Sleep Disorders Associated With Alzheimer's Disease: A Perspective
Open accessAbstract
Sleep disturbances, as well as sleep-wake rhythm disturbances, are typical symptoms of Alzheimer's disease (AD) that may precede the other clinical signs of this neurodegenerative disease. Here, we describe clinical features of sleep disorders in AD and the relation between sleep disorders and both cognitive impairment and poor prognosis of the disease. There are difficulties of the diagnosis of sleep disorders based on sleep questionnaires, polysomnography or actigraphy in the AD patients. Typical disturbances of the neurophysiological sleep architecture in the course of the AD include deep sleep and paradoxical sleep deprivation. Among sleep disorders occurring in patients with AD, the most frequent disorders are sleep breathing disorders and restless legs syndrome. Sleep disorders may influence circadian fluctuations of the concentrations of amyloid-β in the interstitial brain fluid and in the cerebrovascular fluid related to the glymphatic brain system and production of the amyloid-β. There is accumulating evidence suggesting that disordered sleep contributes to cognitive decline and the development of AD pathology. In this mini-review, we highlight and discuss the association between sleep disorders and AD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Inflammatory reactivity could potentially be altered by sleep disturbances.
“inflammatory reactivity could potentially be altered by sleep disturbances”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [82]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The amyloid hypothesis of Alzheimer's disease at 25 years
Selkoe, D. J., & Hardy, J. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606210 · Cited by 6,164 · see citing works
Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824 · see citing works
Sleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411 · see citing works
The global prevalence of dementia: a systematic review and metaanalysis.
Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W., & Ferri, C. P. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.11.007 · Cited by 4,941 · see citing works
Karran, E., Mercken, M., & Strooper, B. D. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3505 · Cited by 2,188 · cited 1× · see citing works
“The primary event in AD is the accumulation of amyloidβ (Aβ) in the brain (Karran et al., 2011).”
BackgroundClearance systems in the brain—implications for Alzheimer disease
Tarasoff-Conway, J. M., Carare, R. O., Osorio, R. S., Glodzik, L., Butler, T., Fieremans, E., Axel, L., Rusinek, H., Nicholson, C., Zlokovic, B. V., et al. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.119 · Cited by 1,678 · see citing works
Impairment of paravascular clearance pathways in the aging brain
Kress, B. T., Iliff, J. J., Xia, M., Wang, M., Wei, H. S., Zeppenfeld, D., Xie, L., Kang, H., Xu, Q., Liew, J. A., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24271 · Cited by 1,521 · cited 1× · see citing works
“During natural sleep, there is a marked increase of the brain’s interstitial space as compared with wakefulness, possibly resulting from the shrinkage of astroglial cells (Mendelsohn and Larrick, 2013; Xie et al., 2013; Kress et al., 2014; O’Donnell et al., 2015).”
BackgroundInflammation in Neurodegenerative Disease—A Double-Edged Sword
Wyss-Coray, T., & Mucke, L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00794-8 · Cited by 1,235 · see citing works
Taoka, T., Masutani, Y., Kawai, H., Nakane, T., Matsuoka, K., Yasuno, F., Kishimoto, T., & Naganawa, S. (2017) · Japanese Journal of Radiology · doi:10.1007/s11604-017-0617-z · Cited by 1,194 · see citing works
Yaffe, K., Laffan, A. M., Harrison, S. L., Redline, S., Spira, A. P., Ensrud, K. E., Ancoli-Israel, S., & Stone, K. L. (2011) · JAMA · doi:10.1001/jama.2011.1115 · Cited by 1,137 · see citing works
Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study
Whitmer, R. A., Gunderson, E. P., Barrett-Connor, E., Quesenberry, C. P., & Yaffe, K. (2005) · BMJ · doi:10.1136/bmj.38446.466238.e0 · Cited by 1,090 · see citing works
Sleep-Disordered Breathing in Community-Dwelling Elderly
Ancoli‐Israel, S., Ancoli-Israel, S., Kripke, D. F., Kripke, D. F., Klauber, M. R., Mason, W. J., Mason, W. J., Fell, R., Fell, R., & Kaplan, O. (1991) · SLEEP · doi:10.1093/sleep/14.6.486 · Cited by 932 · see citing works
Zhao, Q.-F., Tan, L., Wang, H.-F., Jiang, T., Tan, M.-S., Tan, L., Xu, W., Li, J.-Q., Wang, J., Lai, T.-J., et al. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.09.069 · Cited by 916 · see citing works
Neuronal activity regulates the regional vulnerability to amyloid-β deposition
Bero, A. W., Yan, P., Roh, J. H., Cirrito, J. R., Stewart, F. R., Raichle, M. E., Lee, J.-M., & Holtzman, D. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2801 · Cited by 880 · see citing works
Sleep in Normal Aging and Dementia
Bliwise, D. L. (1993) · SLEEP · doi:10.1093/sleep/16.1.40 · Cited by 854 · see citing works
Midlife and Late-Life Obesity and the Risk of Dementia: Cardiovascular Health Study
Fitzpatrick, A. L., Kuller, L. H., Lopez, O. L., Diehr, P., O’Meara, E. S., Longstreth, W. T., & Luchsinger, J. A. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.582 · Cited by 796 · see citing works
Lim, A. S. P., Kowgier, M., Yu, L., Buchman, A. S., & Bennett, D. A. (2013) · Sleep · doi:10.5665/sleep.2802 · Cited by 793 · see citing works
Sleep Quality and Preclinical Alzheimer Disease
Ju, Y.-E. S., McLeland, J. S., Toedebusch, C. D., Xiong, C., Fagan, A. M., Duntley, S. P., Morris, J. C., & Holtzman, D. M. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.2334 · Cited by 744 · see citing works
Prevalence of restless legs syndrome and periodic limb movement disorder in the general population
Ohayon, M. M., & Roth, T. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00443-9 · Cited by 720 · see citing works
Self-reported sleep and β-amyloid deposition in community-dwelling older adults
Spira, A. P., Gamaldo, A. A., An, Y., Wu, M. N., Simonsick, E. M., Bilgel, M., Zhou, Y., Wong, D. F., Ferrucci, L., & Resnick, S. M. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.4258 · Cited by 570 · see citing works
β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation
Mander, B. A., Marks, S. M., Vogel, J. W., Rao, V. R., Lu, B. S., Saletin, J., Ancoli‐Israel, S., Jagust, W. J., & Walker, M. P. (2015) · Nature Neuroscience · doi:10.1038/nn.4035 · Cited by 546 · see citing works
Peter‐Derex, L., Yammine, P., Bastuji, H., & Croisile, B. (2014) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.03.007 · Cited by 457 · see citing works
The Effect of Body Posture on Brain Glymphatic Transport
Lee, H. J., Xie, L., Yu, M., Kang, H., Feng, T., Deane, R., Logan, J., Nedergaard, M., & Benveniste, H. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1625-15.2015 · Cited by 447 · see citing works
Kiviniemi, V. J., Wang, X., Korhonen, V. O., Keinänen, T., Tuovinen, T., Autio, J. A., LeVan, P., Keilholz, S. D., Zang, Y., Hennig, J., et al. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15622047 · Cited by 443 · see citing works
Sleep function: Toward elucidating an enigma
Krueger, J. M., Frank, M. G., Wisor, J. P., & Roy, S. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.08.005 · Cited by 440 · see citing works
Ooms, S., Overeem, S., Besse, K., Rikkert, M. O., Verbeek, M., & Claassen, J. A. H. R. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.1173 · Cited by 438 · see citing works
Changes in the Sleep and Waking EEGs of Nondemented and Demented Elderly Subjects
Prinz, P. N., Peskind, E. R., VITALIANO, P. P., Raskind, M. A., Eisdorfer, C., ZEMCUZNIKOV, H. N., & Gerber, C. J. (1982) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1982.tb01279.x · Cited by 367 · see citing works
Orexinergic System Dysregulation, Sleep Impairment, and Cognitive Decline in Alzheimer Disease
Liguori, C., Romigi, A., Nuccetelli, M., Zannino, S., Sancesario, G., Martorana, A., Albanese, M., Mercuri, N. B., Izzi, F., Bernardini, S., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.2510 · Cited by 355 · see citing works
Bakker, E. N. T. P., Bacskai, B. J., Arbel-Ornath, M., Aldea, R., Bedussi, B., Morris, A. W. J., Weller, R. O., & Carare, R. O. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0273-8 · Cited by 353 · see citing works
Sleep and quantitative EEG in neurodegenerative disorders
Petit, D., Gagnon, J., Fantini, M. L., Ferini‐Strambi, L., & Montplaisir, J. Y. (2004) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2004.02.001 · Cited by 349 · see citing works
Use of Wrist Activity for Monitoring Sleep/Wake in Demented Nursing-Home Patients
Ancoli‐Israel, S., Clopton, P., Klauber, M. R., Fell, R. L., & Mason, W. J. (1997) · SLEEP · doi:10.1093/sleep/20.1.24 · Cited by 348 · see citing works
Simon, M. J., & Iliff, J. J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.10.014 · Cited by 339 · see citing works
Sleep disturbance in mild to moderate Alzheimer's disease
MORAN, M., LYNCH, C., Walsh, C., Coen, R. F., Coakley, D., & LAWLOR, B. A. (2005) · Sleep Medicine · doi:10.1016/j.sleep.2004.12.005 · Cited by 337 · see citing works
Concurrent Impairments in Sleep and Memory in Amnestic Mild Cognitive Impairment
Westerberg, C. E., Mander, B. A., Florczak, S. M., Weıntraub, S., Mesulam, M. M., Zee, P. C., & Paller, K. A. (2012) · Journal of the International Neuropsychological Society · doi:10.1017/s135561771200001x · Cited by 305 · see citing works
2003-2013: A Decade of Body Mass Index, Alzheimer's Disease, and Dementia
Emmerzaal, T. L., Kiliaan, A. J., & Gustafson, D. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141086 · Cited by 295 · see citing works
Sleep Quality and 1-Year Incident Cognitive Impairment in Community-Dwelling Older Adults
Potvin, O., Lorrain, D., Forget, H., Dubé, M., Grenier, S., Préville, M., & Hudon, C. (2012) · SLEEP · doi:10.5665/sleep.1732 · Cited by 267 · see citing works
Tworoger, S. S., Lee, S., Schernhammer, E. S., & Grodstein, F. (2006) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000201850.52707.80 · Cited by 266 · see citing works
Characteristics of Sleep Disturbance in Community-Dwelling Alzheimer's Disease Patients
McCurry, S. M., Logsdon, R. G., Teri, L. L., Gibbons, L. E., Kukull, W. A., Bowen, J. D., McCormick, W. C., & Larson, E. B. (1999) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198879901200203 · Cited by 246 · see citing works
Sharma, R. A., Varga, A. W., Bubu, O. M., Pirraglia, E., Kam, K., Parekh, A., Wohlleber, M. E., Miller, M. D., Andrade, A. G., Lewis, C., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201704-0704oc · Cited by 246 · see citing works
Cooke, J. R., Ayalon, L., Palmer, B. W., Loredo, J. S., Corey‐Bloom, J., Natarajan, L., Liu, L., & Ancoli‐Israel, S. (2009) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27538 · Cited by 244 · see citing works
Protein misfolding and aggregation in Alzheimer’s disease and type 2 diabetes mellitus
Ashraf, G., Greig, N., Khan, T., Hassan, I., Tabrez, S., Shakil, S., Sheikh, I., Zaidi, S., Akram, M., Jabir, N., et al. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666140917095514 · Cited by 236 · see citing works
Self-citationLiguori, C., Mercuri, N. B., Izzi, F., Romigi, A., Cordella, A., Sancesario, G., & Placidi, F. (2017) · SLEEP · doi:10.1093/sleep/zsx011 · Cited by 215 · see citing works
Mendelsohn, A. R., & Larrick, J. W. (2013) · Rejuvenation Research · doi:10.1089/rej.2013.1530 · Cited by 206 · see citing works
Varga, A. W., Wohlleber, M. E., Giménez, S., Romero, S., Alonso, J. F., Ducca, E. L., Kam, K., Lewis, C., Tanzi, E. B., Tweardy, S., et al. (2016) · SLEEP · doi:10.5665/sleep.6240 · Cited by 203 · see citing works
Lutsey, P. L., Misialek, J. R., Mosley, T. H., Gottesman, R. F., Punjabi, N. M., Shahar, E., MacLehose, R., Ogilvie, R. P., Knopman, D., & Alonso, A. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.06.2269 · Cited by 198 · see citing works
Is there a link between sleep changes and memory in Alzheimer's disease?
Rauchs, G., Schabus, M., Parapatics, S., Bertran, F., Clochon, P., Hot, P., Denise, P., Desgranges, B., Eustache, F., Gruber, G., et al. (2008) · NeuroReport · doi:10.1097/wnr.0b013e32830867c4 · Cited by 179 · see citing works
Janssens, J.-P., Metzger, M., & Sforza, É. (2008) · Respiratory Medicine · doi:10.1016/j.rmed.2008.03.013 · Cited by 176 · see citing works
Boespflug, E. L., & Iliff, J. J. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.031 · Cited by 171 · see citing works
Usual sleep duration and cognitive function in older adults in Spain
Faubel, R., López‐García, E., Guallar‐Castillón, P., Graciani, A., Banegas, J. R., & Rodríguez‐Artalejo, F. (2009) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2009.00759.x · Cited by 169 · see citing works
Treatment of sleep apnoea syndrome decreases cognitive decline in patients with Alzheimer's disease
Troussière, A., Charley, C. M., Salleron, J., Richard, F., Delbeuck, X., Derambure, P., Pasquier, F., & Bombois, S. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-307544 · Cited by 143 · see citing works
Chuang, Y.-F., An, Y., Bilgel, M., Wong, D. F., Troncoso, J. C., O’Brien, R., Breitner, J. C. S., Ferrucci, L., Resnick, S. M., & Thambisetty, M. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.129 · Cited by 141 · see citing works
Disease Tracking Markers for Alzheimer's Disease at the Prodromal (MCI) Stage
Drago, V., Babiloni, C., Bartrés‐Faz, D., Caroli, A., Bosch, B., Hensch, T., Didic, M., Klafki, H., Pievani, M., Jovicich, J., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-0043 · Cited by 138 · see citing works
Aliev, G., Priyadarshini, M., Reddy, V., Grieg, N. H., Kaminsky, Y., Cacabelos, R., Ashraf, G., Jabir, N. R., Kamal, M. A., Nikolenko, V. N., et al. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666131227161303 · Cited by 138 · see citing works
Self-citationPolysomnographic and Subjective Sleep Markers of Mild Cognitive Impairment
Hita-Yáñez, E., Atienza, M., & Cantero, J. L. (2013) · SLEEP · doi:10.5665/sleep.2956 · Cited by 135 · see citing works
Symptoms of sleep disturbance in persons with Alzheimer's disease and normal elderly
Tractenberg, R. E., Singer, C. M., & Kaye, J. A. (2005) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2005.00445.x · Cited by 124 · see citing works
Circadian clock disruption in neurodegenerative diseases: cause and effect?
Musiek, E. S. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00029 · Cited by 120 · see citing works
Donepezil Improves Obstructive Sleep Apnea in Alzheimer Disease
Moraes, W. A. D. S., Poyares, D. R., Sukys-Claudino, L., Guilleminault, C., & Tufik, S. B. (2008) · CHEST Journal · doi:10.1378/chest.07-1446 · Cited by 117 · see citing works
Sleep-disordered breathing in normal and pathologic aging.
Hoch, C. C., Reynolds, C. F., Kupfer, D. J., Houck, P. R., Berman, S., & STACK, J. A. (1986) · PubMed · Cited by 115 · see citing works
Death by a Thousand Cuts in Alzheimer’s Disease: Hypoxia—The Prodrome
Daulatzai, M. A. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9379-2 · Cited by 111 · see citing works
Sleep-Disordered Breathing and Agitation in Institutionalized Adults With Alzheimer Disease
Gehrman, P., Martin, J. L., Shochat, T., Nolan, S., Corey‐Bloom, J., & Ancoli‐Israel, S. (2003) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200307000-00005 · Cited by 108 · see citing works
Kyrtsos, C. R., & Baras, J. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139574 · Cited by 106 · see citing works
Sleep dysfunction in Alzheimer’s disease and other dementias
McCurry, S. M., & Ancoli‐Israel, S. (2003) · Current Treatment Options in Neurology · doi:10.1007/s11940-003-0017-9 · Cited by 103 · see citing works
Møst, E. I. S., Aboudan, S., Scheltens, P., & Someren, E. J. W. V. (2012) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e318252e3ff · Cited by 100 · see citing works
Amyloid Burden in Obstructive Sleep Apnea
Yun, C., Lee, H., Lee, S. K., Kim, H., Seo, H. S., Bang, S. A., Kim, S. E., Greve, D. N., Au, R., Shin, C., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161047 · Cited by 100 · see citing works
Sleep apnea, APOE4 and Alzheimer's disease 20 years and counting?
Bliwise, D. L. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00436-1 · Cited by 96 · see citing works
Observed Sleep/Wakefulness and Severity of Dementia in an Alzheimer's Disease Special Care Unit
Bliwise, D. L., Hughes, M., McMahon, P. M., et al. (1995) · The Journals of Gerontology Series A · doi:10.1093/gerona/50a.6.m303 · Cited by 94 · see citing works
Non-rapid eye movement sleep instability in mild cognitive impairment: a pilot study
Maestri, M., Carnicelli, L., Tognoni, G., Coscio, E. D., Giorgi, F. S., Volpi, L., Economou, N.-T., Ktonas, P. Y., Ferri, R., Bonuccelli, U., et al. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2015.04.027 · Cited by 84 · see citing works
Pistollato, F., Cano, S. S., Elío, I., Vergara, M. M., Giampieri, F., & Battino, M. A. (2016) · Advances in Nutrition · doi:10.3945/an.115.011775 · Cited by 81 · see citing works
Cooke, J. R., Ancoli‐Israel, S., Liu, L., Loredo, J. S., Natarajan, L., Palmer, B. S., He, F., & Corey‐Bloom, J. (2009) · Sleep Medicine · doi:10.1016/j.sleep.2008.12.016 · Cited by 79 · see citing works
Change in Body Mass Index Before and After Alzheimer’s Disease Onset
Gu, Y., Scarmeas, N., Cosentino, S., Brandt, J., Albert, M., Blacker, D., Dubois, B., & Stern, Y. (2014) · Current Alzheimer Research · doi:10.2174/1567205010666131120110930 · Cited by 75 · see citing works
O’Donnell, J., Ding, F., & Nedergaard, M. (2015) · Current Sleep Medicine Reports · doi:10.1007/s40675-014-0004-6 · Cited by 69 · see citing works
Sleep Disturbances and Nocturnal Agitation Behaviors in Older Adults with Dementia
Rose, K. M., Beck, C. K., Tsai, P., Liem, P. H., Davila, D., Kleban, M. H., Gooneratne, N. S., Kalra, G. K., & Richards, K. C. (2011) · SLEEP · doi:10.5665/sleep.1048 · Cited by 68 · see citing works
Hassainia, F., Petit, D., Nielsen, T., et al. (2008) · European Neurology · doi:10.1159/000117446 · Cited by 67 · see citing works
Prevalence and Correlates of Periodic Limb Movements in Older Women
Claman, D. M., Redline, S. S., BLACKWELL, T. L., Ancoli‐Israel, S., Surovec, S. A., Scott, N., Cauley, J. A., Ensrud, K. E., & Stone, K. L. (2006) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26661 · Cited by 67 · see citing works
Vascular Impairment in Alzheimer's Disease: The Role of Obstructive Sleep Apnea
Buratti, L., Viticchi, G., Falsetti, L., Cagnetti, C., Luzzi, S., Bartolini, M., Provinciali, L., & Silvestrini, M. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-131046 · Cited by 65 · see citing works
Recent Updates on the Association Between Alzheimer's Disease and Vascular Dementia
Ashraf, G. M., Chibber, S., Mohammad, et al. (2016) · Medicinal Chemistry · doi:10.2174/1573406411666151030111820 · Cited by 56 · see citing works
Self-citationLongitudinal Neuropsychiatric Predictors of Death in Alzheimer’s Disease
Spalletta, G., Long, J. D., Robinson, R. G., Trequattrini, A., Pizzoli, S., Caltagirone, C., & Orfei, M. D. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150391 · Cited by 56 · see citing works
Obstructive sleep apnea associated with cerebral hypoxemia and death
Dyken, M. E., Yamada, T., Glenn, C. L., & Berger, H. A. (2004) · Neurology · doi:10.1212/01.wnl.0000106952.84223.f3 · Cited by 54 · see citing works
Daulatzai, M. A. (2012) · Sleep Disorders · doi:10.1155/2012/251096 · Cited by 51 · see citing works
Sleep apnea in Alzheimer's disease
Bliwise, D. L., Yesavage, J. A., Tinklenberg, J. R., & Dement, W. C. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90046-8 · Cited by 49 · see citing works
Tu, M.-C., Lo, C., Huang, C.-F., Hsu, Y., Huang, W., Deng, J. F., & Lee, Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175143 · Cited by 46 · see citing works
Periodic leg movements in sleep in elderly patients with Parkinsonism and Alzheimer’s disease
Bliwise, D. L., Trotti, L. M., Yesavage, J. A., & Rye, D. B. (2012) · European Journal of Neurology · doi:10.1111/j.1468-1331.2012.03673.x · Cited by 34 · see citing works
Are Sleep Disturbances Preclinical Markers of Parkinson’s Disease?
dos Santos, A. B., Kohlmeier, K. A., & Barreto, G. E. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1488-7 · Cited by 34 · see citing works
Self-citationSynopsis on the Linkage of Alzheimer's and Parkinson's Disease with Chronic Diseases
Jabir, N. R., Firoz, C. K., Baeesa, S. S., Ashraf, G. M., Akhtar, S., Kamal, W., Kamal, M. A., & Tabrez, S. S. M. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12344 · Cited by 31 · see citing works
Self-citationCurrent opinion in Alzheimer's disease therapy by nanotechnology-based approaches
Ansari, S. A., Satar, R., Perveen, A., & Ashraf, G. M. (2016) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000310 · Cited by 31 · see citing works
Self-citationRole of anti-diabetic drugs as therapeutic agents in Alzheimer's disease
Rizvi, S. M. D., Shaikh, S., Waseem, S. M. A., Shakil, S., Abuzenadah, A. M., Biswas, D., Tabrez, S. S. M., Ashraf, G. M., & Kamal, M. A. (2015) · EXCLI journal · doi:10.17179/excli2015-252 · Cited by 28 · see citing works
Self-citationAssociation of body fat composition and obstructive sleep apnea in the elderly: A longitudinal study
Martin, M. S., Roche, F., Thomas, T., et al. (2015) · Obesity · doi:10.1002/oby.21121 · Cited by 27 · see citing works
Optimal-mass-transfer-based estimation of glymphatic transport in living brain
Ratner, V., Zhu, L., Kolesov, I., Nedergaard, M., Benveniste, H., & Tannenbaum, A. (2015) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.2076289 · Cited by 25 · see citing works
Restless Legs Syndrome in a Group of Patients With Alzheimer’s Disease
Talarico, G., Canevelli, M., Tosto, G., Vanacore, N., Letteri, F., Prastaro, M., Troili, F., Gasparini, M., Lenzi, G. L., & Bruno, G. (2012) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317512470208 · Cited by 22 · see citing works
Soursou, G., Alexiou, A. T., Ashraf, G. M., Siyal, A. A., Mushtaq, G., & Kamal, M. A. (2015) · Current Drug Metabolism · doi:10.2174/138920021608151107125049 · Cited by 22 · see citing works
Self-citationAn Overview on Global Trends in Nanotechnological Approaches for Alzheimer Therapy
Ashraf, G. M., Tabrez, S. S. M., Jabir, N. R., et al. (2015) · Current Drug Metabolism · doi:10.2174/138920021608151107125757 · Cited by 21 · see citing works
Self-citationTreatment of sleeping disorders should be considered in clinical management of Parkinson's disease
dos Santos, A. B., Barreto, G. E., & Kohlmeier, K. A. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00273 · Cited by 18 · see citing works
Self-citationBhat, S. A., Kamal, M. A., Yarla, N. S., et al. (2017) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026616666161222121229 · Cited by 18 · see citing works
Self-citationKinugawa, K., Nguyen‐Michel, V., & Mariani, J. (2014) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2014.02.005 · Cited by 12 · see citing works
Profound sleep hypoxia in morbidly obese hypercapnic patients with obstructive sleep apnea.
Brzecka, A., & Sf, D. (1994) · PubMed · Cited by 8 · see citing works
Self-citationA synopsis on the linkage between age-related dementias and vascular disorders
Chibber, S., Alexiou, A. T., Alama, M. N., et al. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666160202121809 · Cited by 7 · see citing works
Taming Alzheimer's disease: New perspectives, newer horizons.
Sen, D., Majumder, A., Arora, V., Yadu, N., & Chakrabarti, R. (2017) · PubMed Central · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479 · see citing works
“It is assumed that the glymphatic system, a waste clearance pathway to eliminate soluble proteins and metabolites from the CNS, flushes amyloid beta away from the brain parenchyma during sleep (60, 81).”
BackgroundMental health in elite athletes: International Olympic Committee consensus statement (2019)
Reardon, C. L., Hainline, B., Aron, C. M., Baron, D., Baum, A. L., Bindra, A., Budgett, R., Campriani, N., Castaldelli-Maia, J. M., Currie, A., et al. (2019) · British Journal of Sports Medicine · doi:10.1136/bjsports-2019-100715 · Cited by 1,277 · see citing works
Dominguez, L. J., Veronese, N., Vernuccio, L., Catanese, G., Inzerillo, F., Salemi, G., & Barbagallo, M. (2021) · Nutrients · doi:10.3390/nu13114080 · Cited by 433 · see citing works
Circadian disruption and sleep disorders in neurodegeneration
Shen, Y., Lv, Q.-K., Xie, W.-Y., Gong, S.-Y., Zhuang, S., Liu, J.-Y., Mao, C.-J., & Liu, C.-F. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00340-6 · Cited by 171 · see citing works
Schubert, J. J., Veronese, M., Marchitelli, L., Bodini, B., Tonietto, M., Stankoff, B., Brooks, D. J., Bertoldo, A., Edison, P., & Turkheimer, F. E. (2019) · Journal of Nuclear Medicine · doi:10.2967/jnumed.118.223834 · Cited by 121 · see citing works
Lloret, M.-A., Cervera-Ferri, A., Nepomuceno, M., Monllor, P., Esteve, D., & Lloret, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031168 · Cited by 68 · see citing works
- Authors
- Brzecka, A., Leszek, J., Ashraf, G. M., Ejma, M., Ávila-Rodriguez, M. F., Yarla, N. S., Tarasov, V. V., Chubarev, V. N., Samsonova, A. N., Barreto, G. E., & Aliev, G.
- Affiliations
- University of Wrocław (PL)
- Wroclaw Medical University (PL)
- King Abdulaziz University (SA)
- Universidad del Tolima (CO)
- GITAM University (IN)
- Sechenov University (RU)
- Institute of Physiologically Active Compounds (RU)
- Pontificia Universidad Javeriana (CO)
- Corresponding author
- Aliev, Gjumrakch
- ORCID
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2018-05-31
- Volume
- 12
- Pages
- 330-330
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC5990625
- OpenAlex
- W2802855384
- Cited by
- 149
- References
- 97
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 24 · 2023: 23 · 2022: 16 · 2021: 24 · 2020: 19 · 2019: 14
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Funders
- Russian Science Foundation (14-23-00160P)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- Alzheimer's disease, sleep disorders, cognitive impairment, prognosis, sleep architecture, REM sleep deprivation, sleep-disordered breathing, restless legs syndrome, amyloid-beta, glymphatic system, circadian rhythm, polysomnography, actigraphy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
