The DOI matches its Crossref record; 258 of the 259 references it cites were found in a registry or an index.
Mesocorticolimbic Dopamine Pathways Across Adolescence: Diversity in Development
Open accessAbstract
Mesocorticolimbic dopamine circuity undergoes a protracted maturation during adolescent life. Stable adult levels of behavioral functioning in reward, motivational, and cognitive domains are established as these pathways are refined, however, their extended developmental window also leaves them vulnerable to perturbation by environmental factors. In this review, we highlight recent advances in understanding the mechanisms underlying dopamine pathway development in the adolescent brain, and how the environment influences these processes to establish or disrupt neurocircuit diversity. We further integrate these recent studies into the larger historical framework of anatomical and neurochemical changes occurring during adolescence in the mesocorticolimbic dopamine system. While dopamine neuron heterogeneity is increasingly appreciated at molecular, physiological, and anatomical levels, we suggest that a developmental facet may play a key role in establishing vulnerability or resilience to environmental stimuli and experience in distinct dopamine circuits, shifting the balance between healthy brain development and susceptibility to psychiatric disease.
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“The adolescent period can be further sub-divided into early (~PND 21–34), middle (~PND 35–45), and late (~PND 45–60) periods [39, 46]”
From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [39]
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“adolescence in rodents is increasingly defined more in line with this larger age window in humans, by counting the period from weaning (~PND 21) where mice and rats gain begin to interact independently with their environments for the first time”
From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [39]
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“it is increasingly recognized to be evolutionarily conserved, with animal species also showing distinct markers of an adolescent state [35–40].”
From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [39]
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“As the dopamine system undergoes a period of profound and dynamic development in adolescence [39]”
From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [39]
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Citations
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eLife assessment: The scheduling of adolescence with Netrin-1 and UNC5C
Ding, J. (2024) · eLife · doi:10.7554/elife.88261.2.sa8
Reviewer #3 (Public Review): The scheduling of adolescence with Netrin-1 and UNC5C
Hoops, D., Kyne, R. F., Salameh, S., et al. (2024) · eLife · doi:10.7554/elife.88261.2.sa5
Reviewer #2 (Public Review): The scheduling of adolescence with Netrin-1 and UNC5C
Hoops, D., Kyne, R. F., Salameh, S., et al. (2024) · eLife · doi:10.7554/elife.88261.2.sa6
Author Response: The scheduling of adolescence with Netrin-1 and UNC5C
Hoops, D., Kyne, R. F., Salameh, S., MacGowan, D., Avramescu, R. G., Ewing, E., He, A. T., Orsini, T., Durand, A., Popescu, C., et al. (2024) · eLife · doi:10.7554/elife.88261.2.sa9
Self-citationReviewer #1 (Public Review): The scheduling of adolescence with Netrin-1 and UNC5C
Hoops, D., Kyne, R. F., Salameh, S., et al. (2024) · eLife · doi:10.7554/elife.88261.2.sa7
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Metadata
- Authors
- Reynolds, L. M., & Flores, C.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Douglas Mental Health University Institute (CA)
- Corresponding author
- Reynolds, Lauren M.
- Flores, Cecilia
- Venue
- Frontiers in Neural Circuits
- Publisher
- Frontiers Media SA
- Published
- 2021-09-08
- Volume
- 15
- Pages
- 735625-735625
- ISSN
- 1662-5110 (ISSN-L)
- PMC
- PMC8456011
- OpenAlex
- W3198497866
- Cited by
- 137
- References
- 259
- Citations by year
- 2026: 29 · 2025: 25 · 2024: 40 · 2023: 28 · 2022: 14 · 2021: 1
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Neural Circuits (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institute on Drug Abuse
- Canadian Institutes of Health Research
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- mesocorticolimbic dopamine system, adolescent brain development, environmental influences on brain development, reward processing, motivation, cognitive function, psychiatric vulnerability, resilience
- MeSH terms
- Adolescent, Brain, Dopamine, Humans, Reward, Dopaminergic Neurons
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