The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Fractalkine regulation of microglial physiology and consequences on the brain and behavior
Open accessAbstract
Neural circuits are constantly monitored and supported by the surrounding microglial cells, using finely tuned mechanisms which include both direct contact and release of soluble factors. These bidirectional interactions are not only triggered by pathological conditions as a S.O.S. response to noxious stimuli, but they rather represent an established repertoire of dynamic communication for ensuring continuous immune surveillance and homeostasis in the healthy brain. In addition, recent studies are revealing key tasks for microglial interactions with neurons during normal physiological conditions, especially in regulating the maturation of neural circuits and shaping their connectivity in an activity- and experience-dependent manner. Chemokines, a family of soluble and membrane-bound cytokines, play an essential role in mediating neuron-microglia crosstalk in the developing and mature brain. As part of this special issue on Cytokines as players of neuronal plasticity and sensitivity to environment in healthy and pathological brain, our review focuses on the fractalkine signaling pathway, involving the ligand CX3CL1 which is mainly expressed by neurons, and its receptor CX3CR1 that is exclusively found on microglia within the healthy brain. An extensive literature largely based on transgenic mouse models has revealed that fractalkine signaling plays a critical role in regulating a broad spectrum of microglial properties during normal physiological conditions, especially their migration and dynamic surveillance of the brain parenchyma, in addition to influencing the survival of developing neurons, the maturation, activity and plasticity of developing and mature synapses, the brain functional connectivity, adult hippocampal neurogenesis, as well as learning and memory, and the behavioral outcome.
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Cites
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
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Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
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Self-citationMicroglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
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Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis
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Self-citationMicroglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
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Self-citationThe role of microglia and macrophages in glioma maintenance and progression
Hambardzumyan, D., Gutmann, D. H., & Kettenmann, H. (2016) · Nature Neuroscience · doi:10.1038/nn.4185 · Cited by 1,683
Modulators of microglial activation and polarization after intracerebral haemorrhage
Lan, X., Han, X., Li, Q., Yang, Q.-W., & Wang, J. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.69 · Cited by 915
Neuroinflammation as a common feature of neurodegenerative disorders
Guzman-Martinez, L., Maccioni, R. B., Andrade, V., Navarrete, L. P., Pastor, M. G., & Ramos-Escobar, N. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01008 · Cited by 702
Inefficient clearance of myelin debris by microglia impairs remyelinating processes
Lampron, A., Larochelle, A., Laflamme, N., Préfontaine, P., Plante, M.-M., Sánchez, M. G., Yong, V. W., Stys, P. K., Tremblay, M.-È., & Rivest, S. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20141656 · Cited by 595
Metadata
- Authors
- Paolicelli, R. C., Bisht, K., & Tremblay, M.-Ã.
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2014-05-13
- Volume
- 8
- Pages
- 129-129
- ISSN
- 1662-5102 (ISSN-L)
- OpenAlex
- W2151241903
- Cited by
- 318
- References
- 26
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
