Inputs to the Dorsal Striatum of the Mouse Reflect the Parallel Circuit Architecture of the Forebrain

“The profound effects of pathological disruptions have indicated a critical role for the processing of excitatory input within the striatum (Albin et al., 1989).”

“The topographical organization of inputs to and outputs from the striatum has long played a central role in both theory and the interpretation of functional data in the basal ganglia (Ragsdale and Graybiel, 1990; Mink, 1996).”

“However, while projections from the amygdala to the ventral striatum have indeed received quite a lot of attention (Gray, 1999; Cardinal et al., 2002; Floresco et al., 2008; Belin et al., 2009; Humphries and Prescott, 2010), the projections to the dorsal striatum that were observed with anterograde…”

“These recent behavioral results have shed light on the critical and specific roles of the dorsal striatum in instrumental conditioning and motor control that complement and extend earlier ideas about roles of striatal subregions in modality specific learning (Graybiel et al., 1994; Packard and Knowlton, 2002).”

“Given the critical requirement of the dorsal striatum in the acquisition and expression of goal-directed instrumental conditioning and the central role that error prediction signals are thought to play in such learning (Schultz, 2006), the amygdalostriatal projection may be an important component of an extended learni…”

“Based upon retrograde and anterograde labeling in the primate it has been previously suggested that dopaminergic neurons may play a critical role in transferring information between the medial and lateral striatum (Haber et al., 2000; Haber, 2003).”

“…an apparent minority of the labeling, the zones of overlap may be disproportionately important to the function of the dorsolateral striatum in the rat (Brown and Sharp, 1995), as has been proposed in the primate (Graybiel et al., 1994; Haber, 2003; Cohen and Frank, 2009; Haber and Calzavara, 2009).”

“At 30 days post-injection (dpi), pSyn positive LB-like accumulations were exclusively ipsilateral to the injection site with the exception of the amygdala, to which the striatum projects bilaterally (23), suggesting that cell-to-cell transmission followed inter-neuronal connectivity.”

“…of rAAV2-retro extended to other circuits, specifically by characterizing the extent to which it labeled various afferents to the dorsomedial striatum (DMS), a part of the basal ganglia that receives long-range inputs from a variety of cortical and subcortical areas (Pan et al., 2010).”