The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods
Open accessAbstract
Sex hormones have been implicated in neurite outgrowth, synaptogenesis, dendritic branching, myelination and other important mechanisms of neural plasticity. Here we review the evidence from animal experiments and human studies reporting interactions between sex hormones and the dominant neurotransmitters, such as serotonin, dopamine, GABA and glutamate. We provide an overview of accumulating data during physiological and pathological conditions and discuss currently conceptualized theories on how sex hormones potentially trigger neuroplasticity changes through these four neurochemical systems. Many brain regions have been demonstrated to express high densities for estrogen- and progesterone receptors, such as the amygdala, the hypothalamus, and the hippocampus. As the hippocampus is of particular relevance in the context of mediating structural plasticity in the adult brain, we put particular emphasis on what evidence could be gathered thus far that links differences in behavior, neurochemical patterns and hippocampal structure to a changing hormonal environment. Finally, we discuss how physiologically occurring hormonal transition periods in humans can be used to model how changes in sex hormones influence functional connectivity, neurotransmission and brain structure in vivo.
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Citations
Cites
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Cited by
Sex differences in autism spectrum disorder: a review
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Let’s talk about sex: Differences in drug therapy in males and females
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Stress is a principal factor that promotes tobacco use in females
Torres, O. V., & O'Dell, L. E. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.04.005 · Cited by 164
Metadata
- Authors
- Barth, C., Villringer, A., & Sacher, J.
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-02-20
- Volume
- 9
- Pages
- 37-37
- ISSN
- 1662-453X (ISSN-L)
- OpenAlex
- W2023482999
- Cited by
- 711
- References
- 29
- FWCI
- 24.88
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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