385789 PMC4575443 · DOI
  135. [153]Kastbom A Verma D Eriksson P Skogh T Wingren G Söderkvist P. Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (the Swedish TIRA project). Rheumatology. (2008) 47: 415– 7. 10.1093/rheumatology/kem372 18263599 · DOI
  136. [154]Mathews RJ Robinson JI Battellino M Wong C Taylor JC Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS). Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment. Ann Rheum Dis. (2014) 73: 1202– 10. 10.1136/annrheumdis-2013-203276 23687262 · DOI
  137. [155]Sode J Vogel U Bank S Andersen PS Thomsen MK Hetland ML. Anti-TNF treatment response in rheumatoid arthritis patients is associated with genetic variation in the NLRP3-inflammasome. PLoS ONE. (2014) 9: e100361. 10.1371/journal.pone.0100361 24967817 PMC4072633 · DOI
  138. [156]Apel M Uebe S Bowes J Giardina E Korendowych E Juneblad K. Variants in RUNX3 contribute to susceptibility to psoriatic arthritis, exhibiting further common ground with ankylosing spondylitis. Arthritis Rheum. (2013) 65: 1224– 31. 10.1002/art.37885 23401011 · DOI
  139. [157]Lian Z Chai W Shi LL Chen C Liu J Wang Y. Analysis of PPARGC1B, RUNX3 and TBKBP1 polymorphisms in Chinese Han patients with ankylosing spondylitis: a case-control study. PLoS One. (2013) 8: e61527. 10.1371/journal.pone.0061527 23637848 PMC3630117 · DOI
  140. [158]Lau MC Keith P Costello M-E Bradbury LA Hollis KA Thomas R. Genetic association of ankylosing spondylitis with TBX21 influences T-bet and pro-inflammatory cytokine expression in humans and SKG mice as a model of spondyloarthritis. Ann Rheum Dis. (2017) 76: 261– 9. 10.1136/annrheumdis-2015-208677 27125523 · DOI
  141. [159]Vecellio M Cohen CJ Roberts AR Wordsworth PB Kenna TJ. RUNX3 and T-bet in immunopathogenesis of ankylosing spondylitis–novel targets for therapy? Front Immunol. (2018) 9: 3132. 10.3389/fimmu.2018.03132 30687330 PMC6335330 · DOI
  142. [160]Ciccia F Guggino G Rizzo A Saieva L Peralta S Giardina A. Type 3 innate lymphoid cells producing IL-17 and IL-22 are expanded in the gut, in the peripheral blood, synovial fluid and bone marrow of patients with ankylosing spondylitis. Ann Rheum Dis. (2015) 74: 1739– 47. 10.1136/annrheumdis-2014-206323 25902790 · DOI
  143. [161]Ciccia F Accardo-Palumbo A Alessandro R Rizzo A Principe S Peralta S. Interleukin-22 and interleukin-22–producing NKp44+ natural killer cells in subclinical gut inflammation in ankylosing spondylitis. Arthritis Rheum. (2012) 64: 1869– 78. 10.1002/art.34355 22213179 · DOI
  144. [162]Luo XM Edwards MR Mu Q Yu Y Vieson MD Reilly CM. Gut microbiota in human systemic lupus erythematosus and a mouse model of lupus. Appl Environ Microbiol. (2018) 84: e02288– 17. 10.1128/AEM.02288-17 29196292 PMC5795066 · DOI
  145. [163]Byrne JC Ní Gabhann J Lazzari E Mahony R Smith S Stacey K. Genetics of SLE: functional relevance for monocytes/macrophages in disease. Clin Dev Immunol. (2012) 2012: 582352. 10.1155/2012/582352 23227085 PMC3511832 · DOI
  146. [164]Gaudreau MC Johnson BM Gudi R Al-Gadban MM Vasu C. Gender bias in lupus: does immune response initiated in the gut mucosa have a role? Clin Exp Immunol. (2015) 180: 393– 407. 10.1111/cei.12587 25603723 PMC4449768 · DOI
  147. [165]Lopez P Sanchez B Margolles A Suarez A Intestinal dysbiosis in systemic lupus erythematosus: cause or consequence? Curr Opin Rheumatol. (2016) 28: 515– 22. 10.1097/BOR.0000000000000309 27466725 · DOI
  148. [166]Zhang H Liao X Sparks JB Luo XM. Dynamics of gut microbiota in autoimmune lupus. Appl Environ Microbiol. (2014) 80: 7551– 60. 10.1128/AEM.02676-14 25261516 PMC4249226 · DOI
  149. [168]Rodríguez-Carrio J López P Sánchez B González S Gueimonde M Margolles A. Intestinal dysbiosis is associated with altered short-chain fatty acids and serum-free fatty acids in systemic lupus erythematosus. Front Immunol. (2017) 8: 23. 10.3389/fimmu.2017.00023 28167944 PMC5253653 · DOI
  150. [169]Vieira SM Hiltensperger M Kumar V Zegarra-Ruiz D Dehner C Khan N Translocation of a gut pathobiont drives autoimmunity in mice and humans. Science. (2018) 359: 1156– 61. 10.1126/science.aar7201 29590047 PMC5959731 · DOI

Cited by

Sorted by citations

Authors
Jiao, Y., Wu, L., Huntington, N. D., & Zhang, X.
Affiliations
  • Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
  • Center for Life Sciences (CN)
  • Monash University (AU)
Corresponding author
  • Huntington, Nicholas D.
  • Zhang, Xuan
ORCID
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2020-02-21
Volume
11
Pages
282-282
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2020.00282
PMC
PMC7047319
OpenAlex
W3008816470
Cited by
321
References
19
Citations by year
2026: 29 · 2025: 58 · 2024: 78 · 2023: 59 · 2022: 72 · 2021: 18 · 2020: 7
FWCI
3.78
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Monash University Research Portal (Monash University) (submittedVersion, other-oa)
  • Minerva Access (University of Melbourne) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Greater South Information System
Funders
National Natural Science Foundation of China (81788101, 81630044, 81601432, 81550023, 81771763, 91542000)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
gut microbiota, innate immunity, autoimmune disease, gut-associated lymphoid tissue, innate lymphoid cells, phagocytes, mucosal homeostasis, dysbiosis, rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, microbiota-immune axis
MeSH terms
Gastrointestinal Microbiome, Animals, Autoimmune Diseases, Homeostasis, Humans, Immune Tolerance, Immunity, Innate, Dysbiosis

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