Gene-Gene-Environment Interactions of Serotonin Transporter, Monoamine Oxidase A and Childhood Maltreatment Predict Aggressive Behavior in Chinese Adolescents
Open accessAbstract
Gene-environment interactions that moderate aggressive behavior have been identified independently in the serotonin transporter (5-HTT) gene and monoamine oxidase A gene (MAOA). The aim of the present study was to investigate epistasis interactions between MAOA-variable number tandem repeat (VNTR), 5-HTTlinked polymorphism (LPR) and child abuse and the effects of these on aggressive tendencies in a group of otherwise healthy adolescents. A group of 546 Chinese male adolescents completed the Child Trauma Questionnaire and Youth self-report of the Child Behavior Checklist. Buccal cells were collected for DNA analysis. The effects of childhood abuse, MAOA-VNTR, 5-HTTLPR genotypes and their interactive gene-gene-environmental effects on aggressive behavior were analyzed using a linear regression model. The effect of child maltreatment was significant, and a three-way interaction among MAOA-VNTR, 5-HTTLPR and sexual abuse (SA) relating to aggressive behaviors was identified. Chinese male adolescents with high expression of the MAOA-VNTR allele and 5-HTTLPR "SS" genotype exhibited the highest aggression tendencies with an increase in SA during childhood. The findings reported support aggression being a complex behavior involving the synergistic effects of gene-gene-environment interactions.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There was a three-way interaction: MAOA-5-HTTLPR-Sexual Abuse (beta=0.127, t = 2.458, p = 0.014).
“Three-way interaction: MAOA-5-HTTLPR-Sexual Abuse (beta=0.127, t = 2.458, p = 0.014)”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Zhang [51]
The Results section (Table 4; page not provided) reports a significant MAOA–5-HTTLPR–sexual abuse interaction with p = 0.014. The citing sentence omits the negative signs: the paper reports β = −0.127 and t = −2.458, not positive values. (LLM, conf=0.94)
Experimental — accuracy not yet measuredHigh MAOA activity (3.5, 4, 5 R) showed a significant SA x 5-HTTLPR interaction (beta=0.327, t = 3.483, p = 0.001).
“High MAOA activity (3.5, 4, 5 R) -> significant SA x 5-HTTLPR (beta=0.327, t = 3.483, p = 0.001)”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Zhang [51]
The Results section reports a significant sexual abuse (SA) × 5-HTTLPR interaction in the high-MAOA-activity group, and Genetic Analysis defines that group as carriers of the 3.5-, 4-, or 5-repeat alleles. However, the reported β and t are −0.327 and −3.483, not the positive values in the claim; p = 0.001 matches. (LLM, conf=0.90)
Experimental — accuracy not yet measuredSome studies failed to report a significant main effect of 5-HTTLPR on aggressive behaviors but demonstrated a significant gene-gene interaction on behavior.
“Although some studies failed to report a significant main effect of 5-HTTLPR on aggressive behaviors, they demonstrated a significant gene-gene interaction on behavior.”
From Genetics of child aggression, a systematic review (2024) · cites this paper as [51]
The Results section reports no significant association between 5-HTTLPR alone and adolescent aggression. It reports a significant three-way interaction involving MAOA, 5-HTTLPR, and sexual abuse, but not a significant gene–gene interaction on its own; the Discussion explicitly says the authors failed to find that two-gene effect. Page numbers were not supplied in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredSeveral studies on European children and adolescents and Chinese adolescents did not report a significant main effect of 5-HTTLPR on aggressive behaviors and related phenotypes.
“Several studies on European children and adolescents [78, 89] and Chinese adolescents [51] did not report a significant main effect of 5-HTTLPR on aggressive behaviors and related phenotypes.”
From Genetics of child aggression, a systematic review (2024) · cites this paper as [51]
There was no significant GxE for MAOA / 5-HTTLPR with childhood maltreatment experience on adolescent aggression.
“Adolescent aggression: NS GxE for MAOA / 5-HTTLPR with childhood maltreatment experience”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Zhang [51]
Males with high MAOA activity, 5-HTTLPR-SS and increased SA had highest aggression.
“Male with high MAOA activity, 5-HTTLPR-SS and increased SA -> highest aggression”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Zhang [51]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(1991) · Medical Entomology and Zoology · Cited by 8,071 · see citing works
Development and validation of a brief screening version of the Childhood Trauma Questionnaire
Bernstein, D. P., Stein, J. A., Newcomb, M. D., Walker, E., Pogge, D., Ahluvalia, T., Stokes, J., Handelsman, L., Medrano, M., Desmond, D., et al. (2003) · Child Abuse & Neglect · doi:10.1016/s0145-2134(02)00541-0 · Cited by 6,419 · see citing works
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162 · see citing works
Role of genotype in the cycle of violence in maltreated children
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002) · Science · doi:10.1126/science.1072290 · Cited by 4,842 · see citing works
Beyond diathesis stress: differential susceptibility to environmental influences
Belsky, J., & Pluess, M. (2009) · Psychological Bulletin · doi:10.1037/a0017376 · Cited by 3,039 · see citing works
Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
Brunner, H. G., Nelen, M., Breakefield, X. O., Ropers, H. H., & van Oost, B. A. (1993) · Science · doi:10.1126/science.8211186 · Cited by 1,644 · see citing works
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Cases, O., Seif, I., Grimsby, J. S., Gaspar, P., Chen, K., Vandormael‐Pournin, S., Müller, U., Aguet, M., Babinet, C., Shih, J. C., et al. (1995) · Science · doi:10.1126/science.7792602 · Cited by 1,225 · see citing works
Kim-Cohen, J., Caspi, A., Taylor, A., Williams, B., Newcombe, R., Craig, I. W., & Moffitt, T. E. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001851 · Cited by 1,158 · see citing works
A functional polymorphism in the monoamine oxidase A gene promoter
Sabol, S. Z., Hu, S., & Hamer, D. (1998) · Human Genetics · doi:10.1007/s004390050816 · Cited by 1,079 · see citing works
Child abuse and neglect and the brain–a review
Glaser, D. (2000) · Journal of Child Psychology and Psychiatry · doi:10.1017/s0021963099004990 · Cited by 827 · see citing works
Wright, M. O., Crawford, E., & Del Castillo, D. (2009) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2008.12.007 · Cited by 657 · see citing works
Teicher, M. H., Anderson, C. M., & Polcari, A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115396109 · Cited by 639 · see citing works
Early Physical Abuse and Later Violent Delinquency: A Prospective Longitudinal Study
Lansford, J. E., Miller-Johnson, S., Berlin, L. J., Dodge, K. A., Bates, J. E., & Pettit, G. S. (2007) · Child Maltreatment · doi:10.1177/1077559507301841 · Cited by 523 · see citing works
Manuck, S. B., Flory, J. D., Ferrell, R. E., Mann, J. J., & Muldoon, M. F. (2000) · Psychiatry Research · doi:10.1016/s0165-1781(00)00162-1 · Cited by 486 · see citing works
Miller, A. B., Esposito-Smythers, C. L., Weismoore, J. T., & Renshaw, K. D. (2013) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-013-0131-5 · Cited by 412 · see citing works
Monoamine oxidase A gene (MAOA) predicts behavioral aggression following provocation
McDermott, R., Tingley, D., Cowden, J., Frazzetto, G., & Johnson, D. D. P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808376106 · Cited by 384 · see citing works
Byrd, A. L., & Manuck, S. B. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.004 · Cited by 378 · see citing works
Widom, C. S., & Brzustowicz, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.039 · Cited by 349 · see citing works
Complex Trauma and Aggression in Secure Juvenile Justice Settings
Ford, J. D., Chapman, J., Connor, D. F., & Cruise, K. R. (2012) · Criminal Justice and Behavior · doi:10.1177/0093854812436957 · Cited by 324 · see citing works
Reif, A., Rösler, M., Freitag, C. M., Schneider, M., Eujen, A., Kissling, C., Wenzler, D., Jacob, C. P., Retz-Junginger, P., Thome, J., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301359 · Cited by 277 · see citing works
Test–retest reliability and criterion validity of the Chinese version of CBCL, TRF, and YSR
Leung, P. W. L., Kwong, S., Tang, C. P., Ho, T. P., Hung, S. F., Lee, C., Hong, S. L., Chiu, C. M., & Liu, W. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2005.01570.x · Cited by 271 · see citing works
Newman, T. K., Syagailo, Y. V., Barr, C. S., Wendland, J. R., Champoux, M., Grässle, M., Suomi, S. J., Higley, J. D., & Lesch, K. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.012 · Cited by 257 · see citing works
Eisenberg, D. T. A., MacKillop, J., Modi, M. E., Beauchemin, J., Dang, D., Lisman, S. A., Lum, J. K., & Wilson, D. S. (2007) · Behavioral and Brain Functions · doi:10.1186/1744-9081-3-2 · Cited by 257 · see citing works
Brain Monoamine Oxidase A Activity Predicts Trait Aggression
Alia-Klein, N., Goldstein, R., Kriplani, A., Logan, J., Tomasi, D., Williams, B. M., Telang, F., Shumay, E., Biegon, A., Craig, I., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0925-08.2008 · Cited by 240 · see citing works
From genes to aggressive behavior: the role of serotonergic system
Popova, N. K. (2006) · BioEssays · doi:10.1002/bies.20412 · Cited by 236 · see citing works
Corticolimbic Function in Impulsive Aggressive Behavior
Coccaro, E. F., Sripada, C., Yanowitch, R. N., & Phan, K. L. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.032 · Cited by 233 · see citing works
Role of Monoamine Oxidase A Genotype and Psychosocial Factors in Male Adolescent Criminal Activity
Nilsson, K. W., Sjöberg, R. L., Damberg, M., Leppert, J., Öhrvik, J., Alm, P. O., Lindström, L., & Oreland, L. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.024 · Cited by 223 · see citing works
Guo, G., Roettger, M. E., & Shih, J. C. (2006) · Human Genetics · doi:10.1007/s00439-006-0244-8 · Cited by 220 · see citing works
Early conduct problems and later life opportunities.
Fergusson, D. M., & Horwood, L. J. (1998) · PubMed · Cited by 217 · see citing works
Is impulsivity a link between childhood abuse and suicide?
Braquehais, M. D., Oquendo, M. A., Baca‐García, E., & Sher, L. (2009) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2009.05.003 · Cited by 200 · see citing works
Childhood Maltreatment, Subsequent Antisocial Behavior, and the Role of Monoamine Oxidase A Genotype
Huizinga, D. H., Haberstick, B. C., Smolen, A., Menard, S., Young, S. E., Corley, R. P., Stallings, M. C., Grotpeter, J. K., & Hewitt, J. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.12.022 · Cited by 186 · see citing works
Jonas, S., Bebbington, P., McManus, S., Meltzer, H., Jenkins, R., Kuipers, E., Cooper, C., King, M., & Brugha, T. S. (2010) · Psychological Medicine · doi:10.1017/s003329171000111x · Cited by 186 · see citing works
Childhood Maltreatment, Intervening Variables, and Adult Psychological Difficulties in Women
Briere, J., & Jordan, C. E. (2009) · Trauma Violence & Abuse · doi:10.1177/1524838009339757 · Cited by 185 · see citing works
Genetic determinants of aggression and impulsivity in humans
Pavlov, K. A., Chistiakov, D. A., & Chekhonin, V. P. (2012) · Journal of Applied Genetics · doi:10.1007/s13353-011-0069-6 · Cited by 184 · see citing works
Relations of serotonin function to personality: Current views and a key methodological issue
Carver, C. S., & Miller, C. J. (2006) · Psychiatry Research · doi:10.1016/j.psychres.2006.03.013 · Cited by 180 · see citing works
A meta-analysis of child physical abuse prevalence in China
Ji, K., & David Finkelhor, B. (2014) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2014.11.011 · Cited by 170 · see citing works
Serotonin Transporter Polymorphisms and Persistent, Pervasive Childhood Aggression
Beitchman, J. H., Baldassarra, L., Mik, H., De Luca, V., King, N., Bender, D., Ehtesham, S., & Kennedy, J. L. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.6.1103 · Cited by 167 · see citing works
Guo, G., Ou, X., Roettger, M. E., & Shih, J. C. (2008) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201999 · Cited by 160 · see citing works
Bradshaw, C. P., Schaeffer, C. M., Petras, H., & Ialongo, N. S. (2009) · Journal of Youth and Adolescence · doi:10.1007/s10964-009-9442-8 · Cited by 150 · see citing works
Beaver, K. M., Wright, J., DeLisi, M., Walsh, A., Vaughn, M. G., Boisvert, D., & Vaske, J. (2007) · Behavioral and Brain Functions · doi:10.1186/1744-9081-3-30 · Cited by 131 · see citing works
Murphy, D. L., Uhl, G. R., Holmes, A., Ren‐Patterson, R. F., Hall, F. S., Sora, I., Detera‐Wadleigh, S. D., & Lesch, K. (2003) · Genes Brain & Behavior · doi:10.1046/j.1601-1848.2003.00049.x · Cited by 129 · see citing works
Biological correlates of intimate partner violence perpetration
Pinto, L. A., Sullivan, E. L., Rosenbaum, A., Wyngarden, N., Umhau, J. C., Miller, M. W., & Taft, C. T. (2010) · Aggression and Violent Behavior · doi:10.1016/j.avb.2010.07.001 · Cited by 123 · see citing works
Early health risk factors for violence: Conceptualization, evidence, and implications
Liu, J. (2010) · Aggression and Violent Behavior · doi:10.1016/j.avb.2010.12.003 · Cited by 115 · see citing works
Hypoactive medial prefrontal cortex functioning in adults reporting childhood emotional maltreatment
van Harmelen, A., van Tol, M., Dalgleish, T., van der Wee, N. J. A., Veltman, D. J., Aleman, A., Spinhoven, P., Penninx, B. W. J. H., & Elzinga, B. M. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu008 · Cited by 113 · see citing works
Enoch, M., Steer, C. D., Newman, T. K., Gibson, N. P. S. J., & Goldman, D. A. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00535.x · Cited by 104 · see citing works
Beach, S. R. H., Brody, G. H., Gunter, T. D., Packer, H., Wernett, P., & Philibert, R. A. (2010) · Journal of Family Psychology · doi:10.1037/a0018074 · Cited by 100 · see citing works
Liao, D., Hong, C., Shih, H.-L., & Tsai, S. (2004) · Neuropsychobiology · doi:10.1159/000080953 · Cited by 97 · see citing works
Haberstick, B. C., Lessem, J. M., Hewitt, J. K., Smolen, A., Hopfer, C. J., Halpern, C. T., Killeya‐Jones, L. A., Boardman, J. D., Tabor, J. W., Siegler, I. C., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.028 · Cited by 93 · see citing works
Nobile, M., Giorda, R., Marino, C., Carlet, O., Pastore, V., Vanzin, L., Bellina, M., Molteni, M., & Battaglia, M. (2007) · Development and Psychopathology · doi:10.1017/s0954579407000594 · Cited by 72 · see citing works
Case‐control and within‐family tests for an association between conduct disorder and 5HTTLPR
Sakai, J. T., Young, S. E., Stallings, M. C., Timberlake, D. S., Smolen, A., Stetler, G. L., & Crowley, T. J. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30278 · Cited by 69 · see citing works
Gene–Environment Interactions and Response to Social Intrusion in Male and Female Rhesus Macaques
Schwandt, M. L., Lindell, S. G., Sjöberg, R. L., Chisholm, K., Higley, J. D., Suomi, S. J., Heilig, M. A., & Barr, C. S. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.016 · Cited by 65 · see citing works
COMT but not serotonin‐related genes modulates the influence of childhood abuse on anger traits
Perroud, N. A., Jaussent, I., Guillaume, S., Bellivier, F., Baud, P., Jollant, F., Leboyer, M., Lewis, C. M., Malafosse, A., & Courtet, P. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00547.x · Cited by 62 · see citing works
Hoeve, M., Colins, O. F., Mulder, E. A., Loeber, R., Stams, G. J. J. M., & Vermeiren, R. R. J. M. (2015) · Aggressive Behavior · doi:10.1002/ab.21586 · Cited by 61 · see citing works
Iffland, B., Sansen, L. M., Catani, C., & Neuner, F. (2012) · BMC Psychiatry · doi:10.1186/1471-244x-12-49 · Cited by 61 · see citing works
Comasco, E., Åslund, C., Oreland, L., & Nilsson, K. W. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.01.010 · Cited by 60 · see citing works
Insomnia and suicidal behaviour in prisoners
Carli, V., Roy, A., Bevilacqua, L. M., Maggi, S., Cesaro, C., & Sarchiapone, M. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.10.001 · Cited by 60 · see citing works
Serotonin system gene polymorphisms are associated with impulsivity in a context dependent manner
Stoltenberg, S. F., Christ, C. C., & Highland, K. B. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.06.012 · Cited by 60 · see citing works
Hernán Silva, I., Iturra, P., Solari, A., Juana Villarroel, G., Sonia Jerez, C., Jiménez, M., Galleguillos, F., & Bustamante, M. L. (2009) · Psychiatric Genetics · doi:10.1097/ypg.0b013e328335125d · Cited by 59 · see citing works
Multi-Cultural Association of the Serotonin Transporter Gene (SLC6A4) with Substance Use Disorder
Cao, J. P., Hudziak, J. J., & Li, D. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.73 · Cited by 56 · see citing works
Hohmann, S., Becker, K., Fellinger, J., Banaschewski, T., Schmidt, M. H., Esser, G., & Laucht, M. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0290-1 · Cited by 53 · see citing works
Nilsson, K. W., Comasco, E., Hodgins, S., Oreland, L., & Åslund, C. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu107 · Cited by 48 · see citing works
Serotonin Transporter Polymorphisms and Persistent, Pervasive Childhood Aggression
Beitchman, J. H. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.6.1103 · Cited by 46 · see citing works
Schmidt, L. A., Fox, N. A., & Hamer, D. H. (2007) · Development and Psychopathology · doi:10.1017/s0954579407000569 · Cited by 45 · see citing works
Nanda, M. M., Reichert, E. L., Jones, U., & Flannery-Schroeder, E. C. (2015) · Journal of Child & Adolescent Trauma · doi:10.1007/s40653-015-0070-z · Cited by 44 · see citing works
Carli, V., Mandelli, L., Zaninotto, L., Alberti, S., Roy, A., Serretti, A., & Sarchiapone, M. (2013) · Nordic Journal of Psychiatry · doi:10.3109/08039488.2012.756061 · Cited by 42 · see citing works
Hart, D. A., & Marmorstein, N. R. (2009) · Development and Psychopathology · doi:10.1017/s0954579409000510 · Cited by 38 · see citing works
Childhood maltreatment and social functioning in adults with sub-clinical psychosis.
Boyda, D., & McFeeters, D. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.01.023 · Cited by 37 · see citing works
Stuart, G. L., McGeary, J. E., Shorey, R. C., Knopik, V. S., Beaucage, K., & Temple, J. R. (2014) · Violence Against Women · doi:10.1177/1077801214528587 · Cited by 31 · see citing works
[Prevalence of childhood sexual abuse among 2508 college students in 6 provinces of China].
Chen, J., Han, P., Lian, G.-L., et al. (2010) · PubMed · Cited by 30 · see citing works
Ming, Q., Zhang, Y., Yi, J., Wang, X., Zhu, X., & Yao, S. (2015) · BMC Psychiatry · doi:10.1186/s12888-015-0639-y · Cited by 29 · see citing works
Self-citationMing, Q., Zhang, Y., Chai, Q., Chen, H.-Y., Hou, C.-J., Wang, M., Wang, Y.-P., Cai, L., Zhu, X., Yi, J., et al. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-142 · Cited by 28 · see citing works
Self-citationMcGeary, J. E., Knopik, V. S., Hayes, J. E., Palmer, R. H. C., Monti, P. M., & Kalman, D. (2012) · Substance Abuse Research and Treatment · doi:10.4137/sart.s8866 · Cited by 24 · see citing works
Qian, Q., Yang, L., Wang, Y., Zhang, H.-B., Guan, L.-L., Chen, Y., Ji, N., Liu, L., & Faraone, S. V. (2009) · Behavior Genetics · doi:10.1007/s10519-009-9314-8 · Cited by 23 · see citing works
Chien, C.-C., Lin, C., Chang, Y., & Lung, F. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622970903304459 · Cited by 18 · see citing works
Stoltenberg, S. F., & Nag, P. (2010) · Behavior Genetics · doi:10.1007/s10519-010-9335-3 · Cited by 16 · see citing works
Paying Attention to All Results, Positive and Negative
Duncan, L. E. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.02.007 · Cited by 15 · see citing works
MAOA–Environment Interactions: Results May Vary
Goldman, D. A., & Rosser, A. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.015 · Cited by 14 · see citing works
Bou-Flores, C., & Hilaire, G. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01653-0 · Cited by 14 · see citing works
Serotonin and Dopamine Candidate Gene Variants and Alcohol- and Non-Alcohol-Related Aggression
Preuss, U. W., Koller, G., Samochowiec, A., Zill, P., Samochowiec, J., Kucharska–Mazur, J., Wong, J., & Soyka, M. (2015) · Alcohol and Alcoholism · doi:10.1093/alcalc/agv057 · Cited by 11 · see citing works
A Functional Polymorphism of the MAOA Gene Modulates Spontaneous Brain Activity in Pons
Lei, H., Zhang, X., Di, X., Rao, H., Ming, Q., Zhang, J., Xiao, G., Jiang, Y., Gao, Y., Yi, J., et al. (2014) · BioMed Research International · doi:10.1155/2014/243280 · Cited by 9 · see citing works
Self-citationEarly Conduct Problems and Later Life Opportunities
Fergusson, D. M., & Horwood, L. J. (1998) · Journal of Child Psychology and Psychiatry · doi:10.1017/s0021963098003175 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- United Nations Children’s Fund (2012). Child Maltreatment: Prevalence, Incidence and Consequences in the East Asia and Pacific Region—A Systematic Review of Research. Bangkok: UNICEF East Asia and Pacific Regional Office (EAPRO).
Cited by
Sorted by citations
Kolla, N. J., & Bortolato, M. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101875 · Cited by 138 · see citing works
Genetics of child aggression, a systematic review
Koyama, E., Kant, T., Takata, A., Kennedy, J. L., & Zai, C. C. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02870-7 · Cited by 33 · see citing works
Wang, M., Li, H., Deater-Deckard, K., & Zhang, W. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.01079 · Cited by 19 · see citing works
- Authors
- Zhang, Y., Ming, Q.-S., Yi, J.-Y., Wang, X., Chai, Q.-L., & Yao, S.-Q.
- Affiliations
- Northwest Minzu University (CN)
- Central South University (CN)
- Venue
- Frontiers in Behavioral Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2017-02-01
- Volume
- 11
- Pages
- 17-17
- ISSN
- 1662-5153 (ISSN-L)
- PMC
- PMC5285338
- OpenAlex
- W2583437510
- Cited by
- 45
- References
- 81
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 8 · 2018: 10 · 2017: 2
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Behavioral Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81471384)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- gene-environment interaction, epistasis, aggression, serotonin transporter gene, 5-HTTLPR, monoamine oxidase A, child abuse, child sexual abuse, Chinese adolescents, adolescent boys, Child Behavior Checklist
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
