Cited by 206Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchPsychedelics and Drug Studies

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

Htr2a gene and 5-HT2A receptor expression in the cerebral cortex studied using genetically modified mice

Open access

Weber·2010·Frontiers in Neuroscience

DOI 10.3389/fnins.2010.00036PMC PMC2928707

Open this paper in CoChat — free account Open PDF

Abstract

Serotonin receptors of the 5-HT(2A) subtype are robustly expressed in the cerebral cortex where they have been implicated in the pathophysiology and therapeutics of mental disorders and the actions of hallucinogens. Much less is known, however, about the specific cell types expressing 5-HT(2A) receptors in cortex. In the current study we use immunohistochemical and electrophysiological approaches in genetically modified mice to address the expression of the Htr2a gene and 5-HT(2A) receptors in cortex. We first use an EGFP-expressing BAC transgenic mice and identify three main Htr2A gene expressing neuronal populations in cortex. The largest of these cell populations corresponds to layer V pyramidal cells of the anterior cortex, followed by GABAergic interneurons of the middle layers, and non-pyramidal cells of the subplate/Layer VIb. We then use 5-HT(2A) receptor knockout mice to identify an antibody capable of localizing 5-HT(2A) receptors in brain and use it to map these receptors. We find strong laminar expression of 5-HT(2A) receptors in cortex, especially along a diffuse band overlaying layer Va. This band exhibits a strong anteroposterior gradient that closely matches the localization of Htr2A expressing pyramidal cells of layer V. Finally we use electrophysiological and immunohistochemical approaches to show that most, but not all, GABAergic interneurons of the middle layers are parvalbumin expressing Fast-spiking interneurons and that these cells are depolarized and excited by serotonin, most likely through the activation of 5-HT(2A) receptors. These results clarify and extend our understanding of the cellular distribution of 5-HT(2A) receptors in the cerebral cortex.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fnins.2010.00036

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A review of central 5-HT receptors and their function
Barnes, N. M., & Sharp, T. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00010-6 · Cited by 3,211
Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP
Feng, G., Mellor, R. H., Bernstein, M., Keller-Peck, C., Nguyen, Q. T., Wallace, M., Nerbonne, J. M., Lichtman, J. W., & Sanes, J. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00084-2 · Cited by 3,042
International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).
Hoyer, D., Clarke, D. E., Fozard, J. R., Hartig, P. R., Martin, G. R., Mylecharane, E. J., Saxena, P. R., & Humphrey, P. P. A. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06783-3 · Cited by 3,025
Interneurons of the neocortical inhibitory system
Markram, H., Toledo-Rodriguez, M., Wang, Y., Gupta, A., Silberberg, G., & Wu, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1519 · Cited by 2,954
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108
Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks
Bartos, M., Vida, I., & Jonas, P. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2044 · Cited by 2,070
Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors
Pazos, Á., & Palacios, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90856-x · Cited by 1,855
Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
The Petilla Interneuron Nomenclature Group (PING) (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2402 · Cited by 1,491
GABAergic cell subtypes and their synaptic connections in rat frontal cortex
Kawaguchi, Y. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.6.476 · Cited by 1,416
Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action
Vollenweider, F. X., Vollenweider-Scherpenhuyzen, M. F. I., Bäbler, A., Vogel, H., & Hell, D. (1998) · NeuroReport · doi:10.1097/00001756-199812010-00024 · Cited by 1,018

Show all 53 references

Sorted by citations

Items 101–200 of 206

Effects of Withdrawal from Cocaine Self-Administration on Rat Orbitofrontal Cortex Parvalbumin Neurons ExpressingCre recombinase: Sex-Dependent Changes in Neuronal Function and Unaltered Serotonin Signaling
Wright, A., Zapata, A. G., Hoffman, A. F., Necarsulmer, J., Coke, L. M., Svarcbahs, R., Richie, C. T., Pickel, J. M., Hope, B. T., Harvey, B. K., et al. (2021) · eNeuro · doi:10.1523/eneuro.0017-21.2021 · Cited by 18
A suite of engineered mice for interrogating psychedelic drug actions
Chiu, Y.-T., Deutch, A. Y., Wang, W., Schmitz, G. P., Huang, K. L., Koçak, D. D., Llorach, P., Bowyer, K., Liu, B., Sciaky, N., et al. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02375-0 · Cited by 20
Activation of 5-HT 2A receptors by TCB-2 induces recurrent oscillatory burst discharge in layer 5 pyramidal neurons of the mPFC in vitro
Spindle, M. S., & Thomas, M. P. (2014) · Physiological Reports · doi:10.14814/phy2.12003 · Cited by 15
5-HT2A Receptors and BDNF Regulation: Implications for Psychopathology
Jaggar, M., & Vaidya, V. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-70474-6_17 · Cited by 15
Neurotoxicological profile of the hallucinogenic compound 25I-NBOMe
Herian, M., Wojtas, A., Maćkowiak, M., Wawrzczak‐Bargieła, A., Solarz, A., Bysiek, A., Madej, K., & Gołembiowska, K. (2022) · Scientific Reports · doi:10.1038/s41598-022-07069-8 · Cited by 15
Gene expression profiling of the hippocampal dentate gyrus in an adult toxicity study captures a variety of neurodevelopmental dysfunctions in rat models of hypothyroidism
Shiraki, A., Saito, F., Akane, H., Akahori, Y., Imatanaka, N., Itahashi, M., Yoshida, T., & Shibutani, M. (2015) · Journal of Applied Toxicology · doi:10.1002/jat.3140 · Cited by 15
Psychiatric Disorders - Worldwide Advances
Uehara, T. (2011) · InTech eBooks · doi:10.5772/1289 · Cited by 16
Pharmacotherapy with sertraline rescues brain development and behavior in a mouse model of CDKL5 deficiency disorder
Fuchs, C., Gennaccaro, L., Ren, E., Galvani, G., Trazzi, S., Medici, G., Loi, M., Conway, E., Devinsky, O., Rimondini, R., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107746 · Cited by 17
The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation
Arias, H. R., Rudin, D., Hines, D. J., Contreras, A., Gulsevin, A., Manetti, D., Anouar, Y., Deurwaerdère, P. D., Meiler, J., Romanelli, M. N., et al. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176329 · Cited by 16
Probing the antidepressant potential of psilocybin: integrating insight from human research and animal models towards an understanding of neural circuit mechanisms
Meccia, J., Lopez, J., & Bagot, R. C. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06297-0 · Cited by 13
From hallucinations to synaesthesia: A circular inference account of unimodal and multimodal erroneous percepts in clinical and drug-induced psychosisPreprint
Leptourgos, P., Bouttier, V., Denève, S., & Jardri, R. (2021) · PsyArXiv (OSF Preprints) · doi:10.1016/j.neubiorev.2022.104593 · Cited by 16
Stimulation of glutamate receptors in the ventral tegmental area is necessary for serotonin-2 receptor-induced increases in mesocortical dopamine release
Pehek, E. A., & Hernan, A. E. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.029 · Cited by 12
Neuromodulation of Hippocampal Cells and Circuits
Cobb, S., & Lawrence, J. J. (2010) · Springer eBooks · doi:10.1007/978-1-4419-0996-1_7 · Cited by 13
Ketamine for Depression: Advances in Clinical Treatment, Rapid Antidepressant Mechanisms of Action, and a Contrast with Serotonergic Psychedelics
Kojic, M., Saelens, J., Kadriu, B., Zarate, C. A., & Kraus, C. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_313 · Cited by 12
Cellular Effects of Serotonin in the CNS
Andrade, R., & Beck, S. G. (2010) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(10)70080-1 · Cited by 12
Gain control of sensory input across polysynaptic circuitries in mouse visual cortex by a single G protein-coupled receptor type (5-HT2A)
Barzan, R., Bozkurt, B., Nejad, M. M., Süß, S. T., Surdin, T., Böke, H., Spoida, K., Azimi, Z., Grömmke, M., Eickelbeck, D., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51861-1 · Cited by 12
The serotonin 2A receptor agonist 25CN-NBOH increases murine heart rate and neck-arterial blood flow in a temperature-dependent manner
Buchborn, T., Lyons, T., Song, C., Feilding, A., & Knöpfel, T. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120903465 · Cited by 13
Dysregulated corticostriatal activity in open-field behavior and the head-twitch response induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine
Rangel‐Barajas, C., Estrada‐Sánchez, A. M., Barton, S. J., Luedtke, R. R., & Rebec, G. V. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.11.001 · Cited by 10
Serotonin 2A receptors and cannabinoids
Ibarra‐Lecue, I., Dı́ez-Alarcia, R., & Urigüen, L. (2021) · Progress in brain research · doi:10.1016/bs.pbr.2021.01.004 · Cited by 11
5-HT2A Receptor Knockout Mice Show Sex-Dependent Differences following Acute Noribogaine Administration
Villalba, S., González, B., Junge, S., Bernardi, A., González, J., Fagúndez, C., Torterolo, P., Carrera, I., Urbano, F. J., & Bisagno, V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020687 · Cited by 10
PACAP–PAC1 Signaling Regulates Serotonin 2A Receptor Internalization
Hayata‐Takano, A., Shintani, Y., Moriguchi, K., Encho, N., Kitagawa, K., Nakazawa, T., & Hashimoto, H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.732456 · Cited by 10
Vesicular Glutamate Release from Feeder-FreehiPSC-Derived Neurons
Baldassari, S., Cervetto, C., Amato, S., Fruscione, F., Balagura, G., Pelassa, S., Musante, I., Iacomino, M., Traverso, M., Corradi, A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810545 · Cited by 10
Probing the functional magnetic resonance imaging response to psilocybin in functional neurological disorder (PsiFUND): study protocol
Butler, M., Bird, C., Maggio, C., Durden, A., Modlin, N. L., Campbell‐Coker, K., Edwards, M. J., Pick, S., Millman, L. S. M., Lowery, E., et al. (2024) · Wellcome Open Research · doi:10.12688/wellcomeopenres.22543.1 · Cited by 9
Serotonin and psilocybin activate 5-HT1B receptors to suppress cortical signaling through the claustrum
Madden, M. B., Schaefgen, C., Vedak, B., Kwon, J., Pedra, K. S. D., Sheats, S. H., Puché, A. C., Wolff, S. B. E., & Mathur, B. N. (2025) · Nature Communications · doi:10.1038/s41467-025-62980-8 · Cited by 14
Intra- and Interhemispheric Propagation of Electrophysiological Synchronous Activity and Its Modulation by Serotonin in the Cingulate Cortex of Juvenile Mice
Rovira, V., & Geijo‐Barrientos, E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150092 · Cited by 9
The effects of serotonergic psychedelics in synaptic and intrinsic properties of neurons in layer II/III of the orbitofrontal cortex
Tang, Z.-H., Yu, Z., Li, Q., Zhang, X., Muhetaer, K., Wang, Z., Xu, P., & Shen, H. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06366-y · Cited by 9
Serotonin 5-HT2A receptor expression is chronically decreased in the anterior cerebral cortex of male rats following repetitive low-level blast exposure
Gasperi, R. D., Garcia, G. S. P., Sosa, M. A. G., Perez, G. M., Abutarboush, R., Kawoos, U., Hof, P. R., Zhu, C. W., Ahlers, S. T., & Elder, G. A. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1594335 · Cited by 7
Role of 5-HT2A Receptor in Modulating Glutamatergic Activity in the Ventrolateral Orbital Cortex: Implication in Trigeminal Neuralgia
Yuan, S., Wang, N., Yao, Y., Liu, J., Gao, M., Mo, H., Zhang, S., & Su, R. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.08.018 · Cited by 7
Neurotransmitters and Intermittent Explosive Disorder
Lee, R., & Coccaro, E. F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813858-8.00005-x · Cited by 8
An ontogenic study of receptor mechanisms by which acute administration of low-doses of methamphetamine suppresses DOI-induced 5-HT2A-receptor mediated head-twitch response in mice
Sun, Y., Chebolu, S., Henry, D., Lankireddy, S., & Darmani, N. A. (2022) · BMC Neuroscience · doi:10.1186/s12868-021-00686-5 · Cited by 7
Stretching and squeezing of neuronal log firing rate distribution by psychedelic and intrinsic brain state transitionsPreprint
Dearnley, B., Dervinis, M., Shaw, M., & Okun, M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.22.457198 · Cited by 8
Cortical Correlates of Psychedelic-Induced Shaking Behavior Revealed by Voltage Imaging
Buchborn, T., Lyons, T., Song, C., Feilding, A., & Knöpfel, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119463 · Cited by 7
The Key Role of Intracellular 5-HT2A Receptors: A Turning Point in Psychedelic Research?
Sapienza, J. (2023) · Psychoactives · doi:10.3390/psychoactives2040018 · Cited by 6
Serotonergic Modulation of the Prefrontal Cortex: From Neurons to Brain Waves
Victoria, M. (2011) · InTech eBooks · doi:10.5772/25572 · Cited by 6
Hallucinogenic activity, neurotransmitters release, anxiolytic and neurotoxic effects in Rat's brain following repeated administration of novel psychoactive compound 25B-NBOMe
Wojtas, A., Herian, M., Maćkowiak, M., Solarz, A., Wawrzczak‐Bargieła, A., Bysiek, A., Noworyta, K., & Gołembiowska, K. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109713 · Cited by 6
Similar serotonin-2A receptor binding in rats with different coping styles or levels of aggression
Visser, A. K. D., Ettrup, A., Klein, A. B., van Waarde, A., Bosker, F. J., Meerlo, P., Knudsen, G. M., & de Boer, S. F. (2015) · Synapse · doi:10.1002/syn.21810 · Cited by 6
Radiosynthesis and Biological Evaluation of [18F]R91150, a Selective 5-HT2A Receptor Antagonist for PET-Imaging
Willmann, M., Hegger, J., Neumaier, B., & Ermert, J. (2021) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.0c00658 · Cited by 6
In Vivo Quantification of 5-HT 2A Brain Receptors in Mdr1a KO Rats with 123 I-R91150 Single-Photon Emission Computed Tomography
Dumas, N., Sallanon, M. M., Fender, P., Tournier, B. B., Ginovart, N., Charnay, Y., & Millet, P. (2015) · Molecular Imaging · doi:10.2310/7290.2015.00006 · Cited by 6
Electrophysiological mechanisms of psychedelic drugs: A systematic review
Jiménez, J. H., Kaup, K., & Aru, J. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106649 · Cited by 7
Effects of low-doses of methamphetamine on d-fenfluramine-induced head-twitch response (HTR) in mice during ageing and c-fos expression in the prefrontal cortex
Sun, Y., Chebolu, S., Skegrud, S., Kamali, S., & Darmani, N. A. (2023) · BMC Neuroscience · doi:10.1186/s12868-022-00766-0 · Cited by 5
Prolonged intermittent hypoxia differentially regulates phrenic motor neuron serotonin receptor expression in rats following chronic cervical spinal cord injury
Gonzalez‐Rothi, E. J., Allen, L. L., Seven, Y. B., Ciesla, M. C., Holland, A., Santiago, J. V., & Mitchell, G. S. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114808 · Cited by 5
Psychedelics in developmental stuttering to modulate brain functioning: a new therapeutic perspective?
Pasculli, G., Busan, P., Jackson, E. S., Alm, P. A., Gregorio, D. D., Maguire, G. A., Goodwin, G. M., Gobbi, G., Erritzøe, D., & Carhart-Harris, R. L. (2024) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2024.1402549 · Cited by 6
Abnormal cell-intrinsic and network excitability in the neocortex of serotonin-deficient Pet-1 knockout mice.
Puzerey, P. A., Kodama, N. X., & Galán, R. F. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00996.2014 · Cited by 6
Development of Tinnitus at a Low Dose of Sertraline: Clinical Course and Proposed Mechanisms
Miller, C. W. T. (2016) · Case Reports in Psychiatry · doi:10.1155/2016/1790692 · Cited by 5
Animal Models and Hallucinogenic Drugs
Kozlenkov, A., & González‐Maeso, J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4121-2_14 · Cited by 5
Subtraction and division of visual cortical population responses by the serotonergic systemPreprint
Azimi, Z., Spoida, K., Barzan, R., Wollenweber, P., Mark, M. D., Herlitze, S., & Jancke, D. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/444943 · Cited by 6
Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociabilityPreprint
Li, L.-F., Zhang, L.-Z., He, Z.-X., Zhang, Y.-T., Ma, H., Xun, Y.-F., Yuan, W., Hou, W.-J., Li, Y.-T., Lv, Z.-J., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.21.307280 · Cited by 5
Psychedelic Modulation of Excitation/Inhibition Balance: A Dual-Phase Neurodevelopmental Model
Kandilakis, C. L., & Papatheodoropoulos, C. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00892 · Cited by 5
Exploring a Druggable Hydrophobic Tunnel in the 5-HT2A Receptor with Potent Phenethylamines
Simon, Í. A., Pottie, E., Jensen, M. K., Harpsøe, K., Jensen, A. A., Kristensen, J. L., Stove, C. P., & Poulie, C. B. M. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c01973 · Cited by 4
Decoupling of cortical activity from behavioral state following administration of the classic psychedelic DOI
Olson, R. J., Bartlett, L., Sonneborn, A., Milton, R., Bretton-Granatoor, Z., Firdous, A., Harris, A. Z., & Abbas, A. I. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110030 · Cited by 6
Neuromodulation of Hippocampal Cells and Circuits
Lawrence, J. J., & Cobb, S. (2018) · Springer series in computational neuroscience · doi:10.1007/978-3-319-99103-0_7 · Cited by 4
Synapsin II Directly Suppresses Epileptic Seizures In Vivo
Schwark, R., Andrade, R., & Bykhovskaia, M. (2022) · Brain Sciences · doi:10.3390/brainsci12030325 · Cited by 4
Making Sense of Psychedelics in the CNS
Fordyce, B. A., & Roth, B. L. (2024) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyae007 · Cited by 4
AN INTEGRATIVE MODEL OF PERSONALITY DISORDER: PART 3: MECHANISM-BASED APPROACH TO THE PHARMACOTHERAPY OF PERSONALITY DISORDER: AN EMERGING CONCEPT
Švrakić, D. M., Mofsen, A. M., Chockalingam, R., Divac-Jovanović, M., & Zorumski, C. F. (2019) · Psychiatria Danubina · doi:10.24869/psyd.2019.290 · Cited by 4
Differential expression of HTR2A and MAOA genes in the prefrontal cortex and hypothalamus of suicide victims from Mexican population
Ramos-Rosales, D. F., Méndez-Hernández, E. M., Salas-Pacheco, J. M., Salas-Leal, A. C., Úrtiz-Estrada, N., Barraza-Salas, M., & Peña, P. P. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136611 · Cited by 3
Absence of sex differences in serotonergic control of orbitofrontal cortex neuronal activity
Mooney, K., Hoffman, A. F., & Lupica, C. R. (2025) · Scientific Reports · doi:10.1038/s41598-025-11208-2 · Cited by 4
Serotonin-endocannabinoid crosstalk selectively regulates inhibitory GABAergic inputs in the medial prefrontal cortex
Meza, R. C., Morales-Weil, K., Ancatén-González, C., Escobar, A. P., Alcaino, A., Sanguinetti, N. K., Delpire, E. J., Moya, P. R., Chiu, C. Q., Fuenzalida, M., et al. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02364-8 · Cited by 3
Rapid dynamics of dorsal raphe serotonin neurons regulate the strength of visual attention
Lehnert, J., Cha, K., Forestell, J., Yang, K., Ma, X., Shariff, S., Britt, J. P., Khadra, A., Cook, E. P., & Krishnaswamy, A. (2026) · Nature Communications · doi:10.1038/s41467-026-70658-y · Cited by 3
Effects of ayahuasca on fear and anxiety: cross-talk between 5HT1A and 5HT2A receptors
Guerra, L. T. L., SANTOS, R. G. D., & Hallak, J. E. C. (2024) · Psychedelics. · doi:10.61373/pp024i.0037 · Cited by 3
Molecular Pathways Potentially Involved in Hallucinatory Experiences During Sleep Paralysis: The Emerging Role of β-Arrestin-2
Rudy, L. M., & Godlewski, M. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157233 · Cited by 4
[Chronic eosinophilic pneumonia presenting as a solitary nodule, suspicious of lung cancer;report of a case].
Matsuoka, T., 上松, 浩., Iwakiri, S., & Itoi, K. (2013) · PubMed · Cited by 2
Cellular effects of serotonin in the CNS
Andrade, R., & Haj‐Dahmane, S. (2020) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-444-64125-0.00015-3 · Cited by 3
N-(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels
Denomme, N., Hernández, C. C., Bock, H. A., Ohana, R. F., Bakshi, S., Sherwood, A. M., McCorvy, J. D., Daley, P. F., Callaway, W. B., Hull, J. M., et al. (2024) · Molecular Pharmacology · doi:10.1124/molpharm.123.000837 · Cited by 2
The compulsive eating paradigm: can psychedelics help in treating obesity?
Ammineni, D., & Park, R. J. (2025) · Journal of Eating Disorders · doi:10.1186/s40337-024-01186-7 · Cited by 2
A chromosome region linked to neurodevelopmental disorders influences locomotor behavior through sex-specific neural circuits
Kim, J., Vanrobaeys, Y. S., Rajan, R., Davatolhagh, M. F., Kelvington, B. A., Chatterjee, S., Ferri, S. L., Angelakos, C. C., Mills, A. A., Fuccillo, M. V., et al. (2026) · Nature Communications · doi:10.1038/s41467-025-68047-y · Cited by 11
Ibogalogs Activate the 5-HT2A Receptor through a Mechanism Involving Outward and Inward Movements of the Respective Transmembrane Segment TM6 and TM7
Rudin, D., Ren, X., Liechti, M. E., Huang, N., & Arias, H. R. (2026) · Neurochemical Research · doi:10.1007/s11064-026-04727-5 · Cited by 3
A gedanken experiment to find a neuroanatomical model for post-traumatic stress disorder
Eggers, A. E. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2014.10.021 · Cited by 2
Neuromodulatory mechanisms of N,N-dimethyltryptamine
Jiménez, J. H. (2023) · Brain Network and Modulation · doi:10.4103/2773-2398.386227 · Cited by 3
Transcriptomically-Guided Pharmacological Experiments in Neocortical and Hippocampal NPY-Positive GABAergic Interneurons
Beerens, S., Winterer, J., Lukacsovich, D., Földy, C., & Wozny, C. (2022) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-225584 · Cited by 2
Crosstalk Between 5-HT2A and mGlu2 Receptors: Implications in Schizophrenia and Its Treatment
Moreno, J. L., & González‐Maeso, J. (2018) · Springer eBooks · doi:10.1007/978-3-319-70474-6_7 · Cited by 2
Revealing the Neurobiology Underlying Interpersonal Neural Synchronization with Multimodal Data FusionPreprint
Lotter, L., Kohl, S. H., Gerloff, C., Bell, L., Niephaus, A., Kruppa, J. A., Dukart, J., Schulte-Rüther, M., Reindl, V., & Konrad, K. (2022) · bioRxiv · doi:10.1101/2022.07.26.501562 · Cited by 51
Persistent large-scale changes in alternative splicing in prefrontal cortical neuron types following psychedelic exposurePreprint
Hsiao, Y., Fonseca, M. A., Tiemroth, A. S., Vasquez, E. J., & Gomez, A. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.16.633439 · Cited by 2
Exploring the therapeutic potential of psychedelics: Fear extinction mechanisms and amygdala modulation
Kelly, T. J., & Liu, Q.-S. (2024) · Psychedelics. · doi:10.61373/pp024b.0019 · Cited by 1
Serotonin engages divergent 5‐HT receptor pathways for cell type‐resolved modulation of prefrontal layer 5 microcircuits
Rama, R., Qi, G., Radnikow, G., Yang, D., & Feldmeyer, D. (2026) · British Journal of Pharmacology · doi:10.1111/bph.70573 · Cited by 1
Snapshot IP 1 Detection Following 5-HT 2 A Receptor Stimulation in the Mouse Brain
Revenga, M. D. L. F., & González‐Maeso, J. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00932 · Cited by 1
Development of a Whole-brain Imaging System at Subcellular Resolution for Analysis of Animal Models of Neuropsychiatric Disorders
Seiriki, K. (2019) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.19-00169 · Cited by 1
[18F]R91150: Improved radiosynthesis and in vivo evaluation as imaging probe for 5-HT2A receptors.
Hoffmann, C., Endepols, H., Urusova, E., Elchine, D., Neumaier, F., Neumaier, B., & Zlatopolskiy, B. (2025) · European journal of medicinal chemistry · doi:10.1016/j.ejmech.2025.117265
Sleep deprivation rapidly upregulates serotonin 2A receptor expression via the immediate early gene Egr3Preprint
Zhao, X., Meyers, K. T., McBride, A., Marballi, K. K., Maple, A. M., Beck, K. L., Kang, P. T., Palner, M., Overgaard, A., Knudsen, G. M., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/634410 · Cited by 1
Neurovascular Uncoupling: Multimodal Imaging Delineates the Acute Effects of MDMAPreprint
Ionescu, T. M., Amend, M., Watabe, T., Hatazawa, J., Maurer, A., Reischl, G., Pichler, B. J., Wehrl, H. F., & Herfert, K. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.14.480365 · Cited by 1
The classic psychedelic DOI induces a persistent desynchronized state in medial prefrontal cortexPreprint
Olson, R. J., Bartlett, L., Sonneborn, A., Bretton-Granatoor, Z., Firdous, A., Harris, A. Z., & Abbas, A. I. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.26.529963 · Cited by 1
Activity of prefrontal cortex serotonin 2A receptor expressing neurons is necessary for the head-twitch response of mice to psychedelic drug DOI in a sex-dependent mannerPreprint
Ozols, A. B., Wei, J., Campbell, J. M., Hu, C., Qiu, S., & Gallitano, A. L. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.21.595211 · Cited by 1
The impact of the serotonergic psychedelic DOI on active vision in freely moving micePreprint
Skyberg, R. J., Fields, C. W., Martins, D. M., & Niell, C. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.14.682230 · Cited by 1
A Randomised, Triple-Blind, Dose-Finding Study of the Impact of Psilocybin on Motor Function in Healthy ParticipantsPreprint
Bhagavan, C., Carter, O. L., Nielsen, G., Berlowitz, D. J., Issak, S., Braat, S., Zaloumis, S. G., Attard, Z., Oliver, G., Mayne, D., et al. (2025) · medRxiv · doi:10.64898/2025.12.22.25342874 · Cited by 1
Cannabinoid Regulation of Serotonin 2A (5-HT 2A ) Receptor Signaling
Franklin, J. M. (2013)
5HT2A Receptor Antagonist Treatment for Repetitive Behaviors and Restricted Interests in BTBR Mice
Amodeo, D. A. (2015) · Figshare
The role of serotonin in cortical excitability and network dynamics
Puzerey, P. A. (2015) · OhioLink ETD Center (Ohio Library and Information Network)
Assessment of Serotonergic Function by Radioligands and Microdialysis
Visser, A. (2014)
Controlling Prefrontal Attention Circuits: Neuromodulation of Cortical Layer 6 and its Local Outputs
Tian, M. K. (2017) · TSpace (University of Toronto)
RELATIONSHIP BETWEEN THE ALLOY FREQUENCY OF THE T102C POLYMORPHISM OF THE 5HT2A GENE WITH ANTHROPOMETRIC AND CARDIOMETABOLIC MEASURES
Mallmanna, B., Tonini, C., Chielle, E., & Chielle, E. O. (2019) · Archives in Biosciences & Health · doi:10.18593/abh.20573
Differential Expression of HTR2A and MAOA Genes in the Prefrontal Cortex and Hypothalamus of Suicide Victims from a Mexican PopulationPreprint
Ramos-Rosales, D. F., Méndez-Hernández, E. M., Salas, J. M., Salas, A. C., Úrtiz-Estrada, N., & Barraza, M. (2020) · doi:10.21203/rs.3.rs-42474/v1
Toxicological Profile of 25I-NBOMe: Brain Distribution, DNA Damage, Apoptotic Signal and Glial AbnormalitiesPreprint
Herian, M., Adam, W., Maćkowiak, M., Agnieszka, B.-W., Solarz, A., Bysiek, A., Katarzyna, M., & Gołembiowska, K. (2021) · Research Square · doi:10.21203/rs.3.rs-963701/v1
The good, the bad, and the intoxicated
Mason, N. L. (2021) · Research Publications (Maastricht University) · doi:10.26481/dis.20210608nm
Faculty Opinions recommendation of Enhanced function of prefrontal serotonin 5-HT(2) receptors in a rat model of psychiatric vulnerability.
Roberts, A. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.5187956.5126054
Snapshot of 5-HT 2A receptor activation in the mouse brain via IP 1 detectionPreprint
Revenga, M. D. L. F., & González‐Maeso, J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.11.617861
Effects of lateral ventricle injection of 5,7-dihydroxytryptamine on neurons in the medial prefrontal cortex of rats: An electrophysiology study
Fan, L., Deng, B., Hao, X., Qiu, X., & Liu, Y. (2024) · Neuroscience Letters · doi:10.1016/j.neulet.2024.138034
Cortical Serotonin Type 2A Receptor Activation Shields Episodic-like Memories from Retroactive Interference in Rodents
Morici, J. F., Imperatori, M., Koss, P., Zanoni, M. B., Sacson, A., Bekinschtein, P., & Weisstaub, N. V. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6c00079
Ethical challenges in the therapeutic application of classical psychedelics for pediatric health conditions: A comprehensive review
Vlotinou, P., Christodoulou, K., Tsiakiri, A., Christidi, F., & Serdari, A. (2025) · Brazilian Journal of Science · doi:10.14295/bjs.v4i10.785
Rôle des récepteurs 5-HT2A et 5-HT6 du cortex préfrontal dans la modulation de la transmission synaptique, la plasticité et la cognition
Berthoux, C. (2017) · theses.fr (ABES) · doi:10.70675/4a004943zc84ez4f85z80d7z47bd0c2b7848
Conséquences de la délétion conditionnelle du gène Tshz3 dans la circuiterie cortico-striée : implications dans les troubles du spectre autistique
Chabbert, D. (2017) · theses.fr (ABES) · doi:10.70675/6ac224e2z22c7z4bd4zb6dazc3f301e5b758
Dynamical circular inference in the general population and the psychosis spectrum : insights from perceptual decision making
Leptourgos, P. (2018) · theses.fr (ABES) · doi:10.70675/dafacdb1z9072z4ec2z8cebz0ca09b93b7ce · Cited by 3

Authors: Weber
Affiliations: Wayne State University (US)
Corresponding author: Weber
Venue: Frontiers in Neuroscience
Publisher: Frontiers Media SA
Published: 2010
Volume: 4
ISSN: 1662-453X (ISSN-L)
DOI: 10.3389/fnins.2010.00036
PMC: PMC2928707
OpenAlex: W2166045982
Cited by: 205
References: 53
Citations by year: 2026: 16 · 2025: 10 · 2024: 16 · 2023: 17 · 2022: 17 · 2021: 17 · 2020: 13 · 2019: 14 · 2018: 12 · 2017: 8 · 2016: 9 · 2015: 16 · 2014: 9 · 2013: 9 · 2012: 8
FWCI: 4.01
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Neuroscience (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health
National Institute of Mental Health (R01MH043985)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Keywords: HTR2A, 5-HT2A receptor, cerebral cortex, serotonin receptors, cortical cell types, layer 5 pyramidal neurons, GABAergic interneurons, parvalbumin interneurons, fast-spiking interneurons, receptor knockout mice, BAC transgenic mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Htr2a gene and 5-HT2A receptor expression in the cerebral cortex studied using genetically modified mice

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks