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Neurovascular coupling and bilateral connectivity during nrem and rem sleep

Turner, Kevin L, Gheres, Kyle W, Proctor, Elizabeth A, Drew, Patrick J·2020·eLife
DOI 10.7554/elife.62071PMC PMC7758068

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Abstract

To understand how arousal state impacts cerebral hemodynamics and neurovascular coupling, we monitored neural activity, behavior, and hemodynamic signals in un-anesthetized, head-fixed mice. Mice frequently fell asleep during imaging, and these sleep events were interspersed with periods of wake. During both NREM and REM sleep, mice showed large increases in cerebral blood volume ([HbT]) and arteriole diameter relative to the awake state, two to five times larger than those evoked by sensory stimulation. During NREM, the amplitude of bilateral low-frequency oscillations in [HbT] increased markedly, and coherency between neural activity and hemodynamic signals was higher than the awake resting and REM states. Bilateral correlations in neural activity and [HbT] were highest during NREM, and lowest in the awake state. Hemodynamic signals in the cortex are strongly modulated by arousal state, and changes during sleep are substantially larger than sensory-evoked responses.

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Cited by

Sorted by citations

Authors
Turner, K. L., Gheres, K. W., Proctor, E. A., & Drew, P. J.
Affiliations
  • Department of Biomedical Engineering, The Pennsylvania State University
  • Center for Neural Engineering, The Pennsylvania State University
ORCID
Venue
eLife
Publisher
eLife Sciences Publications, Ltd
Published
2020-10-29
Volume
9
ISSN
2050-084X
DOI
10.7554/elife.62071
PMC
PMC7758068
Cited by
129
References
11
Language
en
Licence
Funders
National Institutes of Health (R01NS078168, R01NS079737)

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