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Cited by 1Vestibular and auditory disordersFunctional Brain Connectivity StudiesAdvanced MRI Techniques and Applications

Altered amplitude of low-frequency fluctuation and functional connectivity in patients with acute unilateral vestibulopathy: a resting-state fMRI study

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Chen, Zhengwei, Rong, Liangqun, Xiao, Lijie, Rao, Jie, Liu, Haiyan, Liu, Tengfei, Chen, Fei, Zhang, Jun +3 more·2025·Frontiers in Neurology
DOI 10.3389/fneur.2024.1515262PMC PMC11769794
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Abstract

Objective: To investigate changes of brain functional activity in patients with acute unilateral vestibulopathy (AUVP) using functional magnetic resonance imaging (fMRI). Methods: We studied 32 AUVP patients and 30 healthy controls (HC) who received resting-state fMRI scanning. Methods of voxel-based amplitude of low-frequency fluctuation (ALFF) and seed-based functional connectivity (FC) were adopted to compare the difference in brain function between the two groups. In addition, we evaluated the associations between abnormal neuroimaging results and clinical data in AUVP patients. Results: Compared with HC, patients with AUVP showed lower ALFF in brain regions of bilateral insular, right precentral gyrus, left inferior frontal gyrus and right middle frontal gyrus, as well as higher ALFF in left cerebellar anterior lobe. Using these abnormal brain areas as seeds, we observed decreased FC between left insular and left precuneus in AUVP patients. Furthermore, AUVP patients showed increased FC between left insular and left supplementary motor area. Results of correlation analysis indicated that ALFF value (z-value) in left insular was negatively correlated with the canal paresis value (p = 0.005, r = −0.483), and the FC (z-value) between left insular and left precuneus was negatively correlated with dizziness handicap inventory score (p = 0.012, r = −0.438) in patients with AUVP. Conclusion: Patients with AUVP during acute period showed altered functional activity and connectivity in brain regions mainly involved in motor control and vestibular information processing. These changes in brain functional activity and connectivity were potentially attributed to decreased vestibular input resulting from unilateral peripheral vestibular impairment.

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  • The MFG serves as an important region for integrating visual and vestibular information.

    “The MFG serves as an important region for integrating visual and vestibular information.[35]”

    From Brain Rewires to Stabilize Walking During Visual Impairment · cites this paper as [35]

    The Discussion (Altered ALFF in AUVP patients; page not provided) says the MFG receives vestibular information and plays a crucial role in the vestibular cortex circuit. It does not say that the MFG integrates visual and vestibular information; the Introduction discusses visual processing in other brain regions. (LLM, conf=0.84)

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Cited by

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Authors
Chen, Z., Rong, L., Xiao, L., Rao, J., Liu, H., Liu, T., Chen, F., Zhang, J., Wang, L., Li, X., & Wei, X.
Affiliations
  • Second Affiliated Hospital of Xuzhou Medical College (CN)
  • Lishui Central Hospital (CN)
  • Shanghai University (CN)
Corresponding author
  • Li, Xi
  • Wei, Xiue
ORCID
Venue
Frontiers in Neurology
Publisher
Frontiers Media SA
Published
2025-01-13
Volume
15
Pages
1515262-1515262
ISSN
1664-2295 (ISSN-L)
DOI
10.3389/fneur.2024.1515262
PMC
PMC11769794
OpenAlex
W4406338528
Cited by
0
References
0
FWCI
0.00
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Neurology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Jiangsu Commission of Health (H2023014)
  • Government of Jiangsu Province
Topics
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
acute unilateral vestibulopathy, amplitude of low-frequency fluctuation, functional connectivity, resting-state brain activity, insula, precuneus, supplementary motor area, canal paresis, dizziness, vestibular input, cerebellum

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