The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Subacute Combined Degeneration, Pernicious Anemia and Gastric Neuroendocrine Tumor Occured Simultaneously Caused by Autoimmune Gastritis
Open accessAbstract
(VitB12) deficiency. There are many causes contributing to VitB12 deficiency. Autoimmune gastritis might lead to severe VitB12 malabsorption and in its advanced stage pernicious anemia (PA) may occur. Besides, long-term hypergastrinemia arising from achlorhydria in autoimmune gastritis is associated with neuroendocrine tumors (NETs). Patients diagnosed with SCD coexistent with PA and NET are seldomly reported. We describe a 34-year-old woman with an initial complaint of progressive fatigue, weakness and numbness in her limbs and disturbed gait. Physical examination revealed appearance of anemia, ataxia, decrease of superficial and deep sense, and positive Babinski's sign. Laboratory tests disclosed macrocytic anemia, elevated intrinsic factor antibody and spinal MRI showed extensive T2-weighted hyperintensity in the dorsal columns. A gastric polyp was revealed by gastroscopy and histology showed an NET in the background of severe atrophic gastritis. Symptoms of the patient were relieved by a multidisciplinary therapy. In patients with SCD, PA should be suspected and prompt further investigations to elucidate causes and direct treatment.
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Neuroendocrine and Adrenal Tumors, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology
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Autoimmune atrophic gastritis—pathogenesis, pathology and management
Neumann, W. L., Coss, E., Rugge, M., & Genta, R. M. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.101 · Cited by 406
Vitamin B12 deficiency from the perspective of a practicing hematologist
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Cancer Risk After Pernicious Anemia in the US Elderly Population
Murphy, G., Dawsey, S. M., Engels, E. A., Ricker, W., Parsons, R., Etemadi, A., Lin, S.-W., Abnet, C. C., & Freedman, N. D. (2015) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.05.040 · Cited by 180
Diagnosis and classification of pernicious anemia
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Diagnosis and treatment of macrocytic anemias in adults
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Diagnosis and classification of autoimmune gastritis
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Metadata
- Authors
- Zhang, N., Li, R.-H., Ma, L., Li, N., Shan, P.-Y., Wang, X.-B., & Liu, A.-F.
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2019-01-25
- Volume
- 13
- Pages
- 1-1
- ISSN
- 1662-453X (ISSN-L)
- OpenAlex
- W2913412265
- Cited by
- 490
- References
- 11
- FWCI
- 75.35
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhang, N., Li, R.-H., Ma, L., Li, N., Shan, P.-Y., Wang, X.-B., & Liu, A.-F. (2019). Subacute Combined Degeneration, Pernicious Anemia and Gastric Neuroendocrine Tumor Occured Simultaneously Caused by Autoimmune Gastritis. Frontiers in Neuroscience. https://doi.org/10.3389/fnins.2019.00001
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