Is Sleep Disruption a Cause or Consequence of Alzheimer’s Disease? Reviewing Its Possible Role as a Biomarker
Open accessAbstract
In recent years, the idea that sleep is critical for cognitive processing has gained strength. Alzheimer’s disease (AD) is the most common form of dementia worldwide and presents a high prevalence of sleep disturbances. However, it is difficult to establish causal relations, since a vicious circle emerges between different aspects of the disease. Nowadays, we know that sleep is crucial to consolidate memory and to remove the excess of beta-amyloid and hyperphosphorilated tau accumulated in AD patients’ brains. In this review, we discuss how sleep disturbances often precede in years some pathological traits, as well as cognitive decline, in AD. We describe the relevance of sleep to memory consolidation, focusing on changes in sleep patterns in AD in contrast to normal aging. We also analyze whether sleep alterations could be useful biomarkers to predict the risk of developing AD and we compile some sleep-related proposed biomarkers. The relevance of the analysis of the sleep microstructure is highlighted to detect specific oscillatory patterns that could be useful as AD biomarkers.
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Atypical antipsychotics have been associated with an increased risk of stroke and death in older people with dementia-related psychosis.
“Atypical antipsychotics have been associated with an increased risk of stroke and death in older people with dementia‐related psychosis.”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [64]
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Sleep dysfunction in Alzheimer’s disease and other dementias
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The role of sleep in cognitive processing: focusing on memory consolidation
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- [25]Peigneux P. Smith C. Memory Processing in Relation to Sleep Principles and Practice of Sleep Medicine 5th ed. Kryger M. Roth T. Dement W. Elsevier Saunders St Louis, MO, USA 2010 Chapter 29 335347 9781416066453
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2024 Alzheimer's disease facts and figures
(2024) · Alzheimer's & Dementia · doi:10.1002/alz.13809 · Cited by 2,536 · see citing works
ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies
Raulin, A.-C., Doss, S. V., Trottier, Z. A., Ikezu, T. C., Bu, G., & Liu, C.-C. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00574-4 · Cited by 756 · see citing works
Dominguez, L. J., Veronese, N., Vernuccio, L., Catanese, G., Inzerillo, F., Salemi, G., & Barbagallo, M. (2021) · Nutrients · doi:10.3390/nu13114080 · Cited by 433 · see citing works
Sleep disturbances and dementia risk: a multicenter study
Sindi, S., Kåreholt, I., Johansson, L., Skoog, J., Sjöberg, L., Wang, H., Johansson, B., Fratiglioni, L., Soininen, H., Solomon, A., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.05.012 · Cited by 144 · see citing works
- Authors
- Lloret, M.-A., Cervera-Ferri, A., Nepomuceno, M., Monllor, P., Esteve, D., & Lloret, A.
- Affiliations
- Department of Clinical Neurophysiology, University Clinic Hospital of Valencia, Avda. Blasco Ibanez, 17, 46010 Valencia, Spain
- Department of Human Anatomy and Embryology, Faculty of Medicine, University of Valencia, Avda. Blasco Ibanez, 15, 46010 Valencia, Spain
- Universitat de València (ES)
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-02-10
- Volume
- 21
- Issue
- 3
- Pages
- 1168
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC7037733
- OpenAlex
- W3004515622
- Cited by
- 68
- References
- 143
- Citations by year
- 2026: 10 · 2025: 6 · 2024: 12 · 2023: 13 · 2022: 11 · 2021: 10 · 2020: 3 · 2019: 2 · 2018: 1
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Repository of Digital Objects for Teaching Research and Culture (University of Valencia) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, sleep disruption, sleep disorders, biomarkers, memory consolidation, cognitive decline, amyloid-beta, hyperphosphorylated tau, normal aging, sleep microstructure, oscillatory patterns, dementia risk prediction
- MeSH terms
- Alzheimer Disease, Cognition, Humans, Memory, Sleep Wake Disorders, Biomarkers, Amyloid beta-Peptides, tau Proteins
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