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Cited by 336

The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.

Spasticity, Motor Recovery, and Neural Plasticity after Stroke

Open access
Li, Sheng·2017·Frontiers in Neurology

Abstract

Spasticity and weakness (spastic paresis) are the primary motor impairments after stroke and impose significant challenges for treatment and patient care. Spasticity emerges and disappears in the course of complete motor recovery. Spasticity and motor recovery are both related to neural plasticity after stroke. However, the relation between the two remains poorly understood among clinicians and researchers. Recovery of strength and motor function is mainly attributed to cortical plastic reorganization in the early recovery phase, while reticulospinal (RS) hyperexcitability as a result of maladaptive plasticity, is the most plausible mechanism for poststroke spasticity. It is important to differentiate and understand that motor recovery and spasticity have different underlying mechanisms. Facilitation and modulation of neural plasticity through rehabilitative strategies, such as early interventions with repetitive goal-oriented intensive therapy, appropriate non-invasive brain stimulation, and pharmacological agents, are the keys to promote motor recovery. Individualized rehabilitation protocols could be developed to utilize or avoid the maladaptive plasticity, such as RS hyperexcitability, in the course of motor recovery. Aggressive and appropriate spasticity management with botulinum toxin therapy is an example of how to create a transient plastic state of the neuromotor system that allows motor re-learning and recovery in chronic stages.

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Metadata

Authors
Li, S.
Venue
Frontiers in Neurology
Published
2017-04-03
Volume
8
Pages
120-120
ISSN
1664-2295 (ISSN-L)
OpenAlex
W2604940191
Cited by
336
References
112
FWCI
22.41
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Spasticity, Motor Recovery, and Neural Plasticity after Stroke. https://app.cochat.ai/papers/10.3389/fneur.2017.00120
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Li, S. (2017). Spasticity, Motor Recovery, and Neural Plasticity after Stroke. Frontiers in Neurology. https://doi.org/10.3389/fneur.2017.00120

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