The therapeutic promise of ATP antagonism at P2X3 receptors in respiratory and urological disorders
Open accessAbstract
A sensory role for ATP was proposed long before general acceptance of its extracellular role. ATP activates and sensitizes signal transmission at multiple sites along the sensory axis, across multiple synapses. P2X and P2Y receptors mediate ATP modulation of sensory pathways and participate in dysregulation, where ATP action directly on primary afferent neurons (PANs), linking receptive field to CNS, has received much attention. Many PANs, especially C-fibers, are activated by ATP, via P2X3-containing trimers. P2X3 knock-out mice and knock-down in rats led to reduced nocifensive activity and visceral reflexes, suggesting that antagonism may offer benefit in sensory disorders. Recently, drug-like P2X3 antagonists, active in a many inflammatory and visceral pain models, have emerged. Significantly, these compounds have no overt CNS action and are inactive versus acute nociception. Selectively targeting ATP sensitization of PANs may lead to therapies that block inappropriate chronic signals at their source, decreasing drivers of peripheral and central wind-up, yet leaving defensive nociceptive and brain functions unperturbed. This article reviews this evidence, focusing on how ATP sensitization of PANs in visceral "hollow" organs primes them to chronic discomfort, irritation and pain (symptoms) as well as exacerbated autonomic reflexes (signs), and how the use of isolated organ-nerve preparations has revealed this mechanism. Urinary and airways systems share many features: dependence on continuous afferent traffic to brainstem centers to coordinate efferent autonomic outflow; loss of descending inhibitory influence in functional and sensory disorders; dependence on ATP in mediating sensory responses to diverse mechanical and chemical stimuli; a mechanistically overlapping array of existing medicines for pathological conditions. These similarities may also play out in terms of future treatment of signs and symptoms, in the potential for benefit of P2X3 antagonists.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
P2X purinoreceptors 3 are cation channels expressed in sensory neurons, activated by extracellular ATP, and play an important role in peripheral irritation, pain, coughing and potentially itch.
“The P2X purinoreceptors 3 (P2XR3) are cation channels expressed in sensory neurons that are activated by extracellular ATP and exert an important role in peripheral irritation, pain sensation, coughing but potentially also in itch207–209.”
From Atopic dermatitis: an expanding therapeutic pipeline for a complex disease (2022) · cites this paper as [209]
The Introduction and Abstract describe ATP activation of P2X3-containing receptors on sensory neurons and their role in peripheral irritation and pain. The sensitizing-property section calls them cation channels, and the clinical section reports reduced cough frequency with a P2X3 antagonist. Our copy does not link P2X3 receptors to itch; the only itch mention found is in a reference title. Page numbers are not supplied. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Yaşlı Kadınlarda Üreme Sağlığı
Kokanalı, D., & Engin Üstün, Y. (n.d.) · DergiPark (Istanbul University) · Cited by 170,090 · see citing works
(1996) · Institutional Research Information System University of Turin (University of Turin) · doi:10.1111/j · Cited by 5,486 · see citing works
Induced root-secreted phenolic compounds as a belowground plant defense
Lanoue, A., Burlat, V., Schurr, U., & Röse, U. S. R. (2010) · Plant Signaling & Behavior · doi:10.4161/psb.5.8.12337 · Cited by 5,462 · see citing works
Colman (2022) · doi:10.1073/pnas · Cited by 4,370 · see citing works
Cellular and Molecular Mechanisms of Pain
Basbaum, A. I., Bautista, D. M., Scherrer, G., & Julius, D. (2009) · Cell · doi:10.1016/j.cell.2009.09.028 · Cited by 4,344 · see citing works
The neural control of micturition
Fowler, C. J., GRIFFITHS, D. J., & de Groat, W. C. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2401 · Cited by 1,492 · see citing works
P2X receptors as cell-surface ATP sensors in health and disease
Khakh, B. S., & North, R. A. (2006) · Nature · doi:10.1038/nature04886 · Cited by 854 · see citing works
Selective proper name anomia in a patient with asymmetric cortical degeneration
Fadda, L., Turriziani, P., Carlesimo, G. A., Nocentini, U., & Caltagirone, C. (1998) · European Journal of Neurology · doi:10.1046/j.1468-1331.1998.540417.x · Cited by 716 · see citing works
(2014) · doi:10.1523/jneurosci · Cited by 715 · see citing works
Ferguson, D. R., Kennedy, I., & Burton, T. J. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.503bb.x · Cited by 660 · see citing works
Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells
Idzko, M., Hammad, H., van Nimwegen, M., Kool, M., Willart, M. A. M., Muskens, F., Hoogsteden, H. C., Luttmann, W., Ferrari, D., Virgilio, F. D., et al. (2007) · Nature Medicine · doi:10.1038/nm1617 · Cited by 620 · see citing works
A neurologic basis for the overactive bladder
de Groat, W. C. (1997) · Urology · doi:10.1016/s0090-4295(97)00587-6 · Cited by 607 · see citing works
Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade
Ferrere, G., Tidjani Alou, M., Liu, P., Goubet, A.-G., Fidelle, M., Kepp, O., Durand, S., Iebba, V., Fluckiger, A., Daillère, R., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.145207 · Cited by 533 · see citing works
Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses
Gu, J. G., & MacDermott, A. B. (1997) · Nature · doi:10.1038/39639 · Cited by 494 · see citing works
Jarvis, M. F., Burgard, E. C., McGaraughty, S., Honoré, P., Lynch, K. J., Brennan, T. J., Subieta, A. R., van Biesen, T., Cartmell, J., Bianchi, B. R., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252537299 · Cited by 471 · see citing works
P2X3Knock-Out Mice Reveal a Major Sensory Role for Urothelially Released ATP
Vlaskovska, M. V., Kasakov, L., Rong, W., Bodin, P., Bardini, M., Cockayne, D. A., Ford, A. P. D. W., & Burnstock, G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05670.2001 · Cited by 465 · see citing works
Self-citationSubstances Producing Pain and Itch
(1965) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1965.tb18444.x · Cited by 388 · see citing works
Cockayne, D. A., Dunn, P. M., Zhong, Y., Rong, W., Hamilton, S. G., Knight, G. E., Ruan, H., Ma, B., Yip, P. K., Nunn, P. A., et al. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.088435 · Cited by 381 · see citing works
Self-citationCell damage excites nociceptors through release of cytosolic ATP
Cook, S. P., & McCleskey, E. W. (2002) · Pain · doi:10.1016/s0304-3959(01)00372-4 · Cited by 296 · see citing works
Observations on the algogenic actions of adenosine compounds on the human blister base preparation
Bleehen, T., & Keele, C. A. (1977) · Pain · doi:10.1016/0304-3959(77)90066-5 · Cited by 283 · see citing works
North, R. A., & Jarvis, M. F. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.083758 · Cited by 271 · see citing works
Chemogenomic approaches to rational drug design
Rognan, D. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707307 · Cited by 265 · see citing works
Subtypes of vagal afferent C‐fibres in guinea‐pig lungs
Undem, B. J., Chuaychoo, B., Lee, M. G., Weinreich, D. M., Myers, A. C., & Kollárik, M. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.060079 · Cited by 255 · see citing works
Self-citationPollak, K. A., Swenson, J. D., VanHaitsma, T. A., Hughen, R. W., Jo, D. H., Light, K. C., Schweinhardt, P., Amann, M., & Light, A. R. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2013.075812 · Cited by 251 · see citing works
Purinergic signalling: from discovery to current developments
Burnstock, G. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2013.071951 · Cited by 241 · see citing works
ATP and purinergic receptor–dependent membrane traffic in bladder umbrella cells
Wang, E. C. Y., Lee, J.-M., Ruiz, W. G., Balestreire, E. M., von Bodungen, M., Barrick, S., Cockayne, D. A., Birder, L. A., & Apodaca, G. L. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24086 · Cited by 225 · see citing works
Rong, W., Spyer, K. M., & Burnstock, G. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013469 · Cited by 208 · see citing works
Tsuda, M., Koizumi, S., Kita, A., Shigemoto, Y., Ueno, S., & Inoue, K. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-j0007.2000 · Cited by 201 · see citing works
An in vitro study of the properties of single vagal afferents innervating guinea‐pig airways.
Fox, A. J., Barnes, P. J., Urbán, L., & Dray, A. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019802 · Cited by 182 · see citing works
Acute nociception mediated by hindpaw P2X receptor activation in the rat
Bland-Ward, P. A., & Humphrey, P. P. A. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701371 · Cited by 181 · see citing works
Hamilton, S. G., Wade, A., & McMahon, S. B. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702258 · Cited by 176 · see citing works
In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization
Ford, A. P. D. W. (2011) · Purinergic Signalling · doi:10.1007/s11302-011-9271-6 · Cited by 166 · see citing works
Self-citationKo, W. K. D., Li, Q., & Bézard, E. (2014) · INRIA a CCSD electronic archive server · doi:10.1016/j.neulet · Cited by 160 · see citing works
Purinergic Signaling in the Airways
Burnstock, G., Brouns, I., Adriaensen, D., & Timmermans, J. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005389 · Cited by 157 · see citing works
Phenotypic distinctions between neural crest and placodal derived vagal C-fibres in mouse lungs
Nassenstein, C., Taylor‐Clark, T. E., Myers, A. C., Ru, F., Nandigama, R., Bettner, W., & Undem, B. J. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.195339 · Cited by 151 · see citing works
Self-citationHamilton, S. G., Warburton, J., Bhattacharjee, A., Ward, J., & McMahon, S. B. (2000) · Brain · doi:10.1093/brain/123.6.1238 · Cited by 151 · see citing works
Immunomodulation of afferent neurons in guinea‐pig isolated airway.
Riccio, M. M., Myers, A. C., & Undem, B. J. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021234 · Cited by 147 · see citing works
Self-citationKwong, K., Kollárik, M., Nassenstein, C., Ru, F., & Undem, B. J. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90360.2008 · Cited by 147 · see citing works
Self-citationGiniatullin, R. A., Nistri, A., & Fabbretti, E. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8020-5 · Cited by 143 · see citing works
Clinical differences between patients with COPD due to biomass smoke or tobacco
Castro A?on, O., Golpe G?mez, R., P?rez de Llano, L., Sanjuan L?pez, M. D. P., & Cano Jim?nez, E. A. (2011) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · doi:10.1378/chest · Cited by 142 · see citing works
Parada, C. A., Reichling, D. B., & Levine, J. D. (2004) · Pain · doi:10.1016/j.pain.2004.10.021 · Cited by 137 · see citing works
AF‐353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist
Gever, J. R., Soto, R., Henningsen, R. A., Martin, R. S., Hackos, D. H., Panicker, S., Rubas, W., Oglesby, I. B., Dillon, M. P., Milla, M. E., et al. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00796.x · Cited by 132 · see citing works
Self-citationPurinergic Receptor Inhibition Prevents the Development of Smoke-Induced Lung Injury and Emphysema
Cicko, S., Lucattelli, M., Müller, T., Lommatzsch, M., Cunto, G. D., Cardini, S., Sundas, W., Grimm, M., Zeiser, R., Dürk, T., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904042 · Cited by 128 · see citing works
Organization of the neural switching circuitry underlying reflex micturition
de Groat, W. C., & Wickens, C. (2012) · Acta Physiologica · doi:10.1111/apha.12014 · Cited by 126 · see citing works
Intravesical Adenosine Triphosphate Stimulates the Micturition Reflex in Awake, Freely Moving Rats
Pandita, R. K., & Andersson, K. (2002) · The Journal of Urology · doi:10.1016/s0022-5347(05)64631-9 · Cited by 124 · see citing works
Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin
Hamilton, S. G., McMahon, S. B., & Lewin, G. R. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00437.x · Cited by 123 · see citing works
Fox, A. J., Urbán, L., Barnes, P. J., & Dray, A. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00115-y · Cited by 118 · see citing works
The discovery and development of analgesics: new mechanisms, new modalities
Burgess, G. M., & Williams, D. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43195 · Cited by 109 · see citing works
Experimental muscle pain and tenderness following infusion of endogenous substances in humans
Mørk, H., Ashina, M., Bendtsen, L., Olesen, J., & Jensen, R. (2003) · European Journal of Pain · doi:10.1016/s1090-3801(02)00096-4 · Cited by 109 · see citing works
Lung mechanics during induced bronchoconstriction
Pellegrino, R., Wilson, O., Jenouri, G., & RODARTE, J. R. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.2.964 · Cited by 108 · see citing works
Purinergic sensory neurotransmission in the urinary bladder: an in vitro study in the rat
Namasivayam, Eardley, & Morrison (1999) · British Journal of Urology · doi:10.1046/j.1464-410x.1999.00310.x · Cited by 103 · see citing works
The activation of bladder wall afferent nerves
Morrison, J. (1999) · Experimental Physiology · doi:10.1111/j.1469-445x.1999.tb00078.x · Cited by 97 · see citing works
COLLIER, H. O. J., James, G., & Schneider, C. (1966) · Nature · doi:10.1038/212411a0 · Cited by 96 · see citing works
Properties of the major classes of mechanoreceptors in the guinea pig bladder
Zagorodnyuk, V. P., Gibbins, I. L., Costa, M., Brookes, S. J., & Gregory, S. J. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.140244 · Cited by 95 · see citing works
Başoğlu, Ö. K., Pelleg, A., Essilfie-Quaye, S., Brindicci, C., Barnes, P. J., & Kharitonov, S. A. (2005) · CHEST Journal · doi:10.1378/chest.128.4.1905 · Cited by 89 · see citing works
Yu, Y., & de Groat, W. C. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00592.2007 · Cited by 84 · see citing works
Collins, V. M., Daly, D., Liaskos, M., McKay, N. G., Sellers, D., Chapple, C. R., & Grundy, D. (2013) · British Journal of Urology · doi:10.1111/bju.12266 · Cited by 84 · see citing works
Discovery of purinergic signalling, the initial resistance and current explosion of interest
Burnstock, G. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02008.x · Cited by 84 · see citing works
Shinoda, M., Ozaki, N., Asai, H., Nagamine, K., & Sugiura, Y. (2005) · Pain · doi:10.1016/j.pain.2005.03.042 · Cited by 84 · see citing works
Adenosine triphosphate-evoked vascular changes in human skin: Mechanism of action
Coutts, A. A., Jorizzo, J. L., Eady, R. A. J., Greaves, M. W., & Burnstock, G. (1981) · European Journal of Pharmacology · doi:10.1016/0014-2999(81)90110-2 · Cited by 81 · see citing works
Involvement of P2X receptor subtypes in ATP-induced enhancement of the cough reflex sensitivity
Kamei, J., Takahashi, Y., Yoshikawa, Y., & Saitoh, A. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.10.030 · Cited by 79 · see citing works
P2X receptor antagonists for pain management: examination of binding and physicochemical properties
Gum, R. J., Wakefield, B. D., & Jarvis, M. F. (2011) · Purinergic Signalling · doi:10.1007/s11302-011-9272-5 · Cited by 66 · see citing works
ATP responses in human C nociceptors
Hilliges, M., Weidner, C., Schmelz, M., Schmidt, R., Ørstavik, K., Torebjörk, E. H., & Handwerker, H. O. (2002) · Pain · doi:10.1016/s0304-3959(01)00469-9 · Cited by 66 · see citing works
Zagorodnyuk, V. P., Brookes, S. J., Spencer, N. J., & Gregory, S. J. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.172577 · Cited by 64 · see citing works
Adaptation of guinea‐pig vagal airway afferent neurones to mechanical stimulation
McAlexander, M. A., Myers, A. C., & Undem, B. J. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.00239.x · Cited by 64 · see citing works
Self-citationdo Prado, F. C., Araldi, D., Vieira, A. S., Oliveira, M. C. G., Tambeli, C. H., & Parada, C. A. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.11.011 · Cited by 64 · see citing works
ATP and P2X Purinoceptors in Urinary Tract Disorders
Ford, A. P. D. W., & Cockayne, D. A. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-16499-6_22 · Cited by 63 · see citing works
Self-citationDifferential Expression and Pharmacology of Native P2X Receptors in Rat and Primate Sensory Neurons
Serrano, A., Mo, G., Grant, R., Paré, M., O’Donnell, D., Xiao, Y., Tomaszewski, M. J., Perkins, M., Séguéla, P., & Cao, C. Q. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0698-12.2012 · Cited by 60 · see citing works
Influence of antigen on membrane properties of guinea pig bronchial ganglion neurons
Myers, A. C., Undem, B. J., & Weinreich, D. M. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.71.3.970 · Cited by 58 · see citing works
Self-citationKamei, J., & Takahashi, Y. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.07.034 · Cited by 56 · see citing works
Haskell, C. M., Mendoza, E., Pisters, K. M. W., Fossella, F. V., & Figlin, R. A. (1998) · Investigational New Drugs · doi:10.1023/a:1006018610986 · Cited by 55 · see citing works
Jahangir, A. M., Alam, M., Carter, D. S., Dillon, M. P., Bois, D. J. D., Ford, A. P. D. W., Gever, J. R., Lin, C. J., Wagner, P. J., Zhai, Y., et al. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.01.097 · Cited by 52 · see citing works
Self-citationA role for ATP in bronchoconstriction‐induced activation of guinea pig vagal intrapulmonary C‐fibres
Weigand, L. A., Ford, A. P. D. W., & Undem, B. J. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.233460 · Cited by 50 · see citing works
Self-citationIdentification of algogenic substances in human erythrocytes.
Bleehen, T., Hobbiger, F., & Keele, C. A. (1976) · The Journal of Physiology · doi:10.1113/jphysiol.1976.sp011589 · Cited by 43 · see citing works
Gnanasekaran, A., Sundukova, M., van den Maagdenberg, A. M. J. M., Fabbretti, E., & Nistri, A. (2011) · Molecular Pain · doi:10.1186/1744-8069-7-77 · Cited by 36 · see citing works
Beijer, S., Gielisse, E. A. R., Hupperets, P. S. G. J., van den Borne, B. E. E. M., Everdingen, M. H. J. V. D. B.-V., Nijziel, M. R., van Henten, A. M. J., & Dagnelie, P. C. (2007) · Investigational New Drugs · doi:10.1007/s10637-007-9076-1 · Cited by 29 · see citing works
Yu, Y., & de Groat, W. C. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.018 · Cited by 28 · see citing works
Electrophysiological-anatomic correlates of ATP-triggered vagal reflex in dogs
Pelleg, A., Hurt, C. M., Soler-Baillo, J. M., & Polansky, M. (1993) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1993.265.2.h681 · Cited by 28 · see citing works
Transitional Cell Carcinoma of the Bladder in Children
Serrano-Durbá, C. D.-H. A. (1999) · Scandinavian Journal of Urology and Nephrology · doi:10.1080/003655999750016348 · Cited by 27 · see citing works
Cherkas, P. S., Dostrovsky, J. O., & Sessle, B. J. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.08.007 · Cited by 18 · see citing works
Gnanasekaran, A., Sundukova, M., Hullugundi, S. K., Birsa, N., Bianchini, G., Hsueh, Y., Nistri, A., & Fabbretti, E. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12272 · Cited by 17 · see citing works
A novel in vitro bladder pelvic nerve afferent model in the rat
Namasivayam, Eardley, & Morrison (1998) · British Journal of Urology · doi:10.1046/j.1464-410x.1998.00867.x · Cited by 17 · see citing works
P2X₃ Knock-Out Mice Reveal a Major Sensory Role for Urothelially Released ATP
Vlaskovska, M., Kasakov, L., Rong, W., Bodin, P., Bardini, M., Cockayne, D., Ford, A., & Burnstock, G. (2001) · UCL Discovery (University College London) · Cited by 14 · see citing works
Self-citationHurt, C. M., Wang, L., Xu, J., Sterious, W., & Pelleg, A. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.267.3.h1093 · Cited by 10 · see citing works
Ford, A. P. D. W., Smith, S. A., & Dillon, M. P. (2013) · The FASEB Journal · doi:10.1096/fasebj.27.1_supplement.887.5 · Cited by 9 · see citing works
Self-citationPurinergic Regulation of Airway Inflammation
Koeppen, M., Virgilio, F. D., Clambey, E. T., & Eltzschig, H. K. (2011) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-1217-1_7 · Cited by 8 · see citing works
P2X3 receptor: a novel ‘CASKade’ of signaling?
Volonté, C., & Burnstock, G. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12282 · Cited by 5 · see citing works
Fox, A. J., Barnes, P. J., Urbán, L., & Dray, A. (1993) · Neuropeptides · doi:10.1016/0143-4179(93)90115-q · Cited by 4 · see citing works
Smith, S. A., Black, D., Song, D., & Ford, A. P. D. W. (2013) · The FASEB Journal · doi:10.1096/fasebj.27.1_supplement.1103.3 · Cited by 2 · see citing works
Self-citationProperties of major classes of guinea pig bladder mechanoreceptors in vitro
Zagorodnyuk, V. P. (2007) · Autonomic Neuroscience · doi:10.1016/j.autneu.2007.06.090 · Cited by 1 · see citing works
Flagged first, then by citations
2 of the 92 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Abdulqawi R. Dockry R. Holt K. Woodcock A. Layton G. McCarthy B. (2013). Inhibition of ATP-gated P2X3 channels by AF-219: an effective anti-tussive mechanism in chronic cough. Proceedings of the European Respiratory Society Annual Congress, abstract 1965.
- Sun Q. Dong L. Zhang G. Ford A. P. Rong W. F. (2012). P2X3 receptor antagonism attenuates pelvic afferent discharge and visceromotor responses to urinary bladder distension in naïve and cyclophosphamide treated rats. Proceedings of 13th IASP World Congress of Pain, abstract 412.
Cited by
Sorted by citations
Atopic dermatitis: an expanding therapeutic pipeline for a complex disease
Bieber, T. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00266-6 · Cited by 623 · see citing works
Purinergic Signalling: Therapeutic Developments
Burnstock, G. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00661 · Cited by 401 · see citing works
Song, W., Hui, C., Hull, J. H., Birring, S. S., McGarvey, L. P., Mazzone, S. B., & Chung, K. F. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00125-9 · Cited by 376 · see citing works
Update of P2X receptor properties and their pharmacology: IUPHAR Review 30
Illés, P., Müller, C. E., Jacobson, K. A., Grütter, T., Nicke, A., Fountain, S. J., Kennedy, C., Schmalzing, G., Jarvis, M. F., Stojilković, S. S., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15299 · Cited by 315 · see citing works
Medicinal chemistry of adenosine, P2Y and P2X receptors
Jacobson, K. A., & Müller, C. E. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.12.001 · Cited by 262 · see citing works
Purinergic receptors in the carotid body as a new drug target for controlling hypertension
Pijacka, W., Moraes, D. J. A., Ratcliffe, L. E. K., Nightingale, A. K., Hart, E. C., da Silva, M. P., Machado, B. H., McBryde, F. D., Abdala, A. P., Ford, A. P. D. W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4173 · Cited by 192 · see citing works
Self-citationAntonioli, L., Blandizzi, C., Pacher, P., & Haskó, G. (2019) · Pharmacological Reviews · doi:10.1124/pr.117.014878 · Cited by 157 · see citing works
Morice, A. H., Kitt, M. M., Ford, A. P. D. W., Tershakovec, A. M., Wu, W., Brindle, K., Thompson, R., Thackray-Nocera, S., & Wright, C. (2019) · European Respiratory Journal · doi:10.1183/13993003.00439-2019 · Cited by 147 · see citing works
Self-citationDruggable negative allosteric site of P2X3 receptors
Wang, J. Q., Wang, Y., Cui, W.-W., Huang, Y., Yang, Y., Liu, Y., Zhao, W., Cheng, X., Sun, W.-S., Cao, P., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800907115 · Cited by 116 · see citing works
BLU-5937: A selective P2X3 antagonist with potent anti-tussive effect and no taste alteration
Garceau, D., & Chauret, N. (2019) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2019.03.007 · Cited by 99 · see citing works
Versatile spider venom peptides and their medical and agricultural applications
Saez, N. J., & Herzig, V. (2018) · Toxicon · doi:10.1016/j.toxicon.2018.11.298 · Cited by 95 · see citing works
Extracellular Nucleotides and P2 Receptors in Renal Function
Vallon, V., Unwin, R. J., Inscho, E. W., Leipziger, J., & Kishore, B. K. (2019) · Physiological Reviews · doi:10.1152/physrev.00038.2018 · Cited by 92 · see citing works
Richards, D., Gever, J. R., Ford, A. P. D. W., & Fountain, S. J. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14677 · Cited by 93 · see citing works
Self-citationLi, M., Wang, Y., Banerjee, R., Marinelli, F., Silberberg, S. D., Faraldo‐Gómez, J. D., Hattori, M., & Swartz, K. J. (2019) · eLife · doi:10.7554/elife.47060 · Cited by 63 · see citing works
Randomised trial of the P2X 3 receptor antagonist sivopixant for refractory chronic cough
Niimi, A., Saito, J., Kamei, T., Shinkai, M., Ishihara, H., Machida, M., & Miyazaki, S. (2021) · European Respiratory Journal · doi:10.1183/13993003.00725-2021 · Cited by 56 · see citing works
Insights into the channel gating of P2X receptors from structures, dynamics and small molecules
Wang, J. Q., & Yu, Y. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2015.127 · Cited by 53 · see citing works
Michel, M. C., Cardozo, L., Chermansky, C., Cruz, F., Igawa, Y., Lee, K., Sahai, A., Wein, A. J., & Andersson, K. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000523 · Cited by 53 · see citing works
Obrecht, A. S., Urban, N. D., Schaefer, M., Röse, A., Kless, A., Meents, J., Lampert, A., Abdelrahman, A., Müller, C. E., Schmalzing, G., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107749 · Cited by 49 · see citing works
Marucci, G., Ben, D. D., Buccioni, M., Navia, A. M., Spinaci, A., Volpini, R., & Lambertucci, C. (2019) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2019.1693542 · Cited by 44 · see citing works
Role of neurogenic inflammation in local communication in the visceral mucosa
Birder, L. A., & Kullmann, F. A. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0674-0 · Cited by 41 · see citing works
ATP-gated P2X receptors in health and disease
Burnstock, G., Nistri, A., Khakh, B. S., & Giniatullin, R. A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00204 · Cited by 40 · see citing works
Shrimanker, R., Choo, X. N., & Pavord, I. D. (2017) · Clinical Science · doi:10.1042/cs20160028 · Cited by 39 · see citing works
Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies
Shcherbatko, A., Foletti, D. L., Poulsen, K., Strop, P., Zhu, G., Hasa-Moreno, A., Witt, J. M., Loo, C., Krimm, S., Pios, A., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.722330 · Cited by 36 · see citing works
Adaptive study design to assess effect of TRPV4 inhibition in patients with chronic cough
Ludbrook, V. J., Hanrott, K., Kreindler, J. L., Marks-Kończalik, J., Bird, N., Hewens, D. A., Beerahee, M., Behm, D. J., Morice, A. H., McGarvey, L. P., et al. (2021) · ERJ Open Research · doi:10.1183/23120541.00269-2021 · Cited by 36 · see citing works
P2X3 receptors and sensitization of autonomic reflexes
Ford, A. P. D. W., Undem, B. J., Birder, L. A., Grundy, D., Pijacka, W., & Paton, J. F. R. (2015) · Autonomic Neuroscience · doi:10.1016/j.autneu.2015.04.005 · Cited by 34 · see citing works
Self-citationBirder, L. A., & Kerrebroeck, P. V. (2019) · Urology · doi:10.1016/j.urology.2019.07.020 · Cited by 34 · see citing works
Adriaensen, D., Brouns, I., & Timmermans, J. (2015) · Autonomic Neuroscience · doi:10.1016/j.autneu.2015.04.006 · Cited by 28 · see citing works
ATP, an attractive target for the treatment of refractory chronic cough
Zhang, M., Sykes, D. L., Sadofsky, L. R., & Morice, A. H. (2022) · Purinergic Signalling · doi:10.1007/s11302-022-09877-z · Cited by 27 · see citing works
From bench to bedside: The role of cough hypersensitivity in chronic cough
Drake, M. G., McGarvey, L. P., & Morice, A. H. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1343 · Cited by 26 · see citing works
Muñoz, A., Yazdi, I. K., Tang, X., Rivera, C., Taghipour, N., Grossman, R. G., Boone, T. B., & Tasciotti, E. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.12.017 · Cited by 26 · see citing works
Chronic cough: ATP, afferent pathways and hypersensitivity
Turner, R. D., & Birring, S. S. (2019) · European Respiratory Journal · doi:10.1183/13993003.00889-2019 · Cited by 26 · see citing works
P2X3 Receptor Ligands: Structural Features and Potential Therapeutic Applications
Spinaci, A., Buccioni, M., Ben, D. D., Marucci, G., Volpini, R., & Lambertucci, C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.653561 · Cited by 26 · see citing works
In Memoriam Geoffrey Burnstock: Creator of Purinergic Signaling
Verkhratsky, A., Zimmermann, H., Abbracchio, M. P., Illés, P., & Virgilio, F. D. (2020) · Function · doi:10.1093/function/zqaa006 · Cited by 26 · see citing works
Pharmacological Management of Urinary Incontinence: Current and Emerging Treatment
Gandi, C., & Sacco, E. (2021) · Clinical Pharmacology Advances and Applications · doi:10.2147/cpaa.s289323 · Cited by 24 · see citing works
Purinergic receptors modulators: An emerging pharmacological tool for disease management
Mahmood, A., & Iqbal, J. (2022) · Medicinal Research Reviews · doi:10.1002/med.21888 · Cited by 24 · see citing works
Chung, K. F. (2017) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2017.02.003 · Cited by 24 · see citing works
The Cough Reflex: The Janus of Respiratory Medicine
Sykes, D. L., & Morice, A. H. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.684080 · Cited by 26 · see citing works
Friedrich, C., Francke, K., Gashaw, I., Scheerans, C., Klein, S., Fels, L. M., Smith, J. A., Hummel, T. R., & Morice, A. H. (2022) · Clinical Pharmacokinetics · doi:10.1007/s40262-022-01126-1 · Cited by 23 · see citing works
Overview of the role of purinergic signaling and insights into its role in cancer therapy
Virgilio, F. D., Vultaggio-Poma, V., Tarantini, M., & Giuliani, A. L. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108700 · Cited by 22 · see citing works
Chung, K. F., Canning, B. J., & McGarvey, L. P. (2015) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2015.08.009 · Cited by 22 · see citing works
Ferguson, A. C., Sutton, B., Boone, T. B., Ford, A. P. D. W., & Muñoz, A. (2014) · British Journal of Urology · doi:10.1111/bju.13003 · Cited by 21 · see citing works
Self-citationMethods for assessing cough sensitivity
Mai, Y., Fang, L., Zhong, S., de Silva, S. D. S. H., Chen, R., & Lai, K. (2020) · Journal of Thoracic Disease · doi:10.21037/jtd-2020-icc-005 · Cited by 20 · see citing works
The discovery and development of gefapixant
Ford, A. P. D. W., Dillon, M. P., Kitt, M. M., & Gever, J. R. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102859 · Cited by 20 · see citing works
Self-citationSalazar, B., Hoffman, K. A., Zhang, C., Zhang, Y., Cruz, Y., Boone, T. B., & Muñoz, A. (2018) · British Journal of Urology · doi:10.1111/bju.14561 · Cited by 19 · see citing works
The role of ATP in cough hypersensitivity syndrome: new targets for treatment
Zhang, M., Wang, S., Yu, L., Xu, X., & Qiu, Z. (2020) · Journal of Thoracic Disease · doi:10.21037/jtd-20-cough-001 · Cited by 19 · see citing works
Kim, G., Kim, S., Kim, Y. O., Han, X., Nagel, J., Kim, J., Song, D. I., Müller, C. E., Yoon, M. H., Jin, M. S., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01214 · Cited by 18 · see citing works
High, B. A., Jetté, M. E., Li, M., Ramakrishnan, V. R., Clary, M. S., Prager, J. D., Draf, J., Hummel, T. R., & Finger, T. E. (2023) · ERJ Open Research · doi:10.1183/23120541.00007-2023 · Cited by 17 · see citing works
Taidi, Z., Mansfield, K. J., Bates, L. J., Sana-Ur-Rehman, H., & Liu, L. (2019) · Bladder · doi:10.14440/bladder.2019.789 · Cited by 16 · see citing works
Silva‐Ramos, M., da Silva, I. C. B., Faria, M., Ferreirinha, F., & Correia‐de‐Sá, P. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.261610 · Cited by 15 · see citing works
The Prospect for Potent Sodium Voltage-Gated Channel Blockers to Relieve an Excessive Cough
Brozmanová, M., & Pavelková, N. (2020) · Physiological Research · doi:10.33549/physiolres.934395 · Cited by 14 · see citing works
Nimbalkar, S., Guo, X., Colón, A., Jackson, M., Akanda, N., Patel, A. M., Grillo, M., & Hickman, J. J. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1011145 · Cited by 13 · see citing works
The search for the hypersensitivity in chronic cough
Birring, S. S. (2017) · European Respiratory Journal · doi:10.1183/13993003.00082-2017 · Cited by 13 · see citing works
Bibič, L., Herzig, V., King, G. F., & Stokes, L. (2019) · Journal of Natural Products · doi:10.1021/acs.jnatprod.9b00410 · Cited by 12 · see citing works
Mechanistic insights into the selective targeting of P2X3 receptor by camlipixant antagonist
Thach, T. T., Dhanabalan, K., Nandekar, P. P., Stauffer, S., Heisler, I., Alvarado, S. K., Snyder, J. R., & Ramaswamy, S. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.108109 · Cited by 11 · see citing works
Centipede Venom: A Potential Source of Ion Channel Modulators
Luo, A., Wang, A., Kamau, P. M., Lai, R., & Luo, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137105 · Cited by 11 · see citing works
Drug therapy of overactive bladder - What is coming next?
Andersson, K. (2015) · Korean journal of urology · doi:10.4111/kju.2015.56.10.673 · Cited by 11 · see citing works
Zarei, M., Vaighan, N. S., & Ziai, S. A. (2021) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2021.1988102 · Cited by 10 · see citing works
Potential applications of P2X3 receptor antagonists in the treatment of refractory cough
Yi, B., Wang, S., Li, W., Xu, X., & Yu, L. (2023) · Respiratory Medicine · doi:10.1016/j.rmed.2023.107336 · Cited by 10 · see citing works
Geoffery Burnstock’s influence on the evolution of P2X3 receptor pharmacology
Jarvis, M. F. (2020) · Purinergic Signalling · doi:10.1007/s11302-020-09744-9 · Cited by 9 · see citing works
Song, Y., Hou, J., Kwok, J. S. L., Weng, H., Tang, M. F., Wang, M. H., Leung, A. S. Y., Tao, K. P., Wong, G., Chan, R. W. Y., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.792556 · Cited by 9 · see citing works
Deficiency of purinergic P2X4 receptor alleviates experimental autoimmune hepatitis in mice
Liu, Z., Sun, M., Liu, W., Feng, F., Li, X., Jin, C., Zhang, Y., & Wang, J. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116033 · Cited by 8 · see citing works
Purinergic signaling during Marek’s disease in chickens
Akbar, H., Fasick, J. J., Ponnuraj, N., & Jarosinski, K. W. (2023) · Scientific Reports · doi:10.1038/s41598-023-29210-x · Cited by 7 · see citing works
Francke, K., Baumann, S., Gashaw, I., Klein, S., Rohde, B., Zolk, O., Fischer, O. M., & Friedrich, C. (2025) · Pharmaceuticals · doi:10.3390/ph18050758 · Cited by 5 · see citing works
Population pharmacokinetic analysis of the P2X3‐receptor antagonist gefapixant
Chawla, A., Largajolli, A., Hussain, A., Kleijn, H. J., Ait‐Oudhia, S., Antón, J. C., Ananthula, H. K., Nussbaum, J. C., Rosa, C. L., & Gheyas, F. (2023) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12978 · Cited by 5 · see citing works
New P2X3 receptor antagonists. Part 2: Identification and SAR of quinazolinones
Szántó, G., Makó, A., Vágó, I., Hergert, T., Bata, I., Farkas, B., Kolok, S., & Vastag, M. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.07.013 · Cited by 5 · see citing works
Why do asthma patients cough? New insights into cough in allergic asthma
Puebla-Neira, D., & Calhoun, W. J. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.06.030 · Cited by 5 · see citing works
Birder, L. A., Wolf‐Johnston, A., Ritov, V. B., Stern, J. N. H., Moldwin, R., Kuo, H., & Jackson, E. K. (2024) · Scientific Reports · doi:10.1038/s41598-024-73280-4 · Cited by 4 · see citing works
Therapeutic advances for treatment-resistant cough
Belvisi, M. G. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61740-2 · Cited by 4 · see citing works
Stephan, G., Kowalski-Jahn, M., Zens, C., Schmalzing, G., Illés, P., & Hausmann, R. (2016) · Purinergic Signalling · doi:10.1007/s11302-016-9496-5 · Cited by 4 · see citing works
Incidence and Prevalence of Cough in a Rural Health System: A 20‐Year Study
Altman, K. W., Young, A. J., Gupta, M., Pichardo, P. F. A., Troup, M. A., & Blank, J. (2022) · The Laryngoscope · doi:10.1002/lary.30359 · Cited by 4 · see citing works
Bladder/Pelvic Pain and Neurogenic Inflammation
Birder, L. A. (2019) · Neurourology · doi:10.1007/978-94-017-7509-0_54 · Cited by 3 · see citing works
Purinergic P2X Receptors as Therapeutic Targets
Stokes, L., Bidula, S. M., & Sluyter, R. (2024) · Springer eBooks · doi:10.1007/978-3-031-52197-3_13 · Cited by 2 · see citing works
Zang, Y., Li, Q., Li, Y., Ding, X., Liu, R., Liu, L., Sun, H., Qu, L., & Zhang, X. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118116 · Cited by 2 · see citing works
Borselle, D., Kaczorowski, M., Gogolok, B., Patkowski, D., Polok, M., Hałoń, A., & Apoznański, W. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13072109 · Cited by 2 · see citing works
Friedrich, C., Singh, D., Francke, K., Klein, S., Hetzel, T., Zolk, O., Gashaw, I., Scheerans, C., & Morice, A. H. (2024) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.16091 · Cited by 2 · see citing works
Cough Hypersensitivity Syndrome – A Major Advance in the Understanding of Chronic Cough
Chung, K. F. (2018) · European Respiratory & Pulmonary Diseases · doi:10.17925/erpd.2018.4.1.19 · Cited by 1 · see citing works
Cheng, X., Zhang, W., Che, T., Guo, H., Nan, W., Zhang, Y., Fu, Y., Wan, S., & Zhang, J. (2026) · Science Advances · doi:10.1126/sciadv.aea9268 · Cited by 1 · see citing works
Thirumalai, J., Sivakumar, I., & Sekaran, S. (2026) · Purinergic Signalling · doi:10.1007/s11302-026-10172-4 · Cited by 1 · see citing works
Puerarin inhibits acute nociceptive responses via the P2X3 receptor in rat dorsal root ganglia
Xu, C., Fan, S. Y. B., Shuangmei, L., Huangui, X., Gao, G. L. Y., Xu, H., Xiaoli, T., Zhu, Q., Zheng, C., Bing, W., et al. (2014) · African Journal of Pharmacy and Pharmacology · doi:10.5897/ajpp2013.3977 · Cited by 1 · see citing works
Çarıkçı, İ. H. (2016) · Ayrıntı Dergisi · Cited by 1 · see citing works
ATP-gated P2X receptors in health and disease
(2015) · Frontiers research topics · doi:10.3389/978-2-88919-405-6 · Cited by 1 · see citing works
Future Considerations in Overactive Bladder Pharmacotherapy
Andersson, K. (2018) · Springer eBooks · doi:10.1007/978-3-319-97265-7_13 · Cited by 1 · see citing works
A Second Drug Binding Site in P2X3Preprint
Thach, T. T., Dhanabalan, K., Nandekar, P. P., Stauffer, S., Heisler, I., Alvarado, S. K., Snyder, J. R., & Ramaswamy, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.10.598171 · Cited by 1 · see citing works
Emerging Drugs for Chronic Cough
Lavorini, F., Bernacchi, G., & Fabbrizzi, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-48571-9_13
Zhang, C., Li, X., Boone, T. B., Cruz, Y., Zhang, Y., & Muñoz, A. (2020) · International Neurourology Journal · doi:10.5213/inj.2040114.057
Dempsey, J. A. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726713713.793561223
Pain Bladder/Pelvic Pain and Neurogenic Inflammation
Birder, L. A. (2023) · Springer eBooks · doi:10.1007/978-981-16-7939-1_54-1
Pain Bladder/Pelvic Pain and Neurogenic Inflammation
Birder, L. A. (2023) · Springer eBooks · doi:10.1007/978-981-99-1659-7_54
何, 星. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.13112442
Akbar, H., & Jarosinski, K. W. (2024) · Viruses · doi:10.3390/v16071130 · Cited by 1 · see citing works
Discovery of the P2x3 Antagonist Hw091077 for the Treatment of Chronic CoughPreprint
Zang, Y., Li, Q., Li, Y., Ding, X., Liu, L., Sun, H., Qu, L., & Zhang, X. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5357548
Extracellular ATP and the normal respiratory system
Willcox, A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30250-3.00006-0
Targeting P2X receptors for analgesia: Small molecule antagonists in development
He, Z., Huang, X., He, F., huang, Y., Liao, N., Zhang, G., Zhuang, T., Yu, Z., & Xiong, J. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.119150
An, Y.-T., Shu-ze, T., Luo, Y., Huang, L., & Deng, X. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1911091
- Authors
- Ford, A. P., & Undem, B. J.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Ford, Anthony P.
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 7
- Pages
- 267-267
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC3867694
- OpenAlex
- W2063388276
- Cited by
- 95
- References
- 92
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 10 · 2023: 10 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 16 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 6 · 2014: 4
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- P2X3 receptor antagonist, ATP, primary afferent neurons, visceral pain, chronic pain, urological diseases, respiratory diseases, C-fibers, visceral reflexes, autonomic reflexes, descending inhibition, wind-up, sensory sensitization, airway hyperresponsiveness, bladder dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
