The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke
Open accessAbstract
Stroke is a leading cause of adult motor disability. Despite recent progress, recovery of motor function after stroke is usually incomplete. This double blind, Sham-controlled, crossover study was designed to test the hypothesis that non-invasive stimulation of the motor cortex could improve motor function in the paretic hand of patients with chronic stroke. Hand function was measured using the Jebsen-Taylor Hand Function Test (JTT), a widely used, well validated test for functional motor assessment that reflects activities of daily living. JTT measured in the paretic hand improved significantly with non-invasive transcranial direct current stimulation (tDCS), but not with Sham, an effect that outlasted the stimulation period, was present in every single patient tested and that correlated with an increment in motor cortical excitability within the affected hemisphere, expressed as increased recruitment curves (RC) and reduced short-interval intracortical inhibition. These results document a beneficial effect of non-invasive cortical stimulation on a set of hand functions that mimic activities of daily living in the paretic hand of patients with chronic stroke, and suggest that this interventional strategy in combination with customary rehabilitative treatments may play an adjuvant role in neurorehabilitation.
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Cites
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“…that direct stimulation of a motor cortical representation in rodents elicits cortical reorganization (Nudo et al., 1990), while non-invasive cortical stimulation in humans influences motor cortical excitability (Chen et al., 1997; Pascual-Leone et al., 1998; Nitsche and Paulus, 2000, 2001).”
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Cited by
Transcranial direct current stimulation: State of the art 2008
Nitsche, M. A., Cohen, L. G., Wassermann, E. M., Priori, A., Lang, N., Antal, A., Paulus, W., Hummel, F., Boggio, P. S., Fregni, F., et al. (2008) · Brain Stimulation · doi:10.1016/j.brs.2008.06.004 · Cited by 3,057
Self-citationPhysiological basis of transcranial direct current stimulation
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Interventions for improving upper limb function after stroke
Pollock, A., Farmer, S. E., Brady, M. C., Langhorne, P., Mead, G. E., Mehrholz, J., & van Wijck, F. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010820.pub2 · Cited by 909
Metadata
- Authors
- Hummel, F.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-01-05
- Volume
- 128
- Issue
- 3
- Pages
- 490-499
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2108416046
- Cited by
- 1,114
- References
- 10
- FWCI
- 25.91
- Type
- journal article
- Language
- en
- Open access
- green
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