A Corticostriatal Path Targeting Striosomes Controls Decision-Making under Conflict
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A striking neurochemical form of compartmentalization has been found in the striatum of humans and other species, dividing it into striosomes and matrix. The function of this organization has been unclear, but the anatomical connections of striosomes indicate their relation to emotion-related brain regions, including the medial prefrontal cortex. We capitalized on this fact by combining pathway-specific optogenetics and electrophysiology in behaving rats to search for selective functions of striosomes. We demonstrate that a medial prefronto-striosomal circuit is selectively active in and causally necessary for cost-benefit decision-making under approach-avoidance conflict conditions known to evoke anxiety in humans. We show that this circuit has unique dynamic properties likely reflecting striatal interneuron function. These findings demonstrate that cognitive and emotion-related functions are, like sensory-motor processing, subject to encoding within compartmentally organized representations in the forebrain and suggest that striosome-targeting corticostriatal circuits can underlie neural processing of decisions fundamental for survival.
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In rats, a pathway projecting from PLc to the striatal striosomes is implicated in approach-avoidance decision making, with its inactivation increasing approach.
“Using an analogous task in rats, a similar pathway projecting from PLc to the striatal striosomes has been implicated in approach-avoidance decision making, with its inactivation increasing approach [203].”
From Prefrontal cortex and depression (2022) · cites this paper as [203]
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- Authors
- Friedman, A., Homma, D., Gibb, L. G., Amemori, K.-I., Rubin, S. J., Hood, A. S., Riad, M. H., & Graybiel, A. M.
- Affiliations
- McGovern Institute for Brain Research (US)
- Corresponding author
- Graybiel, Ann M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 161
- Issue
- 6
- Pages
- 1320-1333
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4477966
- OpenAlex
- W1554715089
- Cited by
- 309
- References
- 50
- Citations by year
- 2026: 36 · 2025: 19 · 2024: 19 · 2023: 18 · 2022: 18 · 2021: 39 · 2020: 34 · 2019: 27 · 2018: 32 · 2017: 26 · 2016: 33 · 2015: 8
- FWCI
- 19.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH060379)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- striosomes, striatum, corticostriatal circuits, medial prefrontal cortex, decision-making, approach-avoidance conflict, anxiety, striatal interneurons, emotion and cognition
- MeSH terms
- Animals, Caudate Nucleus, Choice Behavior, Conflict, Psychological, Decision Making, Environment, Gyrus Cinguli, Prefrontal Cortex, Maze Learning, Rats
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