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Inputs to the Dorsal Striatum of the Mouse Reflect the Parallel Circuit Architecture of the Forebrain
Open accessAbstract
The basal ganglia play a critical role in the regulation of voluntary action in vertebrates. Our understanding of the function of the basal ganglia relies heavily upon anatomical information, but continued progress will require an understanding of the specific functional roles played by diverse cell types and their connectivity. An increasing number of mouse lines allow extensive identification, characterization, and manipulation of specified cell types in the basal ganglia. Despite the promise of genetically modified mice for elucidating the functional roles of diverse cell types, there is relatively little anatomical data obtained directly in the mouse. Here we have characterized the retrograde labeling obtained from a series of tracer injections throughout the dorsal striatum of adult mice. We found systematic variations in input along both the medial-lateral and anterior-posterior neuraxes in close agreement with canonical features of basal ganglia anatomy in the rat. In addition to the canonical features we have provided experimental support for the importance of non-canonical inputs to the striatum from the raphe nuclei and the amygdala. To look for organization at a finer scale we have analyzed the correlation structure of labeling intensity across our entire dataset. Using this analysis we found substantial local heterogeneity within the large-scale order. From this analysis we conclude that individual striatal sites receive varied combinations of cortical and thalamic input from multiple functional areas, consistent with some earlier studies in the rat that have suggested the presence of a combinatorial map.
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“It sends a direct excitatory projection to the DMS30,31.”
From A dual-pathway architecture for stress to disrupt agency and promote habit (2025) · cites this paper as [30]
In the citing paper
“It sends a direct, likely inhibitory33, projection to the striatum30,34,35 and is, thus, poised to oppose striatal activity.”
From A dual-pathway architecture for stress to disrupt agency and promote habit (2025) · cites this paper as [30]
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“rabies-labeled, DMS D1-projecting cell bodies in the BLA and CeA (right), consistent with prior reports30,34.”
From A dual-pathway architecture for stress to disrupt agency and promote habit (2025) · cites this paper as [30]
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Cited by
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A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons
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Self-citationStriatal circuits for reward learning and decision-making
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A comprehensive excitatory input map of the striatum reveals novel functional organization
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BackgroundInfluentialSelf-citationDifferential Innervation of Direct- and Indirect-Pathway Striatal Projection Neurons
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InfluentialDopamine Is Required for the Neural Representation and Control of Movement Vigor
Panigrahi, B., Martin, K. A., Li, Y., Graves, A. R., Vollmer, A., Olson, L., Mensh, B. D., Karpova, A. Y., & Dudman, J. T. (2015) · Cell · doi:10.1016/j.cell.2015.08.014 · Cited by 330
Self-citationOpponent and bidirectional control of movement velocity in the basal ganglia
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Self-citationStriatal Circuits as a Common Node for Autism Pathophysiology
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BackgroundWhat, If, and When to Move: Basal Ganglia Circuits and Self-Paced Action Initiation
Klaus, A., Alves da Silva, J., & Costa, R. M. (2019) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031033 · Cited by 284
“Additional excitatory afferents to the dorsal striatum, the posterior part in particular, arise from the basolateral amygdala (Kelley et al. 1982, Pan et al. 2010).”
BackgroundEndocannabinoid Modulation of Orbitostriatal Circuits Gates Habit Formation
Gremel, C. M., Chancey, J. H., Atwood, B. K., Luo, G., Neve, R., Ramakrishnan, C., Deisseroth, K., Lovinger, D. M., & Costa, R. M. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.043 · Cited by 251
Propagation of pathological α-synuclein in marmoset brain
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“Using the traditional method of tract tracing, numerous studies have shown that the dorsal striatum receives converging inputs from the cortex, thalamus, SNc, and other subcortical nuclei [22,23,24,25,26,27].”
MethodKarampetsou, M., Ardah, M. T., Semitekolou, M., Polissidis, A., Samiotaki, M. K., Kalomoiri, M., Majbour, N. K., Xanthou, G., El‐Agnaf, O. M. A., & Vekrellis, K. (2017) · Scientific Reports · doi:10.1038/s41598-017-15813-8 · Cited by 184
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Striatal cholinergic dysfunction as a unifying theme in the pathophysiology of dystonia
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Migraine Attacks the Basal Ganglia
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“Given the known connections with these cortical and subcortical regions (involved in symptoms of photophobia, phonophobia, osmophobia and allodynia) and the basal ganglia [20,46] including sensory information [47], these inputs may contribute to alterations observed with increased migraine frequency.”
BackgroundLearning from Action: Reconsidering Movement Signaling in Midbrain Dopamine Neuron Activity
Coddington, L. T., & Dudman, J. T. (2019) · Neuron · doi:10.1016/j.neuron.2019.08.036 · Cited by 150
Self-citationHooks, B. M., Papale, A. E., Paletzki, R. F., Feroze, M. W., Eastwood, B. S., Couey, J. J., Winnubst, J., Chandrashekar, J., & Gerfen, C. R. (2018) · Nature Communications · doi:10.1038/s41467-018-05780-7 · Cited by 158
A Spatiomolecular Map of the Striatum
Märtin, A., Calvigioni, D., Tzortzi, O., Fuzik, J., Wärnberg, E., & Meletis, K. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.096 · Cited by 132
Defining α-synuclein species responsible for Parkinson’s disease phenotypes in mice
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“These brain regions all project to the striatum (34), suggesting that the aggregates are internalized into the axon terminals, and the resulting inclusions spread within the neuron to the soma.”
BackgroundBasal Ganglia Circuits for Action Specification
Park, J., Coddington, L. T., & Dudman, J. T. (2020) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070918-050452 · Cited by 96
“Other subsets of neurons appear to encode other aspects of kinematics, reflecting more delayed components corresponding to amplitude or possibly sensory-mediated feedback during movement (Coffey et al. 2016, Panigrahi et al. 2015, Sales-Carbonell et al. 2018,West et al. 1990).”
BackgroundMethodInfluentialSelf-citationResting state functional connectivity and cognitive task-related activation of the human claustrum
Krimmel, S. R., White, M. G., Panicker, M. H., Barrett, F. S., Mathur, B. N., & Seminowicz, D. A. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.03.075 · Cited by 89
“This contrasts with data from multiple tract tracing studies, which instead show unique patterns of anatomical connectivity across these regions (Nakashima et al., 2000; Mathur et al., 2009; Pan et al., 2010; Sato et al., 2013; Neuroimage.”
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Self-citationRole of anterior cingulate cortex inputs to periaqueductal gray for pain avoidance
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A feature-specific prediction error model explains dopaminergic heterogeneity
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“Consistent with feature-specific variation, descending inputs to DA neurons (especially from the striatum) are topographic 32,33,37,38 .”
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“In accordance to previous studies (Hunnicutt et al., 2016; Pan et al., 2010; Parker et al., 2016; Smith et al., 2014), we observed that these AAV injections labeled cells in the parafascicular region (PFs: parafascicular, posterior, and the centrolateral thalamic nucleus; Figures 1A1, 1A2, and S1D), the centromedial r…”
Premotor cortex is critical for goal-directed actions
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“M2 has been shown to directly project to dorsal striatum (Reep et al., 2003; Mitchell and Macklis, 2005; Pan et al., 2010) as well as to the OFC and MD (Reep et al., 1987; Hoover and Vertes, 2007).”
BackgroundAssociative and sensorimotor cortico‐basal ganglia circuit roles in effects of abused drugs
Gremel, C. M., & Lovinger, D. M. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12309 · Cited by 74
“Dopaminergic innervation of the sensorimotor striatum comes from lateral portions of the SNc (Haber et al. 2000; Ikemoto 2007; Pan et al. 2010), and glutamatergic thalamic input comes largely from the intralaminar nuclei, although there seem to be limited projections from lateral and posterior thalamic nuclei (Pan et…”
BackgroundInfluentialCorticostriatal circuitry and habitual ethanol seeking
Barker, J. M., Corbit, L. H., Robinson, D. L., Gremel, C. M., Gonzales, R. A., & Chandler, L. J. (2015) · Alcohol · doi:10.1016/j.alcohol.2015.03.003 · Cited by 78
“…extensive glutamatergic innervation from associative cortices (McGeorge & Faull, 1989; Pan, Mao, & Dudman, 2010; Voorn, Vanderschuren, Groenewegen, Robbins, & Pennartz, 2004), while DLS is highly innervated by sensory motor cortices (McGeorge & Faull, 1989; Pan et al., 2010; Voorn et al., 2004).”
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“On the other hand, while the direct striatonigral pathway is topographically organized there is considerable divergence in the corticostriatal input in mice (Pan et al., 2010).”
Self-citationSorrentino, Z. A., Brooks, M. M. T., Hudson, V., Rutherford, N. J., Golde, T. E., Giasson, B. I., & Chakrabarty, P. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0182-z · Cited by 79
“Especially, a majority of projections from the posterior aspect of the striatum has been shown to lead into the DA neurons of SN and retrorubral nucleus [37].”
Weisenhorn, D. M. V., Giesert, F., & Wurst, W. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13670 · Cited by 73
“Thus, regarding the projections to the striatum a specific medial to lateral, anterior to posterior and inverted dorsal to ventral topography exists (Pan et al. 2010; Fallon and Moore 1978b; reviewed in Joel and Weiner 2000; Haber 2014).”
BackgroundNormand, E. A., Crandall, S. R., Thorn, C. A., Murphy, E. M., Voelcker, B., Browning, C., Machan, J. T., Moore, C. I., Connors, B. W., & Zervas, M. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.030 · Cited by 67
To move or to sense? Incorporating somatosensory representation into striatal functions
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Striatal Direct Pathway Targets Npas1 + Pallidal Neurons
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Alcohol induces input-specific aberrant synaptic plasticity in the rat dorsomedial striatum
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Anatomical Inputs From the Sensory and Value Structures to the Tail of the Rat Striatum
Jiang, H., & Kim, H. F. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00030 · Cited by 57
“The striatum, however, is a long structure located along the rostral-caudal axis of the brain inside the telencephalon and receives inputs from various brain areas (McGeorge and Faull, 1989; Mcdonald et al., 1996; Pan et al., 2010; Hintiryan et al., 2016; Hunnicutt et al., 2016).”
BackgroundAssous, M., Dautan, D., Tepper, J. M., & Mena‐Segovia, J. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2913-18.2019 · Cited by 58
“, 2018); but given the prominent excitatory innervation originating in the thalamus and other subcortical structures (Kemp and Powell, 1971; Albin et al., 1989; DeLong, 1990; Pan et al., 2010; Wall et al., 2013; Silberberg and Bolam, 2015; Klug et al., 2018), it is likely that they also contribute to shaping the activ…”
BackgroundIntegrated anatomical and physiological mapping of striatal afferent projections
Choi, K., Holly, E. N., Davatolhagh, M. F., Beier, K. T., & Fuccillo, M. V. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13829 · Cited by 51
“…target neuron are associated with specific anatomical connectivity patterns EnvA-pseudotyped-RV tracing of DMS circuits produced distributions of labelled neurons consistent with non-cell type-specific approaches (Pan et al., 2010), including substantial OFC, ACC, M2, PFas and GPe labelling (Fig.”
A Direct Projection from Mouse Primary Visual Cortex to Dorsomedial Striatum
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From Progenitors to Progeny: Shaping Striatal Circuit Development and Function
Knowles, R., Dehorter, N., & Ellender, T. J. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0620-21.2021 · Cited by 49
“Indeed, individual SPNs exhibit considerable heterogeneity in their afferent connectivity patterns (Pan et al., 2010), and populations of SPNs with diverse excitatory inputs are intermingled in striatum (Oh et al.”
BackgroundMethodInfluentialLamothe, H., Schreiweis, C., Mondragón-González, S. L., Rebbah, S., Lavielle, O., Mallet, L., & Burguière, E. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02323-7 · Cited by 51
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“…that project to the rodent striatum, including the amygdala, the substantia nigra pars compacta (SNpc), and several intralaminar and modality-specific thalamic nuclei (Alloway et al. 2006; Cheatwood et al. 2005; Erro et al. 2001, 2002; Kelley et al. 1982; Pan et al. 2010; Redgrave and Gurney 2006).”
BackgroundResultA Preclinical Study Evaluating AAVrh10-Based Gene Therapy for Sanfilippo Syndrome
Winner, L. K., Beard, H., Hassiotis, S., Lau, A. A., Luck, A. J., Hopwood, J. J., & Hemsley, K. M. (2016) · Human Gene Therapy · doi:10.1089/hum.2015.170 · Cited by 45
“21,23 Of important note is that, in a rat study, AAVrh10 evades preexisting immunity to the common AAV serotypes naturally infecting humans (AAV 1, 2, and 5).”
Lau, B., Monteiro, T., & Paton, J. J. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.08.015 · Cited by 41
Dopamine systems adaptation during acquisition and consolidation of a skill
Sommer, W. H., Costa, R. M., & Hansson, A. C. (2014) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2014.00087 · Cited by 39
“The dorsal striatum receives inputs from most cortices (McGeorge and Faull, 1989; Voorn et al., 2004; Pan et al., 2010).”
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Striatum-projecting prefrontal cortex neurons support working memory maintenance
Wilhelm, M., Sych, Y., Fomins, A., Warren, J. L. A., Lewis, C., Capdevila, L. S., Boehringer, R., Amadei, E. A., Grewe, B. F., O’Connor, E. C., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42777-3 · Cited by 45
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Maximizing lentiviral vector gene transfer in the CNS
Humbel, M., Ramosaj, M., Zimmer, V., Regio, S., Aeby, L., Moser, S., Boizot, A., Sipion, M., Rey, M. J., & Déglon, N. (2020) · Gene Therapy · doi:10.1038/s41434-020-0172-6 · Cited by 43
“interest for the treatment of HD (Figure S1) [21, 52, 53] and other neurodegenerative diseases affecting locomotion.”
BackgroundGrimm, C., Frässle, S., Steger, C., von Ziegler, L., Sturman, O., Shemesh, N., Peleg‐Raibstein, D., Burdakov, D., Bohacek, J., Stephan, K. E., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110161 · Cited by 38
“Contrary to this view, tracer studies in non-human primates and rodents have revealed a much more complex anatomical picture (Alexander et al., 1986; Berendse et al., 1992; Oh et al., 2014; Pan et al., 2010), with recent work counting as many as 29 anatomically distinct sub-regions in the mouse dorsomedial (dm) striat…”
Martel, A., & Galván, A. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105878 · Cited by 36
“The corticostriatal inputs have been well described for decades and present an anatomo-functional organization based on the cortical origin of those inputs (Alexander et al. 1986; Pan et al. 2010).”
Corticolimbic Mechanisms of Behavioral Inhibition under Threat of Punishment
Verharen, J. P. H., van den Heuvel, M. W., Luijendijk, M. C. M., Vanderschuren, L. J. M. J., & Adan, R. A. H. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2814-18.2019 · Cited by 34
“It must be noted that we pharmacologically inactivated a relatively anterior part of the dorsal striatum, and there is evidence of a functional–anatomical gradient across its anteroposterior axis (Reynolds and Berridge, 2001; Pan et al., 2010; Mestres-Missé et al., 2012).”
BackgroundSaez, T. M. M., Bessone, I. F., Rodriguez, M. S., Alloatti, M., Otero, M. G., Cromberg, L. E., Devoto, V. M. P., Oubiña, G., Sosa, L. J., Buffone, M. G., et al. (2020) · Development · doi:10.1242/dev.184069 · Cited by 34
“1E,F), which receives inputs from the primary somatosensory cortex (Pan et al., 2010).”
BackgroundA dual-pathway architecture for stress to disrupt agency and promote habit
Giovanniello, J. R., Paredes, N., Wiener, A., Ramírez-Armenta, K., Oragwam, C., Uwadia, H. O., Yu, A. L., Lim, K., Pimenta, J. S., Vilchez, G. E., et al. (2025) · Nature · doi:10.1038/s41586-024-08580-w · Cited by 30
Emotion in action: When emotions meet motor circuits
Braine, A., & Georges, F. E. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105475 · Cited by 37
Robins, M. T., Chiang, T., Mores, K. L., Alongkronrusmee, D., & van Rijn, R. M. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00112 · Cited by 28
A molecularly integrated amygdalo-fronto-striatal network coordinates flexible learning and memory
Li, D. C., Dighe, N. M., Barbee, B. R., Pitts, E. G., Kochoian, B. A., Blumenthal, S. A., Figueroa, J., Leong, T. L., & Gourley, S. L. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01148-9 · Cited by 26
Lee, I. B., Lee, E., Han, N.-E., Slavuj, M., Hwang, J. W., Lee, A., Sun, T., Jeong, Y., Baik, J., Park, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44322-8 · Cited by 33
Conjoint specification of action by neocortex and striatum
Park, J., Polidoro, P., Fortunato, C., Arnold, J., Mensh, B. D., Gallego, J. Á., & Dudman, J. T. (2025) · Neuron · doi:10.1016/j.neuron.2024.12.024 · Cited by 26
Self-citationRhes regulates dopamine D2 receptor transmission in striatal cholinergic interneurons
Sciamanna, G., Napolitano, F., Pelosi, B., Bonsi, P., Vitucci, D., Nuzzo, T., Punzo, D., Ghiglieri, V., Ponterio, G., Pasqualetti, M., et al. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.03.021 · Cited by 27
Foxp2 loss of function increases striatal direct pathway inhibition via increased GABA release
van Rhijn, J.-R., Fisher, S. E., Vernes, S. C., & Kasri, N. N. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1746-6 · Cited by 27
Mehlman, M. L., Winter, S. S., Valério, S., & Taube, J. S. (2018) · Journal of Neurophysiology · doi:10.1152/jn.00143.2018 · Cited by 25
Ioanas, H.-I., Saab, B. J., & Rudin, M. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01812-5 · Cited by 24
Pommer, S., Akamine, Y., Schiffmann, S. N., d’Exaerde, A. D. K., & Wickens, J. R. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1037-20.2021 · Cited by 20
“The striatum receives serotonin innervation from the raphe nuclei in a spatially graded manner, with highest concentrations toward the ventral striatum as well as in the globus pallidus (GP) and substantia nigra (Steinbusch, 1981; Di Matteo et al., 2008; Pan et al., 2010).”
BackgroundNeurexin1α Differentially Regulates Synaptic Efficacy within Striatal Circuits
Davatolhagh, M. F., & Fuccillo, M. V. (2020) · Cell Reports · doi:10.1016/j.celrep.2021.108773 · Cited by 21
“…heterozygous loss-of-function alleles found in ASD, schizophrenia, Tourette syndrome, and obsessive-compulsive disorder (OCD) (Bucan et al., 2009; Castronovo et al., 2020; Ching et al., 2010; Dabell et al., 2013; Kim et al., 2008; Kirov et al., 2009; Lowther et al., 2017; Reichelt et al., 2012).”
Zheng, N., Li, M., Wu, Y., Kaewborisuth, C., Li, Z., Gui, Z., Wu, J., Cai, A., Lin, K., Su, K., et al. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119402 · Cited by 19
Thomas, A. M., Xu, J., Calabresi, P. A., van Zijl, P. C. M., & Bulte, J. W. M. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.116245 · Cited by 19
Kondabolu, K., Doig, N. M., Ayeko, O., Khan, B., Torres, A., Calvigioni, D., Meletis, K., Magill, P. J., & Koós, T. Z. (2023) · eNeuro · doi:10.1523/eneuro.0417-21.2023 · Cited by 18
“However, we did not observe any GFP-expressing (AAV-GFP1) somata in brain structures known to robustly innervate striatum, including the cerebral cortex, intralaminar and motor thalamus, basolateral and central amygdala, ventral tegmental area or substantia nigra pars compacta (Y. Smith et al., 1998; Pan et al., 2010).”
BackgroundGaliñanes, G. L., Braz, B. Y., & Murer, M. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028473 · Cited by 17
“For instance, the degree of functional overlap between the projection fields from different cortical areas [4,5,6], the dependence of corticostriatal plasticity on spontaneous activity and neuromodulators [7], and the control exerted by local inhibitory networks over cortical input [8,9] are only a few still unsolved…”
BackgroundVizcarra-Chacón, B. J., Arias-García, M. A., Perez-Ramirez, M. B., Flores-Barrera, E., Tapia, D., Drucker-Colı́n, R., Bargas, J., & Galarraga, E. (2013) · BMC Neuroscience · doi:10.1186/1471-2202-14-60 · Cited by 16
“It was observed that characteristic responses of dSPNs and iSPNs were maintained no matter the cortical area being stimulated [6-11] or whether the thalamus was present.”
BackgroundRíos, A., Nonomura, S., Kato, S., Yoshida, J., Matsushita, N., Nambu, A., Takada, M., Hira, R., Kobayashi, K., Sakai, Y., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05288-x · Cited by 15
“It is also known that the target DMS and DLS neurons have different functional properties 29,30 , receiving topographical inputs from SNc and various areas of the cerebral cortex 31,32 .”
Lai, I., Porcu, A., Romoli, B., Keisler, M. N., Manfredsson, F. P., Powell, S. B., & Dulcis, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044204 · Cited by 14
Pooters, T., Laeremans, A., Gantois, I., Vermaercke, B., Arckens, L., & D’Hooge, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176295 · Cited by 14
Kirschen, G. W., Liu, H., Lang, T. Z., Liang, X., Ge, S., & Xiong, Q. (2017) · Frontiers in Biology · doi:10.1007/s11515-017-1447-1 · Cited by 13
“We thus examined two such regions, one that projects to neocortex: the anterior nucleus of the thalamus (Thal), and one that receives neocortical projections: the dorsal striatum (DStr) (Irle and Markowitsch, 1982; Pan et al., 2010).”
Identification of Novel BDNF-Specific Corticostriatal Circuitries
Ehinger, Y., Soneja, D., Phamluong, K., Salvi, A., & Dorit Ron, A. (2023) · eNeuro · doi:10.1523/eneuro.0238-21.2023 · Cited by 12
“It is important to note that our study focused specifically on the anterior part of the DS. Interestingly, Pan et al. found no retrograde labeling in the PrL, IL, MO, LO, AI, Cg1 and M2 when they injected the retrograde tracer in posterior part of the DS (pDS) (Pan et al., 2010).”
BackgroundMethodResultInfluentialHaetzel, L. M., Iafrati, J., Cording, K. R., Farhan, M., Noveir, S. D., Rumbaugh, G., & Bateup, H. S. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1264-23.2024 · Cited by 12
“In the dorsal striatum, excitatory inputs come primarily from the cortex and thalamus, but also the amygdala (Pan et al., 2010).”
Nimitvilai, S., Gioia, D. A., Lopez, M. F., Glaser, C. M., & Woodward, J. J. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109463 · Cited by 11
Functional mosaic organization of neuroligins in neuronal circuits
Qin, L., Guo, S., Han, Y., Wang, X., & Zhang, B. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03478-y · Cited by 10
van Heusden, F., Macey-Dare, A. D. B., Gordon, J., Krajeski, R. N., Sharott, A., & Ellender, T. J. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109041 · Cited by 9
“Whole-cell voltage-clamp recordings (at +30 mV) of both dSPNs and iSPNs were made in DMS and combined with brief blue light pulses to activate afferents coming from aIP-derived SPNs (Figure S4B).”
BackgroundInfluentialCilia in the Striatum Mediate Timing-Dependent Functions
Alhassen, W., Alhassen, S., Chen, J., Monfared, R. V., & Alachkar, A. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03095-9 · Cited by 12
A mathematical model of reward and executive circuitry in obsessive compulsive disorder
Rǎdulescu, A., & Marra, R. (2016) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2016.11.025 · Cited by 11
Mehlman, M. L., Winter, S. S., & Taube, J. S. (2018) · Journal of Neurophysiology · doi:10.1152/jn.00144.2018 · Cited by 13
“…are consistent with studies in mice demonstrating that the medial portion of the DS uniquely receives numerous spatial inputs from structures including the anterior thalamic nuclei, entorhinal cortex, RSP, and PPC (Hintiryan et al. 2016; Hunnicutt et al. 2016; Pan et al. 2010; Wall et al. 2013).”
ResultKim, D., Jeon, J., Cheong, E., Kim, D. J., Ryu, H., Seo, H., & Kim, Y. K. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9214-2 · Cited by 11
GABA and Glutamate Synaptic Coadaptations to Chronic Ethanol in the Striatum
Carlson, V. C. C. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_98 · Cited by 10
Kim, H.-J., Woo, R., Yang, E.-J., Kim, H.-B., Jo, E. H., Lee, S., Kim, H.-S., Kim, S., & Kim, H.-S. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02056-z · Cited by 13
“INTRODUCTION The striatum is the major input structure for the basal ganglia, and it integrates excitatory inputs from various brain regions, including the cortex and thalamus, to control diverse functions [1, 2].”
BackgroundHeaton, E. C., Seo, E. H., Butkovich, L. M., Yount, S. T., & Gourley, S. L. (2024) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2024.102629 · Cited by 8
The Mouse Caudate Putamen, Motor System, and Nucleus Accumbens
Schröder, H., Moser, N., & Huggenberger, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-19898-5_13 · Cited by 8
Labeling Dual Presynaptic Inputs using cFork Anterograde Tracing System
Oh, J., Han, J. H., Lee, H., Han, Y.-E., Rah, J., & Park, H. (2020) · Experimental Neurobiology · doi:10.5607/en20006 · Cited by 8
“Because the dorsal striatum receives two major excitatory inputs from the cortex and thalamus, called the corticostriatal and thalamostriatal pathways, respectively [18-20], we aimed to label striatal postsynaptic neurons with EGFP and/or mScarlet, whose expression is defined by presynaptic cortical and/ or thalamic i…”
BackgroundPetroccione, M. A., D’Brant, L. Y., Affinnih, N., Wehrle, P. H., Todd, G. C., Zahid, S., Chesbro, H. E., Tschang, I. L., & Scimemi, A. (2023) · eLife · doi:10.7554/elife.81830 · Cited by 6
“In mice, ∼1/3 of excitatory inputs to the DLS originates from the thalamus (Huerta-Ocampo, Mena-Segovia, and Bolam 2014), and the remaining 2/3 from the frontal associative and sensorimotor cortex (Hunnicutt et al. 2016; Guo et al. 2015; Wall et al. 2013; Pan, Mao, and Dudman 2010).”
BackgroundThe Sapap3-knockout mouse model manifests a spectrum of repetitive behavioursPreprint
Lamothe, H., Schreiweis, C., Mallet, L., & Burguière, E. (2021) · HAL · doi:10.1101/2020.01.22.915215
A dual-pathway architecture enables chronic stress to disrupt agency and promote habit formationPreprint
Giovanniello, J. R., Paredes, N., Wiener, A. J., Ramírez-Armenta, K., Oragwam, C., Uwadia, H. O., Yu, A. L., Lim, K. Y., Pimenta, J. S., Vilchez, G. E., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.03.560731 · Cited by 7
Do housing-induced changes in brain activity cause stereotypic behaviours in laboratory mice?
Kitchenham, L., MacLellan, A., Paletta, P., Patel, A. V., Choleris, E., & Mason, G. J. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.114862 · Cited by 7
Morena, F., Oikonomou, V., Argentati, C., Bazzucchi, M., Emiliani, C., Gritti, A., & Martino, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133179 · Cited by 6
“The STR is part of the basal ganglia of the forebrain [51,59,60].”
BackgroundAnimal models of action control and cognitive dysfunction in Parkinson's disease
Balleine, B. W. (2022) · Progress in brain research · doi:10.1016/bs.pbr.2022.01.006 · Cited by 5
Nimitvilai, S., Lopez, M. F., & Woodward, J. J. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110303 · Cited by 5
“The striatum is considered the main input structure of the basal ganglia and receives projections from many brain areas, including the OFC and BLA (Hoover and Vertes, 2011; Pan et al., 2010; Schilman et al., 2008).”
Zhou, K., Hou, Z.-J., Jiang, X.-L., Xiao, Y.-J., Zhang, L.-C., Xu, W., Xiong, B., Qu, W., Huang, Y., Huang, Z., et al. (2025) · British Journal of Anaesthesia · doi:10.1016/j.bja.2024.10.049 · Cited by 5
Metadata
- Authors
- Pan, W. X., Mao, T., & Dudman, J. T.
- Affiliations
- Howard Hughes Medical Institute (US)
- Oregon Health & Science University (US)
- Corresponding author
- Dudman, Joshua T.
- Venue
- Frontiers in Neuroanatomy
- Publisher
- Frontiers Media SA
- Published
- 2010
- Volume
- 4
- Pages
- 147-147
- ISSN
- 1662-5129 (ISSN-L)
- PMC
- PMC3014656
- OpenAlex
- W2128290890
- Cited by
- 150
- References
- 84
- Citations by year
- 2026: 5 · 2025: 16 · 2024: 8 · 2023: 18 · 2022: 10 · 2021: 11 · 2020: 11 · 2019: 13 · 2018: 12 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 4 · 2013: 8 · 2012: 4
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroanatomy (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dorsal striatum, basal ganglia, retrograde tracing, parallel circuits, raphe nuclei, amygdala, cortical input, thalamic input, mice
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