Neuroactive Steroids and GABAergic Involvement in the Neuroendocrine Dysfunction Associated With Major Depressive Disorder and Postpartum Depression

Neural regulation of endocrine and autonomic stress responses

Ulrich-Lai, Y. M., & Herman, J. P. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2647 · Cited by 3,318

Stress and Depression

Hammen, C. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143938 · Cited by 2,979

From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.

Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206

Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors

Farrant, M., & Nusser, Z. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1625 · Cited by 2,081

The HPA axis in major depression: classical theories and new developments

Pariante, C. M., & Lightman, S. L. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.006 · Cited by 2,009

Antenatal risk factors for postpartum depression: a synthesis of recent literature

Robertson, E., Grace, S., Wallington, T., & Stewart, D. E. (2004) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2004.02.006 · Cited by 1,886

Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo–pituitary–adrenocortical responsiveness

Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586

Sex differences in anxiety and depression clinical perspectives

Altemus, M., Sarvaiya, N., & Neill Epperson, C. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.05.004 · Cited by 1,413

Neuroactive steroids

Paul, S. M., & Purdy, R. H. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.6.1347506 · Cited by 1,413

GABAA receptors: immunocytochemical distribution of 13 subunits in the adult rat brain

Pirker, S., Schwarzer, C., Wieselthaler, A., Sieghart, W., & Sperk, G. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00442-5 · Cited by 1,344

Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond

Zorumski, C. F., Paul, S. M., Covey, D. F., & Mennerick, S. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100196 · Cited by 305

Effect of Zuranolone vs Placebo in Postpartum Depression

Deligiannidis, K. M., Meltzer-Brody, S., Gunduz-Bruce, H., Doherty, J., Jonas, J., Li, S., Sankoh, A. J., Silber, C., Campbell, A. D., Werneburg, B., et al. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.1559 · Cited by 277

Brexanolone for postpartum depression: A meta-analysis of randomized controlled studies

Zheng, W., Cai, D.-B., Zheng, W., Sim, K., Ungvari, G. S., Peng, X.-J., Ning, Y., Wang, G., & Xiang, Y. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.07.006 · Cited by 223

Neuroprotective Potentials of Flavonoids: Experimental Studies and Mechanisms of Action

Bellavite, P. (2023) · Antioxidants · doi:10.3390/antiox12020280 · Cited by 235

Progesterone – Friend or foe?

Poromaa, I. S., Comasco, E., Sumner, R. L., & Eileen Luders, A. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100856 · Cited by 217

Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder

Cutler, A. J., Mattingly, G. W., & Maletic, V. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02514-2 · Cited by 156

The role of the hypothalamic-pituitary-adrenal axis in depression across the female reproductive lifecycle: current knowledge and future directions

Hantsoo, L. V., Jagodnik, K. M., Novick, A. M., Baweja, R., di Scalea, T. L., Özerdem, A., McGlade, E., Simeonova, D. I., Dekel, S., Kornfield, S. L., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1295261 · Cited by 175

Allopregnanolone in postpartum depression: Role in pathophysiology and treatment

Meltzer-Brody, S. E., & Kanes, S. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100212 · Cited by 141

Is Postpartum Depression Different From Depression Occurring Outside of the Perinatal Period? A Review of the Evidence

Batt, M. M., Duffy, K. A., Novick, A. M., Metcalf, C. A., & Epperson, C. N. (2020) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20190045 · Cited by 157

Steroid Hormone Sensitivity in Reproductive Mood Disorders: On the Role of the GABAA Receptor Complex and Stress During Hormonal Transitions

Schweizer-Schubert, S., Gordon, J. L., Eisenlohr-Moul, T. A., Meltzer-Brody, S. E., Schmalenberger, K. M., Słopień, R., Zietlow, A., Ehlert, U., & Ditzen, B. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2020.479646 · Cited by 125

Allopregnanolone: An overview on its synthesis and effects

Diviccaro, S., Cioffi, L., Falvo, E., Giatti, S., & Melcangi, R. C. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12996 · Cited by 119

Sex, stress and steroids

Sze, Y., & Brunton, P. J. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14615 · Cited by 85

Stress, mood, and cortisol during daily life in women with Premenstrual Dysphoric Disorder (PMDD)

Beddig, T., Reinhard, I., & Kuehner, C. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104372 · Cited by 85

Dietary prebiotics alter novel microbial dependent fecal metabolites that improve sleep

Thompson, R. S., Vargas, F., Dorrestein, P. C., Chichlowski, M., Berg, B. M., & Fleshner, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-60679-y · Cited by 70

Stress-Induced Morphological, Cellular and Molecular Changes in the Brain—Lessons Learned from the Chronic Mild Stress Model of Depression

Khan, A. R., Geiger, L., Wiborg, O., & Czéh, B. (2020) · Cells · doi:10.3390/cells9041026 · Cited by 65

Contraception counseling for women with premenstrual dysphoric disorder (PMDD): current perspectives

Rapkin, A. J., Korotkaya, Y., & Taylor, K. C. (2019) · Open Access Journal of Contraception · doi:10.2147/oajc.s183193 · Cited by 66

Pregnancy, postpartum and parity: Resilience and vulnerability in brain health and disease

Deems, N. P., & Leuner, B. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100820 · Cited by 67

Sex differences in stress-related disorders: Major depressive disorder, bipolar disorder, and posttraumatic stress disorder

Swaab, D. F., & Bao, A. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64123-6.00023-0 · Cited by 57

Neurosteroids and Neurotrophic Factors: What Is Their Promise as Biomarkers for Major Depression and PTSD?

Almeida, F. B., Barros, H. M. T., & Pinna, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041758 · Cited by 57

Sex differences in steroid levels and steroidogenesis in the nervous system: Physiopathological role

Giatti, S., Diviccaro, S., Serafini, M. M., Caruso, D., García‐Segura, L. M., Viviani, B., & Melcangi, R. C. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100804 · Cited by 60

GABA System in Depression: Impact on Pathophysiology and Psychopharmacology

Vecchia, A. D., Arone, A., Piccinni, A., Mucci, F., & Marazziti, D. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666211115124149 · Cited by 55

Chronic Stress in a Rat Model of Depression Disturbs the Glutamine–Glutamate–GABA Cycle in the Striatum, Hippocampus, and Cerebellum

Xu, S., Liu, Y., Pu, J., Gui, S., Zhong, X., Tian, L., Song, X., Qi, X., Wang, H., & Xie, P. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s245282 · Cited by 50

Neurosteroid replacement therapy for catamenial epilepsy, postpartum depression and neuroendocrine disorders in women

Reddy, D. S. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13028 · Cited by 46

Progesterone and Its Metabolites Play a Beneficial Role in Affect Regulation in the Female Brain

Stefaniak, M., Dmoch–Gajzlerska, E., Jankowska, K. K., Rogowski, A., Kajdy, A., & Maksym, R. (2023) · Pharmaceuticals · doi:10.3390/ph16040520 · Cited by 51

Stress and drug abuse-related disorders: The promising therapeutic value of neurosteroids focus on pregnenolone-progesterone-allopregnanolone pathway

Tomaselli, G., & Vallée, M. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100789 · Cited by 41

Extrasynaptic δ-subunit containing GABAA receptors

Arslan, A. (2021) · Journal of Integrative Neuroscience · doi:10.31083/j.jin.2021.01.284 · Cited by 36

Zuranolone – synthetic neurosteroid in treatment of mental disorders: narrative review

Marecki, R., Kałuska, J., Kolanek, A., Hakało, D., & Waszkiewicz, N. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1298359 · Cited by 34

Microbial gamma-aminobutyric acid synthesis: a promising approach for functional food and pharmaceutical applications

Fashogbon, R. O., Samson, O. J., Awotundun, T. A., Olanbiwoninu, A. A., & Adebayo‐Tayo, B. C. (2024) · Letters in Applied Microbiology · doi:10.1093/lambio/ovae122 · Cited by 37

Neuroendocrine Effects of Lactation and Hormone-Gene-Environment Interactions

Gust, K. M., Caccese, C., Larosa, A., & Nguyen, T. (2020) · Molecular Neurobiology · doi:10.1007/s12035-019-01855-8 · Cited by 40

Review of psychological stress on oocyte and early embryonic development in female mice

Zhai, Q., Wang, J., Tian, Y., Liu, X., & Song, Z. (2020) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-020-00657-1 · Cited by 37

Relating neurosteroid modulation of inhibitory neurotransmission to behaviour

Belelli, D., Phillips, G., Atack, J. R., & Lambert, J. J. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13045 · Cited by 32

Causal mechanisms of postnatal depression among women in Gondar town, Ethiopia: application of a stress-process model with generalized structural equation modeling

Dadi, A. F., Mwanri, L., Woodman, R. J., Azale, T., & Miller, E. R. (2020) · Reproductive Health · doi:10.1186/s12978-020-00912-z · Cited by 31

Physiopathological role of the enzymatic complex 5α-reductase and 3α/β-hydroxysteroid oxidoreductase in the generation of progesterone and testosterone neuroactive metabolites

Giatti, S., Diviccaro, S., Falvo, E., García‐Segura, L. M., & Melcangi, R. C. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100836 · Cited by 33

New directions in neurosteroid therapeutics in neuropsychiatry

Zorumski, C. F., Covey, D. F., Izumi, Y., Evers, A. S., Maguire, J. L., & Mennerick, S. J. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106119 · Cited by 27

Antidepressant mechanism of classical herbal formula lily bulb and Rehmannia decoction: insights from gene expression profile of medial prefrontal cortex of mice with stress‐induced depression‐like behavior

Zhang, H., Chi, X., Pan, W., Wang, S., Zhang, Z., Zhao, H., Wang, Y., Wu, Z., Zhou, M., Ma, S., et al. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12649 · Cited by 25

The relationship of olfactory function and clinical traits in major depressive disorder

Wang, F., Wu, X., Gao, J., Li, Y., Zhu, Y., & Fang, Y. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112594 · Cited by 28

Novel targets for parkinsonism-depression comorbidity

Tizabi, Y., Getachew, B., Csoka, A. B., Manaye, K. F., & Copeland, R. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.06.004 · Cited by 25

Anxiolytic and Anti-depressive Like Effects of Translocator Protein (18 kDa) Ligand YL-IPA08 in a Rat Model of Postpartum Depression

Ren, P., Ma, L., Wang, J.-Y., Guo, H., Sun, L. J., Gao, M., Liu, Y., Ma, Y., Li, Y., & Guo, W.-Z. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03036-9 · Cited by 25

GABA system as the cause and effect in early development

Topchiy, I., Mohbat, J., Folorunso, O. O., Wang, Z., Lazcano-Etchebarne, C., & Engin, E. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105651 · Cited by 26

Number Needed to Treat and Number Needed to Harm analysis of the zuranolone phase 2 clinical trial results in major depressive disorder

Arnaud, A. M., Suthoff, E. D., Stenson, K., WERNEBURG, B. G., Hodgkins, P., Bonthapally, V., Jonas, J. M., Meyer, K. L., & O’Day, K. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.02.027 · Cited by 22

Efficacy and safety of zuranolone for the treatment of depression: A systematic review and meta-analysis

Li, Z., Wu, Q., Peng, P., Wu, M., Liu, S., & Liu, T. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115640 · Cited by 21

Regulation of GABAA Receptors Induced by the Activation of L-Type Voltage-Gated Calcium Channels

Gravielle, M. C. (2021) · Membranes · doi:10.3390/membranes11070486 · Cited by 21

The immediate and maintained effects of neurosteroids on GABAA receptors

Belelli, D., Peters, J. A., Phillips, G., & Lambert, J. J. (2022) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2022.100333 · Cited by 21

Medical and neurobehavioural phenotypes in male and female carriers of Xp22.31 duplications in the UK Biobank

Gubb, S., Brcic, L., Underwood, J. F. G., Kendall, K. M., Caseras, X., Kirov, G., & Davies, W. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa174 · Cited by 19

Effects of prenatal stress on neuroactive steroid responses to acute stress in adult male and female rats

Sze, Y., & Brunton, P. J. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12916 · Cited by 18

The Role of Extrasynaptic GABA Receptors in Postpartum Depression

Feng, Y. F., Zhou, Y., & Duan, K. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03574-7 · Cited by 20

Altered dynamic amplitude of low-frequency fluctuations in patients with postpartum depression

Dong, F., Zhang, Z., Chu, T., Che, K., Li, Y., Gai, Q., Shi, Y., Ma, H., Zhao, F., Mao, N., et al. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113980 · Cited by 17

The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice

Xu, F.-R., Wei, Z., Xu, X.-X., Zhang, X., Wei, C., Qi, X., Li, Y., Gao, X., & Wu, Y. H. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02976-7 · Cited by 16

Effects of paroxetine treatment and its withdrawal on neurosteroidogenesis

Giatti, S., Diviccaro, S., Cioffi, L., Falvo, E., Caruso, D., & Melcangi, R. C. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105364 · Cited by 16

Preventing Phosphorylation of the GABAAR β3 Subunit Compromises the Behavioral Effects of Neuroactive Steroids

Vien, T. N., Ackley, M. A., Doherty, J., Moss, S. J., & Davies, P. A. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.817996 · Cited by 13

Restoring Wnt signaling in a hormone-simulated postpartum depression model remediated imbalanced neurotransmission and depressive-like behaviors

Ye, B., Yuan, Y., Liu, R., Zhou, H., Li, Y., Sheng, Z., Li, T., Zhang, B., Xu, Z., Liu, Z., et al. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00697-4 · Cited by 12

Neuroactive steroid biosynthesis during pregnancy predicts future postpartum depression: a role for the 3α and/or 3β-HSD neurosteroidogenic enzymes?

Osborne, L. M., Etyemez, S., Pinna, G., Alemani, R., Standeven, L. R., Wang, X., & Payne, J. L. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02052-z · Cited by 11

Approche GABAergique de la dépression du post-partum : une revue critique translationnelle

Verbe, J., Dubertret, C., El‐Hage, W., Bonnet‐Brilhault, F., & Duriez, P. (2019) · L Encéphale · doi:10.1016/j.encep.2019.09.007 · Cited by 10

Kétamine, psilocybine, et antidépresseurs d'action rapide : de nouvelles promesses pour la psychiatrie?

Bottemanne, H., Claret, A., & Fossati, P. (2020) · L Encéphale · doi:10.1016/j.encep.2020.08.006 · Cited by 12

Brexanolone, zuranolone and related neurosteroid GABA A receptor positive allosteric modulators for postnatal depression

Wilson, C. A., Robertson, L., Ayre, K., Hendon, J., Dawson, S., Bridges, C., & Khalifeh, H. (2025) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd014624.pub2 · Cited by 9

Citalopram-induced pathways regulation and tentative treatment-outcome-predicting biomarkers in lymphoblastoid cell lines from depression patients

Barakat, A. K., Scholl, C., Steffens, M., Brandenburg, K., Ising, M., Lucae, S., Holsboer, F., Laje, G., Kalayda, G. V., Jaehde, U., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00900-8 · Cited by 9

Drug Safety and Suicidality Risk of Chronic Pain Medications

Syed, O., Jancic, P., Fink, A. B., & Knežević, N. N. (2023) · Pharmaceuticals · doi:10.3390/ph16101497 · Cited by 9

Approved Steroidal Drugs (2000–2025): A Medicinal Chemistry Perspective

Zhu, J., Luo, G., & Xiang, H. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c03005 · Cited by 8

Protein Kinase C-Dependent Effects of Neurosteroids on Synaptic GABAA Receptor Inhibition Require the δ-Subunit

Littlejohn, E. L., & Boychuk, C. R. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.742838 · Cited by 8

Depressive Symptoms during Pregnancy and the Postpartum Period: A Tertiary Hospital Experience

Mladenovic, D., Kostić, S., Ivanović, K., Jovanović, I., Petronijevic, M. A., Petronijević, M., & Vrzić-Petronijević, S. (2024) · Medicina · doi:10.3390/medicina60081288 · Cited by 7

The pathology of breast cancer: staging and prognostic indicators.

Russo, J., & Russo, I. H. (1992) · PubMed · Cited by 7

Menstrually-related mood disorders and postpartum depression: Convergent aspects in aetiology

Islas-Preciado, D., Estrada-Camarena, E. M., & Galea, L. A. M. (2024) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2024.101171 · Cited by 8

Brexanolone and related neurosteroid GABA(A) positive allosteric modulators for postnatal depression

Wilson, C. A., Robertson, L., Brown, J. V. E., Ayre, K., & Khalifeh, H. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd014624 · Cited by 6

Physiological markers of rapid antidepressant effects of allopregnanolone

Lambert, P. M., Lu, X., Zorumski, C. F., & Mennerick, S. J. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13023 · Cited by 5

Postpartum State, but Not Maternal Caregiving or Level of Anxiety, Increases Medial Prefrontal Cortex GAD65 and vGAT in Female Rats

Ragan, C. M., Ahmed, E. I., Vitale, E. M., Linning‐Duffy, K., Miller, S. M., Maguire, J. L., & Lonstein, J. S. (2022) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2021.746518 · Cited by 6

Neurosteroid involvement in threatened preterm labour

Türkmen, Ş., Bäckström, T. C., Flodin, Y. K., & Bixo, M. (2020) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.216 · Cited by 5

Activational and organizational actions of gonadal hormones on the sexual dimorphism of the α6-subunit containing GABAA receptor in Wistar rats with neuropathic pain

Pizaña-Encarnación, J. M., Escoto-Rosales, M. J., Islas-Espinoza, A. M., Morales-Galindo, D. K., Déciga‐Campos, M., Quintanar, B. G., Reyes, R., Granados‐Soto, V., & Fernández‐Guasti, A. (2025) · Hormones and Behavior · doi:10.1016/j.yhbeh.2025.105746 · Cited by 4

Staying Up to Date With Evolving Postpartum Depression Pathophysiology and Treatment Research

Deligiannidis, K. M., & Vaughn, R. L. (2023) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.sagppd3003sho · Cited by 4

Differentially expressed transcripts associated with depressive symptoms during pregnancy and postpartum

Björvang, R. D., Vrettou, M., Cundin, X. B., Prete, E. D., Rüegg, J., Lager, S., di Bernardo, D., Comasco, E., & Skalkidou, A. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03068-z · Cited by 4

Neurosteroids foster sedation by engaging tonic GABAA-Rs within the mesopontine tegmental anesthesia area (MPTA)

Baron, M., & Devor, M. G. (2024) · Neuroscience Letters · doi:10.1016/j.neulet.2024.138030 · Cited by 4

Perinatal Neuroendocrine Mechanisms in Postpartum Depression and Therapeutic Opportunities

Abey, N. O., Oweh, O. T., & Ebuehi, O. A. T. (2025) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-025-02023-x · Cited by 4

Neuroendocrinology of Perinatal Mental Illness

Pawluski, J. L., Dickens, M. J., & Maguire, J. L. (2024) · Masterclass in neuroendocrinology · doi:10.1007/978-3-031-51138-7_10 · Cited by 3

Antidepressant effects of activation of infralimbic cortex via upregulation of BDNF and β-catenin in an estradiol withdrawal model

Chen, J., Zhou, Y., Lai, M., Zhang, Y., Hu, Y., Zhuang, D., Zhou, W., & Zhang, Y. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06610-z · Cited by 3

The Perinatal Microbiota-Gut-Brain Axis: Implications for Postpartum Depression

Armbruster, M., & Forsythe, P. (2025) · NeuroImmunoModulation · doi:10.1159/000543691 · Cited by 6

Unraveling the Metabolic and Microbiome Signatures in Fecal Samples of Pregnant Women with Prenatal Depression

Li, J., Mei, P.-C., An, N., Fan, X., Liu, Y., Zhu, Q., & Feng, Y. (2025) · Metabolites · doi:10.3390/metabo15030179 · Cited by 3

Assessing suicide risk in chronic pain management: a narrative review across drug classes

Brezić, N., Gligorevic, S., Candido, K. D., & Knežević, N. N. (2024) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2024.2391999 · Cited by 2

Neurosteroids and Depression

Zhukov, D. A., & Виноградова, Е. П. (2021) · Neurochemical Journal · doi:10.1134/s1819712421030144 · Cited by 2

Allopregnanolone and progesterone in relation to a single electroconvulsive therapy seizure and subsequent clinical outcome: an observational cohort study

Thörnblom, E., Cunningham, J. L., Gingnell, M., Landén, M., Bergquist, J., & Bodén, R. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-06167-3 · Cited by 2

Novel Neurosteroid Pharmaceuticals

Susser, L. C., Swanson, C., & Hermann, A. D. (2021) · Advances in Psychiatry and Behavioral Health · doi:10.1016/j.ypsc.2021.05.017 · Cited by 2

Sex-specific Effects of Acute Stress on Emergence from Isoflurane Anesthesia via Brainstem Circuitry in Mice

Zhao, X., Meng, X., Gong, S., Tang, C. L., Yu, Z. J., Wang, X., Liu, S., Cao, J., & Wu, K. (2025) · Anesthesiology · doi:10.1097/aln.0000000000005826 · Cited by 1

Relationship of immune-inflammatory pathway and stress-induced depression with neural regeneration

Yu, Q., Chen, Z., Zhang, J., Cao, Y., Sun, M., Ye, S., Huang, Y., He, J., Wang, L., Li, K., et al. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00324 · Cited by 1

Behavioral and physiological benefits of alpha-pinene in adult rats experiencing chronic stress: A focus on depression and oxidative stress

Hosseini, S. S., Ghotbeddin, Z., Tabatabaei, S. R. F., & Rahimi, K. (2025) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2025.11.014 · Cited by 1

Neuropeptide TIP39 as a pluripotent brain molecule and its potential functions in postpartum depression

Wang, S., Liu, H., Tang, Q., Liao, N., Liu, T., Yang, Z., Wei, Y., & Fu, R. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1674213 · Cited by 1

Zuranolone as a Novel Therapy for Postpartum Depression: A Narrative Review of Current Evidence and Future Directions

Elkashif, I., Vithayathil, S., Walizada, M., Siddi, G., Gumireddy, S. R., Anto, M., & Yu, A. K. (2026) · Cureus · doi:10.7759/cureus.101038 · Cited by 1

Neuroactive Steroids in Hypoxic–Ischemic Brain Injury: Overview and Future Directions

Toro-Urrego, N., Ávila-Rodriguez, M., Herrera, M. I., Aguilar, A., Udovin, L., & Luaces, J. P. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.93956 · Cited by 2

Neuropsychiatric and Neurobehavioral Syndromes of the Human Hypothalamus

Wagner, J. H., Sarfraz, N., Maini, K., & Edinoff, A. N. (2020) · Contemporary Endocrinology · doi:10.1007/978-3-030-62187-2_8 · Cited by 1

Pharmacotherapy in Prader-Willi Syndrome

Forster, J. L. (2022) · Springer eBooks · doi:10.1007/978-3-030-98171-6_22 · Cited by 1

Brexanolone Is the First Drug Specifically for Postpartum Depression

Fantasia, H. C. (2019) · Nursing for Women s Health · doi:10.1016/j.nwh.2019.07.004 · Cited by 1

RETIRED: Maternal and Newborn Safety During the Administration of Brexanolone: AWHONN Practice Brief Number 10

(2020) · Journal of Obstetric, Gynecologic & Neonatal Nursing · doi:10.1016/j.jogn.2020.08.006

Maternal and Newborn Safety During the Administration of Brexanolone: AWHONN Practice Brief Number 10

Association of Women’s Health, O. A. N. N. (2020) · Nursing for Women s Health · doi:10.1016/j.nwh.2020.08.003

Comment on “Understanding the Clinical Effects and Mechanisms of Action of Neurosteroids”

Rubinow, D. R., Lasser, R. A., & Kanes, S. (2021) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20121681

Unipolar Depression And Its Treatment

Stahl, S. M. (2022) · Cambridge University Press eBooks · doi:10.1017/9781009241595.012

Editorial: Translational behavioral approaches in animal models of psychiatry

Tzanoulinou, S., Passecker, J., Stamatakis, A., & Diamantopoulou, A. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1200691

The Taylor Family Institute at Washington University: Novel Treatments in Psychiatry.

Zorumski, C. F., & Mennerick, S. J. (2023) · PubMed Central

Additional file 2 of Restoring Wnt signaling in a hormone-simulated postpartum depression model remediated imbalanced neurotransmission and depressive-like behaviors

Ye, B., Yuan, Y., Liu, R., Zhou, H., Li, Y., Sheng, Z., Li, T., Zhang, B., Xu, Z., Li, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23751772

A Comprehensive Review of Zuranolone's Clinical Efficacy and Safety as a Fast-Acting Oral Postpartum Depression (PPD) Treatment

Prabhakar, M. (2024) · Journal of chemical health risks · doi:10.52783/jchr.v14.i2.3484

Research Progress of HPA Axis and Perinatal Depressive Symptoms

李, 星. (2024) · Nursing Science · doi:10.12677/ns.2024.135077

Patterns of Adverse Childhood Experiences and Postpartum Depressive Symptoms

Shin, S. H., Choi, C., Jiskrova, G. K., Tomlinson, C. A., Corso, C. B., & Kimbrough, T. N. (2025) · Journal of Child & Adolescent Trauma · doi:10.1007/s40653-025-00720-2

Preventing postpartum depression through pre-delivery screening and targeted interventions

Felimban, O., Abdalla, M., Alharbi, F., Altuwairqi, S. S., Alawami, S., Alramel, Z., Alomar, M., Aldarwish, F., & Aldhafeeri, D. A. (2025) · International Journal of Community Medicine and Public Health · doi:10.18203/2394-6040.ijcmph20254067

Additional file 5 of The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice

Xu, F.-R., Wei, Z.-H., Xu, X.-X., Zhang, X.-G., Wei, C.-J., Qi, X.-M., Li, Y.-H., Gao, X.-L., & Wu, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26651028

Development of neuroactive steroids for the treatment of postpartum depression

Gunduz‐Bruce, H., Takahashi, K. U., & Huang, M. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13019 · Cited by 54

Neurosteroids in the context of stress: implications for depressive disorders

Girdler, S. S., & Klatzkin, R. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.05.006 · Cited by 148

Neurosteroid, GABAergic and hypothalamic pituitary adrenal (HPA) axis regulation: what is the current state of knowledge in humans?

Crowley, S. K., & Girdler, S. S. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3572-8 · Cited by 115

The Role of HPA Axis and Allopregnanolone on the Neurobiology of Major Depressive Disorders and PTSD

Almeida, F. B., Pinna, G., & Barros, H. M. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115495 · Cited by 130

GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response

Gunn, B. G., Cunningham, L., Mitchell, S. G., Swinny, J. D., Lambert, J. J., & Belelli, D. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.06.001 · Cited by 149