The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
To Approach or Avoid: An Introductory Overview of the Study of Anxiety Using Rodent Assays
Open accessAbstract
Anxiety is a widely studied phenomenon in behavioral neuroscience, but the recent literature lacks an overview of the major conceptual framework underlying anxiety research to introduce young researchers to the field. In this mini-review article, which is aimed toward new undergraduate and graduate students, we discuss how researchers exploit the approach-avoidance conflict, an internal conflict rodents face between exploration of novel environments and avoidance of danger, to inform rodent assays that allow for the measurement of anxiety-related behavior in the laboratory. We review five widely-used rodent anxiety assays, consider the pharmacological validity of these assays, and discuss neural circuits that have recently been shown to modulate anxiety using the assays described. Finally, we offer related lines of inquiry and comment on potential future directions.
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Citations
Cites
Resolving the neural circuits of anxiety
Calhoon, G. G., & Tye, K. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4101 · Cited by 766 · cited 1×
“In this mini-review article, we will focus on the study of anxiety, which in the animal research literature is often defined as a temporary behavioral state induced by low-threat, uncertain situations and accompanied by increased vigilance and risk assessment (Adhikari, 2014; Calhoon and Tye, 2015; Robinson et al., 20…”
BackgroundDistinct extended amygdala circuits for divergent motivational states
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BackgroundBenzodiazepines revisited—will we ever learn?
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Ruscio, A. M., Hallion, L. S., Lim, C. C. W., Aguilar-Gaxiola, S., Al-Hamzawi, A., Alonso, J., Andrade, L. H., Borges, G., Bromet, E. J., Bunting, B., et al. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.0056 · Cited by 492
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A Corticostriatal Path Targeting Striosomes Controls Decision-Making under Conflict
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Aversive state processing in the posterior insular cortex
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Cited by
Moscarello, J. M., & Penzo, M. A. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01130-5 · Cited by 112
Naeem, A., Prakash, R., Kumari, N., Ali Khan, M., Quaiyoom Khan, A., Uddin, S., Verma, S., AB Robertson, A., Boltze, J., & Shadab Raza, S. (2024) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2023.11.031 · Cited by 96
La-Vu, M. Q., Sethi, E., Maesta-Pereira, S., Schuette, P. J., Tobias, B. C., Reis, F. M., Wang, W., Torossian, A., Bishop, A., Leonard, S. J., et al. (2022) · eLife · doi:10.7554/elife.77115 · Cited by 50
Self-citationDjebari, S., Iborra-Lázaro, G., Temprano-Carazo, S., Sánchez-Rodríguez, I., Nava-Mesa, M. O., Múnera, A., Gruart, A., Delgado-García, J. M., Jiménez-Díaz, L., & Navarro-López, J. D. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.2849-20.2021 · Cited by 48
Metadata
- Authors
- La-Vu, M., Tobias, B. C., Schuette, P. J., & Adhikari, A.
- Venue
- Frontiers in Behavioral Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2020-08-26
- Volume
- 14
- Pages
- 145-145
- ISSN
- 1662-5153 (ISSN-L)
- OpenAlex
- W3081418474
- Cited by
- 182
- References
- 16
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- gold
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