The DOI matches its Crossref record; 207 of the 207 references it cites were found in a registry or an index.
Neuroinflammation after intracerebral hemorrhage
Open accessAbstract
Spontaneous intracerebral hemorrhage (ICH) is a particularly severe type of stroke for which no specific treatment has been established yet. Although preclinical models of ICH have substantial methodological limitations, important insight into the pathophysiology has been gained. Mounting evidence suggests an important contribution of inflammatory mechanisms to brain damage and potential repair. Neuroinflammation evoked by intracerebral blood involves the activation of resident microglia, the infiltration of systemic immune cells and the production of cytokines, chemokines, extracellular proteases and reactive oxygen species (ROS). Previous studies focused on innate immunity including microglia, monocytes and granulocytes. More recently, the role of adaptive immune cells has received increasing attention. Little is currently known about the interactions among different immune cell populations in the setting of ICH. Nevertheless, immunomodulatory strategies are already being explored in ICH. To improve the chances of translation from preclinical models to patients, a better characterization of the neuroinflammation in patients is desirable.
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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
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“Risk factors for ICH include genetic variants of apolipoprotein E, ethnic differences and life style factors such as smoking and alcohol intake (O’Donnell et al., 2010).”
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Cited by
Global brain inflammation in stroke
Shi, K., Tian, D.-C., Li, Z.-G., Ducruet, A. F., Lawton, M. T., & Shi, F.-D. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30078-x · Cited by 911
Neuroinflammation after Intracerebral Hemorrhage and Potential Therapeutic Targets
Tschoe, C., Bushnell, C. D., Duncan, P. W., Alexander-Miller, M. A., & Wolfe, S. Q. (2020) · Journal of Stroke · doi:10.5853/jos.2019.02236 · Cited by 490
Depletion of microglia exacerbates postischemic inflammation and brain injury
Jin, W.-N., Shi, S. X.-Y., Li, Z., Li, M., Wood, K., Gonzales, R. J., & Liu, Q. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17694185 · Cited by 351
Intracerebral hemorrhage: an update on diagnosis and treatment
Hostettler, I. C., Seiffge, D. J., & Werring, D. J. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1623671 · Cited by 341
Zeng, J., Chen, Y., Ding, R., Feng, L., Fu, Z., Yang, S., Deng, X., Xie, Z., & Zheng, S. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0895-5 · Cited by 319
Metadata
- Authors
- Mracsko, E., & Veltkamp, R.
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2014-11-20
- Volume
- 8
- Pages
- 388-388
- ISSN
- 1662-5102 (ISSN-L)
- OpenAlex
- W2166034362
- Cited by
- 344
- References
- 207
- FWCI
- 12.22
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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