Sex differences in autism spectrum disorder: a review

Oxytocin increases trust in humans

Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works

Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2012

Christensen, D. L., Baio, J., Braun, K. V. N., Bilder, D., Charles, J., Constantino, J. N., Daniels, J., Durkin, M. S., Fitzgerald, R. T., Kurzius-Spencer, M., et al. (2016) · MMWR. Surveillance Summaries · doi:10.15585/mmwr.ss6503a1 · Cited by 1,964 · see citing works

Insights into autism spectrum disorder genomic architecture and biology from 71 risk loci

Sanders, S. J., He, X., Willsey, A. J., Ercan-Sencicek, A. G., Samocha, K. E., Cicek, A. E., Murtha, M. T., Bal, V. H., Bishop, S. L., Dong, S., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.016 · Cited by 1,430 · see citing works

“Putting on My Best Normal”: Social Camouflaging in Adults with Autism Spectrum Conditions

Hull, L., Petrides, K. V., Allison, C., Smith, P., Baron-Cohen, S., Lai, M.-C., & Mandy, W. (2017) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-017-3166-5 · Cited by 1,365 · see citing works

Oxytocin improves “mind-reading” in humans

Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298 · see citing works

Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism

Sanders, S. J., Ercan-Sencicek, A. G., Hus, V., Luo, R., Murtha, M. T., Moreno-De-Luca, D., Chu, S. H., Moreau, M. P., Gupta, A. R., Thomson, S. A., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.002 · Cited by 1,263 · see citing works

Oxytocin shapes the neural circuitry of trust and trust adaptation in humans

Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U., & Fehr, E. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.009 · Cited by 1,258 · see citing works

Sex differences in autism spectrum disorders

Werling, D. M., & Geschwind, D. H. (2013) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32835ee548 · Cited by 1,245 · see citing works

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

Tang, G., Gudsnuk, K., Kuo, S.-H., Cotrina, M. L., Rosoklija, G., Sosunov, A., Sonders, M. S., Kanter, E., Castagna, C., Yamamoto, A., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.040 · Cited by 1,146 · see citing works

Sex differences in the brain: implications for explaining autism

Baron-Cohen, S., Knickmeyer, R. C., & Belmonte, M. K. (2005) · Science · doi:10.1126/science.1115455 · Cited by 1,145 · see citing works

The Experiences of Late-diagnosed Women with Autism Spectrum Conditions: An Investigation of the Female Autism Phenotype

Bargiela, S., Steward, R., & Mandy, W. (2016) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-016-2872-8 · Cited by 1,087 · see citing works

Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits

Comery, T. A., Harris, J. B., Willems, P. J., Oostra, B. A., Irwin, S. A., Weiler, I. J., & Greenough, W. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5401 · Cited by 1,046 · see citing works

Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat [published erratum appears in J Neurosci 1992 Oct;12(10):following table of contents]

Woolley, C. S., & McEwen, B. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02549.1992 · Cited by 987 · see citing works

Pten Regulates Neuronal Arborization and Social Interaction in Mice

Kwon, C.-H., Luikart, B. W., Powell, C. M., Zhou, J., Matheny, S. A., Zhang, W., Li, Y., Baker, S. J., & Parada, L. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.023 · Cited by 970 · see citing works

Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders.

Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., & Hickie, I. B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.020 · Cited by 962 · see citing works

Promoting social behavior with oxytocin in high-functioning autism spectrum disorders.

Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910249107 · Cited by 941 · see citing works

Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders

Hutsler, J. J., & Zhang, H. (2010) · Brain Research · doi:10.1016/j.brainres.2009.09.120 · Cited by 765 · see citing works

Why are autism spectrum conditions more prevalent in males?

Baron-Cohen, S., Lombardo, M. V., Auyeung, B., Ashwin, E., Chakrabarti, B., & Knickmeyer, R. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001081 · Cited by 754 · see citing works

Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods

Barth, C., Villringer, A., & Sacher, J. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00037 · Cited by 731 · see citing works

Plasma oxytocin levels in autistic children

Modahl, C., Green, L. A., Fein, D., Morris, M., Waterhouse, L., Feinstein, C., & Levin, H. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00439-3 · Cited by 728 · see citing works

Rare de novo and transmitted copy-number variation in autistic spectrum disorders

Levy, D., Ronemus, M., Yamrom, B., Lee, Y.-H., Leotta, A., Kendall, J., Marks, S., Lakshmi, B., Pai, D., Ye, K., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.015 · Cited by 712 · see citing works

Brain growth across the life span in autism: Age-specific changes in anatomical pathology

Courchesne, E., Campbell, K., & Solso, S. (2011) · Brain Research · doi:10.1016/j.brainres.2010.09.101 · Cited by 711 · see citing works

Quantifying and exploring camouflaging in men and women with autism

Lai, M.-C., Lombardo, M. V., Ruigrok, A. N., Chakrabarti, B., Auyeung, B., Szatmari, P., Happé, F., Baron-Cohen, S., & MRC AIMS Consortium (2017) · Autism · doi:10.1177/1362361316671012 · Cited by 705 · see citing works

Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses

Gilman, S. R., Iossifov, I., Levy, D., Ronemus, M., Wigler, M., & Vitkup, D. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.021 · Cited by 701 · see citing works

Genetics of autism spectrum disorders

Geschwind, D. H. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.07.003 · Cited by 696 · see citing works

Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

Won, H., Lee, H.-R., Gee, H. Y., Mah, W., Kim, J.-I., Lee, J., Ha, S., Chung, C., Jung, E. S., Cho, Y. S., et al. (2012) · Nature · doi:10.1038/nature11208 · Cited by 695 · see citing works

A behavioral comparison of male and female adults with high functioning autism spectrum conditions

Lai, M.-C., Lombardo, M. V., Pasco, G., Ruigrok, A. N. V., Wheelwright, S. J., Sadek, S. A., Chakrabarti, B., MRC AIMS Consortium, & Baron-Cohen, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020835 · Cited by 650 · see citing works

How Different Are Girls and Boys Above and Below the Diagnostic Threshold for Autism Spectrum Disorders?

Dworzynski, K., Ronald, A., Bolton, P., & Happé, F. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.05.018 · Cited by 633 · see citing works

A Higher Mutational Burden in Females Supports a “Female Protective Model” in Neurodevelopmental Disorders

Jacquemont, S., Coe, B. P., Hersch, M., Duyzend, M. H., Krumm, N., Bergmann, S., Beckmann, J. S., Rosenfeld, J. A., & Eichler, E. E. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.02.001 · Cited by 605 · see citing works

Oxytocin is associated with human trustworthiness

ZAK, P., KURZBAN, R., & MATZNER, W. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2005.07.009 · Cited by 595 · see citing works

Sex and gender differences in autism spectrum disorder: summarizing evidence gaps and identifying emerging areas of priority

Halladay, A. K., Bishop, S. L., Constantino, J. N., Daniels, A. M., Koenig, K., Palmer, K., Messinger, D. S., Pelphrey, K. A., Sanders, S., Singer, A., et al. (2015) · Molecular Autism · doi:10.1186/s13229-015-0019-y · Cited by 582 · see citing works

The art of camouflage: Gender differences in the social behaviors of girls and boys with autism spectrum disorder

Dean, M., Harwood, R., & Kasari, C. (2017) · Autism · doi:10.1177/1362361316671845 · Cited by 566 · see citing works

Gender and Age Differences in the Core Triad of Impairments in Autism Spectrum Disorders: A Systematic Review and Meta-analysis

Van Wijngaarden-Cremers, P. J. M., van Eeten, E., Groen, W. B., Van Deurzen, P. A., Oosterling, I. J., & Van der Gaag, R. J. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1913-9 · Cited by 547 · see citing works

Examining and interpreting the female protective effect against autistic behavior

Robinson, E. B., Lichtenstein, P., Anckarsäter, H., Happé, F., & Ronald, A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211070110 · Cited by 531 · see citing works

Microglia Are Essential to Masculinization of Brain and Behavior

Lenz, K. M., Nugent, B. M., Haliyur, R., & McCarthy, M. M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1268-12.2013 · Cited by 526 · see citing works

Microglial Activation in Young Adults With Autism Spectrum Disorder

Suzuki, K., Sugihara, G., Ouchi, Y., Nakamura, K., Futatsubashi, M., Takebayashi, K., Yoshihara, Y., Omata, K., Matsumoto, K., Tsuchiya, K. J., et al. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.272 · Cited by 523 · see citing works

Immune mediators in the brain and peripheral tissues in autism spectrum disorder

Estes, M. L., & McAllister, A. K. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3978 · Cited by 514 · see citing works

Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism

Gupta, S., Ellis, S. E., Ashar, F. N., Moes, A., Bader, J. S., Zhan, J., West, A. B., & Arking, D. E. (2014) · Nature Communications · doi:10.1038/ncomms6748 · Cited by 504 · see citing works

Elevated fetal steroidogenic activity in autism

Baron-Cohen, S., Auyeung, B., Nørgaard-Pedersen, B., Hougaard, D. M., Abdallah, M. W., Melgaard, L., Cohen, A. S., Chakrabarti, B., Ruta, L., & Lombardo, M. V. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.48 · Cited by 471 · see citing works

Regional Gray Matter Growth, Sexual Dimorphism, and Cerebral Asymmetry in the Neonatal Brain

Gilmore, J. H., Lin, W., Prastawa, M. W., Looney, C. B., Vetsa, Y. S. K., Knickmeyer, R. C., Evans, D. D., Smith, J. K., Hamer, R. M., Lieberman, J. A., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3339-06.2007 · Cited by 465 · see citing works

Autism as a disorder of neural information processing: Directions for research and targets for therapy

Belmonte, M. K., Cook, E. H., Anderson, G. M., Rubenstein, J. L. R., Greenough, W. T., Beckel-Mitchener, A., Courchesne, E., Boulanger, L. M., Powell, S. B., Levitt, P. R., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001499 · Cited by 442 · see citing works

Sex differences in oxytocin and vasopressin: Implications for autism spectrum disorders?

CARTER, C. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.025 · Cited by 432 · see citing works

Oxytocin Attenuates Affective Evaluations of Conditioned Faces and Amygdala Activity

Petrovic, P., Kalisch, R., Singer, T., & Dolan, R. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4572-07.2008 · Cited by 424 · see citing works

Behavioral and Cognitive Characteristics of Females and Males With Autism in the Simons Simplex Collection

Frazier, T. W., Georgiades, S., Bishop, S. L., & Hardan, A. Y. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.12.004 · Cited by 409 · see citing works

Oxytocin and autistic disorder: alterations in peptide forms

Green, L., Fein, D., Modahl, C., Feinstein, C., Waterhouse, L., & Morris, M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01139-8 · Cited by 404 · see citing works

An investigation of the ‘female camouflage effect’ in autism using a computerized ADOS-2 and a test of sex/gender differences

Rynkiewicz, A., Schuller, B., Marchi, E., Piana, S., Camurri, A., Lassalle, A., & Baron-Cohen, S. (2016) · Molecular Autism · doi:10.1186/s13229-016-0073-0 · Cited by 404 · see citing works

Sex Differences in the Timing of Identification Among Children and Adults with Autism Spectrum Disorders

Begeer, S., Mandell, D., Wijnker-Holmes, B., Venderbosch, S., Rem, D., Stekelenburg, F., & Koot, H. M. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1656-z · Cited by 402 · see citing works

Sex differences in corticotropin-releasing factor receptor signaling and trafficking: potential role in female vulnerability to stress-related psychopathology

Bangasser, D. A., Curtis, A., Reyes, B. A. S., Bethea, T. T., Parastatidis, I., Ischiropoulos, H., Van Bockstaele, E. J., & Valentino, R. J. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.66 · Cited by 401 · see citing works

Sex differences in the evaluation and diagnosis of autism spectrum disorders among children

Giarelli, E., Wiggins, L. D., Rice, C. E., Levy, S. E., Kirby, R. S., Pinto-Martin, J., & Mandell, D. (2010) · Disability and Health Journal · doi:10.1016/j.dhjo.2009.07.001 · Cited by 398 · see citing works

Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity

Hanamsagar, R., Alter, M. D., Block, C. S., Sullivan, H., Bolton, J. L., & Bilbo, S. D. (2017) · Glia · doi:10.1002/glia.23176 · Cited by 384 · see citing works

Sex Differences in Autism Spectrum Disorder based on DSM-5 Criteria: Evidence from Clinician and Teacher Reporting

Hiller, R. M., Young, R. L., & Weber, N. (2014) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-014-9881-x · Cited by 369 · see citing works

ASD in Females: Are We Overstating the Gender Difference in Diagnosis?

Kreiser, N. L., & White, S. W. (2014) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-013-0148-9 · Cited by 367 · see citing works

Sex Differences in Autism Spectrum Disorder: An Examination of Developmental Functioning, Autistic Symptoms, and Coexisting Behavior Problems in Toddlers

Hartley, S. L., & Sikora, D. M. (2009) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-009-0810-8 · Cited by 355 · see citing works

Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, <i>RORA</i> , whose protein product is reduced in autistic brain

Nguyen, A., Rauch, T. A., Pfeifer, G. P., & Hu, V. W. (2010) · The FASEB Journal · doi:10.1096/fj.10-154484 · Cited by 350 · see citing works

Sex differences in immune responses: Hormonal effects, antagonistic selection, and evolutionary consequences

Roved, J., Westerdahl, H., & Hasselquist, D. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.11.017 · Cited by 348 · see citing works

Sex ratios in early childhood autism and related conditions

Wing, L. (1981) · Psychiatry Research · doi:10.1016/0165-1781(81)90043-3 · Cited by 343 · see citing works

Testosterone administration impairs cognitive empathy in women depending on second-to-fourth digit ratio

van Honk, J., Schutter, D. J. L. G., Bos, P. A., Kruijt, A., Lentjes, E. G. W. M., & Baron‐Cohen, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011891108 · Cited by 332 · see citing works

Autism Symptoms and Internalizing Psychopathology in Girls and Boys with Autism Spectrum Disorders

Solomon, M., Miller, M., Taylor, S. L., Hinshaw, S. P., & Carter, C. S. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-011-1215-z · Cited by 326 · see citing works

SHANK1 Deletions in Males with Autism Spectrum Disorder

Sato, D., Lionel, A. C., Leblond, C. S., Prasad, A., Pinto, D., Walker, S., O'Connor, I., Russell, C., Drmic, I. E., Hamdan, F. F., et al. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.03.017 · Cited by 318 · see citing works

Gender differences in emotionality and sociability in children with autism spectrum disorders

Head, A. M., McGillivray, J. A., & Stokes, M. A. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-19 · Cited by 315 · see citing works

Gender Differences in the Social Motivation and Friendship Experiences of Autistic and Non-autistic Adolescents

Sedgewick, F., Hill, V., Yates, R., Pickering, L., & Pellicano, E. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2669-1 · Cited by 304 · see citing works

The effects of a course of intranasal oxytocin on social behaviors in youth diagnosed with autism spectrum disorders: a randomized controlled trial

Guastella, A. J., Gray, K. M., Rinehart, N. J., Alvares, G. A., Tonge, B. J., Hickie, I. B., Keating, C. M., Cacciotti‐Saija, C., & Einfeld, S. L. (2015) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12305 · Cited by 299 · see citing works

Biological sex affects the neurobiology of autism

Lai, M.-C., Lombardo, M. V., Suckling, J., Ruigrok, A. N. V., Chakrabarti, B., Ecker, C., Deoni, S. C. L., Craig, M. C., Murphy, D. G. M., Bullmore, E. T., et al. (2013) · Brain · doi:10.1093/brain/awt216 · Cited by 298 · see citing works

Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity

Hanamsagar, R., Alter, M. D., Block, C. L., Sullivan, H. K., Bolton, J. L., & Bilbo, S. D. (2017) · Glia · doi:10.1002/glia.23277 · Cited by 297 · see citing works

Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders

Werling, D. M., Parikshak, N. N., & Geschwind, D. H. (2016) · Nature Communications · doi:10.1038/ncomms10717 · Cited by 296 · see citing works

Imprinting, the X-chromosome, and the male brain: explaining sex differences in the liability to autism

Skuse, D. H. (2000) · Pediatric Research · doi:10.1203/00006450-200001000-00006 · Cited by 285 · see citing works

Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators

Duffney, L. J., Zhong, P., Wei, J., Matas, E., Cheng, J., Qin, L., Ma, K., Dietz, D. M., Kajiwara, Y., Buxbaum, J. D., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.064 · Cited by 281 · see citing works

Oxytocin enhances the experience of attachment security

Buchheim, A., Heinrichs, M., George, C., Pokorny, D., Koops, E., Henningsen, P., O’Connor, M.-F., & Gündel, H. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.04.002 · Cited by 277 · see citing works

Post-learning intranasal oxytocin modulates human memory for facial identity

Savaskan, E., Ehrhardt, R., Schulz, A., Walter, M., & Schächinger, H. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.12.004 · Cited by 262 · see citing works

Elevated rates of testosterone-related disorders in women with autism spectrum conditions

Ingudomnukul, E., Baron‐Cohen, S., Wheelwright, S. J., & Knickmeyer, R. C. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.02.001 · Cited by 261 · see citing works

Cortisol circadian rhythms and response to stress in children with autism

Corbett, B. A., Mendoza, S., Abdullah, M., Wegelin, J. A., & Levine, S. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.05.011 · Cited by 258 · see citing works

The experiences and needs of female adults with high-functioning autism spectrum disorder

Baldwin, S., & Costley, D. (2016) · Autism · doi:10.1177/1362361315590805 · Cited by 248 · see citing works

Oxytocin and vasopressin neural networks: Implications for social behavioral diversity and translational neuroscience

Johnson, Z. V., & Young, L. J. (2017) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.034 · Cited by 242 · see citing works

Being a Girl in a Boys’ World: Investigating the Experiences of Girls with Autism Spectrum Disorders During Adolescence

Cridland, E. K., Jones, S. C., Caputi, P., & Magee, C. A. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1985-6 · Cited by 230 · see citing works

Sex Hormones in Autism: Androgens and Estrogens Differentially and Reciprocally Regulate RORA, a Novel Candidate Gene for Autism

Sarachana, T., Xu, M., Wu, R.-C., & Hu, V. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017116 · Cited by 227 · see citing works

Lack of functional estrogen receptor β influences anxiety behavior and serotonin content in female mice

Imwalle, D. B., Gustafsson, J.-Α., & Rissman, E. F. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.11.002 · Cited by 225 · see citing works

Oxytocin treatment, circuitry and autism: a critical review of the literature placing oxytocin into the autism context

Guastella, A. J., & Hickie, I. B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.028 · Cited by 223 · see citing works

Behavioral Effects of Progesterone Associated with Rapid Modulation of Oxytocin Receptors

Schumacher, M., Coirini, H., Pfaff, D. W., & McEwen, B. S. (1990) · Science · doi:10.1126/science.2173139 · Cited by 221 · see citing works

MECP2 disorders: from the clinic to mice and back

Lombardi, L. M., Baker, S. A., & Zoghbi, H. Y. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78167 · Cited by 221 · see citing works

Cognition in males and females with autism: similarities and differences

Lai, M.-C., Lombardo, M. V., Ruigrok, A. N. V., Chakrabarti, B., Wheelwright, S. J., Auyeung, B., Allison, C., MRC AIMS Consortium, & Baron-Cohen, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047198 · Cited by 217 · see citing works

Gender differences in autism spectrum disorders: Divergence among specific core symptoms

Beggiato, A., Peyre, H., Maruani, A., Scheid, I., Rastam, M., Amsellem, F., Gillberg, C. I., Leboyer, M., Bourgeron, T., Gillberg, C., et al. (2017) · Autism Research · doi:10.1002/aur.1715 · Cited by 209 · see citing works

Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2

Hoffman, E. J., Turner, K. J., Fernandez, J. M., Cifuentes, D., Ghosh, M., Ijaz, S., Jain, R. A., Kubo, F., Bill, B., Baier, H., et al. (2016) · Neuron · doi:10.1016/j.neuron.2015.12.039 · Cited by 208 · see citing works

Early sex differences are not autism-specific: A Baby Siblings Research Consortium (BSRC) study

Messinger, D. S., Young, G. S., Webb, S. J., Ozonoff, S., Bryson, S. E., Carter, A., Carver, L., Charman, T., Chawarska, K., Curtin, S., et al. (2015) · Molecular Autism · doi:10.1186/s13229-015-0027-y · Cited by 207 · see citing works

A Novel Mechanism of Dendritic Spine Plasticity Involving Estradiol Induction of Prostaglandin-E2

Amateau, S. K., & McCarthy, M. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08586.2002 · Cited by 206 · see citing works

Gene expression profiling of lymphoblastoid cell lines from monozygotic twins discordant in severity of autism reveals differential regulation of neurologically relevant genes

Hu, V. W., Frank, B. C., Heine, S. J., Lee, N. H., & Quackenbush, J. F. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-118 · Cited by 200 · see citing works

Estradiol Modulates Density of Putative Oxytocin Receptors’ in Discrete Rat Brain Regions

de Kloet, R., Voorhuis, D. A. M., Boschma, Y., & Elands, J. (2008) · Neuroendocrinology · doi:10.1159/000124680 · Cited by 198 · see citing works

Androgen actions on central serotonin neurotransmission: relevance for mood, mental state and memory.

Fink, G., Sumner, B., Rosie, R., Wilson, H., & McQueen, J. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00082-0 · Cited by 198 · see citing works

Gender ratio in a clinical population sample, age of diagnosis and duration of assessment in children and adults with autism spectrum disorder

Rutherford, M., McKenzie, K., Johnson, T., Catchpole, C., O’Hare, A., McClure, I., Forsyth, K., McCartney, D., & Murray, A. (2016) · Autism · doi:10.1177/1362361315617879 · Cited by 197 · see citing works

Gene expression profiling differentiates autism case–controls and phenotypic variants of autism spectrum disorders: evidence for circadian rhythm dysfunction in severe autism

Hu, V. W., Sarachana, T., Kim, K. S., Nguyen, A., Kulkarni, S., Lowe, M. S., Luu, T. V., Lai, Y., & Lee, N. H. (2009) · Autism Research · doi:10.1002/aur.73 · Cited by 196 · see citing works

Sex differences in autism: a resting-state fMRI investigation of functional brain connectivity in males and females

Alaerts, K., Swinnen, S. P., & Wenderoth, N. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw027 · Cited by 193 · see citing works

Grey matter abnormality in autism spectrum disorder: an activation likelihood estimation meta-analysis study

Cauda, F., Geda, E., Sacco, K., D’Agata, F., Duca, S., Geminiani, G. C., & Keller, R. (2011) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.239111 · Cited by 186 · see citing works

Implication of sex differences in the familial transmission of infantile autism

Tsai, L., Stewart, M. A., & August, G. J. (1981) · Journal of Autism and Developmental Disorders · doi:10.1007/bf01531682 · Cited by 183 · see citing works

The EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation

Charman, T., Loth, E., Tillmann, J., Crawley, D., Wooldridge, C., Goyard, D., Ahmad, J., Auyeung, B., Ambrosino, S., Banaschewski, T., et al. (2017) · Molecular Autism · doi:10.1186/s13229-017-0145-9 · Cited by 183 · see citing works

Etiologies underlying sex differences in autism spectrum disorders

Schaafsma, S. M., & Pfaff, D. W. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.03.006 · Cited by 178 · see citing works

Attenuation of Typical Sex Differences in 800 Adults with Autism vs. 3,900 Controls

Baron-Cohen, S., Cassidy, S., Auyeung, B., Allison, C., Achoukhi, M., Robertson, S., Pohl, A., & Lai, M.-C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102251 · Cited by 177 · see citing works

Sex-related alterations of gut microbiota composition in the BTBR mouse model of autism spectrum disorder

Coretti, L., Cristiano, C., Florio, E., Scala, G., Lama, A., Keller, S., Cuomo, M., Russo, R., Pero, R., Paciello, O., et al. (2017) · Scientific Reports · doi:10.1038/srep45356 · Cited by 175 · see citing works

Sex-specific serum biomarker patterns in adults with Asperger's syndrome

Schwarz, E., Guest, P. C., Rahmoune, H., Wang, L., Levin, Y., Ingudomnukul, E., Ruta, L., Kent, L., Spain, M., Baron-Cohen, S., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.102 · Cited by 171 · see citing works

Serum oxytocin levels in patients with depression and the effects of gender and antidepressant treatment

Özsoy, S., Eşel, E., & Kula, M. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.06.034 · Cited by 168 · see citing works

Complementarity of sex differences in brain and behavior: From laterality to multimodal neuroimaging

Gur, R. C., & Gur, R. E. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23830 · Cited by 165 · see citing works

The extreme male brain revisited: gender coherence in adults with autism spectrum disorder

Bejerot, S., Eriksson, J. M., Bonde, S., Carlström, K., Humble, M. B., & Eriksson, E. (2012) · British Journal of Psychiatry · doi:10.1192/bjp.bp.111.097899 · Cited by 161 · see citing works

Convergence of Sex Differences and the Neuroimmune System in Autism Spectrum Disorder

McCarthy, M. M., & Wright, C. L. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.10.004 · Cited by 158 · see citing works

Oxytocin and vasopressin effects on the neural response to social cooperation are modulated by sex in humans

Feng, C., Hackett, P. D., DeMarco, A. C., Chen, X., Stair, S., Haroon, E., Ditzen, B., Pagnoni, G., & Rilling, J. K. (2015) · Brain Imaging and Behavior · doi:10.1007/s11682-014-9333-9 · Cited by 157 · see citing works

A review of rhythm and responsiveness of cortisol in individuals with autism spectrum disorders

Taylor, J. L., & Corbett, B. A. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.07.015 · Cited by 156 · see citing works

Male-biased autosomal effect of 16p13.11 copy number variation in neurodevelopmental disorders

Tropeano, M., Ahn, J. W., Dobson, R. J. B., Breen, G., Rucker, J., Dixit, A., Pal, D. K., McGuffin, P., Farmer, A., White, P. S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061365 · Cited by 154 · see citing works

Sex-related cognitive profile in autism spectrum disorders diagnosed late in life: Implications for the female autistic phenotype

Lehnhardt, F.-G., Falter, C. M., Gawronski, A., Pfeiffer, K., Tepest, R., Franklin, J., & Vogeley, K. (2016) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2558-7 · Cited by 153 · see citing works

Sex differences in pre-diagnosis concerns for children later diagnosed with autism spectrum disorder

Hiller, R. M., Young, R. L., & Weber, N. (2016) · Autism · doi:10.1177/1362361314568899 · Cited by 153 · see citing works

Loss of δ-catenin function in severe autism

Turner, T. N., Sharma, K., Oh, E. C. T., Liu, Y. P., Collins, R. L., Sosa, M. X., Auer, D. R., Brand, H., Sanders, S., Moreno‐De‐Luca, D., et al. (2015) · Nature · doi:10.1038/nature14186 · Cited by 151 · see citing works

Oxytocin and Vasopressin in Children and Adolescents With Autism Spectrum Disorders: Sex Differences and Associations With Symptoms

Miller, M., Bales, K. L., Taylor, S. L., Yoon, J., Hostetler, C. M., Carter, C. S., & Solomon, M. (2013) · Autism Research · doi:10.1002/aur.1270 · Cited by 151 · see citing works

Estrogen Selectively Regulates Spine Density within the Dendritic Arbor of Rat Ventromedial Hypothalamic Neurons

Calizo, L. H., & Flanagan‐Cato, L. M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-04-01589.2000 · Cited by 144 · see citing works

Detection of salivary oxytocin levels in lactating women

White‐Traut, R., Watanabe, K., Pournajafi‐Nazarloo, H., Schwertz, D., Bell, A., & Carter, C. S. (2009) · Developmental Psychobiology · doi:10.1002/dev.20376 · Cited by 142 · see citing works

New roles for estrogen receptor β in behavior and neuroendocrinology☆

Bodo, C., & Rissman, E. F. (2006) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2006.02.004 · Cited by 141 · see citing works

How it’s Made: Organisational Effects of Hormones on the Developing Brain

McCarthy, M. M. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02021.x · Cited by 138 · see citing works

Do women with eating disorders who have social and flexibility difficulties really have autism? A case series

Mandy, W., & Tchanturia, K. (2015) · Molecular Autism · doi:10.1186/2040-2392-6-6 · Cited by 136 · see citing works

Understanding sex bias in autism spectrum disorder

Werling, D. M., & Geschwind, D. H. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301602110 · Cited by 135 · see citing works

Effects of estrogen on oxytocin receptor messenger ribonucleic acid expression in the uterus, pituitary, and forebrain of the female rat

Quiñones-Jenab, V., Jenab, S., Ogawa, S., Adan, R. A. M., Burbach, P. H., & Pfaff, D. W. (2008) · Neuroendocrinology · doi:10.1159/000127160 · Cited by 134 · see citing works

Sex differences in structural organization of motor systems and their dissociable links with repetitive/restricted behaviors in children with autism

Supekar, K., & Menon, V. (2015) · Molecular Autism · doi:10.1186/s13229-015-0042-z · Cited by 134 · see citing works

Dysregulation of estrogen receptor beta (ERβ), aromatase (CYP19A1), and ER co-activators in the middle frontal gyrus of autism spectrum disorder subjects

Crider, A., Thakkar, R., Ahmed, A. O., & Pillai, A. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-46 · Cited by 128 · see citing works

Gender-Dependent Effects of Maternal Immune Activation on the Behavior of Mouse Offspring

Xuan, I. C. Y., & Hampson, D. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104433 · Cited by 127 · see citing works

Sex-specific gene–environment interactions underlying ASD-like behaviors

Schaafsma, S. M., Gagnidze, K., Reyes, A., Norstedt, N., Månsson, K., Francis, K., & Pfaff, D. W. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619312114 · Cited by 126 · see citing works

Molecular genetic studies of the arginine vasopressin 1a receptor (AVPR1a) and the oxytocin receptor (OXTR) in human behaviour: from autism to altruism with some notes in between

Israel, S., Lerer, E., Shalev, I., Uzefovsky, F., Reibold, M., Bachner‐Melman, R., Granot, R., Bornstein, G., KNAFO, A., & Yirmiya, N. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00434-2 · Cited by 119 · see citing works

Does Gender Matter? A One Year Follow-up of Autistic, Attention and Anxiety Symptoms in High-Functioning Children with Autism Spectrum Disorder

May, T., Cornish, K. M., & Rinehart, N. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1964-y · Cited by 119 · see citing works

Visuo-spatial Processing in Autism—Testing the Predictions of Extreme Male Brain Theory

Falter, C. M., Plaisted, K. C., & Davis, G. J. (2007) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-007-0419-8 · Cited by 117 · see citing works

Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain

Basil, P., Li, Q., Dempster, E. L., Mill, J., Sham, P.-C., Wong, C. C. Y., & McAlonan, G. M. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.80 · Cited by 116 · see citing works

Autism Spectrum Disorder in Males with Sex Chromosome Aneuploidy: XXY/Klinefelter Syndrome, XYY, and XXYY

Tartaglia, N. R., Wilson, R., Miller, J. S., Rafalko, J., Cordeiro, L., Davis, S., Hessl, D. R., & ROSS, J. L. (2017) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0000000000000429 · Cited by 113 · see citing works

Narratives of Girls and Boys with Autism Spectrum Disorders: Gender Differences in Narrative Competence and Internal State Language

Kauschke, C., van der Beek, B., & Kamp‐Becker, I. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2620-5 · Cited by 112 · see citing works

Autism Attenuates Sex Differences in Brain Structure: A Combined Voxel-Based Morphometry and Diffusion Tensor Imaging Study

Beacher, F. D. C. C., Minati, L., Baron‐Cohen, S., Lombardo, M. V., Lai, M., Gray, M. A., Harrison, N. A., & Critchley, H. (2011) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2880 · Cited by 111 · see citing works

Recurrence rates provide evidence for sex-differential, familial genetic liability for autism spectrum disorders in multiplex families and twins

Werling, D. M., & Geschwind, D. H. (2015) · Molecular Autism · doi:10.1186/s13229-015-0004-5 · Cited by 110 · see citing works

Increased serum androstenedione in adults with autism spectrum conditions

Ruta, L., Ingudomnukul, E., Taylor, K., Chakrabarti, B., & Baron-Cohen, S. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.02.007 · Cited by 110 · see citing works

Sex Biased Gene Expression Profiling of Human Brains at Major Developmental Stages

Shi, L., Zhang, Z., & Su, B. (2016) · Scientific Reports · doi:10.1038/srep21181 · Cited by 109 · see citing works

Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation

Lee, E., Lee, H., Huang, T., Chung, C., Shin, W., Kim, K., Koh, J., Hsueh, Y., & Kim, E. (2015) · Nature Communications · doi:10.1038/ncomms8168 · Cited by 107 · see citing works

Genetic and pharmacological reactivation of the mammalian inactive X chromosome

Bhatnagar, S., Zhu, X., Ou, J., Lin, L., Chamberlain, L., Zhu, L. J., Wajapeyee, N., & Green, M. R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1413620111 · Cited by 106 · see citing works

Prenatal versus postnatal sex steroid hormone effects on autistic traits in children at 18 to 24 months of age

Auyeung, B., Ahluwalia, J., Thomson, L., Taylor, K., Hackett, G., O’Donnell, K. J., & Baron-Cohen, S. (2012) · Molecular Autism · doi:10.1186/2040-2392-3-17 · Cited by 106 · see citing works

Oxytocin receptor mRNA expression in the ventromedial hypothalamus during the estrous cycle

Bale, T., Dorsa, D. M., & Johnston, C. I. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-07-05058.1995 · Cited by 98 · see citing works

No relationship between prenatal androgen exposure and autistic traits: convergent evidence from studies of children with congenital adrenal hyperplasia and of amniotic testosterone concentrations in typically developing children

Kung, K. T. F., Spencer, D., Pasterski, V., Neufeld, S., Glover, V. A. S., O’Connor, T. G., Hindmarsh, P. C., Hughes, I. A., Acerini, C. L., & Hines, M. (2016) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12602 · Cited by 98 · see citing works

Uncovering steroidopathy in women with autism: a latent class analysis

Pohl, A., Cassidy, S., Auyeung, B., & Baron-Cohen, S. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-27 · Cited by 97 · see citing works

The effect of gender on the neuroanatomy of children with autism spectrum disorders: a support vector machine case-control study

Retico, A., Giuliano, A., Tancredi, R., Cosenza, A., Apicella, F., Narzisi, A., Biagi, L., Tosetti, M., Muratori, F., & Calderoni, S. (2016) · Molecular Autism · doi:10.1186/s13229-015-0067-3 · Cited by 97 · see citing works

Sexually dimorphic effects of prenatal exposure to lipopolysaccharide, and prenatal and postnatal exposure to propionic acid, on acoustic startle response and prepulse inhibition in adolescent rats: Relevance to autism spectrum disorders

Foley, K. A., MacFabe, D. F., Kavaliers, M., & Ossenkopp, K. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.09.032 · Cited by 96 · see citing works

Whole Exome Sequencing in Females with Autism Implicates Novel and Candidate Genes

Butler, M. G., Rafi, S. K., Hossain, W. A., Stephan, D. A., & Manzardo, A. M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16011312 · Cited by 93 · see citing works

Sociability Deficits and Altered Amygdala Circuits in Mice Lacking Pcdh10, an Autism Associated Gene

Schoch, H., Kreibich, A. S., Ferri, S. L., White, R. S., Bohorquez, D., Banerjee, A., Port, R. G., Dow, H. C., Cordero, L., Pallathra, A. A., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.06.008 · Cited by 92 · see citing works

Neonatal Immune Challenge with Lipopolysaccharide Triggers Long-lasting Sex- and Age-related Behavioral and Immune/Neurotrophic Alterations in Mice: Relevance to Autism Spectrum Disorders

Custódio, C. S., Mello, B. S. F., Filho, A. J. M. C., Lima, C. N. D. C., Cordeiro, R. C., Miyajima, F., Réus, G. Z., Vasconcelos, S. M. M., Barichello, T., Quevedo, J., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0616-1 · Cited by 92 · see citing works

Investigation of sex differences in the expression of RORA and its transcriptional targets in the brain as a potential contributor to the sex bias in autism

Hu, V. W., Sarachana, T., Sherrard, R. M., & Kocher, K. M. (2015) · Molecular Autism · doi:10.1186/2040-2392-6-7 · Cited by 90 · see citing works

Sexual divergence in microtubule function: the novel intranasal microtubule targeting SKIP normalizes axonal transport and enhances memory

Amram, N., Hacohen-Kleiman, G., Sragovich, S., Malishkevich, A., Katz, J., Touloumi, O., Lagoudaki, R., Grigoriadis, N., Giladi, E., Yeheskel, A., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.208 · Cited by 90 · see citing works

Examination of Sex Differences in a Large Sample of Young Children with Autism Spectrum Disorder and Typical Development

Reinhardt, V. P., Wetherby, A. M., Schatschneider, C., & Lord, C. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-014-2223-6 · Cited by 89 · see citing works

Association of Sex With Recurrence of Autism Spectrum Disorder Among Siblings

Palmer, N., Beam, A., Agniel, D., Eran, A., Manrai, A., Spettell, C., Steinberg, G., Mandl, K., Fox, K., Nelson, S. F., et al. (2017) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2017.2832 · Cited by 89 · see citing works

A prospective assessment of androgen levels in patients with autistic spectrum disorders: biochemical underpinnings and suggested therapies.

Geier, D. A., & Geier, M. R. (2007) · PubMed · Cited by 86 · see citing works

Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder

Nordahl, C. W., Iosif, A., Young, G. S., Perry, L. M., Dougherty, R. F., Lee, A., Li, D., Buonocore, M. H., Simon, T., Rogers, S. J., et al. (2015) · Molecular Autism · doi:10.1186/s13229-015-0005-4 · Cited by 86 · see citing works

Cellular mechanisms of estradiol-mediated masculinization of the brain

Schwarz, J. M., & McCarthy, M. M. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.03.012 · Cited by 85 · see citing works

Sex differences in cortical volume and gyrification in autism

Schaer, M., Kochalka, J., Padmanabhan, A., Supekar, K., & Menon, V. (2015) · Molecular Autism · doi:10.1186/s13229-015-0035-y · Cited by 84 · see citing works

Hyperactivity and male‐specific sleep deficits in the 16p11.2 deletion mouse model of autism

Angelakos, C. C., Watson, A. J., O'Brien, W. T., Krainock, K. S., Nickl‐Jockschat, T., & Abel, T. (2017) · Autism Research · doi:10.1002/aur.1707 · Cited by 83 · see citing works

Default Mode Hypoconnectivity Underlies a Sex-Related Autism Spectrum

Ypma, R. J. F., Moseley, R. L., Holt, R., Rughooputh, N., Floris, D. L., Chura, L. R., Spencer, M. D., Baron‐Cohen, S., Suckling, J., Bullmore, E. T., et al. (2016) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.04.006 · Cited by 82 · see citing works

Sex Differences and Autism: Brain Function during Verbal Fluency and Mental Rotation

Beacher, F., Radulescu, E., Minati, L., Baron-Cohen, S., Lombardo, M., Lai, M., Walker, A., Howard, D., Gray, M., Harrison, N., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038355 · Cited by 79 · see citing works

Androgenic Activity in Autism

Tordjman, S., Ferrari, P., Sulmont, V., Duyme, M., & Roubertoux, P. L. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.11.1626-a · Cited by 79 · see citing works

Pleiotropic Mechanisms Indicated for Sex Differences in Autism

Mitra, I., Tsang, K. M., Ladd‐Acosta, C., Croen, L., Aldinger, K. A., Hendren, R. L., Traglia, M., Lavillaureix, A., Zaitlen, N., Oldham, M. C., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006425 · Cited by 78 · see citing works

Ketogenic diets improve behaviors associated with autism spectrum disorder in a sex-specific manner in the EL mouse

Ruskin, D. N., Fortin, J. A., Bisnauth, S. N., & Masino, S. A. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.10.023 · Cited by 77 · see citing works

Germline disruption of Pten localization causes enhanced sex-dependent social motivation and increased glial production

Tilot, A. K., Gaugler, M. K., Yu, Q., Romigh, T., Yu, W., Miller, R. H., Frazier, T. W., & Eng, C. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu031 · Cited by 74 · see citing works

Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome

Steeb, H., Ramsey, J. M., Guest, P. C., Stocki, P., Cooper, J. D., Rahmoune, H., Ingudomnukul, E., Bonnie Auyeung, B., Ruta, L., Baron‐Cohen, S., et al. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-4 · Cited by 72 · see citing works

Influence of Low-Level Prenatal Exposure to PCDD/Fs and PCBs on Empathizing, Systemizing and Autistic Traits: Results from the Duisburg Birth Cohort Study

Nowack, N., Wittsiepe, J., Kasper-Sonnenberg, M., Wilhelm, M., & Schölmerich, A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0129906 · Cited by 71 · see citing works

Equivalence of symptom dimensions in females and males with autism

Frazier, T. W., & Hardan, A. Y. (2017) · Autism · doi:10.1177/1362361316660066 · Cited by 71 · see citing works

Prenatal hyperandrogenic environment induced autistic-like behavior in rat offspring

Xu, X., Zhang, H., Shou, X., Li, J., Jing, W.-L., Zhou, Y., Qian, Y., Han, S., Zhang, R., & Han, J. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.09.014 · Cited by 67 · see citing works

Microduplications at the pseudoautosomal SHOX locus in autism spectrum disorders and related neurodevelopmental conditions

Tropeano, M., Howley, D., Gazzellone, M. J., Wilson, C., Ahn, J. W., Stavropoulos, D. J., Murphy, C. M., Eis, P. S., Hatchwell, E., Dobson, R., et al. (2016) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2015-103621 · Cited by 67 · see citing works

The clinician perspective on sex differences in autism spectrum disorders

Jamison, R., Bishop, S. L., Huerta, M., & Halladay, A. K. (2017) · Autism · doi:10.1177/1362361316681481 · Cited by 67 · see citing works

Regulation of oxytocin receptor messenger ribonucleic acid in the ventromedial hypothalamus by testosterone and its metabolites

Bale, T. L., & Dorsa, D. M. (1995) · Endocrinology · doi:10.1210/endo.136.11.7588251 · Cited by 65 · see citing works

Dynamic changes in extracellular release of GABA and glutamate in the lateral septum during social play behavior in juvenile rats: Implications for sex-specific regulation of social play behavior

Bredewold, R., Schiavo, J. K., van der Hart, M., Verreij, M., & Veenema, A. H. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.052 · Cited by 64 · see citing works

Female Autism Phenotypes Investigated at Different Levels of Language and Developmental Abilities

Howe, Y. J., O’Rourke, J. A., Yatchmink, Y. E., Viscidi, E., Jones, R. N., & Morrow, E. M. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2501-y · Cited by 64 · see citing works

Cognitive, behavioral, and neural consequences of sex chromosome aneuploidy

Printzlau, F. A. B., Wolstencroft, J., & Skuse, D. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23951 · Cited by 63 · see citing works

Gender Difference in Age-Related Number of Corticotropin-Releasing Hormone-Expressing Neurons in the Human Hypothalamic Paraventricular Nucleus and the Role of Sex Hormones

Bao, A., & Swaab, D. F. (2007) · Neuroendocrinology · doi:10.1159/000099832 · Cited by 61 · see citing works

Environmental enrichment mitigates the sex-specific effects of gestational inflammation on social engagement and the hypothalamic pituitary adrenal axis-feedback system

Connors, E. J., Shaik, A. N., Migliore, M. M., & Kentner, A. C. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.020 · Cited by 61 · see citing works

The female protective effect in autism spectrum disorder is not mediated by a single genetic locus

Gockley, J., Willsey, A. J., Dong, S., Dougherty, J. D., Constantino, J. N., & Sanders, S. J. (2015) · Molecular Autism · doi:10.1186/s13229-015-0014-3 · Cited by 61 · see citing works

Umbilical cord blood androgen levels and ASD-related phenotypes at 12 and 36 months in an enriched risk cohort study

Park, B. Y., Lee, B. K., Burstyn, I., Tabb, L. P., Keelan, J. A., Whitehouse, A., Croen, L., Fallin, M. D., Hertz‐Picciotto, I., Montgomery, O. C., et al. (2017) · Molecular Autism · doi:10.1186/s13229-017-0118-z · Cited by 61 · see citing works

MeCP2 Modulates Sex Differences in the Postsynaptic Development of the Valproate Animal Model of Autism

Kim, K. C., Choi, C. S., Kim, J.-W., Han, S.-H., Cheong, J. H., Ryu, J. H., & Shin, C. Y. (2016) · Molecular Neurobiology · doi:10.1007/s12035-014-8987-z · Cited by 60 · see citing works

Autism and the amygdala: an endocrine hypothesis.

Schulkin, J. (2007) · Brain and Cognition · doi:10.1016/j.bandc.2006.02.009 · Cited by 59 · see citing works

Males are from Mars, and females are from Venus: sex-specific fetal brain gene expression signatures in a mouse model of maternal diet-induced obesity

Edlow, A. G., Guedj, F., Pennings, J. L. A., Sverdlov, D., Neri, C., & Bianchi, D. W. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.02.054 · Cited by 58 · see citing works

Behavioral and emotional problems in high-functioning girls and boys with autism spectrum disorders: Parents’ reports and adolescents’ self-reports

Pisula, E., Pudło, M., Słowińska, M., Kawa, R., Strząska, M., Banasiak, A., & Wolańczyk, T. (2016) · Autism · doi:10.1177/1362361316675119 · Cited by 57 · see citing works

The connectomes of males and females with autism spectrum disorder have significantly different white matter connectivity densities

Andrei Irimia, A., Torgerson, C. M., Jacokes, Z., & Horn, J. D. V. (2017) · Scientific Reports · doi:10.1038/srep46401 · Cited by 56 · see citing works

Perseverative responding and neuroanatomical alterations in adult heterozygous reeler mice are mitigated by neonatal estrogen administration

Macrı̀, S., Biamonte, F., Romano, E., Marino, R., Keller, F., & Laviola, G. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.03.012 · Cited by 55 · see citing works

Analysis of X chromosome inactivation in autism spectrum disorders

Gong, X., Bacchelli, E., Blasi, F., Claudio Toma, A., Betancur, C., Chaste, P., Delorme, R., Durand, C. M., Fauchereau, F., Goubran‐Botros, H., et al. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30688 · Cited by 55 · see citing works

Atypical Neural Activity in Males But Not Females with Autism Spectrum Disorder

Kirkovski, M., Enticott, P. G., Hughes, M. E., Rossell, S. L., & Fitzgerald, P. B. (2016) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2639-7 · Cited by 54 · see citing works

Increased female autosomal burden of rare copy number variants in human populations and in autism families

Desachy, G., Croen, L. A., Torres, A. R., Kharrazi, M., Delorenze, G. N., Windham, G. C., Yoshida, C. K., & Weiss, L. A. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.179 · Cited by 54 · see citing works

Sex Differences in WISC-III Profiles of Children with High-functioning Pervasive Developmental Disorders

Koyama, T., Kamio, Y., Inada, N., & Kurita, H. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0610-6 · Cited by 54 · see citing works

Early exposure to bisphenol A alters neuron and glia number in the rat prefrontal cortex of adult males, but not females

Sadowski, R. N., Wise, L. M., Park, P. Y., Schantz, S. L., & Juraska, J. M. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.08.038 · Cited by 54 · see citing works

Exploring sex differences in autistic traits: A factor analytic study of adults with autism

Grove, R., Hoekstra, R., Wierda, M., & Begeer, S. (2017) · Autism · doi:10.1177/1362361316667283 · Cited by 54 · see citing works

Sex differences in the reciprocal behaviour of children with autism

van Ommeren, T. B., Koot, H. M., Scheeren, A. M., & Begeer, S. (2016) · Autism · doi:10.1177/1362361316669622 · Cited by 53 · see citing works

NMDA receptor activation regulates sociability by its effect on mTOR signaling activity

Burket, J. A., Benson, A. D., Tang, A., & Deutsch, S. I. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.02.009 · Cited by 50 · see citing works

Fetal androgen exposure and pragmatic language ability of girls in middle childhood: Implications for the extreme male-brain theory of autism

Whitehouse, A., Maybery, M. T., Hart, R. J., Mattes, E., Newnham, J. P., Sloboda, D. M., Stanley, F. J., & Hickey, M. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.02.007 · Cited by 48 · see citing works

Elevated plasma levels of glutamate in children with autism spectrum disorders

Cai, J., Ding, L., Zhang, J., Xue, J., & Wang, L. (2016) · Neuroreport · doi:10.1097/wnr.0000000000000532 · Cited by 48 · see citing works

Lack of evidence for increased genetic loading for autism among families of affected females: A replication from family history data in two large samples

Goin-Kochel, R. P., Abbacchi, A., Constantino, J. N., & Autism Genetic Resource Exchange Consortium (2007) · Autism · doi:10.1177/1362361307076857 · Cited by 47 · see citing works

Investigating diagnostic bias in autism spectrum conditions: An item response theory analysis of sex bias in the AQ‐10

Murray, A. L., Allison, C. L., Smith, P. L., Baron‐Cohen, S., Booth, T., & Bonnie Auyeung, B. (2016) · Autism Research · doi:10.1002/aur.1724 · Cited by 47 · see citing works

Y chromosome haplogroups in autistic subjects

Jamain, S., Quach, H., Quintana‐Murci, L., Betancur, C., Philippe, A., Gillberg, C., Sponheim, E., Skjeldal, O. H., Fellous, M., Leboyer, M., et al. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000968 · Cited by 46 · see citing works

Sex Differences in the Default Mode Network with Regard to Autism Spectrum Traits: A Resting State fMRI Study

Jung, M., Mody, M., Saito, D. N., Tomoda, A., Okazawa, H., Wada, Y., & Kosaka, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143126 · Cited by 46 · see citing works

CRHR1 links peripuberty stress with deficits in social and stress-coping behaviors

Veenit, V., Riccio, O., & Sandi, C. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.02.015 · Cited by 45 · see citing works

Sex differences in frontal lobe connectivity in adults with autism spectrum conditions

Zeestraten, E., Gudbrandsen, M., Daly, E., de Schotten, M. T., Catani, M., Dell’Acqua, F., Lai, M.-C., Ruigrok, A. N. V., Lombardo, M. V., Chakrabarti, B., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.9 · Cited by 43 · see citing works

Dysregulated NMDA-Receptor Signaling Inhibits Long-Term Depression in a Mouse Model of Fragile X Syndrome

Toft, A. K. H., Lundbye, C. J., & Banke, T. G. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3038-15.2016 · Cited by 41 · see citing works

Does Gender Moderate Core Deficits in ASD? An Investigation into Restricted and Repetitive Behaviors in Girls and Boys with ASD

Harrop, C., Gulsrud, A. C., & Kasari, C. L. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2511-9 · Cited by 40 · see citing works

High (feminized) digit ratio (2D : 4D) in Danish men: a question of measurement method?

Voracek, M., & Dressler, S. G. (2006) · Human Reproduction · doi:10.1093/humrep/dei464 · Cited by 39 · see citing works

Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain

Schumann, C. M., Sharp, F. R., Ander, B. P., & Stamova, B. S. (2017) · Molecular Autism · doi:10.1186/s13229-017-0117-0 · Cited by 39 · see citing works

Diffusion tensor imaging reveals no white matter impairments among adults with autism spectrum disorder

Kirkovski, M., Enticott, P. G., Maller, J. J., Rossell, S. L., & Fitzgerald, P. B. (2015) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2015.05.003 · Cited by 36 · see citing works

Positive and negative gaze perception in autism spectrum conditions

Ashwin, C., Ricciardelli, P., & Baron-Cohen, S. (2009) · Social Neuroscience · doi:10.1080/17470910802337902 · Cited by 36 · see citing works

Acute oxytocin improves memory and gaze following in male but not female nursery-reared infant macaques

Simpson, E. A., Paukner, A., Sclafani, V., Kaburu, S., Suomi, S. J., & Ferrari, P. F. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4480-x · Cited by 36 · see citing works

Digit ratio and autism spectrum disorders in the Avon Longitudinal Study of Parents and Children: a birth cohort study

Guyatt, A. L., Heron, J., Knight, B., Golding, J., & Rai, D. (2015) · BMJ Open · doi:10.1136/bmjopen-2014-007433 · Cited by 35 · see citing works

The contribution of environmental exposure to the etiology of autism spectrum disorder

Bölte, S., Girdler, S., & Marschik, P. B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2988-4 · Cited by 509 · see citing works

Executive Function in Autism Spectrum Disorder: History, Theoretical Models, Empirical Findings, and Potential as an Endophenotype

Demetriou, E. A., DeMayo, M. M., & Guastella, A. J. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00753 · Cited by 274 · see citing works

Sex differences in neurodevelopmental disorders

May, T., Adesina, I., McGillivray, J., & Rinehart, N. J. (2019) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000714 · Cited by 235 · see citing works

Brain-based sex differences in autism spectrum disorder across the lifespan: A systematic review of structural MRI, fMRI, and DTI findings

Walsh, M. J. M., Wallace, G. L., Gallegos, S. M., & Braden, B. B. (2021) · NeuroImage: Clinical · doi:10.1016/j.nicl.2021.102719 · Cited by 97 · see citing works

Sociability Deficits and Altered Amygdala Circuits in Mice Lacking Pcdh10, an Autism Associated Gene

Schoch, H., Kreibich, A. S., Ferri, S. L., White, R. S., Bohorquez, D., Banerjee, A., Port, R. G., Dow, H. C., Cordero, L., Pallathra, A. A., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.06.008 · Cited by 92 · see citing works

Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype

Symeonides, C., Vacy, K., Thomson, S., Tanner, S., Chua, H. K., Dixit, S., Mansell, T., O’Hely, M., Novakovic, B., Herbstman, J. B., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48897-8 · Cited by 66 · see citing works

Where Sex Meets Gender: How Sex and Gender Come Together to Cause Sex Differences in Mental Illness

Christiansen, D. M., McCarthy, M. M., & Seeman, M. V. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.856436 · Cited by 65 · see citing works

Sex/gender differences in the human autistic brains: A systematic review of 20 years of neuroimaging research

Mo, K., Sadoway, T., Bonato, S., Ameis, S. H., Anagnostou, E., Lerch, J. P., Taylor, M. J., & Lai, M.-C. (2021) · NeuroImage: Clinical · doi:10.1016/j.nicl.2021.102811 · Cited by 53 · see citing works

Deep phenotyping reveals movement phenotypes in mouse neurodevelopmental models

Klibaite, U., Kislin, M., Verpeut, J. L., Bergeler, S., Sun, X., Shaevitz, J. W., & Wang, S. S.-H. (2022) · Molecular Autism · doi:10.1186/s13229-022-00492-8 · Cited by 41 · see citing works

Endocrine insights into the pathophysiology of autism spectrum disorder

Wilson, H. A., Creighton, C., Scharfman, H., Choleris, E., & MacLusky, N. J. (2021) · The Neuroscientist · doi:10.1177/1073858420952046 · Cited by 23 · see citing works

Hyperactive behavior in female rats <i>in utero</i>‐exposed to group B <i>Streptococcus</i>‐induced inflammation

Allard, M., Brochu, M., Bergeron, J. D., & Sebire, G. (2018) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2018.06.005 · Cited by 22 · see citing works

Excess Neonatal Testosterone Causes Male-Specific Social and Fear Memory Deficits in Wild-Type Mice

Quiñones-Labernik, P., Blocklinger, K. L., Bruce, M. R., Hagan, E., Preuschl, D., Tesar, C., & Ferri, S. L. (2025) · eneuro · doi:10.1523/eneuro.0020-25.2025 · Cited by 4 · see citing works

De novo and inherited variants in ZNF292 underlie a neurodevelopmental disorder with features of autism spectrum disorder

Mirzaa, G., Chong, J. X., Piton, A., Popp, B., Foss, K., Guo, H., Harripaul, R., Xia, K., Scheck, J., Aldinger, K. A., et al. (2019) · Genetics in Medicine · doi:10.1038/s41436-019-0693-9 · Cited by 49 · see citing works

Comorbid Rate of Other Neurodevelopmental Disorder with Autism Spectrum Disorder in a Total Population Sample of 5-Years-Old Children.

Terui, A. (2019) · INSAR 2019 Annual Meeting

Genetic and Neurodevelopmental Influences in Autistic Disorder

Nicolson, R., & Szatmari, P. (2003) · Canadian journal of psychiatry. Revue canadienne de psychiatrie · doi:10.1177/070674370304800804 · Cited by 68 · see citing works

Signaling pathways that are influenced by SHANK3 mutation and related treatment for autism

Han, Y. (2022) · International Conference on Biomedical and Intelligent Systems (IC-BIS) · doi:10.1117/12.2660544

Amino Acids, B Vitamins, and Choline May Independently and Collaboratively Influence the Incidence and Core Symptoms of Autism Spectrum Disorder

Jennings, L., & Basiri, R. (2022) · Nutrients · doi:10.3390/nu14142896 · Cited by 38 · see citing works