Cited by 463Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Direct ventral hippocampal-prefrontal input is required for anxiety-related neural activity and behavior

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Padilla-Coreano, Nancy, Bolkan, Scott S., Pierce, Georgia M., Blackman, Dakota R., Hardin, William D., Garcia-Garcia, Alvaro L., Spellman, Timothy J., Gordon, Joshua A.·2016·Neuron

Abstract

The ventral hippocampus (vHPC), medial prefrontal cortex (mPFC), and basolateral amygdala (BLA) are each required for the expression of anxiety-like behavior. Yet the role of each individual element of the circuit is unclear. The projection from the vHPC to the mPFC has been implicated in anxiety-related neural synchrony and spatial representations of aversion. The role of this projection was examined using multi-site neural recordings combined with optogenetic terminal inhibition. Inhibition of vHPC input to the mPFC disrupted anxiety and mPFC representations of aversion, and reduced theta synchrony in a pathway-, frequency- and task-specific manner. Moreover, bilateral, but not unilateral, inhibition altered physiological correlates of anxiety in the BLA, mimicking a safety-like state. These results reveal a specific role for the vHPC-mPFC projection in anxiety-related behavior and the spatial representation of aversive information within the mPFC.

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Authors
Padilla-Coreano, N., Bolkan, S. S., Pierce, G. M., Blackman, D. R., Hardin, W. D., Garcia-Garcia, A. L., Spellman, T. J., & Gordon, J. A.
Affiliations
  • Columbia University (US)
  • Barnard College (US)
  • New York State Psychiatric Institute (US)
Corresponding author
Gordon, Joshua A.
Venue
Neuron
Publisher
Elsevier BV
Published
2016-02
Volume
89
Issue
4
Pages
857-866
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2254443919
Cited by
463
References
32
Citations by year
2026: 36 · 2025: 45 · 2024: 44 · 2023: 48 · 2022: 58 · 2021: 59 · 2020: 62 · 2019: 46 · 2018: 35 · 2017: 20 · 2016: 9
FWCI
23.33
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Science Foundation
  • National Institutes of Health (5r01mh096274-06)
  • National Institute of Mental Health (R01-MH096274, NIH F31MH102041, F31MH102041, MH081968, MH096274, R01MH081968)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
ventral hippocampus, medial prefrontal cortex, basolateral amygdala, anxiety, neuronal synchronization
MeSH terms
Action Potentials, Animals, Anxiety, Disease Models, Animal, Evoked Potentials, Food Deprivation, Hippocampus, Functional Laterality, Male, Mice, Inbred C57BL, Neural Inhibition, Neural Pathways, Neurons, Reaction Time, Theta Rhythm, Prefrontal Cortex, Statistics, Nonparametric, Maze Learning, Mice, Calcium-Calmodulin-Dependent Protein Kinase Type 2

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