The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Versatility of the complement system in neuroinflammation, neurodegeneration and brain homeostasis
Open accessAbstract
The immune response after brain injury is highly complex and involves both local and systemic events at the cellular and molecular level. It is associated to a dramatic over-activation of enzyme systems, the expression of proinflammatory genes and the activation/recruitment of immune cells. The complement system represents a powerful component of the innate immunity and is highly involved in the inflammatory response. Complement components are synthesized predominantly by the liver and circulate in the bloodstream primed for activation. Moreover, brain cells can produce complement proteins and receptors. After acute brain injury, the rapid and uncontrolled activation of the complement leads to massive release of inflammatory anaphylatoxins, recruitment of cells to the injury site, phagocytosis and induction of blood brain barrier (BBB) damage. Brain endothelial cells are particularly susceptible to complement-mediated effects, since they are exposed to both circulating and locally synthesized complement proteins. Conversely, during neurodegenerative disorders, complement factors play distinct roles depending on the stage and degree of neuropathology. In addition to the deleterious role of the complement, increasing evidence suggest that it may also play a role in normal nervous system development (wiring the brain) and adulthood (either maintaining brain homeostasis or supporting regeneration after brain injury). This article represents a compendium of the current knowledge on the complement role in the brain, prompting a novel view that complement activation can result in either protective or detrimental effects in brain conditions that depend exquisitely on the nature, the timing and the degree of the stimuli that induce its activation. A deeper understanding of the acute, subacute and chronic consequences of complement activation is needed and may lead to new therapeutic strategies, including the ability of targeting selective step in the complement cascade.
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Citations
Cites
1 retracted
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RetractedMicroglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
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Complement: a key system for immune surveillance and homeostasis
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“The complement system also comprises a wide array of specific receptors for complement proteins by which the system induces phagocytosis and triggers the inflammatory response via direct communication with immune cells (Ricklin et al., 2010).”
BackgroundInfluentialFunctional requirement for class I MHC in CNS development and plasticity
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A Dramatic Increase of C1q Protein in the CNS during Normal Aging
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Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death
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Cited by
Dash, U. C., Bhol, N. K., Swain, S. K., Samal, R. R., Nayak, P. K., Raina, V., Panda, S. K., Kerry, R. G., Duttaroy, A. K., & Jena, A. B. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.10.004 · Cited by 700
Lian, H., Litvinchuk, A., Chiang, A. C.-A., Aithmitti, N., Jankowsky, J. L., & Zheng, H. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2117-15.2016 · Cited by 597
Webers, A., Heneka, M. T., & Gleeson, P. A. (2020) · Immunology & Cell Biology · doi:10.1111/imcb.12301 · Cited by 367
Immune Signaling in Neurodegeneration
Hammond, T. R., Marsh, S. E., & Stevens, B. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.016 · Cited by 336
Zhang, Q., Ma, C., Gearing, M., Wang, P. G., Chin, L.-S., & Li, L. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0524-2 · Cited by 165
Metadata
- Authors
- Orsini, F., De Blasio, D., Zangari, R., Zanier, E. R., & De Simoni, M.-G.
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2014-11-07
- Volume
- 8
- Pages
- 380-380
- ISSN
- 1662-5102 (ISSN-L)
- OpenAlex
- W2158443724
- Cited by
- 201
- References
- 18
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- gold
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- Orsini, F., De Blasio, D., Zangari, R., Zanier, E. R., & De Simoni, M.-G. (2014). Versatility of the complement system in neuroinflammation, neurodegeneration and brain homeostasis. Frontiers in Cellular Neuroscience. https://doi.org/10.3389/fncel.2014.00380
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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