Cited by 160Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchNeurological Disease Mechanisms and Treatments

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Glia Crosstalk in Neuroinflammatory Diseases

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Bernaus, Ada, Blanco, Sandra, Sevilla, Ana·2020·Frontiers in Cellular Neuroscience

DOI 10.3389/fncel.2020.00209PMC PMC7403442

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Abstract

Neuroinflammation constitutes a fundamental cellular process to signal the loss of brain homeostasis. Glial cells play a central role in orchestrating these neuroinflammation processes in both deleterious and beneficial ways. These cellular responses depend on their intercellular interactions with neurons, astrocytes, the blood-brain barrier (BBB), and infiltrated T cells in the central nervous system (CNS). However, this intercellular crosstalk seems to be activated by specific stimuli for each different neurological scenario. This review summarizes key studies linking neuroinflammation with certain neurodegenerative diseases such as Alzheimer disease (AD), Parkinson disease (PD), and amyotrophic lateral sclerosis (ALS) and for the development of better therapeutic strategies based on immunomodulation.

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Authors: Bernaus, A., Blanco, S., & Sevilla, A.
Affiliations: Universitat de Barcelona (ES)
Consejo Superior de Investigaciones Científicas (ES)
Corresponding author: Sevilla, Ana
ORCID: Blanco, Sandra
Sevilla, Ana
Venue: Frontiers in Cellular Neuroscience
Publisher: Frontiers Media SA
Published: 2020-07-29
Volume: 14
Pages: 209-209
ISSN: 1662-5102 (ISSN-L)
DOI: 10.3389/fncel.2020.00209
PMC: PMC7403442
OpenAlex: W3046216659
Cited by: 157
References: 134
Citations by year: 2026: 16 · 2025: 20 · 2024: 39 · 2023: 29 · 2022: 32 · 2021: 20 · 2020: 1
FWCI: 7.94
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Ministerio de Ciencia y Tecnología (RYC-2016-19962)
Ministerio de Ciencia, Innovación y Universidades (PGC2018-098626-B100)
Merck Company Foundation
Fundación Científica Asociación Española Contra el Cáncer
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: neuroinflammation, astrocytes, blood-brain barrier, infiltrating T cells, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, immunomodulation, neuron-glia interactions

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