The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index; 4 of the 9 sources its claims cite were checked for support.
Stress-induced cognitive dysfunction: hormone-neurotransmitter interactions in the prefrontal cortex
Open accessAbstract
The mechanisms and neural circuits that drive emotion and cognition are inextricably linked. Activation of the hypothalamic-pituitary-adrenal (HPA) axis as a result of stress or other causes of arousal initiates a flood of hormone and neurotransmitter release throughout the brain, affecting the way we think, decide, and behave. This review will focus on factors that influence the function of the prefrontal cortex (PFC), a brain region that governs higher-level cognitive processes and executive function. The PFC becomes markedly impaired by stress, producing measurable deficits in working memory. These deficits arise from the interaction of multiple neuromodulators, including glucocorticoids, catecholamines, and gonadal hormones; here we will discuss the non-human primate and rodent literature that has furthered our understanding of the circuitry, receptors, and signaling cascades responsible for stress-induced prefrontal dysfunction.
Overview
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TL;DR
This review synthesizes non-human primate and rodent literature showing that stress impairs prefrontal cortex (PFC)-dependent working memory through interacting neuromodulators, principally catecholamines (dopamine and norepinephrine) acting via D1, alpha-1, and alpha-2 receptors, with glucocorticoids and estrogen modulating these effects. It proposes that stress pushes catecholamine signaling to the impairing end of inverted-U curves and that high estrogen may place females "ahead of the curve," increasing stress sensitivity.
Key findings
- Working memory depends on a balanced neurochemical milieu in the PFC; both insufficient and excessive D1 stimulation impair performance, producing the classic "inverted-U" relationship. Stress-induced HPA activation stimulates the VTA, causing excess DA release into the PFC, and these impairments can be reversed by intra-PFC D1 antagonist infusion or by cAMP and PKA inhibitors.
- Under stress, excess NE binds the lower-affinity alpha-1 receptor (rather than the high-affinity alpha-2 receptor active under non-stress conditions), impairing working memory and silencing PFC network activity; alpha-1 antagonists restore PFC function during stress, and PKC inhibition also reverses stress-related working memory impairments.
- Mechanistically, elevated D1 signaling opens HCN channels (via cAMP) on dendritic spines, shunting incoming excitation and suppressing both "noise" and "signal" neurons; alpha-2 receptor activation (Gi-coupled, lowering cAMP) slows HCN conductance and strengthens signal. Pharmacological HCN blockade restores working memory performance and PFC network tuning during stress.
- Glucocorticoids impair PFC working memory directly via GRs (systemic corticosterone reduces Delayed Alternation accuracy; intra-PFC RU 28362 impairs working memory; intra-PFC RU 38486 reverses stress-induced DSWS impairments) and indirectly by blocking extraneuronal catecholamine transporters and by locally driving stress-induced DA efflux in the PFC.
- In female rats, stress sensitivity is driven by high-estrogen phases: females became impaired after lower doses of FG7142 than males, driven by proestrus females; OVX + estrogen rats show impairments similar to proestrus females while OVX + blank-capsule rats perform more like males. A guanfacine dose that rescues stress-induced impairments in males and OVX females has no effect in OVX + estrogen rats.
Methods
- Narrative review of non-human primate and rodent literature on stress-induced PFC dysfunction, covering electrophysiology, pharmacology (receptor agonists/antagonists, cAMP/PKA/PKC inhibitors), microdialysis, lesion, and behavioral studies.
- Behavioral paradigms discussed: Delayed Response task (monkeys), Delayed Alternation and delayed spatial win-shift (DSWS) tasks (rodents); stressors include loud white noise, brief restraint stress, and the anxiogenic drug FG-7142.
- Sex-difference evidence drawn from dose-response studies with FG7142 and restraint stress in male and female rats, including ovariectomized rats with and without estrogen replacement.
Limitations
- The paper states that the vast majority of behavioral neuroscience research is conducted in male animals, so general understanding of stress effects in the PFC is within the context of the male brain, which is problematic from a translational standpoint given that stress-related illnesses like PTSD and major depressive disorder are twice as prevalent in women.
- The paper states that the mechanisms by which estrogen modulates stress-induced impairments are not known, and that estrogen-glucocorticoid interactions have not been investigated in the context of stress-induced working memory impairments.
- Evident from the text: the review is based entirely on animal (non-human primate and rodent) literature, and the estrogen "ahead of the curve" hypothesis is presented as a model (Figure 2) rather than a directly tested mechanism.
Model-written summary. Check it against the paper before relying on it.
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Claims the paper makes
4 of 9 cited sources checked · 2 supported · 0 flagged · accuracy not yet measured
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These deficits arise from the interaction of multiple neuromodulators, including glucocorticoids, catecholamines, and gonadal hormones; here we will discuss the non-human primate and rodent literature that has furthered our understanding of the circuitry, receptors, and signaling cascades responsible for stress-induced prefrontal dysfunction.”
§ Stress-induced cognitive dysfunction: hormone-neurotransmitter interactions in the prefrontal cortex > Abstract
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Rests on an assumption: Findings from non-human primate and rodent studies of stress-induced prefrontal dysfunction generalize to humans.
In the paper
“When the authors divided the females based on estrus cycle phase, they found that this stress sensitivity was driven by females in proestrus, when estrogen levels are highest.”
§ Stress-induced cognitive dysfunction: hormone-neurotransmitter interactions in the prefrontal cortex > Sex differences and estrogen effects
What the sources say
- Not checked — no full text of the sourcecites Shansky et al., 2004 source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes
- It may state two separate claims as one. 6
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“While a lack of D1 activity can impair working memory performance, high levels of D1 stimulation also produce cognitive deficits—the classic “inverted-U” relationship.”
- Also stated in: § Dopamine and norepinephrine · plain
“During stress, HPA axis activation leads to stimulation of the VTA, causing excess DA release into the PFC (Murphy et al., 1996). When this DA binds to the D1 receptor, its downstream signaling cascades lead to working memory impairment (Taylor et al., 1999).”
§ Stress-induced cognitive dysfunction: hormone-neurotransmitter interactions in the prefrontal cortex > Dopamine and norepinephrine
What the sources say
- Not checked — no full text of the sourcecites Murphy et al., 1996 source
- Partly supportedcites Taylor et al., 1999 sourceExperimental — accuracy not yet measured
The section “Possible relevance of PKA activation to stress-induced PFC dysfunction” reports that high D1 stimulation impairs working memory and contributes to stress-induced deficits. It does not establish that D1 blockade impairs working-memory performance, so it does not support both sides of the claimed inverted-U relationship. The section also does not explicitly say that stress causes excess dopamine release. (LLM, conf=0.84)
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Dopamine and norepinephrine · plain
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“stress-related mental illnesses like post-traumatic stress disorder (PTSD) and major depressive disorder are twice as prevalent in women (Becker et al., 2007), suggesting a distinct neurobiology may underlie the stress response in female brains.”
§ Stress-induced cognitive dysfunction: hormone-neurotransmitter interactions in the prefrontal cortex > Sex differences and estrogen effects
What the sources say
- Partly supportedcites Becker et al., 2007 sourceExperimental — accuracy not yet measured
The “Stress and affective disorders” section says women experience depression at approximately twice the rate of men. The “Sex differences in clinical studies” section discusses sex differences in PTSD risk but does not give a twofold prevalence figure for PTSD. The citation therefore supports the depression figure, not its extension to both disorders. (LLM, conf=0.88)
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Partly supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“Exposure to stress, however, can disrupt PFC function, markedly impairing working memory (Arnsten, 2009; Arnsten et al., 2012).”
- Also stated in: § Abstract · plain
“The PFC becomes markedly impaired by stress, producing measurable deficits in working memory.”
§ Stress-induced cognitive dysfunction: hormone-neurotransmitter interactions in the prefrontal cortex > Introduction
What the sources say
- Supportedcites Arnsten, 2009 source
The review states that stress rapidly disrupts PFC function and focuses on PFC working memory (passage 1). In its discussion of acute stress and PFC function, it reports that mild stress impaired spatial working-memory performance in rats and monkeys (passage 5). Page numbers are not supplied in our copy. (LLM, conf=0.94)
- Supportedcites Arnsten et al., 2012 source
In “Working memory vs. classic neuroplasticity” (page not provided), the paper says working-memory abilities are greatly impaired during stress. In “Relationship of neuromodulation in dlPFC to arousal states” (page not provided), it describes stress-related weakening of prefrontal network activity and reports that a mild stressor impairs working memory. (LLM, conf=0.94)
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: Findings from non-human primate and rodent studies of stress-induced prefrontal dysfunction generalize to humans.
- Also stated in: § Abstract · plain
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Pharmacological stimulation of the alpha-2 receptor can increase firing in PFC neurons that code for relevant information, enhancing working memory in monkeys and rodents (Wang et al., 2007).”
- Also stated in: § Dopamine and norepinephrine · plain
“Stimulation of this receptor—either pharmacologically or because of stress-induced NE release—leads to working memory impairment and a silencing of PFC network activity (Arnsten et al., 1999).”
§ Stress-induced cognitive dysfunction: hormone-neurotransmitter interactions in the prefrontal cortex > Dopamine and norepinephrine
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Dopamine and norepinephrine · plain
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Research in non-human primates and rodents has shown that this impairment is driven by increased catecholamine signaling, which may be further modulated or exacerbated by changes in steroid hormone levels.”
§ Stress-induced cognitive dysfunction: hormone-neurotransmitter interactions in the prefrontal cortex > Conclusions
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: Findings from non-human primate and rodent studies of stress-induced prefrontal dysfunction generalize to humans.
In the paper
“While this release is critical to the enhancement of long term memories associated with the event (Rodrigues et al., 2009), glucocorticoid actions in the PFC impair working memory.”
- Also stated in: § Glucocorticoids · hedged
“These findings suggest that glucocorticoids can impair PFC function through direct actions at GRs, but glucocorticoids may also indirectly exacerbate working memory impairments through interactions with the catecholamine systems described above.”
§ Stress-induced cognitive dysfunction: hormone-neurotransmitter interactions in the prefrontal cortex > Glucocorticoids
What the sources say
- Not checked — no full text of the sourcecites Rodrigues et al., 2009 source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Glucocorticoids · hedged
The paper relies on this without support.
Findings from non-human primate and rodent studies of stress-induced prefrontal dysfunction generalize to humans.
“here we will discuss the non-human primate and rodent literature that has furthered our understanding of the circuitry, receptors, and signaling cascades responsible for stress-induced prefrontal dysfunction.”
The paper relies on this without support.
Working memory tasks in animals measure the same executive function as human working memory.
“Working memory in animals is assessed using delay-based tasks, which require an animal to keep a piece of information in mind over the course of a delay period, in order to make an accurate choice when the delay ends.”
The paper relies on this without support.
The prefrontal cortex helps to shut down the stress response.
“Because the PFC also helps to shut down the stress response, this loss of PFC function can lead to prolonged glucocorticoid release, which can exacerbate working memory impairments.”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Opposite directions given for ion flow through open HCN channels
MinorThe text first says that open HCN channels allow positive ions into the cell, then says that opening the same channels lets Na+ and K+ flow out. It does not explain the reversal in direction.
“Traditionally, HCN channels serve to normalize neuronal membrane potential, opening to allow positive ions into the cell to combat post-firing hyperpolarization (Wahl-Schott and Biel, 2009).”
“when cAMP increases (as happens when D1 receptors are over-activated), HCN channels open, letting Na+ and K+ flow out of the cell (Chen et al., 2007).”
Citations
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“…variable to control, as stress is well known to sex-specifically influence cognition and affect in rats (Kokras & Dalla, 2017; Luine et al., 2017; Shansky & Lipps, 2013) and to sex-specifically modulate episodic memory in humans (Andreano & Cahill, 2009; Gagnon & Wagner, 2016; Merz, 2017; Merz &…”
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“Several contributors provided evidence that mood can have enduring consequences for cognition (Morriss et al., 2013; Vaisvaser et al., 2013), perhaps reflecting the comparatively slow dynamics of catecholamine and hormonal neurochemistry (Sacher et al., 2013; Shansky and Lipps, 2013).”
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“This fits with a model adapted from Shansky and Lipps (Shansky and Lipps, 2013) wherein an optimal level of DA neuron activity promotes social interaction whereas both sub-and supra-optimal levels of DA neurotransmission would reduce social interaction (Arnsten, 1997, 2009; Yerkes and Dodson, 1908).”
MethodBartolomeo, M. D., Aroni, S., Serra, M., Serra, V., Martella, F., Gilardini, F., Melis, M., & D'Addario, C. (2025) · Cells · doi:10.3390/cells14120904 · Cited by 5
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The effects of stress on working-memory-related prefrontal processing: an fNIRS study
Geissler, C. F., Frings, C., & Domes, G. (2025) · Stress · doi:10.1080/10253890.2025.2472067 · Cited by 5
“…deactivation in the three back task suggests a negative effect of increased cortisol on prefrontal processing post stress (Ffrench-Mullen, 1995; shansky & lipps, 2013). this fits the fact that we only found a significant cortisol increase but no significant increase in α-amylase activity. a…”
Mariotti, F. F. N., Gonçalves, B. S. M., Pimpão, G., Mônico‐Neto, M., Antunes, H. K. M., Viana, M. D. B., Céspedes, I. C., & Sueur, L. D. P. L. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104805 · Cited by 6
Härpfer, K., Carsten, H. P., Kausche, F. M., & Riesel, A. (2025) · Depression and Anxiety · doi:10.1155/da/9505414 · Cited by 5
“Alternatively, another perspective underscores the organizational and regulatory impact of ovarian hormones on frontal brain regions associated with cognitive control in women [156 – 158].”
Louis, C. C., D’Esposito, M., & Moser, J. S. (2021) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-021-00922-9 · Cited by 6
The Windlass Tourniquet: Is It Taking the Wind Out of the “Stop the Bleed” Sails?
Schlanser, V. L., Tatebe, L. C., Karalius, V. P., et al. (2021) · Journal of Surgical Research · doi:10.1016/j.jss.2021.09.033 · Cited by 5
Weber, V. M. R., Queiróga, M. R., Puranda, J. L., Semeniuk, K., Macdonald, M. L., Dantas, D. B., da Silva, D. F., & Adamo, K. B. (2024) · Sports Medicine - Open · doi:10.1186/s40798-024-00776-8 · Cited by 9
“The effects of aerobic exercise on executive functions are linked to an increase in neurotransmitters, which can stimulate certain brain areas (e.g., pre-frontal cortex) responsible for cognitive functions [86, 87].”
BackgroundLudwig-Borycz, E. F., Lee, H., Ryan, L. H., Heeringa, S. G., McEvoy, C. T., Wolfson, J. A., Agrawal, A., Langa, K. M., & Leung, C. W. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70480 · Cited by 3
“27 53 FI is also associated with poorer nutrition, including lower fruit and vegetable consumption.”
A terrified-sound stress causes cognitive impairment in female mice by impairing neuronal plasticity
Gao, S., Zhang, L., Wang, X., Li, R., Han, L., Xiong, X., Jiang, Q., Cheng, D., Xiao, X., Li, H., et al. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148419 · Cited by 4
Brand, S., Nejat, M., Haghighi, M., Rahimi, A., Jahangard, L., Bahmani, D. S., Bajoghli, H., Holsboer‐Trachsler, E., & Ahmadpanah, M. (2017) · PubMed Central · Cited by 4
The effects of emotional stimuli on Word retrieval in people with aphasia
Blackett, D. S., Borod, J. C., Speer, S. R., Pan, X. J., & Harnish, S. M. (2023) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2023.108734 · Cited by 4
Morava, A., Tari, B., Ahn, J., Shirzad, M., Heath, M. D., & Harry Prapavessis, A. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1157644 · Cited by 4
Coping Styles as Mediators Between Purpose in Life and Cognitive Function: A Longitudinal Study
Miller, A. A., O’Súilleabháin, P. S., Luchetti, M., Terracciano, A., & Sutin, A. R. (2025) · Research on Aging · doi:10.1177/01640275241312195 · Cited by 3
A U-shaped relationship between chronic academic stress and the dynamics of reward processing
Yi, W., Chen, W., Lan, B., Yan, L., Hu, X., & Wu, J. (2024) · NeuroImage · doi:10.1016/j.neuroimage.2024.120849 · Cited by 3
“Previous research has suggested that chronic stress impaired cognitive systems, resulting in alterations in value coding of rewards following an inverted U-shaped pattern (Arnsten, 2009; Lupien et al., 2009; McEwen et al., 2016; Shansky and Lipps, 2013).”
BackgroundKim, Y., Lee, J. G., Lee, D. Y., Park, S. B., Kim, J., & Cho, S. (2025) · Talanta · doi:10.1016/j.talanta.2025.128421 · Cited by 2
Ma, C., Wang, Y., Fu, J., & Zhao, X. (2025) · Contemporary Educational Psychology · doi:10.1016/j.cedpsych.2025.102424 · Cited by 3
Maeng, L. Y., & Milad, M. R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802114-9.00003-2 · Cited by 2
Developmental Exposure to Lead
Cory‐Slechta, D. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800228-5.00007-8 · Cited by 2
Mazaheri, M. M., Radahmadi, M., & Sharifi, M. R. (2024) · International Journal of Neuroscience · doi:10.1080/00207454.2024.2341913 · Cited by 3
“Exposure to stress with limited coping resources may potentially elevate the risk of cognitive dysfunction, mental illness, and other trauma-related outcomes [10–12].”
Self-Study of Cancer Reoccurrence Stress and Effects of Keto Diet and Black Seed Oil
Aslam, D. M., Shen, J., & Mahmood, T. (2023) · IJARCCE · doi:10.17148/ijarcce.2023.12426 · Cited by 2
Impact of Alcohol Abuse and Dependence on the Structure and Function of the Prefrontal Cortex
Glover, E. J., Barker, J. M., Glen, W. B., & Chandler, L. J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405941-2.00015-8 · Cited by 2
The relationship between noise level and sleep quality in wood processing factory workers
Haryawan, I. G. A., Suadnyana, I. A. A., & Cahaya, N. (2023) · Physical Therapy Journal of Indonesia · doi:10.51559/ptji.v4i2.120 · Cited by 1
Acute Stress Alters Behavioral and Neural Mechanisms of Self-Controlled Decision-MakingPreprint
Stein, J., Kirschbaum, C., Korb, F. M., Goschke, T., & Zwosta, K. (2024) · doi:10.31219/osf.io/zbucw · Cited by 2
Du, C., Sun, Y., Wang, J., Zhang, Q., & Zeng, Y. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1534839 · Cited by 1
Bagyinszky, E., & An, S. S. A. (2026) · Cells · doi:10.3390/cells15181710 · Cited by 1
Epigenetics in Major Depressive Disorder
Kaminsky, Z. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00014-0 · Cited by 1
Zalachoras, I., & Meijer, O. C. (2016) · Epigenetics and human health · doi:10.1007/978-3-319-24493-8_3 · Cited by 1
Tabassum, S., & Haider, S. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.12.022 · Cited by 1
Melino, S., & Mormone, E. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.745138 · Cited by 1
“The mechanisms by which E does this are not known, but several intriguing possibilities exist (Shansky and Lipps, 2013).”
BackgroundEffects of motivation on error processing: Controversy and integration
Yaqin, L. I., Ruolan, Z. H. A. O., & Yang, Q. K. (2023) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2024.00085 · Cited by 1
Watermeyer, T. J., Atkinson, E., Howatson, G., McGill, G., Dodds, C., Ansdell, P., & Udeh-Momoh, C. T. (2024) · medRxiv · doi:10.1371/journal.pone.0306149
“Stress, defined as environmental challenges, both internal (e.g. psychological, physiological) and external (e.g. physical injury), exceeding the natural regulatory capabilities of an organism, is also associated with increased risk for cognitive and psychosocial impairment.”
PENURUNAN KOGNITIF PADA PEKERJA DENGAN TULI SENSORINEURAL AKIBAT BISING
Sincihu, Y., & Taurusia, M. (2018) · majalah kesehatan · doi:10.21776/ub.majalahkesehatan.005.04.5 · Cited by 1
Setiaji, W., Handoko, A., & Elfiah, U. (2021) · Journal of Agromedicine and Medical Sciences · doi:10.19184/ams.v7i2.22000 · Cited by 1
Bettencourt, K. (2018) · doi:10.15368/theses.2018.2 · Cited by 1
Papassidero, P. C. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2020.tde-11022020-143504 · Cited by 1
Az ecstasy hatása a kognitív funkciókra
Pázmány, P., Petschner, P., Ádori, C., Kirilly, E., Andó, R. D., Balogh, B., Gyöngyösi, N., & Bagdy, G. (2013) · Repository of the Academy's Library (Library of the Hungarian Academy of Sciences)
Biesalski, H. K. (2015) · Springer eBooks · doi:10.1007/978-3-642-55397-4_11
Does Similar Whole Body Cooling Induce Gender-Specific Attention Stability Deterioration?
Solianik, R., Skurvydas, A., & Brazaitis, M. (2018) · Baltic Journal of Sport and Health Sciences · doi:10.33607/bjshs.v1i96.78
“Shansky and Lipps (2013) stated that most research is conducted in men, and thus our general understanding of the effects of stress on cognitive function is in the context of the men’s brain.”
BackgroundBuuck, S. (2020) · Schriften aus der Fakultät Humanwissenschaften der Otto-Friedrich-Universität Bamberg · doi:10.20378/irb-47638
Hideo, H., Yamano, Mariko, M., Saijo, Tatsuyoshi, & Muratsugu (2016)
Verapamil ameliorates sleep deprivation-induced hepatotoxicity in mice
Eduviere, A. T., & Otomewo, L. O. (2022) · International Journal of Scientific Reports · doi:10.18203/issn.2454-2156.intjscirep20220749
Vulnerability and resilience to stressful and traumatic events
Gruene, T. M. (2017) · Digital Repository Service (Northeastern University) · doi:10.17760/d20252694
Testor, K. (2020) · Springer eBooks · doi:10.1007/978-3-030-61736-3_7
Stress May Not Impair Higher Cognitive Functions Via Depleted Cognitive ResourcesPreprint
Qiu, B., Liu, T., Chen, Y., He, X., Zhou, C. L., & Zhang, W. (2022) · Research Square · doi:10.21203/rs.3.rs-753900/v1
Examining Cognitive-Based Stress Management Interventions in Private Sector Workplaces
Ferszt, E. (2022) · Open Journal of Business and Management · doi:10.4236/ojbm.2022.104109
“Extensive research has shown the direct impact that stress has on an employee’s ability to perform their job (Shansky & Lipps, 2013).”
BackgroundPrediction of Female Sexual Dysfunction Based on Perceived Stress and Body Dysmorphic Disorder
Haghtalab, T., Ahmadpanah, M., & Madanchi, F. (2022) · doi:10.32592/ajnpp.2022.9.3.106
yang, R., zhang, X., li, W., & Guo, C. (2023) · doi:10.22541/au.167508632.24198391/v1
Alam, N., Abbasi, S., & Naeem, S. (2023) · Research Square · doi:10.21203/rs.3.rs-2601074/v1
Alam, N., Abbasi, S., & Naeem, S. (2023) · Research Square · doi:10.21203/rs.3.rs-2601074/v2
Yang, R., Zhang, X., Li, W., & Guo, C. (2023) · Research Square · doi:10.21203/rs.3.rs-3092984/v1
Yang, R., Zhang, X., Guo, C., Li, W., Yue, L., & Liu, Z. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4674188
INVESTIGATING NOVEL METHODS AND METRICS IN CONSUMER NEUROSCIENCE
Saffari, F. (2024) · VBN Forskningsportal (Aalborg Universitet) · doi:10.54337/aau740088548
Neural and behavioral dynamics of error processing under chronic stress in healthy young adults
Hu, N., Qian, C., Zhang, Z., Hu, X., Wang, X., Ma, R., & Long, Q. (2025) · International Journal of Clinical and Health Psychology · doi:10.1016/j.ijchp.2025.100561
“Additionally, long-term stress can decrease levels of neurotransmitters such as dopamine, serotonin, and gamma-aminobutyric acid (GABA), especially in the PFC (Mizoguchi et al., 2000; Shansky & Lipps, 2013).”
Louis, C. C., & Moser, J. S. (2025) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2025.113204
Gedächtnis und Erinnerung, ihre Bedeutungen im Befragungsprozess – Neurokognitive Grundlagen
Markowitsch, H. J., & Staniloiu, A. (2025) · Springer eBooks · doi:10.1007/978-3-658-48432-3_3
Viglietti, P. G., Jäggi, L., Wey, H., Petitpierre, A., Lindh, C. H., Rousseau, K.-L., Donnell, J. M., Röösli, M., Malcolm‐Smith, S., Dalvie, M. A., et al. (2025) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2025.180782
Episodic-autobiographical memory and functional amnesia
Markowitsch, H. J., & Staniloiu, A. (2025) · Translational Neuroscience · doi:10.1515/tnsci-2025-0387 · Cited by 1
“…is that retrieval attempts are followed by the release of glucocorticoids who have most of their receptors in the regions of amygdala and hippocampus [134,135],andthereforeinregionsoftheright hemisphere where fact retrieval and emotional details are combined (synchronized) [45, 59, 136 – 139].”
Coherence Under Acceleration Judgment Integrity In A High-Velocity Convergence EraPreprint
Calloway, D. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.5960914
Song, F., Li, Y., Wang, S., Wang, Y., & Fang, J. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1771513
Pakulanon, S. (2019) · theses.fr (ABES) · doi:10.70675/e1914476z3772z45f0zbcafzbb365b163682
“Executive function and stress: Stress is generally thought to impair executive functioning (Arnsten, 2009; Diamond, 2013; Shansky & Lipps, 2013).”
BackgroundPerez-Rocha, Y., Calderon, L. E., Kogut, K. R., Rojas, N., Eskenazi, B., Warner, M. L., Rojas‐Saunero, L. P., Gunier, R. B., Ambriz, E., & Torres, J. M. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261453615
Investigating the Effects of Acute Stress on Neural Mechanisms of Self-controlled Decision-making
Stein, J., Kirschbaum, C., Korb, F. M., Goschke, T., & Zwosta, K. (2026) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.a.2623 · Cited by 2
Kchaou, K., Rebay, S., Briki, C., Khaldi, S., Mekadmini, I., & Jameleddine, S. B. K. (2026) · Pulmonary Function Diagnostics · doi:10.1016/j.pulmfd.2026.100010
Metadata
- Authors
- Shansky, R. M., & Lipps, J.
- Affiliations
- Northeastern University (US)
- Corresponding author
- Shansky, Rebecca M.
- ORCID
- Shansky, Rebecca M.
- Venue
- Frontiers in Human Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 7
- Pages
- 123-123
- ISSN
- 1662-5161 (ISSN-L)
- PMC
- PMC3617365
- OpenAlex
- W1977773662
- Semantic Scholar
- c29a390e82744bcb70b04e0c370134134cc8802f
- Cited by
- 205
- References
- 55
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 12 · 2023: 25 · 2022: 14 · 2021: 17 · 2020: 11 · 2019: 8 · 2018: 13 · 2017: 17 · 2016: 20 · 2015: 17 · 2014: 14 · 2013: 7
- FWCI
- 8.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Human Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- stress, cognitive impairment, prefrontal cortex, hypothalamic-pituitary-adrenal axis, glucocorticoids, catecholamines, gonadal hormones, working memory, executive function, neuromodulation, stress-induced neuroplasticity, receptor signaling
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