Cognitive Decline, Dementia, Alzheimer’s Disease and Presbycusis: Examination of the Possible Molecular Mechanism

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Hearing Loss and Incident Dementia

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Presbycusis

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Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

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Quality-of-Life Changes and Hearing Impairment

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Hearing Improvement after Bevacizumab in Patients with Neurofibromatosis Type 2

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Hearing Loss and Cognition: The Role of Hearing Aids, Social Isolation and Depression

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Hearing Impairment and Incident Dementia and Cognitive Decline in Older Adults: The Health ABC Study

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Dementia: a global health priority - highlights from an ADI and World Health Organization report

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Relationship of Hearing Impairment to Dementia and Cognitive Dysfunction in Older Adults

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A review of causal mechanisms underlying the link between age-related hearing loss and cognitive decline

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Hearing Loss in Older Adults Affects Neural Systems Supporting Speech Comprehension

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Self‐Reported Hearing Loss, Hearing Aids, and Cognitive Decline in Elderly Adults: A 25‐Year Study

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Reactive Oxygen Species as Downstream Mediators of Angiogenic Signaling by Vascular Endothelial Growth Factor Receptor-2/KDR

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Targeting the AMPK pathway for the treatment of Type 2 diabetes

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Auditory threshold, phonologic demand, and incident dementia

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ROS-induced ROS release orchestrated by Nox4, Nox2, and mitochondria in VEGF signaling and angiogenesis

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AMPK Activation Stimulates Autophagy and Ameliorates Muscular Dystrophy in the mdx Mouse Diaphragm

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Auditory Cortex Signs of Age-Related Hearing Loss

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Ecklonia cava Ameliorates Cognitive Impairment on Amyloid β-Induced Neurotoxicity by Modulating Oxidative Stress and Synaptic Function in Institute of Cancer Research (ICR) Mice

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Exploring Therapeutic Potential of Phytoconstituents as a Gut Microbiota Modulator in the Management of Neurological and Psychological Disorders

Chandel, P., Thapa, K., Kanojia, N., Rani, L., Singh, T. G., & Rohilla, P. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.05.002 · Cited by 12 · see citing works

Differentially expressed miRNA profiles of serum-derived exosomes in patients with sudden sensorineural hearing loss

Zhang, J., Ma, H., Yang, G., Ke, J., Sun, W., Yang, L., Kuang, S., Li, H., & Yuan, W. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1177988 · Cited by 11 · see citing works

Age-related hearing loss associated with differences in the neural correlates of feature binding in visual working memory

Loughrey, D. G., Jordan, C., Ibáñez, A. M., Parra, M. A., LAWLOR, B. A., & Reilly, R. B. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.09.016 · Cited by 9 · see citing works

Role of Fibroblast Growth Factors in Neurological Disorders: Insight into Therapeutic Approaches and Molecular Mechanisms

Upadhayay, S., Soni, D., Dhureja, M., Temgire, P., Kumar, V., Arthur, R., & Kumar, P. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04962-x · Cited by 10 · see citing works

CDK10, CDK11, FOXO1, and FOXO3 Gene Expression in Alzheimer’s Disease Encephalic Samples

Fredi, B. M., de Lábio, R. W., Rasmussen, L. T., Chagas, E. F. B., Chen, E., Turecki, G., Smith, M. D. A. C., & Payão, S. L. M. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01341-9 · Cited by 10 · see citing works

Is Hearing Loss a Risk Factor for Idiopathic Parkinson’s Disease? An English Longitudinal Study of Ageing Analysis

Readman, M. R., Wan, F., Fairman, I., Linkenauger, S. A., Crawford, T. J., & Plack, C. J. (2023) · Brain Sciences · doi:10.3390/brainsci13081196 · Cited by 8 · see citing works

Activation of the Gut–Brain Interaction by Urolithin A and Its Molecular Basis

Kubota, D., Sato, M., Udono, M., Kohara, A., Kudoh, M., Ukawa, Y., Teruya, K., & Katakura, Y. (2024) · Nutrients · doi:10.3390/nu16193369 · Cited by 8 · see citing works

Glucose hypometabolism in the Auditory Pathway in Age Related Hearing Loss in the ADNI cohort

Abidin, F. N. Z., Scelsi, M. A., Dawson, S. J., & Altmann, A. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102823 · Cited by 8 · see citing works

d-Galactose and Hypoxia Induce the Early Onset of Age-Related Hearing Loss Deterioration in a Mouse Model

Batsaikhan, T., Choi, J. S., Ha, S. M., Ahn, Y., & Seo, Y. J. (2023) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-023-00547-8 · Cited by 8 · see citing works

Intranasal delivery of NGF rescues hearing impairment in aged SAMP8 mice

Castelli, V., d’Angelo, M., Zazzeroni, F., Vecchiotti, D., Alesse, E., Capece, D., Brandolini, L., Cattani, F., Aramini, A., Allegretti, M., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06100-8 · Cited by 7 · see citing works

Environmental enrichment modulates silent information regulator 1 (SIRT1) activity to attenuate central presbycusis in a rat model of normal aging

Song, M. K., Kim, Y. J., Kim, S. H., Yeo, S. G., & Kim, Y. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111552 · Cited by 7 · see citing works

Advances in Dementia Research

Ashraf, G. M. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.78252 · Cited by 6 · see citing works

Role of receptor tyrosine kinases in neurodegenerative disorders

Fu, L., & Liu, B. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18677-6.00002-6 · Cited by 6 · see citing works

Protective effect of chlorogenic acid on cognitive impairment in rats with early Alzheimer's disease via Wnt signaling pathway

Wang, L., Wang, X., Hou, L., Liu, Y., Liu, J., Zhang, D., Yao, S., & Zheng, D. (2025) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251315848 · Cited by 6 · see citing works

Machine Learning–Based Bioactivity Prediction and Descriptor-Guided Rational Design of Amyloid-β Aggregation Inhibitors

Bansal, A., Sharma, A. R., Chakraborty, A., Sunkaria, A., & Jain, A. K. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00649 · Cited by 4 · see citing works

Probucol-bile acid nanoparticles: a novel approach and promising solution to prevent cellular oxidative stress in sensorineural hearing loss

Wagle, S. R., Kovačević, B., Foster, T., Ionescu, C. M., Jones, M., Mikov, M., Wise, A. K., Mooranian, A., & Al‐Salami, H. (2024) · Journal of drug targeting · doi:10.1080/1061186x.2024.2349111 · Cited by 4 · see citing works

Global characteristics and trends of presbycusis research from 2002 to 2021: a bibliometric study.

Lv, H., Gao, Z., Wang, Y., Xie, Y., Guan, M., Liao, H., & Xu, Y. (2023) · PubMed Central · Cited by 4 · see citing works

Development of an integrative learning program for community dwelling old people with dementia

Wong, T. K. S., Yang, Y.-H., Chen, J.-H., Lee, C. K. M., Ying, Z., Liping, J., Tang, Q., & Chung, J. W. Y. (2021) · Revista Latino-Americana de Enfermagem · doi:10.1590/1518-8345.4794.3486 · Cited by 4 · see citing works

MD Simulations, DFT and Molecular Docking Studies of Schiff Base–Derived Heterocycles as Potent BuChE Inhibitors for Alzheimer's Disease

Sindhu, T. J., James, J. P., Zakiya Fathima, C., Dixit, S. R., & Kolachi, K. Y. (2026) · ChemistrySelect · doi:10.1002/slct.202503914 · Cited by 3 · see citing works

Beyond the auditory system: cognitive implications of age-related hearing loss

Paciello, F., Pisani, A., Fetoni, A. R., & Grassi, C. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1736579 · Cited by 3 · see citing works

Updates on Hearing Loss and its Rehabilitation

Ciorba, A., & Stavros Hatzopoulos, A. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.110959 · Cited by 3 · see citing works

Dysconnectivity between auditory-cognitive network associated with auditory GABA and glutamate levels in presbycusis patientsPreprint

Li, N., Ma, W., Ren, F., Li, X., Li, F., Zong, W., Wu, L., Dai, Z., Hui, S. C. N., Edden, R. A. E., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.31.466279 · Cited by 3 · see citing works

Bioinformatics approach reveals the critical role of inflammation-related genes in age-related hearing loss

Gu, X., Chen, C., Chen, Y., Zeng, C., Lin, Y., Guo, R., Xu, S., & Lin, C. (2025) · Scientific Reports · doi:10.1038/s41598-024-83428-x · Cited by 2 · see citing works

Age-related hearing loss: the complex interaction of carbohydrate metabolism in auditory and cognitive dysfunction during aging

Zou, S., Liu, Y., Xu, B., Li, J., & He, Z. (2025) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2024.35 · Cited by 2 · see citing works

Assessing the joint prevalence of dementia and hearing loss in Scotland: a growth model for public health planning

Koesters, N. B., McMenemy, A., & Johnson, C. (2023) · Journal of Public Health · doi:10.1007/s10389-023-02016-x · Cited by 2 · see citing works

When Hearing Loss Co-occurs with Dementia: Challenges and Opportunities in Diagnosis and Management

Broome, E., Burgon, C., Heffernan, E., Dening, T., Calvert, S., Rajasingam, S. L., & Henshaw, H. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.1003179 · Cited by 2 · see citing works

Hearing loss among the elderly

Lee, G. J. C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818000-6.00016-0 · Cited by 1 · see citing works

Hearing Loss and Alzheimer Disease

Stadio, A. D., Hamiter, M. J., Roccamatisi, D., & Lalwani, A. K. (2024) · Current topics in behavioral neurosciences · doi:10.1007/7854_2024_526 · Cited by 2 · see citing works

Age-related hearing loss: possible associations with Alzheimer’s disease

Ma, Y., Yang, Y., Zhou, Y.-F., Le, W., & Chai, R. (2024) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2024.24 · Cited by 1 · see citing works

Current Landscape of Indole Hybrids in the Design and Development of Anti‐Alzheimer Agents: Structural Insights, Therapeutic Potential and In Silico Studies

Bagul, A. D., Irfan, M., Jaitak, A., Asati, V., Goyal, K., & Monga, V. (2026) · Archiv der Pharmazie · doi:10.1002/ardp.70248 · Cited by 2 · see citing works

Progress On Sensorineural Hearing Loss: Mechanisms and Therapies

Zhang, Y., Li, S., Zhou, Y., Li, D., Ding, J., Qiao, R., Chen, Y., Ye, F., Wang, L., & Li, P. (2026) · Sensory Neuroscience · doi:10.1002/sen2.70030 · Cited by 1 · see citing works

A Global Burden Perspective on Obstructive Sleep Apnea, Hearing Loss, and Early-Onset Cognitive Decline

Tomaselli, A., Luca, A., Lentini, M., Lechien, J. R., Mollame, F., Caranti, A., Vicini, C., Lazzeroni, M., Capaccio, P., Iannella, G., et al. (2026) · Neurology International · doi:10.3390/neurolint18060117 · Cited by 1 · see citing works

Metabolic Syndrome and Its Biomarkers in the Development and Progression of Alzheimer’s Disease and Other Dementias

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Detection of Parkinson’s Disease in Alzheimer’s Patients Utilizing Brain Imaging

Bhatia, M., Kaur, A., Bhatia, S., Mridula, & Dwivedi, P. (2022) · Traitement du signal · doi:10.18280/ts.390439 · Cited by 1 · see citing works

Effects of C-Terminal-Ethyl-Esterification in a Snake-Venom-Based Peptide Against the Neurotoxicity of Acrolein in PC12 Cells

Bernardes, C. P., dos Santos, N. A. G., Costa, T. R., Menaldo, D. L., Sisti, F., Amstalden, M. K., Ribeiro, D. L., Antunes, L. M. G., Sampaio, S. V., & dos Santos, A. C. (2023) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-023-10517-2 · Cited by 1 · see citing works

Influences of the Global Deterioration Scale according to Routine Blood Chemistry Results

Kim, S.-G., & Park, C.-E. (2019) · Korean Journal of Clinical Laboratory Science · doi:10.15324/kjcls.2019.51.3.351

Current Perspectives in the Management of Neurodegenerative Alzheimer’s Disease: Preclinical and Clinical Status

Muthuraman, A., Ramesh, M., & Kumar, T. V. R. (2020) · Springer eBooks · doi:10.1007/978-981-15-5167-3_6

Modelling Prevalence of Dementia and Hearing Loss in ScotlandPreprint

Koesters, N. B., McMenemy, A., & Johnson, C. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3762171

Autophagy attenuates postoperative cognitive dysfunction by up-regulating cystatin C in aged rats undergoing splenectomyPreprint

Xing-hua, B., Long-yuan, Z., Chang, C., Qi, Y., & Li, Y. (2019) · Research Square · doi:10.21203/rs.2.12725/v2

The Relationship between Hearing Impairment and the Incidence of Dementia in an Elderly Community in Indonesia at 2021

Primadewi, N. (2021) · Public Health Open Access · doi:10.23880/phoa-16000195

Autophagy attenuates postoperative cognitive dysfunction by up-regulating cystatin C in aged rats undergoing splenectomyPreprint

Xing-hua, B., Long-yuan, Z., Chang, C., Qi, Y., & Li, Y. (2019) · Research Square · doi:10.21203/rs.2.12725/v3

Autophagy attenuates postoperative cognitive dysfunction by up-regulating cystatin C in aged rats undergoing splenectomyPreprint

Xing-hua, B., Long-yuan, Z., Chang, C., Qi, Y., & Li, Y. (2019) · Research Square · doi:10.21203/rs.2.12725/v1

Hafif bilişsel bozukluk ve Alzheimer hastalığında dikotik dinleme performansı

Işık, M. (2022) · Sağlık ve Yaşam Bilimleri Dergisi · doi:10.33308/2687248x.202243245

Research Progress of Age-Related Hearing Loss and Cognitive Impairment

孙, 宏. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.133630

Unlocking Memories

Lopes, I. F., Tertuliano, M. L., & Coelho, T. (2023) · Advances in medical technologies and clinical practice book series · doi:10.4018/978-1-6684-9251-2.ch012

Cochlear Amyloid-β42 Accumulation Drives Progressive Auditory Neuropathy in 5XFAD Mice: A Potential Biomarker for Early Alzheimer's DiseasePreprint

Al-Sallami, D., Aameri, R. F. H. A., Tischkau, S., Rybak, L. P., & Ramkumar, V. (2025) · Research Square · doi:10.21203/rs.3.rs-6431143/v1

Immune-metabolic perspective on the association of seven psychiatric disorders and five common auditory diseases: a bidirectional two-sample Mendelian randomization study and mediation analysis

Yang, J., Chen, Y., Dong, G., Ma, Y., Lin, R., & Yuan, Y. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120044

From genomic discovery to application in age-related hearing loss: a global bibliometric and cross-ethnic analysis

Lu, Y., Shen, J., Sou, K. H. K., Lu, H., Huang, S., & Uus, K. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1678115

Links between presbycusis and Alzheimer’s disease: what to expect from mouse models reproducing traits of both conditions?

Gómez, J. M. J., Alvarado, J. C., Fuentes‐Santamaría, V., & Lenarz, T. (2023) · German Medical Science (German Research Foundation) · doi:10.3205/23dga082

Frailty Syndrome and Oxidative Stress as Possible Links Between Age-Related Hearing Loss and Alzheimer’s Disease

Alvarado, J. C., Fuentes‐Santamaría, V., & Juiz, J. M. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.816300 · Cited by 22 · see citing works

Understanding the Relationship Between Age-Related Hearing Loss and Alzheimer’s Disease: A Narrative Review

Tarawneh, H. Y., Jayakody, D. M. P., Sohrabi, H. R., Martins, R. N., & Mulders, W. H. A. M. (2022) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-220035 · Cited by 29 · see citing works

O1‐02‐05: Presbycusis and Dementia: Results From 8 Years of Follow‐Up in the Three‐City Montpellier Study

Meusy, A., Gabelle, A., Gutierrez, L. A., Puel, J., Venail, F., & Berr, C. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.06.302 · Cited by 1 · see citing works

Alzheimer′s disease amyloid pathology correlates with higher auditory thresholds and increased oxidative stress and cochlear inflammation in a mouse model combining presbycusis and Alzheimer′s disease

Juiz, J. M., & Lenarz, T. (2023) · Laryngo-Rhino-Otologie · doi:10.1055/s-0043-1767438 · Cited by 1 · see citing works