The role of GABA in the regulation of GnRH neurons
Open accessAbstract
Gonadotropin-releasing hormone (GnRH) neurons form the final common pathway for the central regulation of reproduction. Gamma-amino butyric acid (GABA) has long been implicated as one of the major players in the regulation of GnRH neurons. Although GABA is typically an inhibitory neurotransmitter in the mature adult central nervous system, most mature GnRH neurons show the unusual characteristic of being excited by GABA. While many reports have provided much insight into the contribution of GABA to the activity of GnRH neurons, the precise physiological role of the excitatory action of GABA on GnRH neurons remains elusive. This brief review presents the current knowledge of the role of GABA signaling in GnRH neuronal activity. We also discuss the modulation of GABA signaling by neurotransmitters and neuromodulators and the functional consequence of GABAergic inputs to GnRH neurons in both the physiology and pathology of reproduction.
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GnRH activity is regulated by neurotransmitters, steroid hormones, and growth factors.
“The activity of GnRH is regulated by neurotransmitters, steroid hormones, and growth factors (Watanabe, Fukuda, & Nabekura, 2014).”
From Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity (2017) · cites this paper as Watanabe, Fukuda, & Nabekura, 2014
The LH surge is inhibited by GABA.
“Different data converge to indicate that the LH surge is stimulated by glutamate [102,103] and inhibited by GABA [104,105]”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [104]
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Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
Excitatory actions of gaba during development: the nature of the nurture
Ben-Ari, Y. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn920 · Cited by 2,448 · see citing works
Messager, S., Chatzidaki, E. E., Ma, D., Hendrick, A. G., Zahn, D., Dixon, J., Thresher, R. R., Malinge, I., Lomet, D., Carlton, M. B. L., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409330102 · Cited by 1,215 · see citing works
A role for kisspeptins in the regulation of gonadotropin secretion in the mouse
Gottsch, M. L., Cunningham, M. J., Smith, J. T., Popa, S. M., Acohido, B. V., Crowley, W. F., Seminara, S., Clifton, D. K., & Steiner, R. A. (2004) · Endocrinology · doi:10.1210/en.2004-0431 · Cited by 1,161 · see citing works
Han, S.-K., Gottsch, M. L., Lee, K. J., Popa, S. M., Smith, J. T., Jakawich, S. K., Clifton, D. K., Steiner, R. A., & Herbison, A. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3328-05.2005 · Cited by 1,036 · see citing works
Immortalization of hypothalamic GnRH by genetically targeted tumorigenesis
Mellon, P. L., Windle, J. J., Goldsmith, P. C., Padula, C. A., Roberts, J. L., & Weiner, R. I. (1990) · Neuron · doi:10.1016/0896-6273(90)90028-e · Cited by 952 · see citing works
Cation-Chloride Cotransporters and Neuronal Function
Blaesse, P., Airaksinen, M. S., Rivera, C., & Kaila, K. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.003 · Cited by 825 · see citing works
Two isoforms of glutamate decarboxylase: why?
Soghomonian, J., & Martin, D. L. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(98)01270-x · Cited by 643 · see citing works
Mechanism of Activity-Dependent Downregulation of the Neuron-Specific K-Cl Cotransporter KCC2
Rivera, C., Voipio, J., Thomas-Crusells, J., Li, H., Emri, Z., Sipilä, S., Payne, J. A., Minichiello, L., Saarma, M., & Kaila, K. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5265-03.2004 · Cited by 515 · see citing works
Spergel, D. J., Krüth, U., Hanley, D. F., Sprengel, R., & SEEBURG, P. H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-02037.1999 · Cited by 415 · see citing works
Roles of the cation–chloride cotransporters in neurological disease
Kahle, K. T., Staley, K. J., Nahed, B. V., Gamba, G., Hébert, S., Lifton, R. P., & Mount, D. B. (2008) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0883 · Cited by 407 · see citing works
Leptin Indirectly Regulates Gonadotropin-Releasing Hormone Neuronal Function
Quennell, J. H., Mulligan, A. C., Tups, A., Liu, X., Phipps, S. J., Kemp, C. J., Herbison, A. E., Grattan, D. R., & Anderson, G. M. (2009) · Endocrinology · doi:10.1210/en.2008-1693 · Cited by 385 · see citing works
Maddocks, O. D. K., & Vousden, K. H. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0735-5 · Cited by 359 · see citing works
Sullivan, S. D., & Moenter, S. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308058101 · Cited by 309 · see citing works
Activation of A-Type γ-Aminobutyric Acid Receptors Excites Gonadotropin-Releasing Hormone Neurons
DeFazio, R. A., Heger, S., Ojeda, S. R., & Moenter, S. M. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0163 · Cited by 287 · see citing works
Neuroendocrine Control of the Ovarian Cycle of the Rat
Freeman, M. R. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50048-8 · Cited by 285 · see citing works
Wetsel, W. C., Valênça, M. M., Merchenthaler, I. J., Liposits, Z., LÓPEZ, F. J., Weiner, R. I., Mellon, P. L., & Negro-Vilar, A. F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.4149 · Cited by 280 · see citing works
Glutamic Acid Decarboxylase-Containing Axons Synapse on LHRH Neurons in the Rat Medial Preoptic Area
Léránth, C., MacLusky, N. J., Sakamoto, H., Shanabrough, M., & Naftolin, F. N. (2008) · Neuroendocrinology · doi:10.1159/000124127 · Cited by 272 · see citing works
Suter, K. J. (2000) · Endocrinology · doi:10.1210/en.141.1.412 · Cited by 270 · see citing works
Reduction of KCC2 Expression and GABAAReceptor-Mediated Excitation after In Vivo Axonal Injury
Nabekura, J., Ueno, T., Okabe, A., Furuta, A., Iwaki, T., Shimizu‐Okabe, C., Fukuda, A., & Akaike, N. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04412.2002 · Cited by 264 · see citing works
Self-citationHerbison, A. E., & Moenter, S. M. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02145.x · Cited by 260 · see citing works
Modulation of neuronal activity by phosphorylation of the K–Cl cotransporter KCC2
Kahle, K. T., Deeb, T. Z., Puskarjov, M., Silayeva, L., Liang, B., Kaila, K., & Moss, S. J. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.08.006 · Cited by 224 · see citing works
Suter, K. J., Song, W. J., Sampson, T. L., Wuarin, J., Saunders, J. T., Dudek, F. E., & Moenter, S. M. (2000) · Endocrinology · doi:10.1210/endo.141.1.7279 · Cited by 223 · see citing works
Lemko, H. M. D., Gottsch, M. L., Zeng, H., Gragerov, A., Bergmann, J. E., Vassilatis, D. K., Clifton, D. K., & Steiner, R. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2748-07.2007 · Cited by 220 · see citing works
Female reproductive maturation in the absence of kisspeptin/GPR54 signaling
Mayer, C., & Boehm, U. (2011) · Nature Neuroscience · doi:10.1038/nn.2818 · Cited by 213 · see citing works
Lagrange, A. H., Rønnekleiv, O. K., & Kelly, M. J. (1995) · Endocrinology · doi:10.1210/endo.136.5.7720682 · Cited by 202 · see citing works
Dual-phenotype GABA/glutamate neurons in adult preoptic area: sexual dimorphism and function
Ottem, E. N., Godwin, J. G., Krishnan, S., & Petersen, S. L. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2267-04.2004 · Cited by 201 · see citing works
Elliott, K. A. C., & Jasper, H. H. (1959) · Physiological Reviews · doi:10.1152/physrev.1959.39.2.383 · Cited by 188 · see citing works
Wake, H., Watanabe, M., Moorhouse, A. J., Kanematsu, T., Horibe, S., Matsukawa, N., Asai, K., Ojika, K., Hirata, M., & Nabekura, J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3104-06.2007 · Cited by 186 · see citing works
Self-citationHan, S., Ábrahám, I. M., & Herbison, A. E. (2002) · Endocrinology · doi:10.1210/endo.143.4.8724 · Cited by 183 · see citing works
GnRH Neurons Elaborate a Long-Range Projection with Shared Axonal and Dendritic Functions
Herde, M. K., Iremonger, K. J., Constantin, S., & Herbison, A. E. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0579-13.2013 · Cited by 170 · see citing works
Kusano, K., Fueshko, S. M., Gainer, H., & Wray, S. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.9.3918 · Cited by 164 · see citing works
The goldfish (Carassius auratus) as a model for neuroendocrine signaling
Popesku, J. T., Martyniuk, C. J., Mennigen, J. A., Xiong, H., Zhang, D., Xia, X., Cossins, A. R., & Trudeau, V. L. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.06.017 · Cited by 159 · see citing works
Endogenous GABA Release Inhibits the Firing of Adult Gonadotropin-Releasing Hormone Neurons
Han, S., Todman, M. G., & Herbison, A. E. (2003) · Endocrinology · doi:10.1210/en.2003-1333 · Cited by 147 · see citing works
Physiology of the Gonadotropin-Releasing Hormone Neuronal Network
Herbison, A. E. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50033-6 · Cited by 139 · see citing works
GABA Has Excitatory Actions on GnRH-Secreting Immortalized Hypothalamic (GT1-7) Neurons
Hales, T. G., Sanderson, M. J., & Charles, A. C. (2008) · Neuroendocrinology · doi:10.1159/000126671 · Cited by 137 · see citing works
Late postnatal reorganization of GABAA receptor signalling in native GnRH neurons
Sim, J. A., Skynner, M. J., Pape, J., & Herbison, A. E. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00261.x · Cited by 135 · see citing works
Herbisorn, A. E., & Dyer, R. G. (2008) · Neuroendocrinology · doi:10.1159/000125735 · Cited by 134 · see citing works
Christian, C. A., & Moenter, S. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4738-06.2007 · Cited by 133 · see citing works
Chu, Z., Andrade, J., Shupnik, M. A., & Moenter, S. M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0352-09.2009 · Cited by 133 · see citing works
Toyoda, H., Ohno, K., Yamada, J., Ikeda, M., Okabe, A., Sato, K., Hashimoto, K., & Fukuda, A. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00721.2002 · Cited by 132 · see citing works
Self-citationEndogenous γ-Aminobutyric Acid Can Excite Gonadotropin-Releasing Hormone Neurons
Moenter, S. M., & DeFazio, R. A. (2005) · Endocrinology · doi:10.1210/en.2005-0788 · Cited by 131 · see citing works
The role of amino acid neurotransmitters in the regulation of pituitary gonadotropin release in fish
Trudeau, V. L., Spanswick, D. C., Fraser, E. J., Larivière, K., Crump, D., Chiu, S., MacMillan, M. L., & Schulz, R. W. (2000) · Biochemistry and Cell Biology · doi:10.1139/bcb-78-3-241 · Cited by 128 · see citing works
ADLER, B. A., & Crowley, W. R. (1986) · Endocrinology · doi:10.1210/endo-118-1-91 · Cited by 126 · see citing works
Farkas, I., Kalló, I., Deli, L., Vida, B., Hrabovszky, E., Fekete, C., Moenter, S. M., Watanabe, M., & Liposits, Z. (2010) · Endocrinology · doi:10.1210/en.2010-0638 · Cited by 120 · see citing works
Self-citationFueshko, S. M., Key, S., & Wray, S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02560.1998 · Cited by 118 · see citing works
Clustering of Neuronal K+-Cl− Cotransporters in Lipid Rafts by Tyrosine Phosphorylation
Watanabe, M., Wake, H., Moorhouse, A. J., & Nabekura, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.043620 · Cited by 116 · see citing works
Self-citationZhang, C., Bosch, M. A., Rønnekleiv, O. K., & Kelly, M. J. (2009) · Endocrinology · doi:10.1210/en.2008-1313 · Cited by 110 · see citing works
Tobet, S. A., Chickering, T. W., King, J. C., Stopa, E. G., Kim, K., Kuo-LeBlanc, V., & Schwarting, G. A. (1996) · Endocrinology · doi:10.1210/endo.137.12.8940365 · Cited by 96 · see citing works
Leptin Signaling in GABA Neurons, But Not Glutamate Neurons, Is Required for Reproductive Function
Zuure, W. A., Roberts, A. L., Quennell, J. H., & Anderson, G. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2278-13.2013 · Cited by 96 · see citing works
Jarry, H., Leonhardt, S., & Wuttke, W. (2008) · Neuroendocrinology · doi:10.1159/000125727 · Cited by 95 · see citing works
Pielecka-Fortuna, J., & Moenter, S. M. (2009) · Endocrinology · doi:10.1210/en.2009-0692 · Cited by 95 · see citing works
Chu, Z. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0913-05.2005 · Cited by 92 · see citing works
Sullivan, S. D., DeFazio, R. A., & Moenter, S. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-24-08578.2003 · Cited by 91 · see citing works
Martin, C., Navarro, V. M., Simavlı, S. A., Vong, L., Carroll, R. S., Lowell, B. B., & Kaiser, U. B. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3003-13.2014 · Cited by 90 · see citing works
Bless, E. P., Westaway, W. A., Schwarting, G. A., & Tobet, S. A. (2000) · Endocrinology · doi:10.1210/endo.141.3.7348 · Cited by 89 · see citing works
Sullivan, S. D., & Moenter, S. M. (2003) · Endocrinology · doi:10.1210/en.2003-1374 · Cited by 87 · see citing works
Jarry, H., Leonhardt, S., Schwarze, T., & Wuttke, W. (2008) · Neuroendocrinology · doi:10.1159/000127037 · Cited by 84 · see citing works
Constantin, S., Iremonger, K. J., & Herbison, A. E. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0533-13.2013 · Cited by 83 · see citing works
Charles, A. C., & Hales, T. G. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.73.1.56 · Cited by 83 · see citing works
Romanò, N., Lee, K., Ábrahám, I., Jasoni, C., & Herbison, A. (2008) · Endocrinology · doi:10.1210/en.2008-0424 · Cited by 80 · see citing works
Sullivan, S. D., & Moenter, S. M. (2003) · Endocrinology · doi:10.1210/en.2003-0634 · Cited by 79 · see citing works
Biphasic Gabaergic Regulation of GnRH Secretion in GT 1 Cell Lines
de la Escalera, G. M., Choi, A. L. H., & Weiner, R. I. (2008) · Neuroendocrinology · doi:10.1159/000126687 · Cited by 78 · see citing works
Wray, S., Fueshko, S. M., Kusano, K., & Gainer, H. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0334 · Cited by 68 · see citing works
Herbison, A. E., Chapman, C., & Dyer, R. G. (1991) · Experimental Brain Research · doi:10.1007/bf00231851 · Cited by 65 · see citing works
Yin, C., Ishii, H., Tanaka, N., Sakuma, Y., & Kato, M. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01697.x · Cited by 65 · see citing works
Donoso, A. O., López, F. J., & Negro-Vilar, A. F. (1992) · Endocrinology · doi:10.1210/endo.131.3.1354606 · Cited by 64 · see citing works
Knockdown of GABAA Receptor Signaling in GnRH Neurons Has Minimal Effects upon Fertility
Lee, K., Porteous, R. W., Campbell, R. E., Lüscher, B., & Herbison, A. E. (2010) · Endocrinology · doi:10.1210/en.2010-0314 · Cited by 62 · see citing works
Herbison, A. E., Augood, S. J., & McGowan, E. M. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90098-v · Cited by 60 · see citing works
Recent Discoveries on the Control of Gonadotrophin‐Releasing Hormone Neurones in Nonhuman Primates
Terasawa, E., Kurian, J. R., Guerriero, K. A., Kenealy, B. P., Hutz, E. D., & Keen, K. L. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02027.x · Cited by 58 · see citing works
Kurian, J. R., Keen, K. L., Guerriero, K. A., & Terasawa, E. (2012) · Endocrinology · doi:10.1210/en.2012-1221 · Cited by 57 · see citing works
Heger, S., Seney, M. L., Bless, E. P., Schwarting, G. A., Bilger, M., Mungenast, A. E., Ojeda, S. R., & Tobet, S. A. (2003) · Endocrinology · doi:10.1210/en.2002-221107 · Cited by 57 · see citing works
SDF and GABA interact to regulate axophilic migration of GnRH neurons
Casoni, F., Hutchins, B. I., Donohue, D. E., Fornaro, M., Condie, B. G., & Wray, S. (2012) · Journal of Cell Science · doi:10.1242/jcs.101675 · Cited by 54 · see citing works
Catalano, P. N., Bonaventura, M. M., Silveyra, P., Bettler, B., Libertun, C., & Lux-Lantos, V. A. (2005) · Neuroendocrinology · doi:10.1159/000093128 · Cited by 53 · see citing works
Leonhardt, Shahab, S., Luft, Wuttke, & Jarry (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00377.x · Cited by 52 · see citing works
Luteinizing Hormone-Releasing Hormone (LHRH) Biosynthesis and Secretion in Embryonic LHRH Neurons
Moore, J. P., & Wray, S. (2000) · Endocrinology · doi:10.1210/endo.141.12.7814 · Cited by 50 · see citing works
Eto, K., Ishibashi, H., Yoshimura, T., Watanabe, M., Miyamoto, A., Ikenaka, K., Moorhouse, A. J., & Nabekura, J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2104-12.2012 · Cited by 50 · see citing works
Self-citationConstantin, S., Jasoni, C. L., Wadas, B. C., & Herbison, A. E. (2009) · Endocrinology · doi:10.1210/en.2009-0817 · Cited by 49 · see citing works
Favit, A., Wetsel, W. C., & Negro-Vilar, A. F. (1993) · Endocrinology · doi:10.1210/en.133.5.1983 · Cited by 49 · see citing works
Kimura, F., & Jinnai, K. (1994) · Hormones and Behavior · doi:10.1006/hbeh.1994.1039 · Cited by 47 · see citing works
Bilger, M., Heger, S., Brann, D. W., Paredes, A., & Ojeda, S. R. (2001) · Endocrinology · doi:10.1210/endo.142.5.8166 · Cited by 46 · see citing works
GABAA Receptors Mediate Excitation in Adult Rat GnRH Neurons1
Watanabe, M., Sakuma, Y., & Kato, M. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.108.074583 · Cited by 45 · see citing works
Self-citationReid, K. H., Guo, S. Z., & Iyer, V. G. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02121-1 · Cited by 44 · see citing works
Bhattarai, J. P., Park, S. A., Park, J. B., Lee, S. Y., Herbison, A. E., Ryu, P. D., & Han, S. K. (2011) · Endocrinology · doi:10.1210/en.2010-1191 · Cited by 43 · see citing works
Constantin, S., Piet, R., Iremonger, K. J., Yeo, S., Clarkson, J., Porteous, R. W., & Herbison, A. E. (2012) · Endocrinology · doi:10.1210/en.2012-1126 · Cited by 43 · see citing works
Chen, P., & Moenter, S. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2509-09.2009 · Cited by 42 · see citing works
Spergel, D. J., Krsmanović, L. Z., Stojilković, S. S., & Catt, K. J. (2008) · Neuroendocrinology · doi:10.1159/000126873 · Cited by 42 · see citing works
Temple, J. L., & Wray, S. (2005) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2005.01348.x · Cited by 42 · see citing works
Curran-Rauhut, M. A., & Petersen, S. L. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2002.00780.x · Cited by 41 · see citing works
Bergen, H., Hejtmancik, J. F., & Pfaff, D. W. (1991) · Experimental Brain Research · doi:10.1007/bf00228505 · Cited by 40 · see citing works
Glanowska, K. M., & Moenter, S. M. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00046.2011 · Cited by 38 · see citing works
Giorgio, N. P. D., Catalano, P. N., López, P. V., González, B., Semaan, S. J., López, G. C., Kauffman, A. S., Rulli, S. B., Somoza, G. M., Bettler, B., et al. (2013) · Neuroendocrinology · doi:10.1159/000355631 · Cited by 34 · see citing works
Kang, S. H., Seong, J. Y., Cho, S., Cho, H., & Kim, K. (2008) · Neuroendocrinology · doi:10.1159/000126871 · Cited by 32 · see citing works
Excitatory Action of GABA in the Terminal Nerve Gonadotropin-Releasing Hormone Neurons
Nakane, R., & Oka, Y. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00910.2009 · Cited by 32 · see citing works
Leupen, S., Tobet, S. A., Crowley, W. F., & Kaila, K. (2003) · Endocrinology · doi:10.1210/en.2002-220995 · Cited by 31 · see citing works
Root, A. R., Sanford, J. D., Kavanaugh, S. I., & Sower, S. A. (2004) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpb.2004.06.011 · Cited by 30 · see citing works
Glutamatergic and GABAergic Innervation of Human Gonadotropin-Releasing Hormone-I Neurons
Hrabovszky, E., Molnár, C. S., Nagy, R., Vida, B., Borsay, B. Á., Racz, K., Herczeg, L., Watanabe, M., Kalló, I., & Liposits, Z. (2012) · Endocrinology · doi:10.1210/en.2011-2106 · Cited by 27 · see citing works
Self-citationConstantin, S., Jasoni, C. L., Romanò, N., Lee, K., & Herbison, A. E. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.11.005 · Cited by 23 · see citing works
Sato, S., Yin, C., Teramoto, A., Sakuma, Y., & Kato, M. (2008) · The Journal of Physiological Sciences · doi:10.2170/physiolsci.rp006208 · Cited by 23 · see citing works
Reed, K. L., MacIntyre, J., Tobet, S. A., Trudeau, V. L., MacEachern, L., Rubin, B. S., & Sower, S. A. (2002) · Brain Behavior and Evolution · doi:10.1159/000064117 · Cited by 22 · see citing works
Ahnert‐Hilger, G., John, M., Kistner, U., Wiedenmann, B. J., & Jarry, H. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00129.x · Cited by 22 · see citing works
Temporal Migration of Gonadotrophin‐Releasing Hormone‐1 Neurones is Modified in GAD67 Knockout Mice
Lee, J. M., Tiong, J. D. R., Maddox, D. M., Condie, B. G., & Wray, S. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01623.x · Cited by 21 · see citing works
Lin, Y., Li, X. F., Shao, B., Hu, M., Goundry, A. L. R., Jeyaram, A., Lightman, S. L., & O’Byrne, K. T. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02270.x · Cited by 20 · see citing works
Hemond, P. J., O’Boyle, M., Roberts, C. B., Delgado, A., Hemond, Z., & Suter, K. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4188-11.2012 · Cited by 20 · see citing works
Kwakowsky, A., Cheong, R. Y., Herbison, A. E., & Ábrahám, I. M. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.08.002 · Cited by 16 · see citing works
Hiruma, H., Sano, A., & Kimura, F. (1994) · Brain Research · doi:10.1016/0006-8993(94)90145-7 · Cited by 16 · see citing works
Vastagh, C., Schwirtlich, M., Kwakowsky, A., Erdélyi, F., Margolis, F. L., Yanagawa, Y., Katarova, Z., & Szabó, G. (2014) · Developmental Neurobiology · doi:10.1002/dneu.22222 · Cited by 9 · see citing works
Cho, B. N., & Kim, K. (1997) · PubMed · Cited by 5 · see citing works
Cho, B.-N., & Kim, K. (1997) · Molecules and Cells · doi:10.1016/s1016-8478(23)13346-2 · Cited by 4 · see citing works
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Oyola, M. G., & Handa, R. J. (2017) · Stress · doi:10.1080/10253890.2017.1369523 · Cited by 710 · see citing works
Salliss, M. E., Farland, L. V., Mahnert, N. D., & Herbst‐Kralovetz, M. M. (2021) · Human Reproduction Update · doi:10.1093/humupd/dmab035 · Cited by 287 · see citing works
Development and regulation of chloride homeostasis in the central nervous system
Watanabe, M., & Fukuda, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00371 · Cited by 230 · see citing works
Self-citationγ-Aminobutyric Acid (GABA): Biosynthesis, Role, Commercial Production, and Applications
Rashmi, D., Zanan, R. L., John, S., Khandagale, K. S., & Nadaf, A. B. (2018) · Studies in natural products chemistry · doi:10.1016/b978-0-444-64057-4.00013-2 · Cited by 171 · see citing works
Hypothalamo-Pituitary axis and puberty
Spaziani, M., Tarantino, C., Tahani, N., Gianfrilli, D., Sbardella, E., Lenzi, A., & Radicioni, A. F. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111094 · Cited by 165 · see citing works
Role of Withania somnifera (Ashwagandha) in the management of male infertility
Sengupta, P., Agarwal, A. K., Pogrebetskaya, M., Roychoudhury, S., Durairajanayagam, D., & Henkel, R. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.11.007 · Cited by 120 · see citing works
Cellular and molecular features of EDC exposure: consequences for the GnRH network
Rodríguez, D. L., Franssen, D., Bakker, J., Lomniczi, A., & Parent, A. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00436-3 · Cited by 109 · see citing works
GABAergic regulation of the HPA and HPG axes and the impact of stress on reproductive function
Camille Melón, L., & Maguire, J. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.11.019 · Cited by 94 · see citing works
Physiology of Gnrh and Gonadotropin Secretion
Marques, P., Skorupskaite, K., George, J. T., & Anderson, R. A. (2015) · Cited by 95 · see citing works
Allaway, H. C. M., Southmayd, E. A., & De Souza, M. J. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0053 · Cited by 89 · see citing works
Hypothalamic hamartoma with epilepsy: Review of endocrine comorbidity
Harrison, V. S., Oatman, O. J., & Kerrigan, J. (2017) · Epilepsia · doi:10.1111/epi.13756 · Cited by 89 · see citing works
Dufour, S., Quérat, B., Tostivint, H., Pasqualini, C., Vaudry, H., & Rousseau, K. (2019) · Physiological Reviews · doi:10.1152/physrev.00009.2019 · Cited by 85 · see citing works
Tsuchiya, R., Kaneshima, A., Kobayashi, M., Yamazaki, M., Takasu, Y., Sezutsu, H., Tanaka, Y., Mizoguchi, A., & Shiomi, K. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2020028118 · Cited by 80 · see citing works
Meta-Analysis of Heifer Traits Identified Reproductive Pathways in Bos indicus Cattle
Tahir, M. S., Neto, L. R. P., Gondro, C., Olasege, B. S., Wockner, K., Tan, W. L. A., Smith, H. R., Gouveia, G. C., Kour, J., & Fortes, M. R. S. (2021) · Genes · doi:10.3390/genes12050768 · Cited by 68 · see citing works
Control of the onset of puberty
Livadas, S., & Chrousos, G. P. (2016) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000386 · Cited by 68 · see citing works
A Multi-Oscillatory Circadian System Times Female Reproduction
Simonneaux, V., & Bahougne, T. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00157 · Cited by 63 · see citing works
A novel GABA-mediated corticotropin-releasing hormone secretory mechanism in the median eminence
Kakizawa, K., Watanabe, M., Mutoh, H., Okawa, Y., Yamashita, M., Yanagawa, Y., Itoi, K., Suda, T., Oki, Y., & Fukuda, A. (2016) · Science Advances · doi:10.1126/sciadv.1501723 · Cited by 54 · see citing works
Self-citationCowell, W., & Wright, R. J. (2017) · Current Environmental Health Reports · doi:10.1007/s40572-017-0165-9 · Cited by 51 · see citing works
Maruska, K. P., Butler, J. M., Field, K. E., & Porter, D. T. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24092 · Cited by 50 · see citing works
Faienza, M. F., Urbano, F., Moscogiuri, L. A., Chiarito, M., Santis, S. D., & Giordano, P. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1019468 · Cited by 50 · see citing works
Cannabinoid signalling and effects of cannabis on the male reproductive system
Maccarrone, M., Rapino, C., Francavilla, F., & Barbonetti, A. (2020) · Nature Reviews Urology · doi:10.1038/s41585-020-00391-8 · Cited by 48 · see citing works
Matsuda, F., Ohkura, S., Magata, F., Munetomo, A., Chen, J., Sato, M., Inoue, N., Uenoyama, Y., & Tsukamura, H. (2019) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14124 · Cited by 48 · see citing works
GABAergic Neurons and Their Modulatory Effects on GnRH3 in Zebrafish
Song, Y., Tao, B., Chen, J., Jia, S., Zhu, Z., Trudeau, V. L., & Hu, W. (2017) · Endocrinology · doi:10.1210/en.2016-1776 · Cited by 43 · see citing works
Endocannabinoid Regulation of Neuroendocrine Systems
Tasker, J. G., Chen, C., Fisher, M. O., Fu, X., Rainville, J. R., & Weiss, G. L. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.09.003 · Cited by 41 · see citing works
GABA-Induced GnRH Release Triggers Chordate Metamorphosis
Hozumi, A., Matsunobu, S., Mita, K., Treen, N., Sugihara, T., Horie, T., Sakuma, T., Yamamoto, T., Shiraishi, A., Hamada, M., et al. (2020) · Current Biology · doi:10.1016/j.cub.2020.02.003 · Cited by 40 · see citing works
Membrane-initiated estrogen signaling via Gq-coupled GPCR in the central nervous system
Vail, G. M., & Roepke, T. A. (2018) · Steroids · doi:10.1016/j.steroids.2018.01.010 · Cited by 39 · see citing works
Tang, C., Ou, J., Kou, L., Deng, J., & Luo, S. (2019) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2019.101478 · Cited by 39 · see citing works
Sivalingam, M., & Parhar, I. S. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100951 · Cited by 38 · see citing works
Chen, C., Wang, N., Zhai, H., Nie, X., Sun, H., Han, B., Li, Q., Chen, Y., Cheng, J., Xia, F., et al. (2016) · Scientific Reports · doi:10.1038/srep37809 · Cited by 38 · see citing works
Intrinsic links among sex, emotion, and reproduction
Yang, L. Y., Comninos, A. N., & Dhillo, W. S. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2802-3 · Cited by 36 · see citing works
Witchel, S. F., & Topaloglu, A. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00017-2 · Cited by 40 · see citing works
Differential gene expression analysis of human cumulus cells
Demiray, S. B., Göker, E. N. T., Tavmergen, E., Yilmaz, O., Calimlioglu, N., Soykam, H. O., Öktem, G., & Sezerman, O. U. (2019) · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine · doi:10.5653/cerm.2019.46.2.76 · Cited by 33 · see citing works
Regulation of the gonadotropin‐releasing hormone neuron during stress
McCosh, R. B., O’Byrne, K. T., Karsch, F. J., & Breen, K. M. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13098 · Cited by 35 · see citing works
Bálint, F., Liposits, Z., & Farkas, I. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00077 · Cited by 30 · see citing works
Developmental aspects of the hypothalamic-pituitary network related to reproduction in teleost fish
Vissio, P. G., Yorio, M. P. D., Sirkin, D. I. P., Somoza, G. M., Tsutsui, K., & Sallemi, J. E. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100948 · Cited by 29 · see citing works
Peter, M. S., & Simi, S. (2017) · Journal of Experimental Neuroscience · doi:10.1177/1179069517733732 · Cited by 26 · see citing works
Ladisa, C., Ma, Y., & Habibi, H. R. (2021) · Journal of Proteomics · doi:10.1016/j.jprot.2021.104237 · Cited by 26 · see citing works
Research Progress on the Effect of Epilepsy and Antiseizure Medications on PCOS Through HPO Axis
Li, S., Zhang, L., Wei, N., Tai, Z., Yu, C., & Xu, Z. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.787854 · Cited by 25 · see citing works
Panda, S. P., Kesharwani, A., Singh, G. D., Prasanth, D., Vatchavai, B. R., Kumari, P. V. K., Panda, S. K., & Mallick, S. P. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102086 · Cited by 24 · see citing works
Phytocannabinoids, the Endocannabinoid System and Male Reproduction
Lim, J., Squire, E., & Jung, K. (2022) · The World Journal of Men s Health · doi:10.5534/wjmh.220132 · Cited by 23 · see citing works
Lee, T.-W., Kim, D. H., & Ryu, J. Y. (2019) · Annals of Occupational and Environmental Medicine · doi:10.35371/aoem.2019.31.e21 · Cited by 23 · see citing works
Troxerutin protects against DHT-induced polycystic ovary syndrome in rats
Gao, Z., Ma, X., Liu, J., Ge, Y., Wang, L., Fu, P., Liu, Z., Yao, R., & Yan, X. (2020) · Journal of Ovarian Research · doi:10.1186/s13048-020-00701-z · Cited by 22 · see citing works
Ilgın, S. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117704 · Cited by 21 · see citing works
Bhattarai, P., Bhattarai, J. P., Kim, M. S., & Han, S. K. (2016) · Reproduction Fertility and Development · doi:10.1071/rd15357 · Cited by 21 · see citing works
Agarwal, D., Gireesh-Babu, P., Pavan‐Kumar, A., KORINGA, P. G., Joshi, C. G., & Chaudhari, A. (2020) · Genomics · doi:10.1016/j.ygeno.2020.07.012 · Cited by 20 · see citing works
Reproductive aging in biological females: mechanisms and immediate consequences
Muhammad, Y. A. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1658592 · Cited by 19 · see citing works
Wang, J. W., Cheng, W., Xu, T., & Yang, Z. (2015) · Genetics and Molecular Research · doi:10.4238/2015.november.18.57 · Cited by 19 · see citing works
Genome-wide association study reveals novel candidate genes for litter size in Markhoz goats
Mahmoudi, P., Rashidi, A., Nazari‐Ghadikolaei, A., Rostamzadeh, J., Razmkabir, M., & Huson, H. J. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.1045589 · Cited by 18 · see citing works
Hilliard, A. T., Xie, D., Ma, Z., Snyder, M. P., & Fernald, R. D. (2019) · BMC Genomics · doi:10.1186/s12864-019-6047-9 · Cited by 17 · see citing works
Salgado, R., Pereiro, N., López-Doval, S., & Lafuente, A. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.05.013 · Cited by 18 · see citing works
Hadžiselimović, F., Verkauskas, G., Vincel, B., & Stadler, M. B. (2019) · Basic and Clinical Andrology · doi:10.1186/s12610-019-0097-3 · Cited by 17 · see citing works
A high plane of nutrition during early life alters the hypothalamic transcriptome of heifer calves
Sánchez, J. M., Keogh, K. A., Kelly, A. K., Byrne, C. J., Lonergan, P., & Kenny, D. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-93080-4 · Cited by 17 · see citing works
Progestogen profiling in plasma during the estrous cycle in cattle using an LC-MS based approach
Hankele, A., Rehm, K., Bérard, J., Schuler, G. C., Bigler, L., & Ulbrich, S. E. (2019) · Theriogenology · doi:10.1016/j.theriogenology.2019.10.005 · Cited by 16 · see citing works
Beall, C., Hanna, L., & Ellacott, K. L. J. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160045 · Cited by 16 · see citing works
Effect of GABA-T on Reproductive Function in Female Rats
Si, W., Li, H., Kang, T., Ye, J., Yao, Z., Liu, Y., Yu, T., Zhang, Y., Ling, Y., Cao, H., et al. (2020) · Animals · doi:10.3390/ani10040567 · Cited by 15 · see citing works
Fibromyalgia pathogenesis explained by a neuroendocrine multistable model
Demori, I., Losacco, S., Giordano, G., Mucci, V., Blanchini, F., & Burlando, B. (2024) · PLOS ONE · doi:10.1371/journal.pone.0303573 · Cited by 14 · see citing works
Robust GABAergic Regulation of the GnRH Neuron Distal Dendron
Liu, X., Porteous, R. W., & Herbison, A. E. (2022) · Endocrinology · doi:10.1210/endocr/bqac194 · Cited by 14 · see citing works
Kronberg, J., Byrne, J. J., Jansen, J. J., Antczak, P., Hines, A., Bignell, J. P., Katsiadaki, I. G., Viant, M. R., & Francesco Falciani, B. (2021) · Scientific Reports · doi:10.1038/s41598-021-90494-y · Cited by 13 · see citing works
Zhang, F.-F., Zhang, Q., Wang, Y.-L., Wang, F., Hardiman, P. J., & Qu, F. (2021) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2021.01.018 · Cited by 13 · see citing works
Calvez, J., de Ávila, C., Guèvremont, G., & Timofeeva, E. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12439 · Cited by 13 · see citing works
Nishida, K., Sawada, D., Yasui, T., Kuwano, Y., & Rokutan, K. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104426 · Cited by 11 · see citing works
Su, Z., Su, W., Li, C., Ding, P., & Wang, Y. (2023) · Scientific Reports · doi:10.1038/s41598-022-27326-0 · Cited by 12 · see citing works
Zhu, J., Xu, X., Knight, G. E., He, C., Burnstock, G., & Xiang, Z. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23610 · Cited by 12 · see citing works
Zhao, Y., Singh, C., Prober, D. A., & Wayne, N. L. (2016) · Endocrinology · doi:10.1210/en.2016-1381 · Cited by 12 · see citing works
de Ávila, C., Chometton, S., Calvez, J., Guèvremont, G., Kania, A., Torz, L., Lenglos, C., Błasiak, A., ROSENKILDE, M. M., Holst, B., et al. (2020) · Neuroendocrinology · doi:10.1159/000513830 · Cited by 12 · see citing works
Xu, W., Mu, R., Gegen, T., Ran, T., Wu, Q., Wen, D., Wang, F., & Chen, Z. J. (2023) · BMC Genomics · doi:10.1186/s12864-023-09895-0 · Cited by 11 · see citing works
Reproductive toxic effects and possible mechanisms of zonisamide in male rats
Karaduman, A. B., Kilic, V., Atli-Eklioglu, O., Baysal, M., Kılıç, G., Uçarcan, Ş., & Ilgın, S. (2019) · Human & Experimental Toxicology · doi:10.1177/0960327119871094 · Cited by 11 · see citing works
Xu, Y., Jiang, D., Liu, J., Fu, Y., Song, Y., Fan, D., Huang, X., Liufu, S., Pan, J., Ouyang, H., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.824228 · Cited by 11 · see citing works
Keogh, K. A., & Kenny, D. A. (2022) · animal · doi:10.1016/j.animal.2022.100527 · Cited by 11 · see citing works
Liu, Q., Liu, J. H., Wang, P., Zhang, Y., Li, B., Yu, Y., Dang, H., Li, H., Zhang, X., & Wang, Z. (2017) · Brain Research · doi:10.1016/j.brainres.2017.04.008 · Cited by 11 · see citing works
Baratange, C., Baali, H., Gaillet, V., Bonnard, I., Delahaut, L., Gaillard, J., Grandjean, D., Sayen, S., Gallorini, A., Bris, N. L., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.165379 · Cited by 10 · see citing works
Pre‐ and post‐synaptic modulation by GABA B receptors of rat neuroendocrine dopamine neurones
Ammari, R., & Broberger, C. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12881 · Cited by 10 · see citing works
Disorders of puberty and neurodevelopment: A shared etiology?
Read, J. E., Vasile‐Tudorache, A., Newsome, A., Lorente, M. J., Agustín‐Pavón, C., & Howard, S. R. (2024) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.15246 · Cited by 10 · see citing works
The impact of GABA and GABAergic pathway in polycystic ovary syndrome: a systematic review
Motafeghi, F. S., Amiri, M., Noroozzadeh, M., & Tehrani, F. R. (2025) · Obstetrics & Gynecology Science · doi:10.5468/ogs.24255 · Cited by 9 · see citing works
Endocannabinoid System in the Neuroendocrine Response to Lipopolysaccharide-induced Immune Challenge
Laurentiis, A. D., Correa, F., & Fernández‐Solari, J. (2022) · Journal of the Endocrine Society · doi:10.1210/jendso/bvac120 · Cited by 10 · see citing works
Satake, H., & Sasakura, Y. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.112122 · Cited by 9 · see citing works
Bar-Sadeh, B., Amichai, O. E., Pnueli, L., Begum, K., Leeman, G., Emes, R. D., Stöger, R. J., Bentley, G. R., & Melamed, P. (2022) · BMC Biology · doi:10.1186/s12915-021-01219-6 · Cited by 9 · see citing works
Supasitdikul, T., Mazariegos, J. R. R., Nhat, N. N., Tung, Y., Yang, D., Lee, L., Gunawan, S. P., & Chen, Y. (2025) · Journal of Sleep Research · doi:10.1111/jsr.70125 · Cited by 7 · see citing works
Joshi, R., Yadav, P., Bagwe‐Parab, S., Tuli, H. S., Buttar, H. S., & Kaur, G. (2023) · Current Bioactive Compounds · doi:10.2174/1573407219666230210101925 · Cited by 6 · see citing works
Kusuma, P. S. W., & Hariani, D. (2017) · The Egyptian Journal of Aquatic Research · doi:10.1016/j.ejar.2017.10.006 · Cited by 7 · see citing works
Medrano, G. A., Singh, M., Plautz, E. J., Good, L. B., Chapman, K. M., Chaudhary, J., Jaichander, P., Powell, H. M., Pudasaini, A., Shelton, J. M., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/405985 · Cited by 7 · see citing works
Rodriguez-Sánchez, A. J., Meza-Herrera, C., Santiago-Miramontes, Á. D., Navarrete-Molina, C., Véliz-Deras, F., Ordoñez-Morales, J., Flores-Salas, J. M., & Marín-Tinoco, R. I. (2024) · Biology · doi:10.3390/biology13090656 · Cited by 7 · see citing works
Ciechanowska, M. O., Łapot, M., Kowalczyk, M., Malewski, T., Brytan, M., Antkowiak, B., & Przekop, F. (2019) · Pharmacological Reports · doi:10.1016/j.pharep.2019.02.019 · Cited by 6 · see citing works
Tong, H., Su, B., Liu, Z., & Chen, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1054048 · Cited by 6 · see citing works
Wu, N., Ning, K., Liu, Y., Wang, Q., Li, N., & Zhang, L. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1564902 · Cited by 6 · see citing works
Genomic Scanning of Inbreeding Depression for Litter Size in Two Varieties of Iberian Pigs
Hervás‐Rivero, C., Srihi, H., López‐Carbonell, D., Casellas, J., Ibáñez‐Escriche, N., Negro, S., & Varona, L. (2023) · Genes · doi:10.3390/genes14101941 · Cited by 5 · see citing works
Anatomy and Physiology of the Female Reproductive System
Vogazianou, A. (2019) · Springer eBooks · doi:10.1007/978-3-319-99817-6_38 · Cited by 5 · see citing works
Peng, J., Cui, Y., Liang, H., Xu, S. C., Weng, L., Meng, R., Ali, R., Wei, Q., Ruan, J., & Huang, J. (2024) · Animal nutrition · doi:10.1016/j.aninu.2024.08.009 · Cited by 4 · see citing works
Physiopathology, Diagnosis, and Treatment of Secondary Female Hypogonadism
Antoniou-Tsigkos, A., Μacut, D., & Mastorakos, G. P. (2018) · Endocrinology · doi:10.1007/978-3-319-44444-4_9 · Cited by 4 · see citing works
Yadav, A., & Mishra, R. K. (2025) · Journal of Reproductive Healthcare and Medicine · doi:10.25259/jrhm_27_2024 · Cited by 3 · see citing works
Abedi, H., Zarrin-Mehr, A., Ebrahimi, B., Haghshenas, H., Parvin, N., & Jahromi, H. K. (2024) · International Journal of Reproductive BioMedicine (IJRM) · doi:10.18502/ijrm.v22i3.16164 · Cited by 3 · see citing works
Polymorphism and expression of GLUD1 in relation to reproductive performance in Jining Grey goats
Wang, W., Wang, Y., Liu, Y., Cao, G., Di, R., Wang, J., & Chu, M. (2023) · Archives animal breeding/Archiv für Tierzucht · doi:10.5194/aab-66-411-2023 · Cited by 3 · see citing works
Grid1 regulates the onset of puberty in female rats
Ye, J., Xiaoqian, L. I., Pan, Z., Zhuoya, W. U., Zhu, Y., Zhang, W., Lu, J., Shuangshuang, X. U., Qin, P., Ya, L. I. U., et al. (2024) · Journal of Veterinary Medical Science · doi:10.1292/jvms.23-0208 · Cited by 3 · see citing works
Osmotic perception of GABAergic synaptic transmission in the supraoptic nucleus of rats
Ohbuchi, T., Saito, T., Yokoyama, T., Hashimoto, H., Maruyama, T., Suzuki, H., & Ueta, Y. (2020) · IBRO Reports · doi:10.1016/j.ibror.2020.06.007 · Cited by 3 · see citing works
Demori, I., Siriya, S., & Burlando, B. (2025) · Applied Sciences · doi:10.3390/app151910483 · Cited by 2 · see citing works
Mohammadpour-Asl, S., Parvin, A., Akbari‐Gharalari, N., Asadi, N., Pooryai, A., & Roshan‐Milani, S. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123778 · Cited by 2 · see citing works
Reversible Sterilization of Channel Catfish via Overexpression of Glutamic Acid Decarboxylase Gene
Ye, Z., Elaswad, A., Su, B., Alsaqufi, A. S., Shang, M., Bugg, W. S., Qin, G. T., Drescher, D., Li, H., Qin, Z., et al. (2024) · Animals · doi:10.3390/ani14131899 · Cited by 2 · see citing works
Multimodal GABAA receptor functions in the development of the central nervous system
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Self-citationInfluence of Stress on the GnRH Neuronal Network
Grachev, P., & O'Byrne, K. T. (2018) · doi:10.1002/9781119233275.ch14 · Cited by 2 · see citing works
Vagal nerve stimulation for the treatment of male factor infertility
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- Authors
- Watanabe, M., Fukuda, A., & Nabekura, J.
- Affiliations
- Hamamatsu University (JP)
- The Graduate University for Advanced Studies, SOKENDAI (JP)
- Corresponding author
- Watanabe, Miho
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2014-11-28
- Volume
- 8
- Pages
- 387-387
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC4246667
- OpenAlex
- W2135581544
- Cited by
- 140
- References
- 111
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 12 · 2023: 12 · 2022: 12 · 2021: 12 · 2020: 17 · 2019: 13 · 2018: 9 · 2017: 12 · 2016: 10 · 2015: 9
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Society for the Promotion of Science (26670512, 25460312, 25293052)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- GABA, GnRH neurons, GABAergic inhibition, neuroendocrine regulation of reproduction, neurotransmitter modulation, neuromodulators, GABA receptors, reproductive physiology, reproductive disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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